Peroxiredoxin V Regulates Aco2, Acadm, and Acox1 Activity in Hypoxic Kidney

Tae‐Hoon Lee,Hee‐Young Yang,Joseph Kwon,Hoon‐In Choi,Lina Ren,Ung Yang,Byung‐Ju Park,Zae Young Ryoo 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1

Peroxiredoxin V, an atypical thioredoxin peroxidase, is widely expressed in mammalian tissues. In addition, Prdx V is localized in mitochondria, peroxisome, cytosol, and nucleus. Prdx V has been reported to protect a wide range of cellular environments as antioxidant enzyme, and its dysfunctions may be implicated in several diseases, such as cancer, inflammation, and neurodegenerative disease. Identification and relative quantification of proteins affected by Prdx V may help identify novel signaling mechanisms that are important for oxidative stress response. However, the role of Prdx V in the modulation of hypoxia‐related cellular response is not studied yet. In order to examine the function of endogenous Prdx V in hypoxic condition in vivo, we generated a transgenic mouse model with Prdx V siRNA expression controlled by U6 promoter. Of many tissues, the knockdown of Prdx V expression was displayed in kidney, lung, and liver, but not spleen and skin. We conducted on the basis of nano‐UPLC‐MSE proteomic study to identify the Prdx V‐affected protein networks in hypoxic kidneys. In this study, we identified protein networks associated with oxidative stress, fatty acid metabolism, and mitochondrial dysfunction. Our results indicated that Prdx V affected to regulation of kidney homeostasis under hypoxia stress.

치근단절제 및 역충전와동 형성방법이 치근단누출에 미치는 영향

권태경,김성교,양정옥 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.2

거골의 박리성 골연골염

하권익,한성호,양보규,김치홍,김태성 대한스포츠의학회 1995 대한스포츠의학회지 Vol.13 No.1

거골의 박리성 골연골염은 연골과 연골하골이 균열되고 관절 면으로부터 부분적 혹은 전체적으로 분리되는 병변으로 흔치 않은 병변이다. 거골의 박리성 골연골염은 잘 알려져 있음에도 불구하고, 수술적 치료의 결과에 대한 지식은 적은 편이다. 저자들은 1998년 1월부터 1992년 12월까지 만 5년간 16명, 16례의 거골 박리성 골연 골염 환자를 평균 29개월 추시관찰 및 분석하여 다음과 같은 결과를 얻었다. 1) 연령 분포는 최소 15세에서 최장 58세 였으며 평균 30세 였다. 2) 16명의 환자중 남자가 14례 여자가 2례였고 우측 거골이 10례, 좌측 거골이 6례 였다. 3) 외상과 관계있는 환자는 16례중 15례였으며 거골의 내측에 병변이 있는 경우가 10례, 외측이 6례 였으며 양측인 경우는 없었다. 4) 증상 발현후 수술까지의 기간은 최단 3개월에서 최장 7년이 였으며 평균 25.9개월 이었다. 16명 전례에서 동통을 호소하였으며 6명에서 강직 및 불안정성을 각각 호소하였다. 5) Berndt와 Harty에 의한 병변 분류는 stage Ⅰ은 없었으며 stage Ⅱ는 4례, stage Ⅲ가 7례, stage Ⅳ는 5례로 stage Ⅲ이 가장 많았다. 6) 치료는 관절 개방술에 의한 절제술(1례), 절제술과 소파술 및 다발성 천공술(8례), 절제술 및 소파술 (3례), 소파술 및 bone peg(1례), 관절경적 소파술 및 다발성 천공술 (3례) 시행하였으며 치료결과는 O'Farrell 등이 사용한 평가 방법에 의하면 우수 13례 (81%), 양호 2례(12.5%), 불량 1례 (6.5%)였다. Osteochondritis dissecans of the talus is defined as a subchondral bony lesion of small fragment of bone, usually under two centimetres in diameter, with overlying intact articular cartilage. This fragment then becomes separated from its bed and undergoes necrosis. Although the lesion of osteochondritis dissecans of the talus is well known, there is little information in the literature concerning the results of surgical treatment. Sixteen cases of osteochondritis dissecans of the talus, operated on between January 1988 and December 1992, were studied. All were available for follow-up an average 29 months later and clinical analysis were as follows; 1. Age incidence was distributed from 15 years to 58 years (average 28) 2. 16 patients (14 male, 2 female) were examined and followed-up ; in ten the right ankle was involved and six the left ankle. 3. Of the 16 patients, 14 patients were associated with a history of trauma and 10 patients had medial lesions and 6 patients, lateral lesions. 4. The duration of symptom on these cases ranged from 3 months to 7 years, with an average of 25.9 months. All patients complain of pain when using the ankle and 6 patients complain of stiffness of the ankle and sensation of Berndt and Harty, four ankles had a stage Ⅱ lesion, nine had a stage Ⅲ lesion and five had a stage Ⅳ lesion. 6. The methods of treatment were excision (1 case), excision, curettage and drilling (8 cases), excision and curettage (3 cases), curettage with bone pegging (1 case) and arthroscopic curettage and drilling (3 cases). According to O'Farrell grading system which combined subjective with the objective assessment, 13 patients (81%) had good results, 2 patients (12.5%) had fair results, and 1 patient (6.5%) had a poor result.

환자의 마취전후 병력 또는 불편요서의 현황(2)

강태훈,양홍석,김진윤,최병권,조형상 중앙대부설한국의과학연구소 1990 한국의과학 Vol.22 No.4

잡음환경을 적용한 음성인식기 구현

김태윤,권태휘,권영헌,양성일,이건상 한양대학교 이학기술연구소 2002 이학기술연구지 Vol.4 No.-

조용한 환경에서 훈련된 음성인식시스템은 여러 종류의 잡음이 섞인 실생활에서 적용될 경우 급격히 성능이 저하된다. 본 연구에서는 여러 대역별 소음을 추가한 음성으로 훈련된 모델들을 가지고서, 다양한 잡음에 대한 인식실험을 수행하여 잡음환경에 따른 인식률의 상관관계를 구하였다. 깨끗한 음성에 비해 40-45snr의 잡음을 인식엔진에 추가하였을 경우 17%의 인식률 향상을 보였다. A Speech recognition systems trained in the silent environment may seriously degrade performance at real world wit various. In this paper, we make a recognition experiment for the various noises using the model trained with a multiple range of noises and find the correlation between noise environment and recogniton rate. Comparing with clean speech, there is an impovement by 17% when we insert noise into recognition engine with 40-45snr

High Pressure Liquid Chromatography에 의한 김치중의 Nitrosodimethylamine의 檢出

李泰圭,權泰英,梁熙天 又石大學校 1983 論文集 Vol.5 No.-

Winter Kimchi added with salted Anchovy was fermented for 25 days at 5℃. Then, this Kimchi was gone under the process of steam distillation with alkaline condictions, and High Pressure Liquid Chromatography was employed to detect nitrosodimethylamine(NDMA). It was concluded that NDMA contents and recovery ratio were 0.15ppm and 61.0%, repectively. Sucrose and radish juice effected on the formation of NDMA in Kimchi.

복합재료-금속 접착접합부의 피로손상의 실시간 평가기법

김태현,권오양 韓國非破壞檢査學會 1999 한국비파괴검사학회지 Vol.19 No.6

복합재료-금속 접착접합부가 사용 중 반복하중을 받을 때 발생하는 피로손상을 실시간에 평가할 수 있는 기법으로 음향초음파(acousto-ultrasonics: AU)법을 채택하였으며, 피로시험 중의 단일겹치기(single-lap) 및 이중겹치기(double-lap) 평판형 시험편에서 취득한 신호로부터 계산된 음향초음파변수(acousto-ultrasonic parameters: AUP)와 피로손상도 사이의 상관관계를 나타내는 곡선을 얻을 수 있었다. 곡선은 피로손상에 의한 고분자기지 복합재료의 강성율 저하(E/E )를 나타내는 곡선과 매우 유사하며, 이를 바탕으로 피로손상도의 실시간 예측이 가능하다. 다만 단일겹치기 시험편의 경우에는 Amplitude와 AUP2를, 이중겹치기 시험편의 경우에는 Amplitude와 AUP1을 기준 변수로 채택할 때 보다 일관성 있는 결과를 얻고 있는 점으로부터 실제 구조물에 적용함에 있어서는 각각의 형상에 따른 최적 변수를 선택하여 활용해야 할 것으로 사료된다. One of the problems for practical use of fiber-reinforced plastics is the performance degradation by fatigue damage in the joints. The study is to develop a nondestructive technique for real-time evaluation of adhesively bonded composite-metal joints. From the prior study we confirmed that the bonding strength can be estimated from the correlation between the quality of bonded parts and AUP's. We obtained a curve showing the correlation between the degree of fatigue damage and AUP's calculated from signals acquired during fatigue loading of single-lap and double-lap joints of CFRP and Al6061. The curve is an analogy to the one showing stiffness reduction (E/E ) of polymer matrix composites by fatigue damage. From those facts, it is plausible to predict the degree of fatigue damage in real-time. Amplitude and AUP2 appeared to be optimal parameters to provide more reliable results for single-lap joints whereas Amplitude and AUP2 did for double-lap joints. It is recommended to select optimal parameters for different geometries in the application for real structures.

한국어 명칭말하기 검사 개발과 타당도 및 신뢰도 평가

김태유,김상윤,최성혜,양동원,김재우,손정은,임병훈,인연권 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.2

Background: Confrontational naming test is useful in evaluating the language function. It reveals memory and cognitive processing dysfunctions in many neurologic diseases including dementia. Although the Korean version of the Boston Naming Test (K-BNT) has been a popular and useful test, it takes much time and effort in dementia patients of moderate to severe stage of disease or in elderly individual with low educational level. So we developed the Korean Naming Test (KNT). Methods: KNT consists of relatively easy 40 items. Each item was familar materials around us and simplified figures with black thick line. Ninety two of probable Alzheimer's patients received the Korean version of Mini-Mental State Examination (K-MMSE), the Korean version of expanded Clinical Dementia Rating Scale (CDR), K-BNT and KNT. We tested reliability and validity of KNT and also evaluated scores of the KNT along with CDR. Results: The KNT correlated with K-BNT [0.75(p;0.01)], CDR [-0.49(p;0.01)], K-MMSE [0.55(p;0.01)]. The internal consistency was 0.91 (Cronbach's alpha). The KNT score decreased as the disease progressed. Conclusions: The KNT is a brief and good test for evaluating language function of moderate to severe dementia patients with low educational level. Also it is sensitive to mild stage of disease and has a excellent reliability and validity.

A. 高校 科學 (生物·地球科學) 및 數學科 探究學習의 評價模型 定立과 評價紙 開發

李相協,權炳奎,林在圭,孫文求,吳岱燮,楊洪準,梁承榮,姜用熙,林成圭,金正遠,金吉民,兪正在 경북대학교 과학교육연구소 1982 科學敎育硏究誌 Vol.6 No.-

Currently the evaluation of high school science and mathematics learning has been too much knowledge-centered without concerning the inquiring ability or scientific attitude. This study, therefore, was made for the purpose of establishing of evaluation model for high school science (biology and earth science) and mathematics learning and its evaluation items. In this paper, the research was done about three fields, biology, earth science and mathematics. 1. For the biology, the evaluation methods of inquiry learning were studied with the foreign references, and proper evaluation items were suggested. 2. For the earth science, after analizing 5 kinds of earth science textbook of current using in high school, essential 19 items were selected. 5 of them were tested in test group and control group, then, the results were analized. 3. For the mathematice, the teaching elements of「Set」and「Flow chart」in mathematics (Ⅰ) were selected and structured. Detailed teaching objects were established and evaluation items were introduced.

새로운 Ca^2+ 길항제의 혈압강하효과

함원훈,임태균,정윤성,정윤호,양재권,최원철 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1

Diltiazem and nifedipine, have been used throughout the world as an effective antianginal and antihypertensive agent. In order to increase the activity of these drugs, we synthesized the diltiazem-nifedipine coupling compounds. These compounds^(1-8) were tested for antihypertensive effect. Unfortunately, these compounds didn't show any promising activities.