2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242) induces apoptosis via modulating E7 expression and inhibition of PI3K/Akt pathway in SiHa human cervical cancer cells.

Kim, Man Sub,Kim, Jung Hee,Bak, Yesol,Park, Yun Sun,Lee, Dong Hun,Kang, Jeong Woo,Shim, Jung-Hyun,Jeong, Heon Sang,Hong, Jin Tae,Yoon, Do Young Lawrence Erlbaum Associates, Publishers [etc.] 2012 Nutrition and cancer Vol.64 No.8

<P>The Maillard reaction is a chemical reaction occurring between an amino acid and a reducing sugar, usually requiring thermal processing. Maillard reaction products (MRPs) have antioxidant, antimutagenic, and antibacterial effects, and although 2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242), a fructose-tyrosine MRP, appears to inhibit proliferation of cancer cells, its mechanism of action has not been studied in detail. We found that HPB242 treatment modulated expression of cyclins and tumor suppressor genes in SiHa human cervical cancer cell lines: cyclins and phospho-pRB were downregulated, whereas the expression of CDK inhibitors and p53 was enhanced. HPB242 induced apoptosis dose-dependently by suppressing E7 expression and leading to sub-G1 cell-cycle arrest in SiHa cell lines; treatment also led to the proteolytic cleavage of caspase-3, -9, and poly (ADP-ribose) polymerase. Moreover, HPB242 upregulated Fas expression, altered expressions of pro- and antiapoptotic factors, and also inhibited nuclear translocation of nuclear factor κB and phosphorylation of IκB. HPB242 treatment decreased phosphatidyl inositol-3 kinase and p-Akt expression levels, demonstrating that this survival pathway may also be inhibited by HPB242. Cumulatively, HPB242 promotes apoptosis by influencing E7 expression, inducing cell-cycle arrest at sub-G1 phase, and promoting both intrinsic (mitochondrial) and extrinsic (Fas-dependent) apoptosis in SiHa human cervical cancer cells.</P>

Causal Relationships between Firms Performance, Usage Level, and Customer Satisfaction in the Organizational Market of Hospitality

Kim,See-hyung,Kwock,Yong-sub,Kim,Young-tae 한국문화관광학회 2000 문화관광연구 Vol.2 No.1

The objectives of this study were to develop theoretical model that outlined the antecedents of satisfaction in an industrial buying context, to investigate product usage level as an outcome of the two economic factors, and to examine the relationships of product, usage level and service factor with customer satisfaction as the organizational market for hospitality is growing. To figure out the relevant constructs and variables for this study, related literature was reviewed. Then, to satisfy the purposes of the study, structural equation modeling method was utilized with a confirmatory factor analysis. A confirmatory factor analysis examined a four-factor solution developed from the factor analysis. Also, goodness-of-fits for measurement model and structural model were evaluated to test the reliability of both models. The various measures of overall model goodness-of-fit lend acceptable level of support to deeming the results an acceptable representation of the hypothesized constructs. Based on the acceptable level of support for the goodness-of-fit tests, the relationships among the constructs in the model were examined. Finally, two alternative models were proposed and compared to the original model.

특수체육 전공자들의 윤리적 민감성에 영향을 미치는 요인 분석

김지태 ( Ji Tae Kim ),이원섭 ( Won Sub Lee ) 한국특수체육학회 2012 한국특수체육학회지 Vol.20 No.1

이 연구는 특수체육 전공자들의 인구사회학적 특성에 따른 윤리적 민감성의 차이를 분석하고, 특수체육 전공자들의 개인적 요인과 조직적 요인이 윤리적 민감성에 어떠한 영향을 미치는지를 분석하는 것을 연구의 목적으로 하였다. 연구대상자는 2011년 현재 한국특수체육학회에 등록된 특수체육 전공자들을 모집단으로 하여 유목적 표집법(purposive sampling method)에 의해 추출된 특수체육 전공자 200명 이었다. 이에 수집된 자료 중조사내용 일부가 누락되었거나 불성실하게 답변한 23부를 제외한 총 177부의 자료를 최종 유효 표본으로 사용하였다. 이 연구의 조사도구로는 선행연구에서 조사된 설문지를 수정 및 보완하여 사용하였고, 조사절차는 연구자가 직접 기관을 방문하여 연구대상자들에게 설문에 대한 충분한 안내와 함께 설문참여에 대한 동의를 구한 후, 설문지를 배포하여 자기평가기입법으로 작성하게 한 후 현장에서 즉시 회수하였다. 조사된 자료의 분석방법은 SPSS WIN Ver 18.0 통계프로그램을 사용하여 독립 t-검증(independent t-test), 일원분산분석(one-way ANOVA), 상관관계분석(correlation analysis), 위계적 다중회귀분선(hierarchical multiple regression) 등을 활용하였으며, 그 결과 다음과 같은 결론에 도달하였다. 첫째, 특수체육 전공자들의 인구사회학적 변인 중 연령, 직업 경력, 윤리교육 유/무는 윤리적 민감성에 유의한 차이를 나타냈다. 둘째, 특수체육 전공자들의 개인적 요인과 조직적 요인은 윤리적 민감성에 영향을 미치는 것으로 나타났다. 구체적으로 살펴보면, 개인적 요인으로는 통제위치에서 정(+)적으로 마키아벨리즘에서 부(-)적으로 윤리적 민감성에서 유의한 영향을 미치는 것으로 나타났으며, 조직적 요인은 윤리풍토의 하위요인 중 하나인 원칙주의에서 정(+)적으로 유의한 영향을 미치는 것으로 나타났다. The purpose of this study was to analyze factors that affect ethical sensibility of adapted physical education majors. The population of this study was set to be apecial physical education majors who are registered in Korean Society of Adapted Physical Activity and Exercise (KOSAPE) in 2011. Data collection was done by using widely-used purposive sampling method, from non-probability sampling methods to extract 200 copies in total from adapted physical education majors who have participated in spring and autumn symposium and who are currently working in Korea Sports Association for the Disabled (KOSAD) or related institutions. Here, 177 copies were used as the final valid samples for quantitative research, disregarding 23 incomplete copies. As the research methods, surveys that are revised and complemented ones from the previous researches, research procedures included visiting institutions and asking for agreement after explaining about surveys, and then distributing surveys to be completed by self- administered method and taking them back at sight. For the data analysis of this study, SPSS WIN Ver 18.0 was used with independent t-test, one-way ANOVA, correlation analysis, and hierarchical multiple regression, to reach the following conclusion. First, age, job experiences, and whether they received ethics lessons out of variables of population sociology for Special Physical Education majors have shown meaningful differences on ethical sensibility. Second, individual factors and institutional factors were found out to be affecting ethical sensibility. Upon the individual factors, while locus of control was affecting ethical sensibility positively and Machiavellism was affecting ethical sensibility negatively. And on the institutional factors, principlism, one of the sub-factors of ethical climate, was influencing ethical sensibility.

SPIM 벡터제어를 위한 태양광 발전 시스템

고재섭(Jae-Sub Ko),최정식(Jung-Sik Choi),정병진(Byung-Jin Jung),김도연(Do-Yeon Kim),박기태(Ki-Tae Park),최정훈(Jung-Hoon Choi),정동화(Dong-Hwa Chung) 한국조명·전기설비학회 2007 한국조명·전기설비학회 학술대회논문집 Vol.2007 No.11월

This paper presents the photovoltaic(PV) water pumping system with a maximum power point tracking(MPPT). The water pumping system uses a variable speed single phase induction motor(SPIM) driven a centrifugal pump by field oriented control(FOC) inverter. The MPPT using a DC-DC converter controlled the duty cycle to track maximum power from PV under different insolation conditions. The duty cycle directly relate with a flux producing current control(i<SUB>ds</SUB>). The FOC inverter uses a current control voltage source inverter(CC-VSI). The simulation results are shown that the characteristics and performance of drive system, which varies as each conditions of light by expresses in voltage(V<SUB>dq</SUB>), current(I<SUB>dq</SUB>), speed of motor and torque.

유기질비료 시비량에 따른 오미자 묘목의 초기 생육특성에 관한 연구

이경아,박태호,박성용,김도현,오문국,김민수,안태진,이상원,김영국,안영섭,박충범,차선우,송범헌 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.1

This study was carried out to have basic and applied informations to find the optimum nitrogen fertilization level for organic cultivation and to investigate early growth characteristics of Schizandra chinensis Baillon. Different application levels of the organic fertilizer were based on the recommended rate of N fertilizer. Five different levels of the organic fertilizer were applied to S. chinensis and early growth responses such as the length of vine, the diameter of vine, the number of leaves, and the number of branches were investigated. Lengths of main and total vines were shown longer at the level of 1.0 time organic fertilizer than those at others. The vine length at early growth was the highest at the level of 1.0 time organic fertilizer among the treatments. Stem diameter was shown thicker level of 1.0 time organic fertilizer than others on August and September, whereas on October it was the thickest in the conventional cultivation. Number of leaf was increased higher at the level of 1.0 and 2.0 times organic fertilizer than that in the compared to conventional. The number of branches was appeared the lowest at the level of 1.0 time organic fertilizer at early growth, however they were increased through progressing their growth stages. They were not significantly difference among the treatments except for the level of 2.0 times organic fertilizer. Based on the research results, the growth of S. chinensis was commonly higher at the level of 1.0 time organic fertilizer compared to other treatments.

IPMSM 드라이브의 최대토크를 위한 적응 FNN 제어기

김도연(Do-Yeon Kim),고재섭(Jae-Sub Ko),최정식(Jung-Sik Choi),정병진(Byung-Jin Jung),박기태(Ki-Tae Park),최정훈(Jung-Hoon Choi),정동화(Dong-Hwa Chung) 한국조명·전기설비학회 2007 한국조명·전기설비학회 학술대회논문집 Vol.2007 No.11월

Interior permanent magnet synchronous motor(IPMSM) has become a popular choice in electric vehicle applications, due to their excellent power to weight ratio. This paper proposes maximum torque control of IPMSM drive using adaptive fuzzy neural network controller and artificial neural network(ANN). This control method is applicable over the entire speed range which considered the limits of the inverter's current and voltage rated value. For each control mode, a condition that determines the optimal d-axis current i<SUB>d</SUB> for maximum torque operation is derived. This paper considers the design and implementation of novel technique of high performance speed control for IPMSM using Adaptive-FNN controller and ANN controller. The hybrid combination of neural network and fuzzy control will produce a powerful representation flexibility and numerical processing capability. Also, this paper proposes speed control of IPMSM using Adaptive-FNN and estimation of speed using ANN controller. The back propagation neural network technique is used to provide a real time adaptive estimation of the motor speed. The proposed control algorithm is applied to IPMSM drive system controlled Adaptive-FNN and ANN controller, the operating characteristics controlled by maximum torque control are examined in detail. Also, this paper proposes the analysis results to verify the effectiveness of the Adaptive-FNN and ANN controller.

척추분리증이 동반된 요추 추간판 탈출증

신병준,김광섭,윤태경,이재철,김경제,김연일 대한척추외과학회 2001 대한척추외과학회지 Vol.8 No.1

연구계획 : 척추분리증이 동반되어 있는 추간판탈출증의 수술적 치료에 관한 후 후향적 연구이다. 연구목적 : 본 연구의 목적은 추간판탈출증 환자 중 척추분리증이 동반되어 있는 빈도를 알아보고, 추간판탈출증을 단순히 수핵제거술 만으로 치료한 경우에 단순한 추간판탈출증의 치료에 비하여 예후에 차이가 있는지를 비교하고자 하였다. 대상 및 방법 : 1989년 3월부터 1999년 2월까지 수핵제거술을 시행받은 환자 273명 중 척추분리증이 있으나, 척추불안정이 없고, 1년 이상 추시 관찰이 가능하였던 9명을 대상으로 하였다. 남자가 5명, 여자가 4명이었고, 평균 연령은 42.7세(30세 64세)였고, 평균 추시 기간은 54.6개월(15개월 114개월)이었다. 추간판탈출의 형태, 척추분리증이 있는 부위 등을 조사하였고 환자들의 이환 기간, 증상의 정도 및 양상, 신경학적 소견 등을 술 전 및 추시 시의 결과를 Kim등의 평가기준에 따라 평가하였다. 결과 : 척추분리증이 동반된 추간판탈출증의 비율은 3.7%로 나타났다. 임상적 증상을 보면 동통은 7례(78%)에서 양성이었는데, visual analogue scale에 의한 통증평가의 평균은 술전 2.1(0 8), 최종 2.1(0 5)이었고, 방사등 9례(100%)모두에서 나타났으며 통증평가의 평균은 술전 7.6(4 10)에서 최종 0.8(0 3)로 호전되었다. 하지 직거상 검사상 7례(78%)에서 양성 소견을 보였고 7명 모두에서 증상의 호전이 있었다. 근력의 약화는 6례(67%)에서 관찰되었는데 6례모두 증상의 호전이 있었다. 감각의 저하는 8례(89%)에서 나타났으며 ?M 우 7례는 증상의 호전을 보였다. 심부 건반사의 이상은 5례(56%)에서나타났으며 2례에서 증상의 호전을 보였다. 임상적 결과는 탁월 2명, 우수 6명, 양호가 1명이었다 결론 : 추간판탈출증에서 척추분리증이 동반된 비율은 3.7%로 일반적인 척추분리증의 빈도와 큰 차이는 없었다. 술후 임상증상의 회복율이나 동통지수의 변화를 볼 때 척추분리증이 동반된 추간판탈출증환자들의 수술결과도 일반적으로 추간판탈출증만이 있는 환자를 치료한 결과와 큰 차이가 없는 것으로 보아 척추분리증이 동반되었다고 하여 척추고정술을 고려하는 등 추간판탈출증 자체의 수술방법을 변경할 필요는 없다고 판단된다. Study Design : This is a retrospective study determining the surgical result of lumbar HlVD associated with spondylolysis. Objectives : To analyze the incidence of lumbar HlVD associated with spondylolysis and to compare the results of open discectomy for lumbar HlVD associated with spondylolysis to simple lumbar HlVD. Summary of Literature Review : Lumbar HlVD associated with spondylolysis need be treated by spinal fusion. Materials and Methods : Nine patients(5 males and 4 females) who had lumbar HlVD with spondylolysis, no instability. follow-up period of 1yr were identified out of 273 patients with lumbar HlVD, treated by open discectomy from March 1989 to Feb. 1999. The type of HlVD and level of spondylolysis were evaluated, the clinical symptoms and signs including SLR. motor deficit, sensory deficit, change of DTR and severity of radiating pain were periodically followed up on the predesigned protocoL Results : The incidence of lumbar HlVD associated with spondylolysis is 3.7%. The recovery of back pain was 2.1 to 2.1 by visual analogue scale, radiating pain was 7.6 to 0.8. The recovery rate of SLR was 100%, motor deficit; 100%. sensory deficit: 85%, change of DTR 4O%. The clinical evaluation was excellent(2), good(6). fair(1). Conclusions : According to the recovery rate of the clinical symptoms, the results of open discectomy for lumbar HlVD associated with spondylolysis without spinal instability and simple HIVD was not different. Therefore, we conclude that lumbar HlVD associated with spondylolysis need not be treated by spinal fusion.

사업장(事業場) 근로자(勤勞者)의 사상체질(四象體質)에 따른 생활습관(生活習慣), 자각증상(自覺症狀), 건강인식(健康認識)에 관(關)한 연구(硏究)

서명효,강홍구,장두섭,왕명자,차남현,김삼태,권소희,정해경,송용선,이기남,Seo Muoung-Hoy,Kang Hong-Goo,Jahng Doo-Sub,Wang Myoung-Ja,Cha Nam-Hyun,Kim Sam-Tae,Kwon So-Hee,Jung Hae-Kyoung,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2003 대한예방한의학회지 Vol.7 No.2

The study was conducted to evaluate the difference of life style, subjective symptoms and health cognition depending on the Sasang Constitution in the industrial workers. The results were as follows ; Constitutional distribution among exposed group were Tae-eum In(38.4%), So-eum In(35.2%), and So-yang In(26.4%) and it was turned out that Tae-eum In took a higher portion of Sasang constitution than other constitutions in technician workers. 'Exercise' and 'Obesity' were found most in Tae-eum In, In So-eum In there were many 'Normal' weight and 'Having digestive disorders' were found most in So-eum In. There were no significant difference in the health cognition among the constitutions. The closer to 'normal' weight, the higher prevalence in 'having' concern about health condition and the more 'normal' condition in sleeping, the higher prevalence of 'having' self-confident in present health.

大學 男女 球技選手들의 最大無機的 Power

김태운,유재충,안덕균,선우섭,이한,손두욱,박충서 慶熙大學校 社會體育硏究所 1994 體育科學論叢 Vol.- No.7

The purpose of the present research is to compare characteristics of maximal anaerobic power observed in different types of sports and player's sex differences. We have reached the following conclusions from the results we obtained by measuring maximal anaerobic power and blood lactate concentration of 60 elite university male and female players during the exercise of bicycle ergometer: 1. As to absolute and relative values of maximal anaerobic power, male players are higher in the order of rugby and handball, whereas female players are higher in the order of hockey and soccer, but no significant differences are observed between types of sports. 2. Male players are noticably higher in absolute values of maximal anaerobic power(p<0.001), but relative value is very simi1ar to that of female players. 3. It is estimated that the fact, that female players show obvious higher mean anaerobic power(p<0.001) during the 3,4KP excercise is due to sex differences in ocdurrence work load of maximal anaerobic power. 4. Comparison of blood lactate concentration at each work load in different types of sports and player's sex differences show an increase in proportion to mean anaerobic power. The results given above clearly show the differences between the type of sports such as rugby and hockey requiring power and speed, and the type of sports such as handball and soccer requiring edurance.

여러가지 전해질-금속이온의 착물화(제2보),수용액중에서 Poly(ethyleneimine)-Ni(Ⅱ),-Cu(Ⅱ)및-Pd(Ⅱ)이온의 생성상수

김동수,조태섭 嶺南大學校附設 基礎科學硏究所 1985 基礎科學硏究 Vol.5 No.-

The Complexation of poly (ethyleneimine) (PEI) with copper (Ⅱ), nickel(Ⅱ) and palladium(Ⅱ) ions was studied in 1M KCL at 25℃. The potentiometrically determind logarithms of the overall formation constants (log ??) at 6.0 and 10.0 mole ratio of PEI/M(Ⅱ) was as follows: 13.94 and 11.20 for log K₂ of PEI ??, 18.97 or log K₃ and 12.12 for log K₂ of PEI ??, and 13.98 and 11.08 for log K₂ of PEI-??, respectively The order of successive formation constants was increased as follows: when mole ratio of PEI/M(Ⅱ) is 6.0, Ni<Cu<Pd for log k₁ and Pd<Cu<Ni for log k₂; when mole ratio of PEI/M(Ⅱ) is 10.0, Pd??Cu<Ni for log k₁ and log k₂.