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      • Lipopolysaccharide 로 유발된 생쥐 무릎관절낭 염증에 관한 형태학적 연구 : 윤활관절막과 섬유관절막의 변화를 중심으로 Based on the Morphological Changes of Synovial Membrane and Fibrous Membrane

        김진택,안상현,최난희,정재만,박인식,강윤호,김호현,이해풍 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2

        본 연구는 관절염 유발시 일어나는 관절낭의 형태학적 변화를 조사하기위해 ljpopolysaccharide(LPS)주사로 인위적 관절낭 염증을 유발시킨 후 시간경과에 따른 윤활관절막과 섬유관절막의 형태 변화를 관찰하였다. BALB/C 암컷 생쥐 오른쪽 무릎관절낭에 LPS 300㎍/㎏를 주사한 후 3, 7 그리고 14일에 무릎관절을 얻었다. 무릎관절은 4주동안 EDTA용액에 탈회한 후 통상적 방법으로 paraffin에 포매하였다. 또한 윤활관절막의 미세구조변화는 embed812로 포매한 후 관찰하였다. LPS 주사후 관절연골 인접부위의 윤활관절막에서 시작된 세포과형성(hyperplasia)은 시간 경과후 전체 윤활관절막으로 확대되었다. 윤활관절막내의 미세구조의 변화로는 윤활포식세포(type 1)가 관절강내로의 많은 돌기(filopodia)를 내었고, 잘 발달된 과립형질내세망을 가지는 type 2 윤활분비세포의 숫적 증가가 보였다. 한편 LPS 주사후 섬유관절막에서 나타나는 형태학적 변화는 collagen fiber 생성에 의한 섬유화가 증가되며, 이러한 섬유화를 주도하는 섬유모세포의 이주증가파 관찰되었다. 또한 혈관 주위에서는 백혈구의 이주 증가가 나타났으며, 탈과립형(degranulated type) 비만세포가 많이 관찰되었다. 이상의 결과로 LPS 주사로 관절낭에서 염증이 유발되어 윤활관전막과 섬유관절막에서 형태학적 변화가 나타났다. 이러한 일련의 형태학적 변화는 발병초기 류마티스성 관절염에서 나타나는 병리학적 소건과 동일한 결과로서, 앞으로 진행될 치료제 개발과 유발기전에 관한 해석을 위한 in vivo 실험의 적절한 모델로 기여한 것으로 기대된다. Synovial joint of BALB/C mice were injeced with Lipopolysaccharide(LPS) were observed to investigate the morphological changes of synovial capsule caused by rheumatoid arthritis(RA). The RA on female Balb/c mice were induced by LPS injection, as dose of 300㎍/㎏, into synovial cavity of knee joint. And then these specimen were fixed in 10% neutral buffered formalin and were decalcificated in EDTA solution for 4 weeks. The hyperplasia of synovium were appeared in synovial membrane. The filopodia of phagocytic like synoviocyte(type Ⅰ synoviocyte) projected into synovial cavity and the number of fibroblast like synoviocyte(type Ⅱ synoviocyte) with well-developed endoplasmic reticulum were increased in synovium. In fibrous membrane, the fibrosis induced by synthesis of collagen fiber were enlarged to all fibrous membrane, and the number of fibroblast were increased. A great number of inflammation component cell as Iymphocyte and neutrophil leukocyte were infiltrated around capillary and the degranulate typed mast cell were increased. As results indicated that the hyperplasia of synovium induced by LPS, subsequently to cause the fibrosis, infiltration of imflammation component cell, and increase of degranulated type mast call as same as symptoms of RA.

      • 營利經營面에서 본 私有林營林計劃의 實踐性에 대한 硏究

        權雷澤,李相植 東國大學校 1967 論文集 Vol.3-4 No.-

        1. According to the 8th article of forest law, a owner of forest land of 100 chong-bo or more should prepare by himself a forest management plan as a specific working section and get the approval of is from the concerned local governor to manage an enterprise on the forest. The government forest policy of requiring each specific working section to prepare it's working plan within 3years between 1965-1967 and enforce it is an epoch-making one for cultivating the forest recources, promoting the land productivity and enterprising the forestry. 2. Among the private forests, the professional and reasonable working plan of the specific section plays a vital role, and its achievement would become the barometer for successfully leading the management of other general private forest 3. The collision of the permanent benefit of the public and private interest could be seen most often in the forest management. Encouraging the forest enterprise of the specific working sections of private forests fits to the public benefit and the better national economy, Therefore positive assistance with finance and technology should be provided for them. 4, Cho-Kye san specific working section. location: Sung Joo Gun, Chun-Nam. area: 300. 00chung-bo. owner: Dongguk university foundation. The forest stock in this section have been completely devasted by illegal and uneconomic cuttings, and it's devastation represents many other private forest as we see. Ultimately it's forest working plan consists of only planting plan, in other word, without cutting plan. For the first management period, we can't expect production of woods and must only invest for silviculture. For enforcing the working plan of such forest land, a consideration must be given for the following matters. a) The forest enterprise is a long range project for return, compared to other product enterprises, the forest enterprises produces a law profit. Most of forest land owners are financially poor, so capital investment can't be expected to them. Especially for a proprietor for poor capital, his courage is likely to be killed by the prospect of poor economic loan, and the high interest of loan and so forth. Therefore, a government loan of low interest is urgently needed. b) For the first management period where no production of woods and timbers can be expected and the investment silviculture only require, a financial subsidy policy is needed to enable the preparation and enforcement of the working plan. c) Present principle of organizing the forest working plan fits to the production of wood and timber only thus, a long rage investment is invitable. A Multiple forest working plan of long rage, middle rage and short rangemust be born, combining forestry, agriculture, and pasturage. d) For those forest lands which had been bought or rent with the actual purpose, of managing an enterprise, a special measure of diminishing the financial burden, such as, tax, and registration fee from the preparation of forest working plan should be provided. 5. Un-Mun San specific working section. location: chungdo gun, Kyung-puk. area: 570.40 chung-bo. owner: Dong guk university foundation. This section has the most prospective conditions for the forest management. It's site is good, and it has he forest volume stock approximately 64 cubic meters(㎥)per chung bo. It is one of the bests among the private forest through the country. To develop such prospective working section, a consideration must be given to the following situations. a) Present principle of preparation of working plan regulates to adapt the allotment method for continnal volume yield, and thus, an unreasonable financial sacrifice is inevitable and the properietor is not allowed the using of his own ideas. The insect, desease and forest fire or over-grown trees should be cut immediatelly, and the incomes from them should be invested for the establishing of second growth. A system of inspection over the resources building with such special forest budget system is more needed than the cutting control under inspection only for the purpose of continual volume yield, b) The system of designating the use of produced log should be conducted in accordance with the quality of log, and so an unreasonable financial sacrifice on the part of propretor should be aboided. c) The specific working section should be managed by the professional forest propretor engaging in the whole forest production process.―such as, nursery practice, establishing, developing, protecting and logging. The government subsidy for seedling should be used for the direct benefit of such professional proprietor, and the system of mechanically allocating the seedlings should be avoided. 6. The Dongguk University foundation owns several specific forest working sections over the country. For such big owner, the government should directly control and guide them so that the management could be conducted harmoniously with a creative approach.

      • 韓國寺刹林의 風致浩成에 관한 硏究

        李相植,權雷澤 東國大學校 1975 論文集 Vol.14 No.-

        1. The forest owned by 964 temples belonging to Korean Buddhism Jo-Gye order and registered as of 21 May, 1969 according to the special Act for Transferring of the forest is 85,605ha in area. The temple forest has, as its first and foremost purpose, a religious purpose to maintain scenic beauty and to glorify the temples to increase the Buddhistic faith in those who visit the temples. Therefore, any economical consideration, such as timber production, should be secondary. 2. The protect forest in Korea designated by the article 18 of forest Act is 747,373ha in area and of it, the protect forest for Recreation, public health, and forestscape is 93,132ha, 26.5% of which (24,809ha) is the temple forest. (Table No:2) Furthurmore of all the temple ferest of 85,605ha, 24,809ha (28.9%) is protect forest for forestscape which implies that The Temple forest is of vital importance to the health and recreation of the nation. if we investigate the figur by the forest area of each Temple, the result is as follows: The numbler of Temples whose forest is completely disignated as the Protect forest for forestscape:30(7,768ha) The number of temples more than 70% of whose forest is designated as the protect forest for forestscape: 17 (6,781ha) The figure suggests that both the temple forest and the protect forest for forest scape have the same and common purposes and should be treated with the same technique based upon the asthetic value. 3. The developed and developing nations, including Korea, face such problems as population, urbinization, and pollution while welfare and recreoction problem of the people resulting from the forestscape development became acute and vital. It is incresingly evident that the ideal working plan and praticial method of protect forest fer forestscape was aimed in this study. 4. The guide line--species, silviculture system, rotation, and cutting year--for the management of the forestscape was studied in the view of the aesthetic value. 5. The authers worked out the forestscape working plan based upon the foregoing idea, selecting 646.67ha of the Jik-ji sa. temple of Kyung Sang buk-do, Korea. the forestscape working plan (1) the selection of tree species. (2) Silviculture system. (3) Rotation and cutting year. (4) plan of reforestation and tending 6. The Korean buddhist order must work out the policy of the temple forest management to create and maintain the scenic beauty and all the temples belonging to the order are storongly recommended to organize the special staffs and appropriate the special budget for that nearest future 7. It is also strongly suggested for the government in establish the policy of the management of protect forest for forest scape to increase its economic Value, systematizing the aesthetic Value.

      • 운동전략이 기립자세의 기능적 전방 팔뻗기에 미치는 영향

        박제상,권오윤,최흥식,김택훈 한국전문물리치료학회 2000 한국전문물리치료학회지 Vol.7 No.1

        The purpose of this study is to determine whether movement strategies affect functional forward reach distance in a standing position. Forty-seven healthy subjects were selected for this study: 23 men and 24 women, with an average age of 22.3. Functional forward reach distances were measured as hip strategy and squat strategy(included knee and ankle movement strategy) in a standing position, respectively. The mean values of functional forward reach distance in hip strategy, squat strategy were 33.57㎝, 29.48㎝, respectively. There was significantly difference in functional forward reach distance between hip strategy and squat strategy(p<.001). There was no difference of functional forward reach distance between male and female in hip strategy, but there was significant difference in other strategy(p<.05). These results suggest that movement strategies should be considered during functional forward reach test in standing. Further study is required to determine whether movement strategies affect functional reach distance in elderly and disabled groups.

      • 밀양강 수질관리를 위한 STREAM MODEL 적용

        김상희,김봉진,이규환,이찬원,권영택 경남대학교 환경문제연구소 1995 환경연구 Vol.17 No.-

        The Milyang River in one of the tributaries which affects the water qualify of the Nakdong river. The STREAM(Segment Travel River Ecosystem Autograph Model) was applied to estimate the purification capacity of the Milyang river. The entire study area(23 ㎞) was divided into 13 reachs. Each reach was then subdivided into uniform reaction cell of 0.1 ㎞. Field data were obtained from two field sampling surveys during Summer(Agust, 1993) and Fall (November, 1993) periods. The model was calibrated by the August survey data and verified by the Fall survey data. The computed values by the model were in good agreement with the measured values. The concentrations of BOD_(5), COD, total suspended solids(TSS), orthophosphate (PO₄-P), and ammonia nitrogen(NH₃-N) were increased by stair style at the segment of 7.0~11.0 ㎞ where input waste loads were directly coming from the downtown of Milyang City. The water quality of downstreams after this stair-style increase was not recovered as before. The increases of carboneous organic, nitrogen and phosphorus showed the limitation of purification capacity downstreams before joing to the Nakdong River.

      • 무지 외반증 환자의 hard insole 착용에 의한 중족지절관절 각도의 변화

        임성태,김택훈,최흥식,노정석,김장환 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.2

        The purpose of this study was to investigate the effect of donning of a hard insole in patients with hallux valgus. Fourteen subjects were selected from patients with foot pain at Lee Chang-Heon Foot Clinic from August 4,2000 to September 15, 2000. The hallux valgus angle and the first-second intermetatarsal angle were radiographically measured before and after donning the hard insole. Based on these two kinds of angles, a mild hallux valgus deformity group was characterized by the hallux valgus angle of less than 20 degrees, and a moderate hallux valgus deformity group was characterized by the hallux valgus angle of 20 to 40 degrees. After three weeks with the hard insole donned, the foot angles of the patients with hallux valgus were measured again. The data were analyzed by Wilcoxon signed ranks test, and the following results were obtained: 1) After the trial, both mild hallux valgus deformity group and moderate hallux valgus deformity group demonstrated that the hallux valgus angles were significantly decreased. 2) After the trial, mild hallux valgus deformity group demonstrated that the first-second intermetatarsal angle was significantly decreased. 3) After the trial, moderate hallux valgus deformity group demonstrated that the first-second intermetatarsal angle was not significantly decreased. The above findings revealed that according to donning hard insole, the hallux valgus angles of mild and moderate hallux valgus deformity groups and the first-second intermetatarsal angle of mild hallux valgus deformity group were significantly decreased. The results of this study have some limitation for generalization due to the limited number of subjects. Further studies are needed to evaluate the effect of hard insole on hallux valgus with more precise laboratory equipments and measurements in patients with hallux valgus.

      • SCOPUSKCI등재

        골분진과 섬유소 접합물을 이용한 두안면부 골결손의 치료

        권성택,박양수,김진환 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

        In the field of plastic surgery, various forms of craniofacial bone defects may be encountered under such conditions as trauma, congenieal defect, and postoperative condition. Until now, autogenous bone graft, processed homograft or heterograft, and alloplastic implants have been used for the reconstruction of those defecrs. Although each method has its own pros and cons, autogenous bone graft is most widely used because of its high survival rate, low postoperative complication rate, and longterm stability, Recently, the calvarium has become the favorite source of autogenous bone graft since it has many advantages. However, it is not easy to fabricate bone graft to fit in the defect accurately, paricularly for cystic or irregularly shaped depressions of craniofacial bone defects. In 1970, Shehadi reported the use of calvarial bone dust in reconstruction of cranial defects. Bone dust is harvested easily and in reasonably sufficient amount, but has not been used widely due to problems in fixation and survival rate. In our previous study, authors experimentally proved that a miture of fibrin sealant and autogenous bone dust plays an effective role to form a new bone in bone healing process. Fibrin controls bleeding, serves as a surface for adherence and degranulation of platelets, and accelerates would healing in general. In the healing process of bone grafting, fibrin trellis is known to contribute to osteoconduction and osteoinduction by supplying moving channels for undifferentiated mesechymal cells and bone morphogenic protein. Clinically, authors successfully treated 7 cases of craniofacial bony defects using bone dust and fibrin sealant and concluded as follows ; 1. Bone dust is easy to harvest in sufficient amount and is useful in reconstruction of various forms of bony defects. 2. Bone dust can be easily fixed when mixed with fibrin sealant. 3. Fibrin sealant stimulates bone union of bone dust graft. 4. Bone dust can also be harvested simultaneously when harvesting calvarial bone graft and be used in various craniofacial reconstruction as mixture with fibrin sealant.

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