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- 저자 : Yoonjin Shin (검색결과 34 건)
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Shin, Yoonjin,Kim, Yangha The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.3
The aim of this study was to investigate the association of CD36, a class B scavenger receptor, rs6969989 polymorphism with the serum lipid profiles in Korean women, together with their modulation by oily fish consumption. Subjects were participants from the Korean Genome Epidemiology Study (KoGES), which was initiated in 2001 as a large-scale. A total of 4,210 women aged 39 to 70 were included in this study. Data were collected using self-administered questionnaires, anthropometric measurements, and blood chemical analysis. Dietary intake was analyzed using a semi-quantitative food frequency questionnaire. The minor allele frequency for rs6969989 was found in 12% of this population. Homozygotes minor G allele at the rs6868989 exhibited significantly higher high density lipoprotein cholesterol (HDLC) concentrations (P-trend=0.043) and lower fasting glucose (P-trend=0.013) than major allele A carriers. The risk of low HDL-C was significantly lower in homozygotes for the G allele than the A allele carriers (P-trend=0.032). Gene-diet interaction effects between rs6969989 and oily fish intake were significantly associated with the risk of dyslipidemia (P-interaction=0.004). Subjects with homozygotes minor G allele and high oily fish intake generally had a lower risk of dyslipidemia than did those with major allele homozygotes and low oily fish intake. These findings supported that oily fish consumption may modulate the contributions of CD36 rs6969989 on genetic predisposition to the risk of dyslipidemia.
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Yoonjin Shin,Yangha Kim 한국식품영양과학회 2016 Preventive Nutrition and Food Science Vol.21 No.3
The aim of this study was to investigate the association of CD36, a class B scavenger receptor, rs6969989 polymorphism with the serum lipid profiles in Korean women, together with their modulation by oily fish consumption. Subjects were participants from the Korean Genome Epidemiology Study (KoGES), which was initiated in 2001 as a largescale. A total of 4,210 women aged 39 to 70 were included in this study. Data were collected using self-administered questionnaires, anthropometric measurements, and blood chemical analysis. Dietary intake was analyzed using a semi-quantitative food frequency questionnaire. The minor allele frequency for rs6969989 was found in 12% of this population. Homozygotes minor G allele at the rs6868989 exhibited significantly higher high density lipoprotein cholesterol (HDLC) concentrations (P-trend=0.043) and lower fasting glucose (P-trend=0.013) than major allele A carriers. The risk of low HDL-C was significantly lower in homozygotes for the G allele than the A allele carriers (P-trend=0.032). Gene-diet interaction effects between rs6969989 and oily fish intake were significantly associated with the risk of dyslipidemia (P-interaction= 0.004). Subjects with homozygotes minor G allele and high oily fish intake generally had a lower risk of dyslipidemia than did those with major allele homozygotes and low oily fish intake. These findings supported that oily fish consumption may modulate the contributions of CD36 rs6969989 on genetic predisposition to the risk of dyslipidemia.
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Relationship Between Nutrient Intake and Bone Mineral Density in 20~30 Year-old Korean Women
Yoonjin Shin,In-Sook Kwun,Youngjun Woon,Yangha Kim 한국식품영양과학회 2009 Preventive Nutrition and Food Science Vol.14 No.3
The achievement of maximal peak bone mineral density (BMD) in early life is one of the most important strategies for the prevention of osteoporosis, which is affected by nutritional status. However, it has been reported that young Korean women do not consume the optimal levels of nutrients because of the frequent practice of body weight reduction. Therefore, this study was conducted to investigate the relationship between nutrient intakes and BMD in young Korean women. Bone mineral density was measured at the lumbar spine by dual-energy X-ray absorptiometry. Information on health status, lifestyle and physical activity was obtained by questionnaire. Dietary intake was ascertained from a 3-day dietary record. The study sample included 112 Korean women aged 20~39 yr. In accordance with the energy intake of subjects, individuals who had an energy intake that was greater than 80% of the Korean Dietary Reference Intake (KDRI) were assigned to the control group (Control), while those who had an energy intake lower than 80% of the KDRI were assigned to the low intake group (LI). The intake of all nutrients in the LI group was significantly lower than that of the Control. Control subjects also showed nutrient intakes higher than the KDRI, except for Ca and folate. However, LI subjects showed intakes of energy, fiber, Ca, Fe, K, Zn, vitamin A, vitamin B1, vitamin B2 and folate that were lower than the KDRI. The BMD of the lumbar spine in LI subjects was significantly lower than that of the Control subjects. These results suggested that lower nutrient intake has a negative impact on BMD in young women.
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신윤진(Yoonjin Shin),주민정(Minjeong Ju),김양하(Yangha Kim) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.6
본 연구는 젊은 성인을 대상으로 운동 목적에 따른 영양섭취 실태를 조사하고자 수행되었다. 규칙적으로 운동하고 있는 20~30대 남녀를 대상으로 운동 목적에 따라 근육증가군 107명과 체중감소군 107명을 나누어 비교 분석하였다. 그룹별 성별구성을 분석한 결과, 근육증가군은 주로 남성(75.2%)이 많은 반면 체중감소군은 여성(74.3%)이 많이 분포하고 있었다. BMI 판정결과 두 그룹간의 유의적인 차이는 없었으며, 체중감소군의 절반 이상(56%)이 저체중 또는 정상체중으로 나타났다. 근육증가군의 하루 운동시간 및 규칙적으로 운동한 기간이 체중감소군에 비하여 유의적으로 많았다(p<0.01). 영양지식의 상태는 근육증가군의 점수가 체중감소군에 비하여 유의적으로 높은 것으로 나타났다(p<0.05). 식행동 또한 근육량 증가군의 점수가 체중감소군에 비하여 유의적으로 높았다(p<0.05). 영양섭취 상태를 살펴보면, 한국인영양섭취기준과 비교하였을 때 근육증가군의 에너지 섭취비율이 에너지필요추정량의 83.72%로 체중감소군의 74.53%에 비하여 유의적로 높았다(p<0.01). 권장섭취량에 대한 단백질 섭취비율은 근육증가군이 199.62%, 체중감소군은 136.36%로 나타났으며 근육증가군이 체중감소군에 비해 유의적으로 매우 많은 양을 섭취하고 있었다(p<0.001). 권장섭취량에 대한 칼슘 섭취비율은 근육증가군이 67.75%, 체중감소군은 68.64%로 조사되었으며, 두 군 모두 권장섭취량과 비교하여 매우 부족한 수준으로 나타났다. 이와 같이 본 연구에서는 근육증가를 목적으로 운동하는 경우 과량의 단백질을 섭취하고 있었으며, 체중감소를 목적으로 운동하는 경우 필요량에 미치지 못하는 에너지 섭취를 하는 것으로 나타났다. The aim of this study was to investigate the eating behavior and nutritional status of subjects according to their purpose of exercise. A total of 214 subjects, 20 to 30 years of age, who visited fitness centers in Seoul were enrolled. Anthropometrics, exercise habits, nutritional knowledge, and eating behaviors were analyzed using a questionnaire. Nutritional status was assessed by serial 24 h recalls. The subjects were divided into two groups based on their purpose of exercise: increasing muscle (Muscle growth, n=107) or losing body weight (Weight loss, n=107). The Muscle growth group contained a higher percentage of men, whereas the Weight loss group contained a higher percentage of women. The Muscle growth group showed significantly higher scores of nutritional knowledge and eating behaviors compared to the Weight loss group. The Muscle growth group also had a significantly higher intake of energy and protein compared to the Weight loss group. In fact, the intake of energy in the Weight loss group was lower than the estimated energy requirement (EER) for both men and women subjects. The intake of protein in the Muscle growth group was twice as much as the recommended nutrient intake (RNI). The intake of calcium in both groups was less than the RNI. In conclusion, those who exercised with the aim of increasing muscle took excess dietary protein and those who exercised with the aim of weight loss had a lower energy intake than the EER.
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Proposal on Guideline for Quality Assurance of Radiation Treatment Planning System
Oh, Yoonjin,Shin, Dong Oh,Kim, Juhye,Kwon, Nahye,Lee, Soon Sung,Choi, Sang Hyoun,Ahn, Sohyun,Park, Dong-wook,Kim, Dong Wook Korean Society of Medical Physics 2017 의학물리 Vol.28 No.4
We develop guidelines for the quality assurance of radiation treatment planning systems (TPS) by comparing and reviewing recommendations from major countries and organizations, as well as by analyzing the AAPM, ESTRO, and IAEA TPS quality assurance guidelines. We establish quality assurance items for acceptance testing, commissioning, periodic testing, system management, and security, and propose methods to perform each item within acceptable standards. Acceptance includes tests of hardware and network environments, data transmission, software, and benchmarking as specified by the system supplier, and apply the IAEA classification criteria. Commissioning includes dosimetric and non-dosimetric items for assessing TPS performance by applying the AAPM classification criteria and the latest technical items from the IAEA. Periodic quality assurance tests include daily, weekly, monthly, yearly, and occasional items by applying the AAPM classification criteria. System management and security items include the state and network connectivity of TPS, periodic data backup, and data access security. The guidelines for TPS quality assurance proposed in this study will help to improve the safety and quality of radiotherapy by preventing incidents related to radiotherapy.
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Comparative Analysis of Terminology and Classification Related to Risk Management of Radiotherapy
Oh, Yoonjin,Kim, Dong Wook,Shin, Dong Oh,Koo, Jihye,Lee, Soon Sung,Choi, Sang Hyoun,Ahn, Sohyun,Park, Dong-wook Korean Society of Medical Physics 2016 의학물리 Vol.27 No.3
We analyzed the terminology and classification related to the risk management of radiation treatment overseas to establish the terminology and classification system for Korea. This study investigated the terminology and classification for radiotherapy risk management through overseas research materials from related organizations and associations, including the IAEA, WHO, British group, EC, and AAPM. Overseas risk management commonly uses the terms "near miss", "incident", and "adverse event", classified according to the degree of severity. However, several organizations have ambiguous terminologies. They use the term "near miss" for events such as a near event, close call, and good catch; the term "incident" for an event; and the term "adverse event" for the likes of an accident and an event. In addition, different organizations use different classifications: a "near miss" is generally classified as "incident" in most cases but not classified as such in BIR et al. Confusion might also be caused by the disunity of the terminology and classification, and by the ambiguity of definitions. Patient safety management of medical institutions in Korea uses the terms "near miss", "adverse event", and "sentinel event", which it classifies into eight levels according to the severity of risk to the patient. Therefore, the terminology and classification for radiotherapy risk management based on the patient safety management of medical institutions in Korea will help in improving the safety and quality of radiotherapy.
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Nah, Yoonjin,Shin, Na-Young,Yi, Sehjung,Lee, Seung-Koo,Han, Sanghoon ACADEMIC PRESS, INC 2018 NEUROBIOLOGY OF LEARNING AND MEMORY Vol.150 No.-
<P><B>Abstract</B></P> <P>Numerous studies have suggested that postpartum women show a decline in cognitive abilities. However, to date, no study has investigated the presence of qualitative alterations in recognition memory processes in postpartum women that may lead to a decline in cognitive ability. To address this issue, we employed the Remember/Know procedure and functional magnetic resonance imaging (fMRI). Behavioral results demonstrated that compared with the matched control (CTRL) group, the postpartum (PP) group endorsed “Remember” less and “Know” more to old items. A univariate analysis of fMRI data indicated lower neural activity of the subjective recollection network in the PP group than in the CTRL group. We also performed a large-scale functional connectivity multivariate pattern analysis (fcMVPA) using task-dependent time-series to detect differences in functional connectivity patterns and neural interactivity between the PP and CTRL groups. The fcMVPA results revealed that the PP group exhibited altered functional connectivity patterns from which machine learning algorithms could discriminate group membership with 94% accuracy. Collectively, these findings demonstrated that altered subjective recollection processes in the PP group during episodic memory decisions are associated with diminished neural activity and abnormal interactivity across the subjective recollection network. We believe that this is one of the first studies demonstrating qualitative alterations in recognition memory processes in postpartum women.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We investigated recognition memory processes in postpartum women (PP). </LI> <LI> PP endorsed old items with “Remember” responses less often than control women. </LI> <LI> PP showed decreased neural activity across the subjective recollection network. </LI> <LI> We applied iterative functional connectivity multivariate pattern analysis. </LI> <LI> Large-scale functional connectivity patterns across the network were altered in PP. </LI> </UL> </P>
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