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( Sung Yong Han ),( Hyun Young Woo ),( Jeong Heo ),( Sang Gyu Park ),( Sung Ik Pyeon ),( Young Joo Park ),( Dong Uk Kim ),( Gwang Ha Kim ),( Hyung Hoi Kim ),( Geun Am Song ),( Mong Cho ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.3
Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical factors predicting sustained virological response 12 weeks (SVR12) after the end of SOF/RBV treatment. Methods: A total of 181 patients with HCV GT2 with/without cirrhosis were treated with SOF/RBV for 16/12 weeks. Rapid virological response (RVR) was defined as non-detectable HCV RNA at 4 weeks. Results: The RVR rate was 80.7% (146/181), the end of treatment response rate was 97.8% (177/181) and the SVR12 rate was 92.8% (168/181). Of eight patients with relapse, four did not achieve RVR. Three patients had a history of hepatocellular carcinoma (HCC). Multivariable analysis showed that RVR (p = 0.015) and no previous history of HCC (p = 0.007) were associated with SVR12. Factors significantly contributing to RVR included cirrhosis, creatinine concentration, and pre-treatment HCV RNA level. SVR12 rate was significantly higher in RVR (+) than RVR (-) patients (95.2% vs. 82.9%, p = 0.011) and also significantly higher in patients without than with a history of HCC (94.1% vs. 72.7%, p = 0.008). During treatment, 80/181 patients (44.2%) experienced mild to moderate adverse events, with 32 (17.7%) requiring RBV dose reductions due to anemia. Conclusions: SOF/RBV treatment was effective and tolerable in HCV GT2 patients. RVR and no previous history of HCC were positive predictors of SVR12.
Case Report : Primary Rectal Amyloidosis in a Patient with Human Immunodeficiency Virus
( Sang Hyun Lee ),( Tae Oh Kim ),( Jung Ho Bae ),( Jin Hyun Park ),( Yun Kyung Jeon ),( Tae Kyung Kim ),( Geun Am Song ) The Editorial Office of Gut and Liver 2009 Gut and Liver Vol.3 No.1
Amyloidosis can involve a single organ or multiple organs. The gastrointestinal tract is a common site of amyloid deposition. We report a rare case of solitary rectal amyloidosis in a patient with human immunodeficiency virus who had experienced recurrent oral candidiasis for 3 months and intermittent diarrhea for 6 months. The lesion was confirmed histologically and there were no detectable amyloid lesions at other gastrointestinal sites or systemic involvement. (Gut and Liver 2009;3:57-59)
A Numerical Approach to Shape Correction of Stamped Products Using Laser Forming Techniques
Song, Jung Han,Zhang, Y.,Lee, J.,Lee, Geun An,Lee, Sang Mok,Lee, H.W.,Park, S.J. Trans Tech Publications, Ltd. 2013 Key Engineering Materials Vol.535 No.-
<P>Laser forming is an advanced process in sheet metal forming in which a laser heat source is used to shape the metal sheet. In this paper, shape correction of stamped product using the laser forming technique is numerically invesitgaed. As a fundamental study, laser irradiated bending process has been analyzed through the thermo-mechanical FE analysis. Laser scanning experiments has been also conducted for varificaiton of numerical simulations. Finally, the laser forming technique is applied to the u-shaped channel member for springback compensation. It is observed that laser irradiation gives the desired bending angle to compensate the springback by controlling the process parameters such as the laser power, scanning speeds and the number of laser scanning.</P>
Song, Jae Geun,Lee, Sang Hoon,Han, Hyo-Kyung Dove Medical Press 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>This study aimed to evaluate aminoclay (3-aminopropyl-functionalized magnesium phyllosilicate) as an effective protectant for the stabilization of protein formulation in freeze-drying. Bovine serum albumin (BSA), as a model protein, was freeze-dried with aminoclay at various concentrations, and the effects of aminoclay on the structural stability of proteins were compared with those of the conventional stabilizers. The structural characteristics of the protein were determined by size exclusion chromatography (SEC), circular dichroism (CD), and Fourier transform infrared (FTIR) spectroscopy. Furthermore, physicochemical and morphological characteristics were examined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). XRPD and DSC patterns indicated that the glass transition temperature (Tg) of the amorphous formulation of aminoclay mixed with proteins was gradually elevated as the concentration of aminoclay increased. FTIR and CD spectral analysis suggested that the protein structure was well maintained with aminoclay during the freeze-drying process and 3 months of storage at 4°C and 40°C. Furthermore, aminoclay conferred the greatest protection against aggregation and retained the monomer content of BSA even at a high temperature. The morphological characteristics of lyophilized proteins were also well conserved during the storage with aminoclay. These results suggested that aminoclay may be useful as an alternative stabilizer for maintaining the structural stability of protein formulations.</P>
Song, Geun Cheol,Im, Hyunjoo,Jung, Jihye,Lee, Soohyun,Jung, Man‐,Young,Rhee, Sung‐,Keun,Ryu, Choong‐,Min BLACKWELL SCIENCE 2019 ENVIRONMENTAL MICROBIOLOGY Vol.21 No.3
<P><B>Summary</B></P><P>Archaea have inhabited the earth for a long period of time and are ubiquitously distributed in diverse environments. However, few studies have focused on the interactions of archaea with other organisms, including eukaryotes such as plants, since it is difficult to cultivate sufficient numbers of archaeal cells for analysis. In this study, we investigated the interaction between soil archaea and <I>Arabidopsis thaliana</I>. We demonstrate for the first time that soil archaea promote plant growth and trigger induced systemic resistance (ISR) against the necrotrophic bacterium <I>Pectobacterium carotovorum</I> subsp. <I>carotovorum</I> SCC1 and biotrophic bacterium <I>Pseudomonas syringae</I> pv. <I>tomato</I> DC3000. Ammonia‐oxidizing archaeon <I>Nitrosocosmicus oleophilus</I> MY3 cells clearly colonized the root surface of <I>Arabidopsis</I> plants, and increased resistance against both pathogenic species via the salicylic acid‐independent signalling pathway. This mechanism of bacterial resistance resembles that underlying soil bacteria‐ and fungi‐mediated ISR signalling. Additionally, volatile emissions from <I>N. oleophilus</I> MY3 were identified as major archaeal determinants that elicit ISR. Our results lay a foundation for archaea–plant interactions as a new field of research.</P>
Management of Patients with Ischemic Heart Disease in Spine Surgery
Song Myung-Geun,Kim Chang-Won,Song Sang-Youn,Kim Han-Gyul,Kim Dong-Hee 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.6
In ischemic heart disease (IHD), the myocardium does not receive enough blood and oxygen. Although the IHD-related mortality rate is decreasing, the risk remains and is a major predictor of cardiac complications following noncardiac surgery. Given the increase in the older population, the number of patients with spinal diseases requiring surgery is increasing. Among these patients, those with underlying IHD or a high risk of cardiac complications before and after surgery are also increasing. Given that cardiac complications following spinal surgery are associated with delayed patient recovery and even death, spinal surgeons should be knowledgeable about overall patient management, including medication therapy in those at high risk of developing perioperative cardiac complications for successful patient care. Before surgery, the underlying medical conditions of patients should be evaluated. Patients with a history of myocardial infarction should be checked for a history of surgical treatments, and the anticoagulant dose should be controlled depending on the surgery type. In addition, the functional status of patients must be examined before surgery. Functional status can be assessed according to the metabolic equivalent of task (MET). More preoperative cardiac examinations are needed for patients who are unable to perform four METs in daily because of the high risk of postoperative cardiac complications. Patients with a history of IHD require appropriate preoperative management and further postoperative evaluation. When considering surgery, spinal surgeons should be knowledgeable about patient care before and after surgery.
Song,Hyung Geun,Sung,Rohyun,Park,Seong Hoe,Lee,Geon Kook 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1
세포간의 상호작용은 림프구 등의 면역세포들이 완벽한 면역기능을 수행하기 위해 필수적이며, 림프구의, 특히 흉선세포의 분화 및 교육과정에 대단히 중요하다. 동질성 세포유착은 생리적인 상태에서의 세포간의 상호작용을 체외에서 재현하는 모델로 생각되며, 이 같은 현상이 제대로 일어나기 위해서는 일반적으로 에너지 대사가 필요하고 기능적으로 온전한 세포골격(cytoskeleton)이 요구된다. 최근에 인체 백혈구동통항원인 AP4항원은 대부분의 백혈구 및 인체 백혈병세포주들에 비교적 널리 표현되며, 그 세포질내 부분이 protein tyrosine phosphatase의 활성을 가지고 있어 림프구에서의 활성화 초기 신호전달에 관여한다고 알려져 있다. 하지만 백혈구공통항원의 기능에 대해서는 아직 많은 부분이 알려져 있지 않다. 저자들은 항-AP4 항체에 의해 인체 백혈병세포주 Molt-4의 동질성 유착이 유발되었으며, 이 같은 동질성 유착은 에너지 대사와 기능적으로 온전한 세포골격 및 온도, 그리고 Mg²+ 이온의 존재가 요구됨을 알 수 있었다. 그리고 okadaic acid와 같은 인산분해효소 억제제에 의해 흉선세포간의 동질성 세포유착이 저해되었다. 또한 림프구 등의 세포간 유착에 기여한다고 이미 알려져 있는 LFA-1-α 및 -β에 대한 항체들에 의해서는 동질성 유착이 방해받지 않았다. 상기 결과들을 토대로 AP4 항원은, 적절한 리간드의 교합 (engagement)에 의해 인체 백혈병세포주 Molt-4의 동질성 세포유착을 유발하는, 세포표면 수용체의 기능을 가지는 물질임을 확인하였다. 또한 종양세포에서 확인된 이상의 결과는 정상 림프구 혹은 흉선세포에서의 백혈구공통항원의 역할 및 기능을 제시하는 것이라고 할 수 있다. Cell-cell interaction is essential for an immune response of immunocytes to various antigens and for the differentiation and maturation of lymphocytes. Homotypic cell aggregation in the test tube is thought to reflect the important physiologic cell-cell adhesion events; it requires energy, a functionally intact cytoskeleton, and a number of cell adhesion molecules, and can be triggered nonspecifically by phorbol esters. We produced a mAb against leukocyte common antigen (LCA), AP4, which is a cell surface glycoprotein and its molecular weight is 180 to 220 kDa. We now show here that anti-AP4 mAb induce homotypic aggregation of human T-lymphocytic leukemic cell line, Molt-4, which is temperature-, energy-, Mg²+- and Ca²+-dependent, and requires an intact cytoskeleton. hese adhesion properties are rather characteristic of integrins. Nevertheless, mAbs against LFA-1α and -β, which are known to be involved in aggregation of human lumphocytes induced by mAbs against human LCA, are unable to block Molt-4 aggregation. Therefore, the homotypic adhesion pathway triggered by AP4 engagement is most likely to be LFA-1-independent. In addition, inhibition by okadaic acid suggested the requirement of functionally intact protein phosphatases in AP4-induced homotypic aggregation of leukemic cell lines.