한번의 간질발작 후 혈청 Neuron-Specific Enolase 농도 변화

최승호,박영춘,이장준,임정근,김지언,이상도 啓明大學校 醫科大學 1999 계명의대학술지 Vol.18 No.4

An increase in neuron-specific enolase (NSE) levels in serum and CSF has been shown to be an useful marker of brain damage after stroke, global ischemia, and coma. We report the changes of serum NSE levels after seizure attacks in epileptic patients compared with the levels in normal controls and epileptic patients without seizure attack at least 7 days (epileptic controls). Twenty-four seizures were included in this study. Blood was drawn within 1 hour, at 12 hour, 24 hour, and 48 hour after seizure attack. Serum NSE levels were measured with radioimmunoassay. The mean NSE levels for normal controls and epileptic controls were 6.94 ng/ml and 7.46 ng/ml, respectively. There were significant increase in level of serum NSE measured within 1 hour after seizure attack in epileptics compared with the level in normal controls (15.10ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (15.10ng/ml versus 7.46ng/ml, p<0.05). Serum NSE measured at 12 hours after seizure also increased compared with normal controls (12.32ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (12.43ng/ml versus 7.46ng/ml, p<0.05). Between normal controls and epileptic controls, there were no significant difference in serum NSE levels. We conclude that serum NSE level was elevated in epileptic patients who had seizure attack within 12 hours. Serum NSE levels can be useful marker for seizure within 12 hours after onser. The elevated serum NSE level after single seizure attack may suggest that the brain was injured in single seizure.

수목추출물의 생리활성에 관한 연구(Ⅸ) : 아까시나무 심재의 항산화활성 물질 Antioxidative Compounds from Heartwood of Robinia pseudo-acacia

최돈하,이학주,이성숙,김윤근,강하영 한국목재공학회 2002 목재공학 Vol.30 No.4

항산화활성이 우수한 아까시나무 심재 에탄올 조추출물로부터 항산화물질을 탐색할 목적으로 4종의 화합물을 단리하였으며, MS, NMR 등의 분광학적 방법에 의해 그 화학적 구조를 3-β-stigmast-5-en-3-ol(daucosterol)를 비롯하여 스틸베노이드 화합물인 3,3' ,4' ,5-tetrahydroxystilbene과 후라보노이드인 3,3' ,4' ,5' ,7-pentahydroxyflavone(robinetin) 및 3,3' ,4' ,7-tetrahydroxyflavanone(fustin)으로 각각 동정하였다. 단리된 화합물의 프리라디칼 소거능을 측정하여 항산화활성을 검정한 결과, 페놀성 수산기가 5개인 3,3' ,4' ,5' ,7-pentahydroxyflavone은 천연항산화제 및 합성항산화제보다 높은 항산화활성을 나타내어 단리화합물 중 가장 항산화활성이 높은 것으로 나타났다. 또한, 페놀성 수산기가 4개인 3,3' ,4' ,5-tetrahydroxystilbene과 3,3' ,4' ,7-tetrahydroxyflavanone도 천연항산화제인 α-tocopherol보다 높은 항산화활성을 나타내었으나 3-β-stigmast-5-en-3-ol은 항산화활성이 없는 것으로 나타나 프리라디칼 소거능에 의한 항산화활성은 화합물의 페놀성 수산기수에 크게 좌우되는 것으로 판단되었다. 이상의 결과 아까시나무의 높은 항산화활성은 3,3' ,4' ,5' ,7-pentahydroxyflavone. 3,3' ,4' ,5-tetrahydroxystilbene 및 3,3' ,4' ,7-tetrahydroxyflavanone에 기인하는 것으로 사료되었다. Antimicrobial and antioxidative activities on heartwood extractives of domestic species were investigated to develop a natural fungicide or preservative. One steroid, stilbene derivatives and two flavonoids were isolated from heartwood of Robinia pseudo-acacia which has been selected due to its high antioxidative activity among the tested species. The structures were determinded as : 3-β-stigmast-5-en-3-ol(daucosterol), 3,3',4,5-tetrahydroxystilbene, 3,3',4',5',7-pentahydroxyflavone(robinetin) and 3,3',4',7-tetrahydroxyflavanone(fustin) respectively on the basis of spectroscopic data and chemical correlations. According to the results of free radical scavenging activity, 3,3',4',5',7-pentahydroxyflavone was evaluated as the highest antioxidative compound among the four compounds and showed higher radical scavenging activity than those of α-tocopherol and butylated hydroxytoluene(BHT), one of the strongest synthetic antioxidants. 3,3',4',5-Tetrahydroxystilbene and 3,3',4',7-tetrahydroxyflavanone showed higher antioxidative activities than that of α-tocopherol. However, 3-β-stigmast-5-en-3-ol did not show free radical scavenging activity. In this regard, it could inferred that high antioxidative activity of extractives of R. pseudo-acacia was derived from 3,3',4',5',7-pentahydroxyflavone, 3,3',4',5-tetrahydroxystilbene and 3,3',4',7-tetrahydroxyflavanone.

거골 골절의 수술적 치료

최호림,이장근,최훈휘,최성우 대한골절학회 2003 대한골절학회지 Vol.16 No.1

목 적 : 거골 골절 수술적 치료 후 임상 결과를 분석하여 얻은 결과를 보고하며 향후 적절한 치료 방침을 결정하는데 도움이 되고자 한다. 대상 및 방법 : 1990년 3월부터 2000년 11월까지 본원에서 거골 골절로 치료한 환자 60례중 수술적 치료후 1년 이상 추시가 가능하였던 34례의 수술 전,후 및 추시 방사선 사진과 의무 기록지를 후향적으로 분석하였으며 현 환자의 상태는 외래 진료를 통한 직접 면담이나, 서면 또는 전화를 이용한 질문표에 대한 답변 등을 이용하여 분석하였다. 임상 결과의 판정은, 동통과 파행, 거골하 관절 및 족근 관절에서의 운동 범위등, 네 가지 요소에 따라 판정하는 Hawkins 평가 방법을 이용하였다. 결 과 : 총 34례중 25례(74%)에서 양호 이상의 만족스러운 임상 결과를 보였으나, 분쇄 정도가 심하여 조기에 정확한 해부학적 정복을 얻지 못했거나 주위 조직의 심한 손상 또는 타과적 손상이 동반되어 치료가 지연된 경우에서는 만족스럽지 못하였다. 무혈성 괴사는 Hawkins 징후가 보이지 않았던 8레중 6례에서 발생하였으며, 보존적 치료를 시행하여 만족할만한 임상 결과를 얻을 수 있었다. 결론 : 거골 경부 골절 치료후 임상 결과는 가능한 조기의 관혈적 정복을 통한 정확한 해부학적 정복 및 내고정이 무엇보다 중요하다고 생각되며, 더불어 적극적인 재활치료의 여부도 예우에 큰 영향을 줄 수 있다. 수술적 도달법에 의한 차이나 사용된 내고정물에 의한 임상 결과의 차이는 보이지 않았다. 무혈성 괴사 유무와 임상 결과는 반드시 일치하는 것은 아니었다. Purpose : To evaluate the clinical results and develop guidelines for surgical treatment of talus fracture. Materials and Methods : Among the 60 cases that were treated during March 1990 to November 2000, 34 cases were treated operatively and followed up for more than one year( range : 1~4.4 years). They were analyzed retrospectively with questionnaire directly or by telephone interview, radiograms and medical records. Clinical results were evaluated by Hawkins' scoring system. Results : 25 out of 34 cases showed satisfactory results. Unisatisfactory results were seen in cases that we couldn't achieve anatomical reduction due to severe communication, and also in case of delayed treatment due to severe communition, and also in case of delayed treatment due to associated trauma and soft tissue injury. Six out of 8 cases that showed no Hawkins' sign developed avascular necrosis. However, satisfactory results were achieved through conservative treatment. Conclusion : Satisfactory results could be achieved through early anatomical reduction and rigid internal fixation followed by aggressive rehabilitation. There was no differences in clinical results either by the surgical approach or method of internal fixation. Avascular necrosis was not essentially related to the clinical results.

기제와 피부투과촉진제가 아포모르핀의 피부투과에 미치는 영향

최영근,최옥,김건남,박은석,지상철 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of apomorphine, the skin permeation rates of apomorphine from vehicles of different composition were determined using Franz diffusion cells fitted with excised rat skins. Solubility of apomorphine in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of apomorphine. The solvents used were propylene glycol (PG), Transcutol^??, Labrasol^??, Labrafac hydro WL^??, Labrafil WL 2609 BS^?? and isopropyl alcohol. Even though permeation rates of apomorphine from each vehicle were low (0.08-0.36㎍/㎠/hr), the combination of PG and Labrafac^?? increased it significantly. The permeation rates of apomophine from PG/Labrafac^?? mixtures increased as the volume fraction of PG in the mixture increased. The maximum permeation rate of 18㎍/㎠/hr was achieved at 30% of PG, which decreased with further increase of PG fraction. A series of fatty acids, alcohols and monoterpenes were employed as penetration enhancers. Incorporation of each enhancer in the PG/Labrafac^?? (30:70) mixture at the level of 10% improved the skin permeation significantly. The highest permeation rate, 117㎍/㎠/hr, was attained with myristic acid.

저 유전상수 시클로헥산계 플라즈마 고분자 박막의 특성

최자영,권영춘,여상학,정동근 성균관대학교 기초과학연구소 1999 論文集 Vol.50 No.-

In this work, we report on the investigation of the properties of cyclohexane-based plasma polymers (CHexPP) as functions of the deposition pressure and the plasma power. As the deposition pressure was decreased from 2 torr to 0.2 ton with a fixed plasma power of 60W, k value of the CHexPP thin film increased from 2.42 to 3.24. CHexPP thin films deposited at lower deposition pressure showed very good thermal stability, even the one deposited at 0.2 torn was stable up to 400℃. As the plasma power was increased from 10W to 90W with a fixed deposition pressure of 0.2 ton, k value increased from 2.61 to 3.39. The CHexPP thin film deposited at 90W were stable up to 450℃. All the deposited films were insulating. Under applied fields less than 1 MV/cm, leakage current densities were less than 10^-7 A/㎠.

사과'후지' 生理障害果에 있어서 果汁內 이온 濃度와 과실조직의 無機含量과의 관계

吳成都,崔東根 全北大學校 1994 論文集 Vol.37 No.-

Relationship between ion concentrations in fruit Juice and total contents of nitrogen, potassium and calcium in the fruit tissue was investigated in the physiological disordered apples in order to know whether juice ion measurement can be used to estimate the cause of physiological disordered Fuji apples (Malus domestics Borkh.). Juice ion concentrations were analyzed of pH/ion meter. Significant relationship between nitrate ion concentration of juice and total nitrogen was existed, while correlation coefficient was lower than that of normal fruits. There was no relationship between potassium and calcium. Total contents of N, K and Ca were lower in physiological disordered fruits than in normal fruits. Consequently, total contents of N, K and Ca in the fruit tissue can not be estimated by measuring ion concentrations in fruit juice of physiological disordered apples.

중추성 요붕증으로 발현된 랑거한스세포 조직구증식증 1례

김준성,윤원상,김근모,최영권,박기원,김병희,유용상 대한소아내분비학회 2004 Annals of Pediatirc Endocrinology & Metabolism Vol.9 No.1

유럽의 사례로 본 MVNO 제도의 국내 도입 방안

박명근,최성호 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

The fierce competition between the carriers has made domestic mobile communication industry run up rapidly. Instead of such dazzling outward growth, however, the activation effect of such competition is not enough for our expectation in the view point of the mobile communication users. The several related surveys say that the dissatisfaction of the users has been increasing. This appearance has the root in the peculiar market structure where the carrier can exercise its exclusive possession after the secure of its subscribers. In the study, we look into the introduction case of the European MVNO system, and examine the introduction validity of MVNO system to Korea with the considering of the recent mutation trend in domestic mobile communication market.

담관 낭선암 1례

박건욱,홍기봉,정재열,노명환,한상영,최석렬,신우원,나서희 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

교흔으로 인해 발생한 Eikenella corrodens 간농양 1예

고근준,이은재,최형섭,김상수,최정은,임환섭,김준명,이꽃실 대한감염학회 2004 감염과 화학요법 Vol.36 No.2

E. corrodens는 면역저하 환자에서 주로 문제를 일으키며, 감염시 두경부, 폐, 복부 등에 위험을 초래할 수 있어 치료의 적절성에 대한 중요성이 부각되고 있다. Eikenella corrodens는 균 동정을 위해 CO₂의 공급을 필요로 하며 서서히 자라는 특성상 까다로운 배양조건을 필요로 하는 균주이다. 혐기성 균주이지만 metronidazole이나 clindamycin과 같은 항균제에는 반응을 안하는 특이한 항생제 감수성에 의해 보편적인 구강내 상재균에 대한 경험적 치료에 실패할 수 있다. 치료에 있어 잘못된 초기 항생제 선택이나 외과적 시술이 적절히 시행되지 않은 경우에 치료실패의 요인이 될 수 있으므로 적절한 항생제 사용과 함께 외과적 처치가 동반되어야 한다. 저자들은 정상 면역력을 가진 성인에서 사람에게 물리고 난 후 발생한 E. corrodens에 의한 간농양의 적절한 치료의 결과를 문헌고찰과 함께 보고하는 바이다. Eikenella corrodens is a slow growing, facultatively anaerobic gram-negative rod that is part of the normal flora of the oral cavity and upper respiratory tracts. In most patients with E. corrodens infections, host defenses are compromised due to surgery, or chronic debilitating illness such as malignancies, or immunosuppressive therapy. This organism causes abscesses and infections that are at times fatal. We experienced a case of E. corrodens isolated from liver abscess in an immunocompetent patient. A 50-year-old man who is a dentist, was hospitalized because of fever and myalgia of 10 days' duration. Abdominal ultrasonography showed non-septated, 3.8×4.6 ㎝ sized abscess in the segment 6/7 of the liver. E. corrodens was isolated from aspiration of liver abscess. This organism was presumably acquired from his patient's oral cavity during dental procedure. We hope that increased awareness to E. corrodens will raise the index of suspicion, and contribute to optimal management of these infections, minimizing the significant morbidity associated with this organism.