경피적 겸자 정복 및 골수강내 금속핀 고정을 이용한 쇄골 골절의 치료

홍기도,하성식,정남식,심재천,김경호 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적 : 경피적 겸자 정복 및 골수강내 금속판 고정술을 이용한 쇄골 간부 골절의 치료에 대해 유용성을 규명해 보고자 하였다. 대상 및 방법 : 2002년 1월부터 2003년 7월까지 본원에서 쇄골 간부 골절 환자 중 신경 및 혈관 손상이 없었고, 골절의 분쇄상이 비교적 적었던 총 16례를 대상으로 겸자를 이용한 경피적 정복 후에 골수강에 금속판을 삽입하여 고정하였다. 술 후 유합 정도 및 결과를 임상적, 방사선학적으로 분석하였다. 결과 : 방사선학적으로 골유합을 보인 경우가 총 15례였으며, 술 후 평균 9.1주에 유합 소견을 관찰하였다, 임상적으로 강 등의 기준에 따라 구분한 결과, 우수 이상이 14례로 나타났다. 1례에서 1주 만에 K-강선의 내측전위로 골절부위가 재전위되어 관혈적 정복 및 금속판 내 고정을 시행한 이외에 다른 주요 합병증은 없었다. 결론 : 저자들의 방법은 수술시간이 짧고 간단하며, 연부조직의 추가적 손상이 적어 골유합율이 높고, 수술 반흔을 남기지 않아 수술적 적응을 신중히 고려한다면 쇄골 간부 골절의 치료법의 하나로 유용할 것으로 사료된다. Purpose: To investigate the utility of surgical treatment of clavicle shan fracture using a percutaneous towel clip reduction and intramedullary fixation. Materials and Methods : This study was conducted for total 16 case of patients who had no neurovascular injury and a few comminuted bone fragment among patients with clavicle shaft fracture from January 2002 to July 2003. The method of operation was percutaneous towel clip reduction and intramedullary fixation. The clinical and radiological results were evaluated. Results : Radiologically, 15 cases showed bone unions and the avenge time was 9.1 weeks. According to Kang's criteria clinically, there were 14 cases which were more than an excellence. One case substituted open reduction and nailing fixation due to a medial migration of K-wire and re-displacement of fracture even in 1 week. However, there wasn't any other major complication. Conclusion : Due to its having no additional injury to soft tissues, no scar formations, and its short operation time, percutaneous towel clip reduction and intramedullary fixation will be very useful as one of the treatments of clavicular shaft fracture if it follows correct surgical indications.

한국인 강박장애와 Val-158-Met Catechol-O-Methyltransferase 유전자 다형성 간의 상관성 연구

천근아,김세주,김찬형,구민성,남윤영,박성혁,이홍식 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

목적 COMT(Catechol-O-Methyltransferase) 효소는 도파민성과 노어아드레날린성 체계의 조절에서 매우 중요한 작용을 하며 염색제 22q11에 위치해 있다. 일부의 강박장애 환자들은 도파민 차단제에 좋은 치료 반응을 보이며 이런 현상은 COMT가 강박장애의 병인론에 역할을 하고 있을 가능성을 말해준다. Val-158-Met COMT 유전자의 다형성은 효소의 감소를 유도하는 L(저활성) 대림형질, 활성의 증가를 유발하는 H(고활성) 대립형질로 알려져 있으며 L 대립형질 또는 LL 유전형이 강박장애와 연관이 있다는 보고가 있으나, 아직까지 강박장애와 COMT 다형성 사이의 연관성에 대한 연구결과들은 일관되지 않다. 따라서 본 연구에서는 한국인 강박장애 환자들을 대상으로 Val-158-Met COMT 유전자의 다형성과의 연관성을 알아보고자 하였다. 방법 2002년 3월부터 2004년도 2월까지 약 24개월동안 서울지역 일 대학병원과 경기지역 일 대학병원 강박장애 클리닉을 방문하여 강박장애로 진단받은 124명의 환자들을 연구대상으로 하였고 정상 대조군으로는 나이와 성별을 고려하여 자원자 170명이 선별되어 포함되었다. 강박장애군과 정상 대조군의 혈액으로부터 유전자 추출 후 COMT 유전자 형벌 (genotyping)을 시행하였다. 다형성을 H/H 와 H/L, L/L 유전형으로 나눈 뒤 강박장애와 정상대조군 사이의 유전자 빈도를 카이 검정법으로 비교하여 연관성을 관찰하었다. 또한 강박장애 환자들에게 시행한 YBOCS로부터 측정한 강박장애 심각도 및 Hamilton Depression Raing Scale (HDRS) 총점과 COMT 유전자 다형성 사이의 연관성을 비교하였다. 결과 본 연구 결과 한국인 강박장애와 COMT 다형성 간에는 유의한 상관성이 관찰되지 않았다. YBOCS 심각도와 COMT 유전자형과의 유의한 연관성이 관찰되지 않았다. 그러나, 강박장애 환자군들의 COMT 유전자형 세 군 사이의 우울증상 점수에서는 유의한 차이가 관찰되었다. 결론 한국인에서 강박장애와 COMT 유전자 다형성 사이에는 연관성이 없었다. 그러나, COMT의 H 대립형질과 강박장애 군에서 공존하는 우울증상 척도가 유의한 연관성을 보인 현상은 COMT 유전자의 다형성이 강박장애의 공존 우울증상에 영향을 미칠 수 있는 가능성을 시사한다고 생각된다. Objectives : The definite cause of obsessive-compulsive disorder (OCD) is still unknown. Evidences from familial, twin and segregation studies support the role of a genetic factor. There are also growing evidence indicating that OCD has specific neurochemical and neuroanatomical basis. Derived from the effectiveness of treatment with dopamine receptor blocker in certain part of OCD patients (eg. SSRI treatment-resistant OCD), several candidate genes related to dopamine dysregulation have been hypothesized to play an important role in the development of OCD. One of them is the Catechol-O-Methyltransferase (COMT) gene. The aim of this study was to investigate the association between COMT and OCD in Korean population. Methods : 124 OCD patients and 170 normal controls participated in this study. Genomic DNA was extracted from their blood. The genotypes and allele frequencies of the COMT polymorphism between OCD group and control group were compared. We investigated the association between severity of OCD assessed by Yale-Brown obsessive compulsive symptom scale (YBOCS) and Hamilton depression rating scale (HDRS) scores and COMT polymorphism. Results : In this case-control study, we could not find any association between COMT gene polymorphism and development of OCD. In OCD group, patients with H/H genotype had significantly higher scores for the HDRS than those with H/L or L/L genotype. Conclusion : In this study, there was no difference in genotype distributions of COMT between OCD and control groups. However, H/H genotype of COMT gene polymorphism might be related to depressive symptoms in OCD patients.

소아 대퇴골 간부 골절에대한 Nancy정 고정술

홍기도,하성식,정남식,심재천,김재영 대한골절학회 2003 대한골절학회지 Vol.16 No.4

中·老人層 人口의 建康管理 實態 分析에 의한 社會體育 活性化 方案

李淳川,金相洪,李源才 啓明大學校 生活科學硏究所 1991 科學論集 Vol.17 No.-

This study is to find out the activating plan of sociophysical education by analyzing a questionnaire for health management in their forties to sixties. The questionnaire are collected from men and women of 1,215 who are living at Taegu city(Dong-gu, Seogu, Nom-gu, Pook-gu, Joong-gu, Susung-gu, and Dalseo-gu). The results of this study are summaried as follows. 1. Self-confidence for health care is decreased with age in men and women. 2. Regular physical examination is performed about 8%, when they are in pain, it is performed some 4%. Though they are in pain, 28.8% of them didn't go to a hospital and clinic. 3. A medicine for promoting nutrition and meals are used to main and promote their health care and physical fitness. A physical exercise and a stroll and regular life style are in 25% subjects. Unfortunately, it shown that men and women subjects do not nearly take their physical exercise. 4. The means of health management are ordered jogging, mountaineering, a stroll, physical exercise, tennis, a ball game, table tennis, swimming, badminton, and ect., but mountaineering and aerobic dance, a stroll, tennis, table tennis, physical exercise, health club, jogging for women. Men are performed a stroll, aerobic dance, but women are performed physical exercise in their sixties. 5. Motivation of joining in club or a fellow member is facilities and instruments, and spaces. 6. When they are in pain at first they visit drug store(48.72%), and use self-treatment(12.10%). They do not make use of a hospital and clinic and public health center. 7. The most difficult problem showed such order as when they are in pain and problem of sons and daughters in men and women in forties. They have nothing to do and alone and they are in pain in men and women in sixties. 8. They wish to be sports lecture room of every kind(23.21%), opening and complete equipment of facilities in school physical education(22.20%), regular physical fitness chapter(15.38%), and publicity activities for sports(12.43%).

專門大學 職業敎育 내실화와 産學協同 활성화 방안 : 위생사를 중심으로

김남천,이상건,우세홍,김을환,이형춘,이인길 서울保健大學 1987 論文集 Vol.7 No.1

鬱陵島 稀貴植物의 分布 및 生態에 關한 硏究

李愚升,鄭載東,洪盛千 慶北大學校 1986 論文集 Vol.41 No.-

Ulreung island harbors more diverse and rare native plants than any other area of Korea due to its geographic and climatic peculiarity. Many of the native plants have been used as famine crops, medicinal herbs, vegetables, and ornamentals. Some of them are important sources of income for residents on the island nowadays. This survey was conducted to select the promising native plants for use as vegetable or ornamentals, and to help residents economy by studying the methods for preservation and propagation of the valuable native plants. 1. Current native vegetation on Ulreung island consists of pure coniferous forests, 550 ha(10%), pure broad-leaved forests, 3,518ha(64%), and mixed forests, 636ha(12%). 2. Among the wild native plants, Lilium hansonil, Allium victorials var. platypliyllum, Arumcus diolicus var. kamtschaticus, Solidago virgaurea var. gigantea, Pteridium aqu-ilinum var. latiusculium, Osmunda japonica, Reynoutria sachalinensis, Aralia continentalis are used as vegetable and their edible parts are either young stems, sprouts or bulbs. While Gynostemma pentaphyllum is exported as a material for tea. 3. Those plants that were considered worthwhile to improve and propagate as ornamentals were Calanthe striata, Cymbidium goeringii, Hepatica maxima, Adiantum pedatum, Sorbus commixta, Thymus quinguecostatus etc. Those that appeared promising for garden tree or terrarium were Taxus cuspidata var. latifolia Nak, Tsuga sieboldii, Pinus parviflora, Tilia insularis, and Sorbus commixta etc. 4. As an ecological characteristic, Allium victorialis var. platypliyllum was distributed as a community on the slopes of mountains or uneven areas. They were thriving especially on humus rich area under tall or medium trees. 5. Natural habitats of Aruncus diolicus var. kamtschaticus and Solidago virgaurea var. gigantea etc. were found under the trees with dominance and sociability range of 5.5 to +. Therefore, more or less shading would be necessary for production of high quality crops. 6. Pteridium aquilimum var. latiusculium was distributed around the fields or paddy fields at the foot of mountains and on vestiges of slash-and-burn fields. Osmunda japonica was thriving on slightly humid low slopes and under the trees with high dominance. 7. Calanthe strialata, Cymbidium goeringii, Hepatica maxima, Adiantum pedatum, and Asplenium scolopendrium have either beautiful flower or leaves. They were distributed in dense forests of tall trees. Adiantum pedatum was found between rocks, Asplenium scolopendrium and Reynoutria sachalinensis, along the valley line, Ardisia japonica under Tsaga sieboldii, Pinus parviflora and Fagus crenata var. multinervis communities on Taewharyung and Thymus quinguecostacus, on a sunny area of Nan-Dong in large communities. 8. Propagation of the native plants would be possible as follows: Aruncus diolicus var. kamtschaticus, Allium victorialis var. platypliyllum, Thymus quinguecostatus and Soli-dago virgaurea var. gigantea by either division or seed, Hepatica maxima, Pinus parviflora, Tsuga sieboldii and Sorbus commixta by seed, those ferns such as Osmunda japonica, Adiantum pedatum and Pteridium aquilinum var. latiusculium by germinating spores aseptically in laboratory or in the greenhouse, Lilium hansonii by bulbscale cutting or by bulbscale tissue culture, Ardisia japonica and Taxus cuspidata var. latifolia by either seed or cutting and Thymus quinquecostatus by cutting. 9. Humus content of native soil was ranging from 19.1% to 91.2% and pH, from 4.7 to 5.3.

中世 體育이 지닌 現代的 意味 : 유럽地域의 各 階層別 中心으로

金相洪,李淳川,裵永相 啓明大學校 生活科學硏究所 1986 科學論集 Vol.12 No.-

This study was conducted to research into the gymnastic circumstances according to medieval thought and its classified classes. The results of medieval physical education and their contributions to us on the basis of characteristics of their classes and their physical activity are as follows: 1. The gymnastics development of the Middle Ages was hindered by Christian view on physical culture. 2. The aristocratic view on gymnastics was changed into equalitarian by the birth of Christianity. 3. The physical education of Knight was actual military training in the early age and a formal one in later age, moralism was introduced into physical education through knighthood. 4. The medieval gymnastics activities avoided by knight, chmchemn, and aristocracy were highly popular among guidsmen, bourgeois and the peasantry as a recreation like ball-game and dancing. This was developed into modern gymnastic tendency. 5. The medieval gymnastics which was called dark age of physical education owing to the gymnastics view of Stoic asceticism was advanced through the middle of medieval era to ward the modern form of sportmanship in later age.

백서 심근위축에 관한 실험적 연구

이순천,김상홍,배영상 啓明大學校 生活科學硏究所 1986 科學論集 Vol.12 No.-

Daunorubicin을 ㎏당 0.5㎎을 1주 및 2주간 투여하여 심근위축을 유발코자 한 본 실험에서 다음과 같은 결론을 얻었다. 1. 실험군의 심장의 무게는 대조군에 비해 현저하게 감소하였고 체중에 대한 심장무게비도 대조군에 비해 감소하였다. 2. 혈청내 효소 활성치는 CPK, LDH, SGOT 모두 Daunorubicin투여 1주에서 크게 증가하였고 특히 LDH가 증가폭이 가장 컸다. 3. Daunorubicin투여로 인한 심근의 미세구조변화로 1주에서는 mitochondria의 condensation과 sarcoplasmic reticulum의 확장, 근원섬유의 fraying 및 contraction band등이 형성되었고, 2주에서는 mitochondria의 swelling과 cristae의 파괴, intercalated disc의 분리 및 세포간질의 증식이 관찰되었다. 4. 약물투여기간에 따른 심근세포내 소기관의 양적인 변화로 단위면적당 mitochondria의 수 및 volume density는 1주에서는 다소 감소를 보이다가 2주에서는 약간 상승하였다. Myofibril의 volume density는 1주에서 현저히 감소되었으며 sarcommere의 길이는 약물투여기간에 따라 점차 감소였다. The present studies were designed to determine the feasibility of using the rats as models for induction of cardiac atrophy. Daunorubicin (DNR), on antracyclin antibiotics, has a potent cytotoxicity in rotents. A total of 40 rats were divided into two groups for experiment. The group I consisted of 20 animals were used for the saline control, the group Ⅱ 20 animals were injected 0.5㎎/㎏/day for 7 to 14 days. The morphological change in myocardium of the rats were observed for each time interval by electron microscopy. In addition to morphological studies, changes in the activity of serum enzyme-CPK, LDH, SGOT-were checked to correlate with the morphological changes. The result were summerized as follow: 1. There was a signigicant decrease in the weight of heart of the experimental group. The ratio of the wet weight of the heart to the body weight(H/B) showed a tendency of decrease with time. 2. Serum enzyme, CPK, LDH, SGOT were all elevated as early as early as 1 weeks after the initation of drug injection and steadly increased there after. 3. Electron microscopically, 1 week after injection of daunorubicin condensation of mitochondria, dilation of sarcoplasmic reticulum and fraying and contraction band of myofibrils were characterized. After 2 week, followed by swelling and cristae disruption of mitochondria, severe separation of intercalateded discs and interstitial fibrosis. 4. On quantitative study, number and volume density of mitochondria in the unit area decrease decrease on 1 week after injection. Thereafter it showed increased. Volume density of myofibrils significantly decrease on 1 week and the length of sarcolemma decrease with time.

달리기 자세에 대한 생체역학적 연구

이순천,김상홍 啓明大學校 生活科學硏究所 1988 科學論集 Vol.14 No.-

The purposes of this study are to examine changes in stride length and stride frequency, running form with increase in running speed. Five male mid-distance runner are instructed to run at three different speeds and are filmed with a high speed camera. The result can be summarized as follows; 1) Although the stride frequency become more rapid as the speed increases, the stride length does not increase. 2) As the speed increases, the forword lean angle increases further and the center of gravity of the latter half of the support phase takes a longer horizontal displacement. 3) As the speed increases, the supporting time and a rate of unsupporting time to supporting time represent a shorter. 4) As the speed increases, the foot is somewhat more elevated toward the front during the latter half of recovery phase and takes a longer course until contact.

28세 여성에서 Epinephrine 국소 주사 후 발생한 스트레스성 심근병증 1예

임주견,곽성동,박재영,천재홍,최성열,차태준,이준상 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Stress induced cardiomyopathy is characterized by transient left ventricular dysfunction with typical regional wall motion abnormality of basal segment hyperkinesia and apical hypokinesia after physical or psychological stress. Stress induced cardiomyopathy mimics acute myocardial infarction but coronary angiography shows normal and usually recovers rapidly. Stress induced cardiomyopathy appears to occur almost exclusively in old females. Only a few cases have been reported in younger women but not yet in korea. The pathogenesis is not well known. Currently, it is thought that catecholamine may play important role. Especially, epinephrine may be most important catecholamine in the pathogenesis of steress induced cardiomyopathy. We report a case of stress induced cardiomyopathy occurred in young female after local epinephrine injection for hemostasis during tonsillectomy. 스트레스성 심근병증은 고령의 여성에서 주로 발생하며 카테콜라민 중 특히 epinephrine이 병리기전의 주요한 원인의 하나로 생각되어지고 있다. 저자들은 28세의 젊은 여성에서 편도절제술 도중 지혈을 목적으로 epinephrine을 국소 주사한 후 발생한 스트레스성 심근병증 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.