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흰쥐 신장에서 Prednisone의 산소 독성에 대한 Liposomal Superoxide Dismutase의 보호효과
이인길,백광진,이희성 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.3
The activity changes of superoxide dismutase (EC 1. 15. 1. 1, SOD), catalase (EC 1. 11. 1. 6), peroxidasc (EC 1. 11. 1. 7) and xanthine oxidase (EC 1. 1. 3. 22) were observed in rat kidney treated with prednisone (10mg/100g body weight) (experimental group A) or liposomal superoxide dismutase (3,000 units) followed by prednisone (10mg/100g body weight) (experimental group B). The results were summarized as follows: 1. Activities of Cu, Zn-SOD, Mn-SOD, catalase and peroxidase in experimental group B appeared to be higher than those in experimental group A. 2. In both experimental groups, the activity of peroxidase showed higher than those in the controls. 3. The activity of xanthine oxidasc in both experimental groups were similar to those in controls. In conclusion, it seems likely that the prednisone is not influence on xanthine oxidase activity in rat kidney, but liposomal SOD enhance the activity of Cu, Zn-SOD, Mn-SOD, catalase and peroxidase and inhibit the oxygen toxicity in rat kidney. Therefore, the SOD, catalase and peroxidase, scavengers of oxygen radicals, may be one of the factors in rat kidney defence mechanism against the oxygen toxicity.
Azide투여가 고농도산소 노출에 의한 마우스 간내 반응성 산소의 발생과 제거에 미치는 영향
이인길,박건택,김승욱,백광진,권년수,이희성 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.2
An increased production of reactive oxygen species has been postulated as a major pathogenic factor of the tissue demage occurring in high oxygen environment. Azide could enhance the oxygen toxicity by inhibiting superoxide dismutase and catalase, enzymes which remove reactive oxygen species. Mice were treated intraperitoneally with azideI8.1㎎/㎏ body weight), and placed in a chamber saturated with 100 % O_2 for 3, 6, 12, 24, 48 or 72 h. Superoxide radical generation, and activities of xanthine oxidase, superoxide dismutase and catalase in homogenate of the mouse liver were measured. At 3 h of the treatment with azide/100 % O_2, superoxide radical generation was enhanced to more than 12 times of the control. Such increment was much higher in the liver of mice treated with both azide and 100 % O_2 than in that with either azide or 100 % O_2 alone. On the other hand, the activities of mitochondrial Mn-superoxide dismutase and catalase were decreased, while Cu, Zn-superoxide dismutase activity was elevated by the azide/oxygen treatment. Xanthine oxidase activity was markedly increased by the azide/oxygen treatment. These results indicate that superoxide radical generation in the mouse liver by the azide/oxygen treatment may be due to the inhibiton of Mn-superoxide dismutase and catalase, and due to increased xanthine oxidase activity. Treatment with azide alone did not decrease the activities of Mn-superoxide dismutase and catalase. This result suggested that azide did not effectively inhibit these enzymes in vivo.
李仁吉(In Kil Lee) 한국환경보건학회 1985 한국환경보건학회지 Vol.11 No.1
The studies on the carotenoids in the visæra the brine shrimp( Penaeus OrientaJis Kis_ hinouye) have been carried out. The brine shrimps were caught around the western coa_stal area of Korea from Aug. to Oct. The individual carotenoids in the acetone extracts were separated and purified by the silica gel TLC. Two isolated carotenoids were investigated and identified by epoxide test , partition test , alkaline hydrolysis , reduction with sodium borohydride and vlsible absorption spectroph~tometry. As the results of the series of experiments, esterified Astaxanthin was discovered as one of main pigments of Penaeus Orientalís Kishinouye.
이인길,이근후 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1
This study was conducted to see the difference of defense mechanisms among normal control, acute and chronic schizophrenias with paranoid subtype using korean defense mechanism test based on the traditional proverbs. The results were as follows ; 1) Projection, denial, rationalization, displacement, acting out, passive-aggressive behavior, regression and brag were increased in chronic schizophrenics compared to control group, but sublimation was decreased in chronic schizophrenics compared to control group. 2) Projection, denial, somatization and rationalization were increased on acute schizophrenics compared to control group. 3) There was no significant difference between the acute schizophrenic patients and the chronic schizophrnic patients in all defense mechanisms.
김종헌,이인상,서한길,정순일,박철수,우성일,Kim, Jong-Hun,Lee, In-Sang,Seo, Han-Gil,Jung, Sun-Il,Park, Chul-Soo,Woo, Sung-Il 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1
This study was done to examine whether cigarette smoking improved smooth pursuit eye movement(SPEM) abnormalities in chronic schizophrenic inpatients. Fifteen schizophrenic and twelve alcoholic subjects abstained from their usual cigarette smoking for a minimum of nine hours and their baseline performances during the constant velocity smooth pursuit tasks were assessed. Then, the subjects smoked as much as they desired in a 10 minutes period and were retested immediately after smoking and 15 minutes after smoking. Electrooculographic recordings during the eye movements were converted and saved as digitized files. Power spectral density curves and natural logarithm value of signal/noise(Ln S/N) ratios were computed from them. In the schizophrenic patients, Ln S/N ratios increased significantly immediately after smoking compared to baseline. But, Ln S/N ratios showed no statistically significant changes after 15 minutes compared to baseline. In alcoholic subjects, Ln S/N ratios showed no statistically significant changes immediately after smoking and after 15 minutes compared to baseline. In conclusion, SPEM was improved in schizophrenic patients immediately after smoking and we hypothesized that nicotinic receptor dysfunction maybe a candidate mechanism for smooth pursuit eye movement abnormalities in schizophrenia.