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Khurshid Ahmed,정명호,Rabin Chakraborty,Sumera Ahmed,홍영준,심두선,박근호,김주한,안영근,강정채,조명찬,Chong Jin Kim,김영조 대한심장학회 2012 Korean Circulation Journal Vol.42 No.12
Background and Objectives: Chronic kidney disease (CKD) is associated with poor outcomes after percutaneous coronary intervention (PCI). We sought to compare different coronary stents used during primary PCI in patients with ST-elevation myocardial infarction (STEMI) and CKD. Subjects and Methods: We selected 2408 consecutive STEMI patients with CKD (estimated glomerular filtration rate <60 mL/min/1.73 m 2 )undergoing primary PCI and divided them into 5 groups based on the type of stent implanted: 1) bare metal stent (BMS), 2) paclitaxel-eluting stent (PES), 3) sirolimus-eluting stent (SES), 4) zotarolimus-eluting stent (ZES), or 5) everolimus-eluting stent (EES). The study end-point was the number of major adverse cardiac events (MACE) at 12 months. Results: There was no significant difference in the incidence of 12-month myocardial infarction, target lesion revascularization, or target vessel revascularization between stent groups; however, the overall rate of repeat revascularization differed significantly between groups. All-cause death differed significantly among the groups. The incidence of 12-month MACE in BMS, PES, SES, ZES, and EES was 8.3%, 9.8%,8.6%, 5.5%, and 2.6%, respectively (p<0.001). Kaplan-Meier analysis did not show a significant differences in 12-month MACE-free survival among the groups (log-rank p=0.076). This finding remained the same after adjusting for multiple confounders (p=0.147). Conclusion: Any of the 5 stents can be used to treat STEMI patients with CKD undergoing primary PCI; all have similar risk of 12-month MACE. This result is hypothesis-generating and warrants further evaluation with a long-term randomized study.
Khurshid Ahmed,정명호,Rabin Chakraborty,홍영준,심두선,Sumera Ahmed,Seung Hwan Hwang,Min Goo Lee,Keun Ho Park,김주한,안영근,조명찬,Chong Jin Kim,김영조,Jong Chun Park,강정채,성인환,배장호 대한의학회 2012 Journal of Korean medical science Vol.27 No.11
The aim of this study was to compare safety and efficacy of 4 homogenous overlapping drug-eluting stents (DES) in acute myocardial infarction (AMI) patients. We selected 1,349consecutive patients (62.1 ± 14.9 yr, 69.4% male) who received homogenous overlapping DESs in diffuse de novo coronary lesions from Korea Acute Myocardial Infarction Registry from April 2006 through September 2010. They were divided into 4 groups based on type of DES implanted – Paclitaxel (PES), Sirolimus (SES), Zotarolimus (ZES) and Everolimus (EES)-eluting stents. Primary endpoint was 12-month MACE. We also studied EES versus other DESs (PES + SES + ZES). Mean stent length was 26.2 ± 7.5 mm and mean stent diameter was 3.1 ± 0.4 mm. Average number of stents used per vessel was 2.2 ± 0.5. Incidence of major adverse cardiac events (MACE) in PES, SES, ZES, and EES groups were 9.5%, 9.2%, 7.5%, and 3.8%, respectively (P = 0.013). In EES group, overall MACE and repeat revascularization were lowest, and no incidence of stent thrombosis was observed. Non-fatal MI was highest in PES, almost similar in SES and EES with no incidence in ZES group (P = 0.044). Cox proportional hazard analysis revealed no differences in the incidence of primary endpoint (P = 0.409). This study shows no significant differences in 12-month MACE among 4 groups.
Muhammad Afaq Javed,Muhammad Irfan,Sumera Khalid,Yulong Chen,Saeed Ahmed 대한토목학회 2016 KSCE Journal of Civil Engineering Vol.20 No.7
In recent years, Fiber Reinforced Polymers (FRP) have emerged as useful materials for structural strengthening and rehabilitation. The main aspire of this research is towards evaluating the efficiency of Carbon Fiber Reinforced Polymers (CFRP) in enhancing the shear strength of deep beams. The research work included construction and testing of eight (08) reinforced concrete deep beams. Two of the beams, designated as control beams, were without any shear reinforcement. Remaining six beams were divided into three groups, with each group having two identical beams. Beams in one of these groups were strengthened with conventional type of steel web reinforcement. Remaining two groups were strengthened externally by CFRP sheets with different orientations of CFRP. Magnitude of load causing shear cracks to initiate, and the failure load of each beam was recorded. Significant increase in overall load carrying capacities was observed with both CFRP sheets and web steel reinforcement. CFRP was found to be considerably effective in delaying the initial appearance of shear cracks, thereby improving the serviceability limit state of beams. Beams with CFRP orientation perpendicular to the shear cracks showed higher increment in shear strength. In conclusion, CFRP laminates could effectively be used to strengthen existing RC structures deficient in shear strength, and also to reduce/replace internal steel web reinforcement in new RC structures. Material cost comparison of CFRP reinforced beams with conventional web reinforcement is presented, and the general cost effectiveness of structural rehabilitation by means of CFRP is also discussed.
Muhammad Rizwan Maqsood,Muhammad Hanif,Muhammad Rafiq,Muhammad Saleem,Sumera Zaib,Aftab Ahmed Khan,Mazhar Iqbal,Jamshed Iqbal,Nasim Hasan Rama,서승염,Ki-Hwan Lee 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.
Maqsood, Muhammad Rizwan,Hanif, Muhammad,Rafiq, Muhammad,Saleem, Muhammad,Zaib, Sumera,Khan, Aftab Ahmed,Iqbal, Mazhar,Iqbal, Jamshed,Rama, Nasim Hasan,Seo, Sung-Yum,Lee, Ki-Hwan Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, $^1H$ NMR, $^{13}C$ NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.