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Muhammad Rafiq,Muhammad Saleem,Muhammad Hanif,Muhammad Rizwan Maqsood,Nasim Hasan Rama,Ki-Hwan Lee,서승염 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
A series of aromatic hydrazides 3a-j were prepared by refluxing esters 2a-j with hydrazine hydrate in methanol, which were prepared by the esterification of 1a-j. Acetohydrazides 3a-j upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazate salts 4a-j, which on refluxing with hydrazine hydrate yielded substituted 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-j. The target compounds 6a-j were synthesized by condensing furan-3-carboxylic acid in the presence of polyphosphoric acid under reflux. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their urease, acetylcholine esterase inhibition, antioxidant and alkaline phosphatase inhibition activity. Almost all of the compounds 6a-j showed good to excellent activities against urease and acetylcholine esterase more than the reference drugs. Compounds 6f and 6g were more potent scavenger of free radicals than the reference n-propyl gallate. Compound 6b and 6h showed excellent activities of alkaline phosphatase as compare to the reference KH2PO4.
Muhammad Rizwan Maqsood,Muhammad Hanif,Muhammad Rafiq,Muhammad Saleem,Sumera Zaib,Aftab Ahmed Khan,Mazhar Iqbal,Jamshed Iqbal,Nasim Hasan Rama,서승염,Ki-Hwan Lee 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.
Maqsood, Muhammad Rizwan,Hanif, Muhammad,Rafiq, Muhammad,Saleem, Muhammad,Zaib, Sumera,Khan, Aftab Ahmed,Iqbal, Mazhar,Iqbal, Jamshed,Rama, Nasim Hasan,Seo, Sung-Yum,Lee, Ki-Hwan Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, $^1H$ NMR, $^{13}C$ NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.
Rafiq, Muhammad,Saleem, Muhammad,Hanif, Muhammad,Maqsood, Muhammad Rizwan,Rama, Nasim Hasan,Lee, Ki-Hwan,Seo, Sung-Yum Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.12
A series of aromatic hydrazides 3a-j were prepared by refluxing esters 2a-j with hydrazine hydrate in methanol, which were prepared by the esterification of 1a-j. Acetohydrazides 3a-j upon treatment with carbon disulfide and methanolic potassium hydroxide yielded potassium dithiocarbazate salts 4a-j, which on refluxing with hydrazine hydrate yielded substituted 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-j. The target compounds 6a-j were synthesized by condensing furan-3-carboxylic acid in the presence of polyphosphoric acid under reflux. The structures of newly synthesized compounds were characterized by IR, $^1H$ NMR, $^{13}C$ NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their urease, acetylcholine esterase inhibition, antioxidant and alkaline phosphatase inhibition activity. Almost all of the compounds 6a-j showed good to excellent activities against urease and acetylcholine esterase more than the reference drugs. Compounds 6f and 6g were more potent scavenger of free radicals than the reference n-propyl gallate. Compound 6b and 6h showed excellent activities of alkaline phosphatase as compare to the reference $KH_2PO_4$.
Muhammad Hanif,양홍추안,Gary Boudreau,Edward Sich,Hossein Seyedmehdi 한국통신학회 2018 Journal of communications and networks Vol.20 No.2
Massive MIMO technology is a promising candidate forthe next generation wireless communication systems. The basicidea is to implement a large number of antennas at the base station(BS) of a cell to serve a relatively small number of users. Such an approach brings many benefits in terms of the throughputand energy efficiency. Two major challenges associated withmassive MIMO systems are high power consumption and high systemcomplexity. These problems can effectively be dealt with byperforming antenna-subset selection at the BS. In this paper, wepropose low-complexity antenna-subset selection schemes for bothsingle-cell and multiple-cell cooperative massive MIMO systemsfor equal-rate zero-forcing beamforming transmission at the BS. These schemes sequentially select an antenna that contributes themost to the overall system sum rate. Simulation results show thatour proposed schemes outperform other schemes with similar computationalcomplexities and even surpass some of the higher computationalcomplexity schemes in a massive MIMO setting.
Hanif Muhammad Khan,김성관 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.8
We report a study on monocrystalline nickel thin films using the atomic force microscope (AFM) based scratching process to understand the associated wear mechanism. As for the nano level fabrication, better understanding of abrasive wear mechanism is a prerequisite. A three-dimensional molecular dynamics (MD) study has been performed and we have used a new parameter wear volume to distinguish between different wear zones. A reduced number of zones have been proposed to understand the wear mechanism during nanoscratching process. Also, centrosymmetry parameter has been used to validate the findings.
Muhammad Saleem,Muhammad Rafiq,Muhammad Hanif,Nasim Hasan Rama,Sung-Yum Seo,Ki-Hwan Lee 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
A new series of 2,5-disubstituted-1,3,4-thiadiazoles 6a-i was synthesized by overnight stirring various 1,4- disubstituted thiosemicarbazides 5a-i in polyphosphoric acid followed by neutralization. The structures of newly synthesized compounds 5a-i and 6a-i were characterized by IR, 1H and 13C NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were evaluated for their urease and acetylcholine esterase inhibition activities. Thiosemicarbazides 5a-i are found to possess excellent potential for urease inhibition, more than the standard drug. Thiosemicarbazides 5a-i are more potent urease inhibitor than their cyclic analogues thiadiazoles 6a-i. Almost all of the compounds are excellent inhibitors of acetylcholine esterase. The inhibition of acetylcholine esterase of compounds 5a, 5c, 5d, 5g, 5i, 6e, 6f, 6g, and 6i is much more than that of standard drug.
Muhammad Rafiq,Muhammad Saleem,Muhammad Hanif,Sung Kwon Kang,SungYum Seo,Ki-Hwan Lee 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.2
In this study, a series of ten triazole Schiff base derivatives 6a–j were synthesized through microwave assisted imine formation by reacting substituted amino triazole 5 with different substituted aldehydes. All the synthesized compounds were evaluated for their inhibitory activity against mushroom tyrosinase. Two of the compounds 6a and 6b among the series 6a–j were found to be highly potent tyrosinase inhibitors with IC50 values of 10.09 ± 1.03 and 6.23 ± 0.85 lM, respectively, which were even higher than that of the reference inhibitor kojic acid (IC50 = 16.6 ± 2.8 lM). Compounds 6e and 6f with IC50 values of 20.27 ± 2.78 and 26.02 ± 4.14 lM, respectively, were comparable to the reference inhibitor, and the remaining compounds had a moderate inhibitory activity against mushroom tyrosinase. The most potent compounds (6a, 6b) were used in the kinetic and optical analyses. The inhibition kinetics analyzed with Lineweaver– Burk plots revealed that both compounds 6a and 6b were non-competitive inhibitors of tyrosinase with inhibition constant values of 0.023 and 0.022 mM, respectively.
Ginseng saponins and the treatment of osteoporosis: mini literature review
Muhammad Hanif Siddiqi,Muhammad Zubair Siddiqi,Sungeun Ahn,Sera Kang,Yeon-Ju Kim,Natarajan Sathishkumar,Dong-Uk Yang,Deok-Chun Yang 고려인삼학회 2013 Journal of Ginseng Research Vol.37 No.3
The ginseng plant (Panax ginseng Meyer) has a large number of active ingredients including steroidal saponins with a dammarane skeleton as well as protopanaxadiol and protopanaxatriol, commonly known as ginsenosides, which have antioxidant, anticancer, antidiabetic, anti-adipocyte, and sexual enhancing effects. Though several discoveries have demonstrated that ginseng saponins (ginsenosides) as the most important therapeutic agent for the treatment of osteoporosis, yet the molecular mechanism of its active metabolites is unknown. In this review, we summarize the evidence supporting the therapeutic properties of ginsenosides both in vivo and in vitro, with an emphasis on the different molecular agents comprising receptor activator of nuclear factor kappa-B ligand, receptor activator of nuclear factor kappa-B, and matrix metallopeptidase-9, as well as the bone morphogenetic protein-2 and Smad signaling pathways.
Competitive residual neural network for image classification
Muhammad Shehzad Hanif,Muhammad Bilal 한국통신학회 2020 ICT Express Vol.6 No.1
We propose a novel residual network called competitive residual network (CoRN) for image classification. The proposed network is composed of residual units having two identical blocks each containing convolutional filters, batch normalization, and a maxout unit. The maxout unit enables the competition among the convolutional filters and reduces the dimensionality of the convolutional layer. The proposed network outperforms the original residual network by a significant margin and test errors on benchmark datasets (CIFAR-10/100 and SVHN) are comparable to the state-of-the-art. Using the ensemble network, we achieve a test error of 3.85% on CIFAR-10, 18.17% on CIFAR-100 and 1.59% on SVHN.