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Development of an integrated breeding platform for data-driven crop improvement
Yeisoo Yu(Yeisoo Yu),SeungWook Lee(SeungWook Lee),Suhyeon Park(Suhyeon Park),Changyuel Lee(Changyuel Lee),Youngsil Kim(Youngsil Kim),Daegyu Kim(Daegyu Kim),Seok Jae Yun(Seok Jae Yun),Dae Kwan Kim(Da 한국육종학회 2023 한국육종학회 공동학술발표집 Vol.2023 No.-
Suhyeon Kim,Si-Yeon Lee,Seoyoon Bae,Jin-Kwan Lee,Kyungrim Hwang,고현정,이창우 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Psoriasis is one of the most common immune-mediated chronic inflammatory skin diseases. However, little is known about the molecular mechanism underlying the immunological circuits that maintain innate and adaptive immune responses in established psoriasis. In this study, we found that the Pellino1 (Peli1) ubiquitin E3 ligase is activated by innate pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), and is highly upregulated in human psoriatic skin lesions and murine psoriasis-like models. Increased Peli1 expression is strongly correlated with the immunopathogenesis of psoriasis by activating hyperproliferation of keratinocytes in the S and G2/M phases of the cell cycle and promoting chronic skin inflammation. Furthermore, Peli1-induced psoriasis-like lesions showed significant changes in the expression levels of several T helper 17 (Th17)-related cytokines, such as IL-17a, IL-21, IL-22, IL-23, and IL-24, indicating that overexpression of Peli1 resulted in the sequential engagement of the Th17 cell response. However, the overexpression of Peli1 in T cells was insufficient to trigger psoriasis, while T cells were indispensable for disease manifestation. In summary, our findings demonstrate that Peli1 is a critical cell cycle activator of innate immunity, which subsequently links Th17 cell immune responses to the psoriatic microenvironment.
( Suhyeon Lee ),( Yeonsil Yu ),( Jinyoung An ),( Jeongmin Lee ),( Jin Sung Son ),( Young Kyung Lee ),( Sook Hee Song ),( Hyeok Kim ),( Suhyun Kim ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.77 No.4
Here, we report a case of pulmonary paragonimiasis that was improved with initial anti-tuberculosis (TB) therapy but confused with reactivated pulmonary TB. A 53-year-old Chinese female presented with a persistent productive cough with foul smelling phlegm and blood streaked sputum. Radiologic findings showed subpleural cavitary consolidation in the right upper lobe (RUL). Bronchoscopic and cytological examination showed no remarkable medical feature. She was diagnosed with smear-negative TB, and her radiologic findings improved after receiving a 6-month anti-TB therapy. The chest CT scans, however, obtained at 4 months after completion of anti-TB therapy showed a newly developed subpleural consolidation in the RUL. She refused pathologic confirmation and was re-treated with anti-TB medication. Nevertheless, her chest CT scans revealed newly developed cavitary nodules at 5 months after re-treatment. She underwent thoracoscopic wedge resection; the pathological examination reported that granuloma caused by Paragonimus westermani. Paragonimiasis should also be considered in patients assessed with smear-negative pulmonary TB.
A Novel Vector-matrix Multiplication (VMM) Architecture based on NAND Memory Array
Suhyeon Kim,Myung-Hyun Baek,Sungmin Hwang,Taejin Jang,Kyungchul Park,Byung-Gook Park 대한전자공학회 2020 Journal of semiconductor technology and science Vol.20 No.3
We propose a novel vector-matrix multiplication (VMM) architecture based on NAND synaptic array using a pMOSFET which is an analog switch shape cell for neural network (NN) applications. A NAND FLASH memory string is consisting of a NAND cell and a pMOSFET not to open string. A NAND cell’s resistance can be modulated by threshold voltage (Vth) depending on the amount of trapped charge when an input signal applies. If there is no input spike, a NAND cell is turned off and a pMOSFET acts as a pass gate so that only a constant voltage drop exists. Based on this NAND cell and a pMOSFET pair series, we confirm VMM operation. And inference method 1 layer fully-connected network (FCN) is implemented by circuit simulation to test 8x8 MNIST. The result of 84% recognition accuracy compared to software artificial neural networks (ANN) 86% accuracy.
Development of A Novel Framework for Liquid Bulk Cargo Volume Analysis
Suhyeon Kim,Wonho Sohn,Dongcheol Lim,Junghye Lee 대한산업공학회 2019 대한산업공학회 추계학술대회논문집 Vol.2019 No.11
Port cargo volume analysis is a challenging task for researchers because of non-stationary and highly volatile data affected by external factors. Nevertheless, it is important to establish an analysis system for the port cargo volume as the analysis of the port cargo volume can provide information on the establishment of strategies for port planning and management. In this paper, we propose a new framework to analyze port cargo volume, which consists of three parts: item segmentation, exploratory data analysis, and time series forecasting specifically for liquid bulk cargo volume. We firstly create an item dictionary containing main keywords to characterize each item and then categorize items based on the dictionary. Next, we perform an exploratory data analysis to understand the volume characteristics of each subcategorized item. Lastly, we use representation learning- and deep learning-based time series techniques to forecast their port volume and compare the results with existing statistical models. Experimental results for the three steps show the usefulness of our novel framework in several aspects including forecasting accuracy. It is believed that our proposed method will be a helpful system for stakeholders in port logistics to have insights and to make better decisions.
Kim, Suhyeon,Kim, Songhee H.,Ahn, Jinsook,Jo, Inseong,Lee, Zee-Won,Choi, Sang Ho,Ha, Nam-Chul Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.12
The Gram-negative opportunistic pathogen, Pseudomonas aeruginosa, has multiple multidrug efflux pumps. MexT, a LysR-type transcriptional regulator, functions as a transcriptional activator of the MexEF-OprN efflux system. MexT consists of an N-terminal DNA-binding domain and a C-terminal regulatory domain (RD). Little is known regarding MexT ligands and its mechanism of activation. We elucidated the crystal structure of the MexT RD at 2.0 Å resolution. The structure comprised two protomer chains in a dimeric arrangement. MexT possessed an arginine-rich region and a hydrophobic patch lined by a variable loop, both of which are putative ligand-binding sites. The three-dimensional structure of MexT provided clues to the interacting ligand structure. A DNase I footprinting assay of full-length MexT identified two MexT-binding sequence in the mexEF-oprN promoter. Our findings enhance the understanding of the regulation of MexT-dependent activation of efflux pumps.