結晶學에 관한 論題(Ⅱ)

徐日煥,金光柱,徐鍾命,林星秀 충남대학교 자연과학연구소 1989 忠南科學硏究誌 Vol.16 No.2

結晶의 32個 三次元的 點群의 誘導

徐日煥,金光柱,徐種命,李珍昊,林星秀,金文執 충남대학교 1990 忠南科學硏究誌 Vol.17 No.1

結晶들의 外的인 모양은 매우 規則的이며 많은 對稱性을보인다. 結晶들이 나타내는 外的인 對稱要素들은 10가지로 分類되는데 이 對稱要素들은 모든 結晶들을 7個의 系로 分類한다. 이 對稱要素들이 한 固定點올 지나도록 모을 수 있는 個別의 集合의 數는 32個뿐으로 이를 三次元的 點群이라 한다. 이 論題에서는 32個 點群을 誘導하고 整理하였다. Crystals are very regular in external shape and clearly exhibit a great deal of symmetry. The external symmetry elements exhibited by crystals are categorized into a limited number of ten and they classify all crystals into the seven crystal systems. The total number of distinctly different sets of the symmetry elements passing through a fixed point comes out to be only thirty two which are termed as the three-dimensional point groups. The thirty two point groups are derived and summarized here.

結晶學에 關한 論題(Ⅲ)

徐日煥,趙成浩,朴倧序,金光柱,秋錦洪,李珍昊 충남대학교 1991 忠南科學硏究誌 Vol.18 No.1

本 論題에서는 (1) 結圖格子에 存在하는 3個의 回빼輪이 서로 交叉할 때 滿足하는 Euler關係式을 誘導하고, (2) 結晶內의 原子가 熱振動을 하므로써 생기는 非等方性 溫度因子를 3가지 모양으로 表示하고,이를 國際結晶學會에서 勸奬하는 等價 等方性 變位因子로 나타내었으며, (3) 7個 結晶系에 該當하는 原子間 距離 計算式과, 結合角 및 비틀림角 計算方法을 보였고, (4) 分解能에 따른 Miller指數 範圍, 測定時間의 節約을 위한 hkl의 變化順序, 對稱中心이 생기는 位置, 浮游法, goniometer head에 있는 孤의 曲率半慶計算, 2θBrag角, simple cube, bcc, fcc, diamond, hcp의 原子의 配位數 및 충진율, fcc를 trigonal로 變換 했을때 輪間角, 直接法에 使用되는 Cauchy의 不等式을 다루었다. 1. 交叉하는 두 回轉輪 Xl, X2를 回轉角 α, β만큼 回轉하면 回轉角 r의 第3의 回轉輪 X_3가 생기며, Xl, X2輪사이角을 C라 하고,X2, X3輪 사이角을 A라하며, Xl, X3사이 角을 B라 할때 A, B, C, α, β, r사이에는 다음 關係가 있다. cos A=(cos(β/2)cos(r/2)+cos(α/2))/(sin(β/2)sin(r/2)) cos B=(cos(r/2)cos(α/2)+cos(β/2))/(sin(r/2)sin(α/2)) cos C=(cos(α/2)cos(β/2)+cos(r/2))/(sin(α/2)sin(β/2))

Trioxalatochromate(Ⅲ) 이온의 Polarographic Reduction에 對한 양이온의 영향

徐宗德,李哲熙,金大廣 영남이공대학 1972 論文集 Vol.1 No.-

Trioxalatochromate() ions are reduced to chrominum(0) in the univalent and the bivalent electrolyte solutions. The reduction potentials of these complex anions depend on the nature and the concentration of cations of electrolytes present in the solution, and shift to less negative potentials with increasing ionic charges of the cation and, at the constant ionic charge, with decreasing radii of the hydrated ion and increasing concentrations of the cation present.

성인 막성신병증의 임상적 고찰

양종오,이상주,박기현,장윤경,이강욱,서광선,신영태 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

Membranous nephropathy (MN) is a glomerular disease characterized by diffuse thickening of the glomerular basement membrane without significant mesangial proliferative change and is usually manifested by the nephrotic syndrome. To evaluate the clinical and pathologic characteristics of this disease in adults, we analyzed 65 patients with primary membranous nephropathy who were diagnosed at Department of Internal Medicine, Chungnam National University Hospital from February 1986 to February 2001. The results are as follows: 1) Of total 96 patients with membranous nephropathy, 67.7% was primary MN. Hepatitis B-associated MN and lupus MN were 22.9%, and 9.4%, respectively. Median duration of follow-up was 35.1 months(0.3∼177) in primary MN, 49.6 months(2.5∼103) in lupus MN, and 35.6 months(0.5∼108) in hepatitis B-associated MN. 2) Mean age of the patients with primary MN at the time of diagnosis(43.3 years) was significantly higher than that of lupus MN(30.4 years) and HBV-associated MN(36.2 years). Male to female ratio of primary MN was 1.03:l. 3) At the time of diagnosis, 89.2% of primary MN was presented with nephrotic syndrome. Twenty seven percent of patients showed hypertension. Hematuria was found in 58.5% of primary MN patients. Azotemia was noted in 3.1 %. 4) Global sclerosis, tubular atrophy and interstitial fibrosis were noted in 39.8, 16.1 and 11.3% of primaty MN, respectively. IgG and C3 were deposited on the glomerular capillary loop in 92.7% and 29% of primary MN patients. There was no significant correlation between the electron microscopic pathologic stage and clinical findings. 5) Of 56 patients with primary MN followed more than 6 months, 50(90.9%) patients were treated with prednisolone, cyclophosphamide or cyclosporin. Complete remission was obtained in 29 patients(51.8%), partial remission in 6 patients(10.7%), and no response in 18 patients(32.1%). Of 6 patients who were not treated with immunosuppressive drugs, 3 patients showed spontaneous complete or partial remission. Three patients who did not show clinical improvement progressed to end-stage renal failure. There were no significant clinical difference including renal pathology at the time of diagnosis between the patients who showed complete or partial remission and patients who did not. In conclusion, it was difficult to predict the long-term prognosis of primary MN at the time of diagnosis, clinically. The response to therapeutic modality would be the most important to predict long-term prognosis of primary MN.

부분 신절제 백서모델에서 Angiotensin Converting Enzyme Inhibitor 및 Angiotensin II ATI 수용체 길항제가 Plasma Renin Activity 및 Angiotensin II level에 미치는 영향

김종학,구영선,강민규,황평주,나기량,이강욱,서광선,신영태 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Renin-angiotensin-system(RAS) has been thought to have a pivotal role in renal injury mechanism. Many reports state that the inhibition of RAS prevents the progression of renal disease in 5/6 nephrectomized rats as a typical chronic renal failure model. Angiotensin converting enzyme inhibitor blocks the conversion from Angiotensin I to Angiotensin Ⅱ (A-Ⅱ ), and ATI RA inhibits the action of A-Ⅱ at the level of AT1 receptor. Therefore the PRA and A-Ⅱ level may be influenced independently by each treatment modality with these drugs. In this study, the influence of long term treatment with ACEI or AT1RA in these models on systolic blood pressure, PRA, and A-Ⅱ level was evaluated. Male Sprague-Dawley rats weighing 270-300 grams were anesthesized with thiopental sodium(50 mg/kg) and underwent right nephrectomy and partial(approximately two thirds) infarction of the left kidney by ligation of two-three segmental arterial branches. The rats were divided into four groups : sham group, control group, 5/6 subtotal nephrectomized and ACEI treated group (enalapril 100 mg/L in drinking water), 5/6 subtotal nephrectomized and ATIRA treated group (losartan, 200 mg/L in drinking water). They were treated for twelve weeks. In the twelve weeks, both groups treated with ACEI and AT1RA ingestion demonstrated a significant decrease in systolic blood pressure(165±23 vs. 132±9, mmHg, control vs. ACEI, M±SEM, p<0.05, 165±23 vs. 124±7 mmHg, control vs. ATIRA, M±SEM, p<0.01) compare to the control group. In both group treated with ACEI and AT1RA showed a significant increase in PRA(ACEI ; 7.2±2.9, AT1RA ; 4.7±0.4, control ; 2.7±1.1, sham ; 2.7±1.4, ng/ml/hr, ACEI vs. control and sham, M±SEM, p<0.05). However no significant differences were found in the sham vs. control(p>0.05), and in ACEI vs. control. The plasma A-II level was significantly increased in AT1RA treated group compared to sham and ACEI treated group(2,753±543 vs. 484±169.3, ng/ ml, AT1RA vs. Sham, p<0.01). In conclusion, treatment with ACEI and AT1RA for twelve weeks normalized systolic blood pressure, proteinuria and increased PRA compared to the control group; whereas plasma A-II level was increased only by AT1RA treatment.

牛乳의 常溫保存時 細菌數, 酸度 및 外觀上의 經時變化

신광순,조종후,서정순 서울保健大學 1981 論文集 Vol.1 No.1

IgA 腎病症에 對한 病理學的 및 免疫病理學的 硏究

이종대,서광선,이충식 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

A clinicopathologic analysis for 88 cases of IgA nephropathy has been carried cut from a series of 333 renal biopsy specimens which were studied at Department of Pathology, College of Medicine, Chungnam National University, during a period of 54 months from October 1983 to March 1988. The results were as follows: 1. IgA nephropathy was 26.4% of renal biopsy specimens and 30.4% of primary glomerulonephritis. It was common in young adults and 77.3% of patients were between 16 years and 39 years. Male to female ratio was 1.1 : 1. 2. Modified classification of Meadow et al. for Henoch-Schoenlein nephritis was adopted for the histologic grading of glomerular lesions. The result was as follows; Grade I 5.7%, Ⅱ 46.6%, M 45.5%, Ⅳ 1.1%, an V 1.1%. The clinical class was possible in 70 cases; Class B38.6 %, C 61.4%. 97.1% of these. 70 cases were within the histologic Grade Ⅲ. 3. The results of immunofluorescent study were as follows; All cases showed granular mesangial deposits of IgA. Complement 3 was found, in same manner as IgA, in 83 0%, fibrinogen 23.9%, IgM 18.23%, and IgG 3.4%. 10.2% of these cases showed clumps of fluorescent deposits involving the mesangium and continuous loops. 4. Among the chief complaints on admission, gross hematuria was observed in 59.1%, microscopic hematruia 39.8%, and proteinuria 69.3%, including nephrotic range protein uria 6.8%. Along the histologic grading, the frequency of gross hematuria was different, as follows; Grade I 100.0%, Grade Ⅱ 65.9%, and Grade Ⅲ 47.5%. Statistically, these differences were significant(P<0.01) On serologic study, hepatitis B surface antigen was positive in 6.7% and level of serum IgA was significantly increased in 27.6%.

Tetracaine이 개의 大腦皮質 Na^+-K^+-ATPase의 活性에 미치는 影響

이진영,김광용,서영,서경종,박영순 圓光大學校 基礎自然科學硏究所 1990 基礎科學硏究誌 Vol.9 No.1

본 實驗은 tetracaine이 개의 大腦皮質의 Na^+ - K^+ - ATPase의 活性에 어떻게 影響을 미치는 가를 알아보기 위하여 실시한 것이다. 그 酵素에 대한 tetracatine의 沮害效果와 그 機作은 酵素反應速度論的 分析方法 즉 Dixon-plot, Lineweaver-Burk plot, Arrhenius-plot 등으로 分析하였다. 그 結果는 다음과 같다. 1. Na^+ - K^+ - ATPase는 全 ATPase와 Mg^++ - ATPase의 活性보다 tetracaine에 의하여 더 많은 沮害를 받는다. 2. Tetracaine의 50% 沮害效果는 沮害常數 5㎎/㎖와 동일하였다. 3. Tetracaine은 그 酵素의 Km값을 변화시키지 못하였으나 最高速度(Vmax)는 변화시키기 때문에 tetracaine은 可逆的 非競爭的 沮害劑로 作用한 것 같다. 4. Q_10 값은 tetracaine의 농도가 증가함에 따라 감소되는데 이 값으로 Arrhenius-plot를 作成해 본 結果 切點(transition state)이 나타나지 않으므로 tetracaine은 脂質에는 작용하지 않고 오직 Na^+ - K^+ - ATPase에 작용하는 것 같다. The present experiments were disigned to investigate the effect of tetracaine on the dog brain cortex Na^+ - K^+ - ATPase activity. The inhibitory effects of tetracaine on the enzyme avtivity and its mechanism were analyzed by Dixon plot, Lineweaver-Burk plot, and Arrhenius plot. The results obtained here were as follows : 1. The Na^+ - K^+ - ATPase activity was inhibited more than the total ATPase and Mg^++ - ATPase in the presence of tetracaine. 2. The concentration of 50% inhibition for tetracaine was identical with the inhibition constant (Ki), the Ki value was 5 ㎎/㎖ for tetracaine. 3. In this study tetracaine did not change the Km value (2.5) but decreased the Vmax of the Na^+ - K^+ - ATPase activity, suggesting that tetracaine acts as reversible and noncompetitive inhibitor on the enzyme. 4. Q_10 value and energies of activation (20.1 Kcal/mole) decreased as the concentrations of trtracaine increased and the transition state did not appeared. These results suggest that trtracaine inhibits the enzyme activity by reversible and noncompetitive inhibition.

154kV용 활선 안전 경보기 개발에 관한 연구

정민규,조현광,우종수,안창회,서영석,김응태,박창기,오세득 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

In this report we developed a high voltage alarm for the safety of workers who check and repair the 154kV power line. This high voltage alarm we developed is attached on workers' helmet and alarms automatically in order to let workers know when workers work over the safety distance near 154kV power line. Until now the exact safety distance hasn't been regulated and high voltage alarm we've been using was for the range of 6∼22.9kV power line. We fabricated this high voltage alarm on the basis of electric density and actual measurement of power line. The experimental result was that high voltage alarm at 66kV power line alarmed near 90cm, at 154kV power line alarmed near 160cm from the line. Accordingly, we developed the new high voltage alarm which is operated in the range of 66∼154kV power line.