Converting Weak Neutralizing Antibody against SARS-CoV-2 into Potent Antiviral Using Fc-binding Nanodiscs

Soyun CHOI,Jaehyeon Hwang HWANG,Wonbeom PARK,Soomin KIM,SeungJoo KIM,Suhyun KIM,Nayoon CHOI,Eunkhang PARK,Hwanju KIM,Mina KIM,Hyunjoo CHOO,MinKyeom KIM,YeonJin CHO,Dae-Hyuk KWEON 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.10

시각-언어 모델을 활용한 오픈 어휘 기반 퓨-샷 장면 분할

최소연(Soyun Choi),장요우지아(Youjia Zhang),홍성은(Sungeun Hong) 대한전자공학회 2023 대한전자공학회 학술대회 Vol.2023 No.6

Flavonoids and Functional Properties of Germinated Citron (Citrus junos Sieb. ex TANAKA) Shoots

Inwook Choi,Soyun Choi,Joongryung Ji 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.5

The main objective of this study was to investigate possible application of citron (Citrus junos Sieb. ex TANAKA) seeds, which are massively produced as by-products during citron tea process, into functional food materials. First of all, citron seeds were germinated and produced citron shoots were examined for their functional properties. When contents of flavonoids in citron seeds and their germinated shoots were compared, naringenin, neohesperitin, and hesperitin were remarkably increased in shoots after germination while naringin and didymin were decreased. Concentrations of limonin and nomilin were decreased by germination otherwise their unidentified derivatives were newly formed. A methanol extract of citron shoot had lower IC?? values [0.13 and 0.07 ㎎/㎖ for 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and ABTS, respectively] than citron seed extract in radical scavenging activities. Addition of 500 mg/mL of citron shoot extract suppressed fat accumulation in 3T3-L1 adipocytes by 36.9%. Oral administration of olive oil along with citron shoot extract (33 ㎎/㎏ body weight) to Sprague Dawley rats effectively inhibited absorption of lipid into a body by decreasing blood triglyceride levels from 105.1 to 74.9 ㎎/㎗ 2 hr after olive oil administration. According to these results, citron shoot extract as a rich source of flavonoids can be utilized for functional food ingredients with effective antioxidant and anti-adipogenic properties.

합성곱 신경망 기반 RGB-D 영상 분할 모델의 형상 편향성 분석

최소윤(Soyun Choi),김지윤(Jiyun Kim),홍성은(Sungeun Hong) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6

Pain Passport as a tool to improve analgesic use in children with suspected fractures in emergency departments

Hwang, Soyun,Choi, Yoo Jin,Jung, Jae Yun,Choi, Yeongho,Ham, Eun Mi,Park, Joong Wan,Kwon, Hyuksool,Kim, Do Kyun,Kwak, Young Ho The Korean Pain Society 2020 The Korean Journal of Pain Vol.33 No.4

Background: In the emergency department (ED), adequate pain control is essential for managing patients; however, children with pain are known to receive less analgesia than adults with pain. We introduce the Pain Passport to improve pain management in paediatric patients with suspected fractures in the ED. Methods: This was a before-and-after study. We reviewed the medical records of paediatric patients who were primarily diagnosed with fractures from May to August 2015. After the introduction of the Pain Passport, eligible children were enrolled from May to August 2016. Demographics, analgesic administration rates, time intervals between ED arrival and analgesic administration, and satisfaction scores were obtained. We compared the analgesic prescription rate between the two periods using multiple logistic regression. Results: A total of 58 patients were analysed. The baseline characteristics of subjects during the two periods were not significantly different. Before the introduction of the Pain Passport, 9 children (31.0%) were given analgesics, while after the introduction of the Pain Passport, a significantly higher percentage of patients (24/29, 82.8%) were treated with analgesics (P < 0.001). The median administration times were 112 (interquartile range [IQR], 64-150) minutes in the pre-intervention period and 24 (IQR, 20-74) minutes in the post-intervention period. The median satisfaction score for the post-intervention period was 4 (IQR, 3-5). The adjusted odds ratio for providing analgesics in the post-intervention period was 25.91 (95% confidence interval, 4.36-154.02). Conclusions: Patient-centred pain scoring with the Pain Passport improved pain management in patients with suspected fractures in the paediatric ED.

Associations nurses’ bullying experiences with posttraumatic stress symptoms and coping styles

Soyun Hong,Heejung Kim,Sunah Kim,Eun Kyoung Choi 한국간호과학회 2019 한국간호과학회 학술대회 Vol.2019 No.10

Environmental influence on failure of urethane acrylate layer between metal surfaces

Choi, Gyuheong,Cho, Yunho,Bae, Soo Min,Kim, Soyun,Yoon, Sung Ho,Lee, Jonghwi Elsevier 2019 Journal of industrial and engineering chemistry Vol.71 No.-

<P><B>Graphical abstract</B></P> <P>The failure modes of urethane acrylate on metal substrates exhibited dramatic changes when exposed to certain environmental conditions such as water or heat. The diffusion of both water and thermal energy along the interfaces is a not negligible mechanism.</P> <P>[DISPLAY OMISSION]</P>

Beneficial effects of blood group antigen synthesis- increasing natural plant extracts and monosaccharides on extracellular matrix protein production in vivo

( Mira Choi ),( Jang Hee Oh ),( Min Kyeong Shin ),( Se Rah Lee ),( Dong Hun Lee ),( Seon Pil Jin ),( Soyun Cho ),( Jin Ho Chung ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Recent study has indicated that expression of ABO blood group (ABH) antigens are reduced in the sun exposed skin, suggesting that ABH antigens may be implicated in photoaging process. Objectives: To investigate the potential effects of ABH antigen synthesis-increasing molecules on the extracellular matrix protein production in human skin, which are mixtures of 5 natural plant extracts (Camellia sinensis leaf extract, Polygonum cuspidatum root extract, Ginkgo biloba leaf extract, Cynara scolymus leaf extract, Selaginellatamariscina extract) and 5 monosaccharides (D-Glucose, D-Galactose, L-fucose, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine). Methods: Effects of one-time topical application with composition TYPE I (5 natural plant extracts) and TYPE II (5 monosaccharides) to the human buttock skin (n=6) and 24-week application with TYPE III (all of the ingredients) to the facial skin (n=22 for each) on extracellular matrix (ECM) protein expressions, wrinkle, and elasticity were determined by immunohistochemistry, Skin Viosiometer, and Cutometer. Results: One-time application of TYPE I and II increased perlecan and fibrillin-1 staining, respectively. 24-week application of TYPE III showed no significantimprovement of wrinkle and elasticity. However, it increased procollagen 1メ, tropoelastin, and fibrillin-1staining. Conclusion: These results suggest that these ingredients may help ECM protein production in human skin by long-term application for anti-aging cosmetic products.

일반논문 : 점자형 선거공보 규정을 통해 본 시각장애선거인의 선거정보접근권 보장 문제 -헌법재판소 2014. 5. 29. 선고 2012헌마913 결정(구 공직선거법 제65조 제4항 위헌확인)을 중심으로

양소연 ( Soyun Yang ),이보형 ( Bo Hyoung Lee ),장시원 ( Siwon Zhang ),최지민 ( Jeemin Choi ) 서울대학교 BK21 법학연구단 공익인권법연구센터 2015 공익과 인권 Vol.15 No.-

장애는 개인에게 크고 작은 불편을 끼치며, 심한 경우 경제적인 빈곤은 물론 사회적 배제를 유발하기도 한다. 그러나 장애가 장애인에게 필연적으로 부정적인 결과를 초래하는 것은 아니며, 장애로 인한 제약 또는 배제의 정도는 구체적인 사회환경에 따라 좌우된다. 장애인의 사회통합을 위한 환경을 조성하려면, 사회생활의 핵심이 곧 정치적 생활이라는 점에 주목할 필요가 있다. 참정권, 그 중에서도 선거권은 개인이 사회생활을 영위하고 공동체의 당당한 주체로 자리 잡기 위해 꼭 필요한 권리이다. 본 논문은 이러한 문제의식에 바탕을 두고 점자형 선거공보 발간을 재량사항으로 둔 구 공직선거법 상의 규정이 합헌이라고 판단한 <헌법재판소 2014. 5. 29. 선고 2012헌마913 결정>을 비판적으로 검토하였다. 법정의견은 선거권의 일부를 이루는 권리인 선거정보접근권에 대하여 별도의 판단을 내리지 않았다. 그러나 선거정보접근권이 선거권의 핵심 영역을 이루는 권리이며 특히 일반 매체를 통한 정보 습득이 어려운 시각장애인에게 더욱 중요하다는 점을 고려한다면, 강화된 과잉금지원칙을 통해 그 침해 여부를 심사하였어야 할 것이다. 점자형 선거공보의 발행을 재량으로 두는 심판대상조항은 피선거인의 선거운동의 자유를 존중하고 국가의 선거비용 부담을 경감한다는 점에서 그 목적은 정당하나, 선거공보의 고유한 특성과 다른 선거정보 제공 매체의 한계를 함께 고려할 때, 결국 시각장애선거인의 기본권을 침해함을 알 수 있다. 나아가, 단순히 점자형 선거공보를 의무화하는 것만으로 선거정보접근권의 실질적 보장이 담보되지 않는다는 점에 유념해야 한다. 우선 점자형 선거공보 의무화에 필요한 세부 규정은 물론 인력, 시설, 그리고 무엇보다도 사회적 합의가 부족하다. 또한 점자를 읽지 못하는 시각장애인이 많다는 점도 고려하여야 한다. 해외 사례 등을 참고하여 음성 매체 등 대안 매체를 적극적으로 활용하여 선거공보를 제작할 필요가 있다. 장애인이 참정권을 자유롭게 행사하고 보호의 대상을 넘어 당당한 주체로 자리매김할 수 있는 사회를 만들기 위해, 헌법재판소 안팎의 다양한 노력이 요구된다. Disability is likely to cause inconvenience to the disabled, and it sometimes causes poverty and social exclusion. However, they are not the necessary consequences of disability; how much disability causes hindrances to the disabled depends on social context which can be enhanced through public effort. Among the various dimensions of society, political sphere is one of the most important areas in social life. The constitutional right to vote is an imperative prerequisite for a citizen to be included as a social actor. When the social context allows the disabled to easily access the voting process and consequently the political sphere, disability itself becomes less of an obstacle to the disabled’s social life. The social context more favorable to the disabled can also lead to their enhanced status. This paper critically analyzes the Constitutional Court’s decision on the constitutionality of the clause related to the duty to print campaign brochure in braille(2012Hun-Ma913 decided on May 29, 2014). The court denied that the right to access election information (especially the information about each candidate) constitutes Disability is likely to cause inconvenience to the disabled, and it sometimes causes poverty and social exclusion. However, they are not the necessary consequences of disability; how much disability causes hindrances to the disabled depends on social context which can be enhanced through public effort. Among the various dimensions of society, political sphere is one of the most important areas in social life. The constitutional right to vote is an imperative prerequisite for a citizen to be included as a social actor. When the social context allows the disabled to easily access the voting process and consequently the political sphere, disability itself becomes less of an obstacle to the disabled’s social life. The social context more favorable to the disabled can also lead to their enhanced status. This paper critically analyzes the Constitutional Court’s decision on the constitutionality of the clause related to the duty to print campaign brochure in braille(2012Hun-Ma913 decided on May 29, 2014). The court denied that the right to access election information (especially the information about each candidate) constitutes.

Leukemia cutis mimicking banal folliculitis of the face and upper torso

( Sungjun Choi ),( Soyun Cho ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Various skin findings can be observed in leukemia but leukemia cutis (LC) is rarely seen. LC, defined as the infiltration of leukemic cells into the skin, occurs more commonly in acute myeloid leukemia (AML), especially M4 and M5 variants. Multiple erythematous nodules, papules or plaques distributed on the extremities and trunk is the typical presentation. However, LC sometimes can masquerade as benign inflammatory skin diseases such as rosacea and contact dermatitis. We report a case of 83-year-old man with AML who presented with a month history of severely pruritic scaly erythematous patches and papules on the face and upper torso that clinically mimicked eczema and folliculitis, respectively. Skin biopsy from a facial papule revealed atypical lymphocytic infiltration in the superficial and deep dermis. On immunohistochemical stain, the tumor cells were positive for CD43 and myeloperoxidase, which confirm the diagnosis of LC. He refused chemotherapy and only received symptomatic treatment with oral and topical steroid, topical tacrolimus and oral anti-histamine. The lesions and symptoms partially resolved in a month. It should be noted that benign-looking skin lesions in a patient with hematologic malignancy may actually be associated with malignant cell infiltration. However benign the skin lesions may appear, the possibility of malignancy should be kept in mind when it comes to a patient with hematologic malignancy.