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Development of a minipig physical phantom from CT data
Park, Sooyeun,Lee, Pilsoo,Ha, Wi-Ho,Kim, Han Sung,Park, Byeong Ryong,Kim, Jae ,Seok,Shim, Sehwan,Park, Sunhoo,Kim, Young-su,Kim, Chan Hyeong,Jin, Young-Woo JAPAN RADIATION RESEACH SOCIETY 2017 JOURNAL OF RADIATION RESEARCH Vol.58 No.5
<P><B>ABSTRACT</B></P><P>Quantification of pathological progression of radiation-induced injury is essential in development of treatment methods, and a proper animal model is necessary for relevant radiological and medical studies. A minipig is a current animal model selected because of its similarities to humans in anatomy and pathology. In the present study, a minipig physical phantom was developed using computed tomography (CT) data. For dosimetry purposes, the minipig physical phantom was constructed on a slice-by-slice basis, with an array of holes to accommodate dosimeters. The phantom is constituted of three major organs, i.e. bone, lung, and remaining soft tissue, and the organs are clearly distinguishable on each 20-mm-thick axial slice. The quality of the tissue-equivalent (TE) substitutes was analyzed in terms of the atomic compositions and Hounsfield units (HUs). The density (in g/cm<SUP>3</SUP>) and effective atomic number of TE substitutes for the bone, lung, and soft tissue are 1.4 and 7.9, 0.5 and 10.0, and 1.0 and 5.9, respectively. Although the TE substitutes have slightly different physical properties, we think the phantom is acceptable because the HU values of the TE substitutes lie in the HU range of real tissues.</P>
Park, Sung-Ik,Kim, Sooyeun,Choi, Jung-Oh,Song, Ji-Hyeon,Taya, Minoru,Ahn, Sung-Hoon Elsevier 2015 THIN SOLID FILMS - Vol.589 No.-
<P><B>Abstract</B></P> <P>We report the deposition of tungsten oxide (WO<SUB>3</SUB>) thin films on fluorine-doped tin oxide (FTO) and indium-doped tin oxide (ITO) glass substrates by using a room-temperature deposition system based on low-vacuum air-spray for the fabrication of inorganic electrochromic windows. The structure of the WO<SUB>3</SUB> films was characterized using X-ray diffraction, and the surface morphology and film thickness were investigated using scanning electron microscopy and atomic force microscopy. The color of the prepared WO<SUB>3</SUB> films changed from slight yellow to dark blue under applied voltages, demonstrating electrochromism. The WO<SUB>3</SUB> film coated FTO glass exhibited a large electrochromic contrast of up to 50% at a wavelength of 800nm. The electrochemical properties of the films were examined using cyclic voltammetry and chronocoulometry.</P> <P><B>Highlights</B></P> <P> <UL> <LI> WO<SUB>3</SUB> thin films were fabricated using an air-spray based deposition system at room temperature under low-vacuum conditions. </LI> <LI> Dry WO<SUB>3</SUB> particles were directly deposited on FTO and ITO glasses by using a low-cost deposition system. </LI> <LI> The FTO glass based WO<SUB>3</SUB> film showed the optical contrast of 50% at a wavelength of 800nm. </LI> </UL> </P>
Progesterone Receptor Expression as a Prognostic Factor in Luminal B Breast Cancer
Sooyeun Lim,Yoojin Lee,Jungbin Kim,조현진,Keunho Yang,Kyeongmee Park,Jiyoung Kim,Youngjoo Sin,Yeyoung Seo,Geumhee Gwak 한국유방암학회 2022 Journal of Breast Disease Vol.10 No.1
Purpose: The luminal subtype of breast cancer has heterogeneous biological characteristics with respect to the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and Ki-67. We analyzed luminal B breast cancer subcategorized by PR expression and identified clinically relevant prognostic factors. Methods: We collected the clinical and pathologic data of 247 breast cancer patients (stage 1-4) who were diagnosed with luminal B subtype, defined as ER- and/or PR-positive and/or HER2-positive and with a high Ki-67 proliferation index (>14%). We classified them into PR intact and PR low groups according to PR expression pattern. We also analyzed the clinical and pathological data of each group, including age at diagnosis, tumor size, node metastasis, breast and axillary operative method, margin involvement, tumor-node-metastasis (TNM) stage, histological grade, nuclear grade, number of tumors, and expression of ER, PR, Ki-67, and Bcl-2; evaluated recurrence or metastatic characteristics; and analyzed disease-free survival (DFS) and overall survival (OS) in both groups. Results: Among the 247 luminal B breast cancer patients (stage 1-4), 141 were classified into the PR intact group (57.1%) and 106 into the PR low group (42.9%). The PR low group was associated with age >50 years (p=0.001), low Bcl-2 expression (p<0.001), and high proportion of mastectomies (p<0.001). DFS and OS were significantly lower in the PR low group (p=0.025 and 0.024, respectively). Conclusion: This study showed that decreased in PR expression (PR low group) in luminal B breast cancer was related to poor prognosis compared to normal PR expression (PR intact group).