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- 저자 : Jungbin Kim (검색결과 104 건)
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Interferon Alpha-2a Reduces Early Erythema After Full-Thickness Skin Graft in the Pig
KIM, JUN SIK,SON, DAEGU,CHOI, TAE HYUN,HAN, KIHWAN,KIM, JUN HYUNG,CHO, HYUN MI,KIM, WON HEE,KIM, SANG-HYON,KIM, NAM GYUN,LEE, KYUNG SUK,HWANG, O. HYUN,ROH, GU SEOB,PARK, JUNGBIN Blackwell Publishing Inc 2009 Dermatologic surgery Vol.35 No.10
<P>BACKGROUND</P><P>Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.</P><P>OBJECTIVE</P><P>We examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN-α) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group.</P><P>METHODS</P><P>Vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer.</P><P>RESULTS</P><P>In the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks.</P><P>CONCLUSION</P><P>IFN-α may be one of the agents that reduces erythema by suppressing excessive revascularization.</P>
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Kim, Jungwon,Kim, Jungbin,Kim, Junghyun,Hong, Seungkwan Elsevier 2018 Journal of membrane science Vol.554 No.-
<P><B>Abstract</B></P> <P>Managing shale gas produced water (SGPW) is one of the greatest challenges for shale gas industry due to its high salinity and water volume. Osmotically enhanced dewatering (OED) has great potential for treating SGPW because of its higher water recovery and lower energy consumption. This study systematically investigated the effects of operating conditions on OED performance through numerical simulation of membrane modules. The simulation results first showed that OED achieved higher water recovery over forward osmosis (FO) due to less internal concentration polarization (ICP). Water recovery could be higher with decreasing feed flow fraction, increasing normalized membrane area, and increasing hydraulic driving force fraction. It was also demonstrated that OED-RO hybrid process was able to yield more water with similar energy efficiency as one-stage RO, for SGPW of 28.5 g/L total dissolved solids (TDS) under realistic conditions considering inefficiency associated with pump and energy recovery device (ERD). Lastly, to validate our findings, OED experiments were performed with pre-treated real SGPW as a feed solution, and exhibited good agreement with the simulation results. Specifically, water recovery was achieved up to 67% with a high rejection rate of over 97% for most ions at a hydraulic pressure of 30 bar. Our modeled and experimental observations suggest that the OED-RO process can be an energy-efficient process in concentrating high salinity wastewater.</P> <P><B>Highlights</B></P> <P> <UL> <LI> OED process at module-scale was simulated for treating SGPW with high salinity. </LI> <LI> OED exhibited higher water recovery over FO due to less ICP. </LI> <LI> OED-RO yielded more water with the similar energy efficiency as one-stage RO. </LI> <LI> OED was able to extract water up to 67% from real SGPW with a pressure of 30 bar. </LI> <LI> SGPW treatment by OED-RO agreed well with the simulation results. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Kim, Jungbin,Hong, Seungkwan Elsevier 2018 Journal of membrane science Vol.568 No.-
<P><B>Abstract</B></P> <P>Internally staged design (ISD) was introduced as a method to lower front reverse osmosis (RO) element fluxes, yielding operational benefits. Systematic selection of the best ISD combinations has not been conducted as it is dependent on operating conditions (i.e., RO recovery and average flux). This study aimed to optimize seawater reverse osmosis (SWRO) operations using ISD for better product water quality and energy efficiency. A total of 36 ISD combinations were configured with three commercial SWRO membranes and systematically examined under varying operating conditions which were simulations of typical SWRO operation. A Pareto-optimal front, a non-dominated feasible solution set, was created to understand the tradeoff relationship between permeate quality and specific energy consumption while considering all parameters. The Pareto-optimal front was classified into five phases, and an analysis of phase changes provided optimal parameter settings for SWRO operation. However, the occurrence of colloidal fouling altered optimal ISD combinations on the Pareto-optimal front. Particularly, when SWRO membranes were fouled at high-recovery and -flux conditions, ISD combinations employing three different membrane types exhibited superior performance in terms of energy efficiency. With these results, the best SWRO operation was suggested depending on its performance requirements, and the advantages of ISD were further delineated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SWRO with ISD was optimized to achieve better water quality and energy efficiency. </LI> <LI> Efficient SWRO performance control was examined by Pareto-optimal front analysis. </LI> <LI> Colloidal fouling changes the best ISD combinations on the Pareto-optimal front. </LI> <LI> ISD with three SWRO membrane types is feasible at high-recovery and -flux operations. </LI> <LI> The optimal SWRO operation mode is proposed based on its performance requirements. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Kim, Jungbin,Hong, Seungkwan Elsevier Scientific Pub. Co 2018 Desalination Vol. No.
<P><B>Abstract</B></P> <P>Seawater reverse osmosis (SWRO) desalination is required to produce high-quality water to meet stricter water standards, which could be satisfied with single-pass RO through the advancement of reverse osmosis (RO) membranes. In this study, a novel single-pass RO configuration was proposed to further improve permeate quality. Split partial single-pass (SSP) RO is a design in which the permeate from the rear RO element(s) in a pressure vessel is blended with the RO feed. This blending resulted in the dilution of the feed, leading to the production of high-quality permeate with lower energy demand. Modeling of the RO process demonstrates that SSP RO had the highest energy efficiency when the permeate from the 7th element (i.e., the last one in the single pass RO configuration) was circulated back and mixed with the feed. For typical SWRO operating conditions, SSP RO was effectively able to improve permeate quality. In fact, SSP RO produced an approximately 15% purer permeate compared to conventional single-pass RO. SSP RO was also always more energy-efficient than the two-pass RO configurations. The economic feasibility of the design was assessed further and the possibility of its practical application explored.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new single-pass RO configuration was proposed for high-purity permeate production. </LI> <LI> SSP RO required low hydraulic pressure and can mitigate fouling due to feed dilution. </LI> <LI> A purer permeate was obtained without the need for second-pass RO. </LI> <LI> The SSP RO was energy-efficient compared to the two-pass RO systems. </LI> <LI> The SSP RO was the most economical RO design that still met TDS standards. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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A comprehensive review of energy consumption of seawater reverse osmosis desalination plants
Kim, Jungbin,Park, Kiho,Yang, Dae Ryook,Hong, Seungkwan ELSEVIER 2019 APPLIED ENERGY -BARKING THEN OXFORD- Vol.254 No.-
<P><B>Abstract</B></P> <P>High specific energy consumption (SEC) is the main barrier for the expansion of seawater reverse osmosis (SWRO). Therefore, the main objective of current SWRO research is to lower the SEC of SWRO plants. However, SEC of SWRO plants has not been systemically explored or analyzed, despite the need for information to develop appropriate strategies to reduce SEC. Therefore, this study aims to review and analyze SWRO plants for a comprehensive understanding of their SEC. First, trends in SWRO application are investigated using more than 70 datasets on large-scale SWRO. The analysis explains the increasing number of large-size SWRO plants, the SEC reduction by isobaric energy recovery devices (ERDs), and the use of different SWRO configurations to meet the energy and quality requirements. Factors associated with SEC (<I>i.e.</I>, feed conditions, target conditions, and equipment efficiency) are also analyzed. High salinity increases energy demand, whereas the temperature effect on energy consumption is not entirely clear. High-efficiency ERDs and pumps can reduce SEC, but overall SEC cannot be explained by these factors alone. SEC is also affected by target water quality and quantity. Moreover, specific SWRO designs can improve the system to efficiently achieve the established goals. Furthermore, future directions to develop low-energy SWRO plants are discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Critical review of energy consumption of seawater reverse osmosis plants. </LI> <LI> Collection of more than 70 datasets for large-size seawater reverse osmosis plants. </LI> <LI> Investigation of trends in the application of seawater reverse osmosis plants. </LI> <LI> Analysis of factors associated with energy consumption of seawater reverse osmosis. </LI> <LI> Future directions to reduce energy consumption of seawater reverse osmosis plants. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Kim, Sang-Hyon,Chang, Hyuk Won,Choi, Tae Hyun,Kim, Jun Hyung,Son, Daegu,Han, Kihwan,Lee, So Young,Park, Jungbin,Suh, Euy-Hoon,Park, Sung-Hwan Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2010 Annals of plastic surgery Vol.64 No.4
<P>The purpose of this study was to investigate the efficacy of cilostazol for prevention of thrombosis in microsurgical anastomosis. We used not only a patency test, but also ultrasonography to evaluate the blood flow volume (FV) more accurately and objectivity. In addition, we evaluated the accuracy and sensitivity of the patency test. Thrombogenic anastomoses were performed on rat external iliac arteries. Forty-six rats were randomly allocated into the following 5 experimental groups: negative control, without any surgery and medication; control, received distilled water orally; group A, received aspirin orally; group B, received cilostazol orally; and group C, received aspirin and cilostazol orally 3 hours before a thrombogenic artery anastomosis. The artery was evaluated by FV using ultrasonography and a patency test 10, 30, and 120 minutes after clamp removal. The FV in group C was significantly larger than the control group 30 minutes after clamp removal. The FVs in groups A, B, and C were significantly larger than the control group 120 minutes after clamp removal. The FV decreased in all groups with time. The patency rate between the control group and group C 120 minutes after clamp removal was significantly different. There were 8 false negatives in a total of 114 patency tests. The total accuracy and sensitivity of the patency test were 93.0% and 92.7%, respectively. Cilostazol plus aspirin therapy is recommended for reducing thrombosis and increasing FV without increasing the risk of bleeding during microsurgery. The patency test cannot evaluate the state of the anastomotic vessels accurately and objectively.</P>
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Kim, Hee Jung,Yoon, Jungbin,Matsuura, Atsushi,Na, Jung-Hyun,Lee, Won-Kyu,Kim, Hyunook,Choi, Ji Woong,Park, Ji Eun,Park, Sung-Jean,Kim, Kyung Tae,Chang, Rakwoo,Lee, Byung Il,Yu, Yeon Gyu,Shin, Yeon-Kyu National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.40
<P><B>Significance</B></P><P>Germ cells possess the inherent ability to inactivate cell abscission through TEX14 (testis-expressed gene 14), and they may provide information on inactivation of the abscission in abnormal cells, including cancer cells. Structural and functional studies of how TEX14 inactivates germ cell abscission reveal that the AxGPPx<SUB>3</SUB>YxPP motif of TEX14 competitively binds to CEP55-EABR [endosomal sorting complex required for transport (ESCRT) and ALIX-binding region] to prevent the recruitment of ALIX, which is a component of the ESCRT machinery and which contains the AxGPPx<SUB>3</SUB>Y motif. Multiexperiment analyses of CEP55-EABR–TEX14 interactions showed how the TEX14 peptide binds dominantly to CEP55-EABR in the presence of ALIX and safeguards the intercellular bridges of germ cells.</P><P>Intercellular bridges are a conserved feature of spermatogenesis in mammalian germ cells and derive from arresting cell abscission at the final stage of cytokinesis. However, it remains to be fully understood how germ cell abscission is arrested in the presence of general cytokinesis components. The TEX14 (testis-expressed gene 14) protein is recruited to the midbody and plays a key role in the inactivation of germ cell abscission. To gain insights into the structural organization of TEX14 at the midbody, we have determined the crystal structures of the EABR [endosomal sorting complex required for transport (ESCRT) and ALIX-binding region] of CEP55 bound to the TEX14 peptide (or its chimeric peptides) and performed functional characterization of the CEP55–TEX14 interaction by multiexperiment analyses. We show that TEX14 interacts with CEP55-EABR via its AxGPPx<SUB>3</SUB>Y (Ala793, Gly795, Pro796, Pro797, and Tyr801) and PP (Pro803 and Pro804) sequences, which together form the AxGPPx<SUB>3</SUB>YxPP motif. TEX14 competitively binds to CEP55-EABR to prevent the recruitment of ALIX, which is a component of the ESCRT machinery with the AxGPPx<SUB>3</SUB>Y motif. We also demonstrate that a high affinity and a low dissociation rate of TEX14 to CEP55, and an increase in the local concentration of TEX14, cooperatively prevent ALIX from recruiting ESCRT complexes to the midbody. The action mechanism of TEX14 suggests a scheme of how to inactivate the abscission of abnormal cells, including cancer cells.</P>
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