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Self-organized wrinkling patterns of a liquid crystalline polymer in surface wetting confinement
Na, Jun-Hee,Kim, Se-Um,Sohn, Youngjoo,Lee, Sin-Doo The Royal Society of Chemistry 2015 SOFT MATTER Vol.11 No.24
<P>Self-organized wrinkling patterns of a liquid crystalline polymer, dictated by the chemico-physically anisotropic nature of surface wettability, are demonstrated in confined geometries. The symmetry of the geometrical constraints of the confinement primarily governs the periodic wrinkling patterns of such a polymer in the wetting region. In a circular geometry, the number of the radial domains with multi-fold symmetries is linearly proportional to the radius of the confinement. The physical origin of the wrinkling process comes from the periodic bend-splay distortions through the relaxation of the curvature elasticity.</P>
Dynamic Manipulation of Charged Lipids in Model Membrane for Bio-Microarrays
Ryu, Yong-Sang,Suh, Jeng-Hun,Kim, Min-Hoi,Sohn, Youngjoo,Lee, Sin-Doo American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.6
<P>We describe the dynamic manipulation of the charged lipids in a confined geometry where two dispersive factors arising from the random diffusion-based Brownian motion and the field-induced drift of target lipids compete with each other. It is found that the lateral distribution of the target lipids is well controlled through a combined effect of an external electric field and the geometric restrictions by the confinement. The dynamic manipulation scheme for the charged lipids in two-dimension would be useful for understanding the spatial organization of membrane components in a supported lipid membrane mimicking a real cell membrane and for producing membrane-based microarrays.</P>
Biocompatible patterning of proteins on wettability gradient surface by thermo-transfer printing.
Kim, Sungho,Ryu, Yong-Sang,Suh, Jeng-Hun,Keum, Chang-Min,Sohn, Youngjoo,Lee, Sin-Doo American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.8
<P>We develop a simple and biocompatible method of patterning proteins on a wettability gradient surface by thermo-transfer printing. The wettability gradient is produced on a poly(dimethylsiloxane) (PDMS)-modified glass substrate through the temperature gradient during thermo-transfer printing. The water contact angle on the PDMS-modified surface is found to gradually increase along the direction of the temperature gradient from a low to a high temperature region. Based on the wettability gradient, the gradual change in the adsorption and immobilization of proteins (cholera toxin B subunit) is achieved in a microfluidic cell with the PDMS-modified surface.</P>
Progesterone Receptor Expression as a Prognostic Factor in Luminal B Breast Cancer
Sooyeun Lim,Yoojin Lee,Jungbin Kim,조현진,Keunho Yang,Kyeongmee Park,Jiyoung Kim,Youngjoo Sin,Yeyoung Seo,Geumhee Gwak 한국유방암학회 2022 Journal of Breast Disease Vol.10 No.1
Purpose: The luminal subtype of breast cancer has heterogeneous biological characteristics with respect to the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and Ki-67. We analyzed luminal B breast cancer subcategorized by PR expression and identified clinically relevant prognostic factors. Methods: We collected the clinical and pathologic data of 247 breast cancer patients (stage 1-4) who were diagnosed with luminal B subtype, defined as ER- and/or PR-positive and/or HER2-positive and with a high Ki-67 proliferation index (>14%). We classified them into PR intact and PR low groups according to PR expression pattern. We also analyzed the clinical and pathological data of each group, including age at diagnosis, tumor size, node metastasis, breast and axillary operative method, margin involvement, tumor-node-metastasis (TNM) stage, histological grade, nuclear grade, number of tumors, and expression of ER, PR, Ki-67, and Bcl-2; evaluated recurrence or metastatic characteristics; and analyzed disease-free survival (DFS) and overall survival (OS) in both groups. Results: Among the 247 luminal B breast cancer patients (stage 1-4), 141 were classified into the PR intact group (57.1%) and 106 into the PR low group (42.9%). The PR low group was associated with age >50 years (p=0.001), low Bcl-2 expression (p<0.001), and high proportion of mastectomies (p<0.001). DFS and OS were significantly lower in the PR low group (p=0.025 and 0.024, respectively). Conclusion: This study showed that decreased in PR expression (PR low group) in luminal B breast cancer was related to poor prognosis compared to normal PR expression (PR intact group).