Methylprednisolone투여가 흰쥐 척수손상모델의 운동유발전위의 변화에 미치는 영향

황용순,박상근 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

Objectives: For the last two decades. various chemicals have been applied for the treatment of spinal cord injury but no chemicals were found to be as effective as methylprednisolone. And motor evoked potentials(MEPs) have been utilized clinically in monitoring and diagnosis of the motor disorders. To evaluate the efficacy of methylprednisolone on functional recovery following spinal cord injury and to determine the usefulness of motor evoked potential as a monitoring tool in spinal cord injury, the author used spinal cord injury model in rats. Methods: In the present study, the effects of methylprednisolone on functional recovery after spinal cord injury were carefully quantified behaviorally as well as electrophysiologically in white rats. Spinal cord injury was produced using NYU-spinal cord impactor. BBB(Basso, Beattie, and Bresnahan) test was conducted to measure the change of neurological status behaviorally, and MEPs and somatosensory evoked potentials (SSEPs) were recorded to determine the effects of methylprednisolone electrophysiologically. The results of these studios were compared each other to determine the usefulness of MEPs. Results: 1. According to the behavioral test using BBB test, methylprednisolone - treated animals showed improved functional recovery compared to the saline-treated animals. 2. MEP latencies in methylprednisolone-treated group were shorter than those in control group. Peak amplitudes of MEPs were larger in methylprednisolone-treated group than those in control group. 3. Peak amplitudes of SSEPs were larger in methylprednisolone-treated group than those in control group. In summary, the amplitudes of MEPs were recovered more rapidly in methylprednisolone-treated group than those of SSEPs and the latencies of MEPs showed similar tendency compared to those of SSEPs. 4. The thresholds of MEPs and SSEPs tended to be lower in methylprednisolone-treated group than those of control group. Conclusions: These results suggest that methylprednisolone may minimize the secondary spinal injury and improve the functional recovery after spinal cord injury. And motor evoked potential seems to be reliable as a tool monitoring the functional recovery after spinal cord injury, and be compensatory with SSEPs.

Polyozellus multiplex가 생산하는 지질과산화 저해물질

황지숙,송경식,김양섭,석순자,이태호,유익동 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.5

담자균류로부터 지질과산화 저해물질을 탐색하던 중 강원도 오대산 지역에 자생하는 버섯의 한 종류로 부터, Sparague-Dawley계 rat의 간 mirosome 분획의 지질과산화를 강하게 억제하는 물질이 있음을 발견하였다. 이 버섯의 미생물학적 특성을 관찰한 결과 민주름버섯목, 굴뚝버섯과에 속하는 까치버섯(Polyzellus multiplex)으로 동정하였으며 본 버섯의 자실체 methanol 추출물을 benzene, ethylacetate로 순차적으로 추출하고 각종 chromatography를 이용하여 활성물질을 정제한 결과, ethylacetate층으로 부터 황산화활성을 나타내는 PM1을 benzene층으로 부터 지방산 계열의 PM2와 PM3 화합물을 순수하게 분리 정제하였다. PM1은 정색반응 및 각종 기기분석 결과 thelephoric acid계의 화합물로 동정되었으며 PM2 및 PM3는 각각 linoleic acid와 oleic acid로 동정되었다. 지질과산화 활성물질로 분리정제한 PM1 화합물의 IC_50 값은 1.96 ppm이었으며 LD_50 값은 500 mg/Kg 이상이었다. In the course of screening lipid peroxidation inhibitor from basidiomycetes, a mushroom, which was collected at O-Dae mountain in Kangweon-Do, was found to have active compound. The mushroom was identified as Polyzellus multiplex, which belongs to Aphylloporalles Thelephoraceae, on the basis of macroscopic and microscopic characteristics of the fruiting body. The methanol extract of fruiting body was extracted with benzene and ethylacetate, sequentially. By using various kinds of chromatographies, PM1, and PM2 and PM3, were purified from the ethylacetate extract and the benzene extract, respectively. Color reaction and analyses of IR, UV, and NMR spectra indicated that PM1 was a derivative of thelephoric acid, and PM2 and PM3 were linoleic acid and oleic acid, respectively. IC_50 of PM1 for inhibition of lipid peroxidation was 1.96 ppm and LD_50 was 500 mg/kg.

새마을 運動 實績評價模型 作成에 관한 硏究

黃明燦,玄斗日,梁始浩,朴英熙,金龍國,申大淳 건국대학교 1974 學術誌 Vol.17 No.1

The New Village (Sae-ma-eul) movement is Korean version of Community Development that has under-gone widespread exploration, experimentation and application in developing countries throughout the world in recent years. In most countries the national governments have undertaken the iniative in Community Development through appropriate ministries or special agencies. The New Village Movement was initiated in 1970 by Korean government. But it became a people's movement for self-development as more and more people participated in the developmental programs. The major objectives of the New Village movement are to redress the economic disparities between the rural and urban areas by improving the economic, social and cultural conditions of rural Communities, to reform the way of life in rural villages by encouraging the attitude of self-help, and to increase the income of the farmers and fisher man. Since 1971, An enormous amount of public and priate money has been invested into the New Village Movement. It seems that the time has arrived when some framework for evaluating the whole program is to be developed. Thus, The objective of this study is to develop an appropriate to evaluate the new village project at the village level. Ten major factors which are supposed to be relevant for evaluation of the project was selected. The evaluation model thus developed can be summarized in the following format. ◁표 삽입▷ (원문을 참조하세요)

광에너지 총량에 따른 광중합 콤포짓트레진과 콤포머의 중합도에 관한 연구

황경란,이용근,임범순,김철위 대한치과기재학회 2000 대한치과재료학회지 Vol.27 No.4

Dental composite resin is filler added, particle reinforced composite material, and the usage range had been enlarged in the posterior restoration through improvement of physical properties. Recently, resin modified glassionomer and compomer are used for various purposes. The degree of polymerization of cross-liked polymer has great importance in determining the mechanical properties and clinical availability of materials. Residual carbon-carbon double bonds have been implicated in causing reduced wear resistance, strength and color stability. The degree of polymerization is an important factor for longevity of a restoration. However the higher the degree of polymerization in resin composites, the higher the shrinkage will result. It has been elucidated that the degree of polymerization was significantly affected by the intensity of the curing light, wavelength of light and irradiation time. In this experiment, 16 kinds of restorative materials such as five kinds of universal composite resin, five kinds of condensable composite resin, two kinds of flowable composite resin, and four kinds of compomer were used. This study examined the effect of light intensity and irradiation time on the polymerization behavior such as the heat release during polymerization and the rate of polymerization by DSC (differential scanning calorimeter), and the degree of double bond conversion by FT-IR. With DSC, the irradiation modes were three different light intensity of 300, 400, 600 ㎽/㎠ and for 40 seconds. With FT-IR, the levels of irradiation energy were 1,500, 40,000, 8,000, 16,000 and 24,000 mJ/㎠ by combining the light intensity of 300, 400, 600 ㎽/㎠ and irradiation time of 5, 10, 20 and 40 seconds. From this experiment, The following results were obtained : 1.In the DSC result, heat of polymerization of composite resin was 23.22∼55.17J/gram and exothermic energy of compomer was 26.50∼52.68 J/gram 2.At the isothermal condition of 27℃, there were exothermal peaks at 40.812∼44.724 seconds from the start of irradiation. The percentage of polymerization by released heat was 19.12∼49.44% after 18 seconds, 37.23∼82.07% after 36 seconds, and 93.57∼98.53% after 54 seconds from the start of irradiation. 3.From FT-IR, the degree of polymerization of composite resin was 17.17∼60.91% and that of compomer was 7.74∼40.82%, and the degree of final conversion was influenced by the kinds of restorative materials and the irradiation energy(p<0.01). 4.As the irradiation energy was increased from 1,500 mJ/㎠ to 16,000 mJ/㎠, the degree of conversion was increased also. However, the degree of final conversion was no significant differences with the irradiation energy of 24,000 mJ/㎠ and 16,000 mJ/㎠(p>0.05). The wavenumber of absorbance peak of aromatic double bond was similar regardless of the restorative materials, and appeared around 1606.67∼1610.67 cm-1. The absorbance peak of aliphatic double bond appeared around 1636.64∼1638.52 cm-1 from FT-IR.

미숙아에서 총 정맥영양으로 인한 담즙 정체성 황달 발생에 관한 임상적 고찰

황지성,김영민,문순정,배종우,최용묵 경희대학교 2002 慶熙醫學 Vol.18 No.3-4

통신프로토콜의 적합성시험열 생성을 위한 경로 탐색 방법

황익순,장민석,이상배,이재용 延世大學校 電波通信共同硏究所 1996 電波通信論文誌 Vol.2 No.1

본 논문에서는 적합성 시험에서 EFSM(Extend Finite State Machine) 모델에 대한 데이타부분 시험열을 효율적으로 생성시켜 주는 탐색 방법에 대해 제안하였다. 이 탐색 방법에서는 depth-first search와 같은 기존의 탐색 방법과는 달리 탐색 초기에 다양한 경로가 찾아진다. 이미 제안된 시험열 생성 방법인 데이타 값을 바탕으로 하여 시험열을 생성하는 방법에서 이 탐색 방법을 이용하였을 경우 기존의 탐색방법을 이용하는 것보다 효율적으로 시험열을 생성할 수 있다. 본 논문에서는 Inres 프로토콜에 이 탐색 방법과 기존의 탐색 방법인 depth-first search를 각각 적용하여 시험열을 생성, 비교하여 보았으며, 제안된 탐색 방법을 이용하면 같은 시험 범주를 가지면서도 짧은 길이를 갖는 시험열을 효율적으로 생성할 수 있음을 알 수 있다. In this paper we proposed a searching algorithm for generating test cases, which can test data part of EFSM model in conformance test. In a different way to existing algorithm like depth-first search algorithm, this one can find various paths in the early stage of searching. When it is used in readily proposed test case generation method which is based on the value of variables and parameters it can generate test cases efficiently than in the case of depth-first search algorithm being used. We generated test cases for Inres protocol using each of proposed and depth-first search algorithm, and compared these two methods. proposed algorithm can generate much shorter test sequences efficiently than existing one.

마케팅윤리의 내용 고찰

현학순,황용철 제주대학교 경상대학 경영경제연구소 1999 경영경제연구 Vol.1 No.-

금자양중(가네코 카즈시게) 기증 박형 호의 복원 : -경질토기를 중심으로-

황현성,이해순,이용희 국립중앙박물관 2001 박물관보존과학 Vol.3 No.-

이번 가네코 카즈시게 선생이 기증한 여러 유물 중 金子124 수호는 약 60여개 정도의 파편을 접합하고, 자체 하중을 견딜 수 있는 접착제를 적절하게 사용하여 결손부분을 복원하였다. 또한 보존처리를 하는 동안에도 항상 가역성을 염두에 두면서 처리하였고, 색맞춤도 미관상 어색함이 없는 범위 내에서 처리하였다. 그 결과, 기형이 둥근 점토질의 박형(珀形) 항아리로 새롭게 탄생하였다. This article examines the conservation process of a donated Gourd-style jar (Object No. Geumja No. 124), which was broken into several fragments (more than 60) in the past. After assessing the condition of the object, each of the fragments were re-attached, and missing areas were gap-filled and re-touched. The authors discuss considerations, which were taken into account during the decision making process. These include the integrity of the object and the section of treatment materials, such as the reversibility of adhesives and filling materials. After its conservation, the authors believe that the object is in a better condition and ready for display in the future.

기계적으로 정착된 철근의 이음길이에 관한 실험적 연구

이용택,황홍순 한밭대학교 2004 한밭대학교 논문집 Vol.21 No.-

In this study, the lap length of headed bars are evaluated through the experimental works. Headed bars are lap-spliced perpendicular to the direction of longitudinal bars in beam. Five beam specimens were tested for the performance evaluation on lap splice. Their variable examined was the lap length of headed bars. Two concentrated loads were applied at the end of lapped bars to make the same magnitude of bending moment for the lapped region. Performances of lap splice were evaluated on the basis of strength, stiffness, and drift capacity. Test results show that 14 times the diameter of bar is suitable as lap length.

표고 폐골목으로 제조한 목질보드의 성질

최용순,황원중,한태형,김남훈,권진헌 江原大學校 森林科學硏究所 1998 Journal of Forest Science Vol.14 No.-

要約표고폐골목의 재활용을 목적으로 폐골목과 정상재의 칩을 일정비율로 혼합하여 얻은 목질보드의 성질을 조사, 검토하였다. 그 결과 폐골목의 목섬유는 정상재보다 다소 짧고 표 면이 거칠었으며 폐골목 변재부의 밀도는 정상재에 비해 상당히 낮았다. 파티클보드의 두께 팽윤율 및 파괴계수의 시험결과 폐골목을 25~50% 정도 혼합한 경우는 정상재와 비슷한 값 을 나타냈다.결론적으로 폐골목은 파티클보드의 재료로 사용될 수 있고 정상재와의 혼합비율은 25~50% 범위에서 조정되어야 할 것으로 생각되었다.ABSTRACTTo provide further information for reutilization of the bed-logs decayed by oak mushroomfLentinus edodes), the properties of wood-based board prepared with mixed materials of normal wood and bed-logs were examined.Wood fibers in bed-logs showed different morphology from normal wood fibers, that is, shorter length and rough surface. Thickness swelling increased with increasing mixing ratio of bed-log. On the other hand, modulus of rupture(MOR) in bending strength decreased. In products, the visual surface of board prepared from higher mixing rate of bed-log chips was smooth.Consquently, it is considered that the optimum mixing rate of bed-log to normal wood is the range of 25-50% and the bed-log can be used for raw material of board instead of normal wood.