초등학교 학생의 정보 처리 유형과 인지 양식에 따른 과학 문제 해결

신애경,최병순 한국교원대학교 과학교육연구소 2000 청람과학교육연구논총 Vol.10 No.1

이 연구는 초등학교 6학년 235명을 대상으로 학생의 정보 처리 유형과 인지 양식에 따른 과학 문제 해결 정도를 알아보는 것을 목적으로 하였다. 이 연구의 결과는 다음과 같다. 첫째, 학생들은 두 가지 정보 처리 방식에서 높은 점수를 받을수록 과학 성취 문항과 창의적 문제해결 문항을 잘 해결하였다. 그리고 동시적 정보 처리 검사에서 높은 점수를 받을수록 과학개념 이해 문항을 잘 해결하였다. 둘째, 학생들이 장독립적 성향이 높을수록 과학 성취 문항과 창의적 문제해결 문항을 잘 해결하였다. 그리고 과학개념 이해 문항의 해결에서는 특히 좀 더 높은 장독립적 성향이 요구되었다. 마지막으로, 정보 처리 유형에 따른 인지 양식의 분포에 통계적으로 유의미한 차이가 있었다. 학생들이 두 가지 정보 처리 방식에서 높은 점수를 받을수록 그들의 인지 양식은 장독립적 성향이 높았다. The purpose of this study was to find out the degree of science problem solving by the information processing types and cognitive styles of 235 6th grade students. The results of this study were as follows. First, as the students got higher scores in the two types of information processing, they could solve more science achievement items and creative problem solving items correctly. And as the students got higher scores in simultaneous information processing test, they could solve more scientific concept understanding items. Secondly, as the students were more field-independent, they could solve more science achievement items and creative problem solving items. And especially in solving scientific concept understanding items, much higher field-independence was required. Finally, there was a significant difference on the distributions of cognitive styles by the information processing types. As the students got higher scores in the two types of information processing, their cognitive style tended to be more field-independent.

자궁적출술을 경험한 여성의 통증과 냉증완화를 위한 쑥뜸요법 효과의 예비연구

신경림,곽순애,신수진 성인간호학회 2001 성인간호학회지 Vol.13 No.1

The Purpose of this pilot study was to identify the effects of hand moxibustion therapy to decrease pain and relieve coldness of the body in women who had a hysterectomy. The conceptual framework of this study was derived from Ying-Yang, Khi and other corresponding theories. The data were collected from February to May 1997 A Graphic Rating scale was used to measure the degree of pain and Digital Infrared Thermographic Imaging(D.I.T.I) was used to examine the degree of coldness. The subjects were women who resided in Seoul and had a hysterectomy within five years. An experimental group was composed of five women who received moxibustion and a control group was composed of five who did not. The research procedure began with having both the experimental group and control group describe their general characteristics and the degree of pain they perceived. Then, Digital Infrared Thermographic Imaging(D.I.T.I) was conducted. Moxibustion was only given to the experimental group on both hands twice every day for a total of five weeks. Their perception of pain and D.I.T.I were examined weekly. The control group received no therapy. After finishing therapy. the perception of pain and D.I.T.I for both groups were also measured. According to this study, moxibustion therapy resulted in a change of body temperature on the right shoulder joint(p=0.00074), abdomen(p=0.0047), waist(p=0.0068) and hands(p=0.0317) respectively. Also, the study results showed significant decrease (p=0.0001) in pain over time and significant improvement over body coldness.

GG-38 : Minimal invasive surgery (LESS) for huge cystic adnexal tumors in whole abdomen

( In Young Choi ),( Ji Hye Lee ),( Mi Hyun Park ),( Ji Kwoun Park ),( Jeong Kyu Shin1 ),( Won Jun Choi1 ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

Laparoendoscopic single-site surgery (LESS) is helpful if not an evidence of suspicious malignancy in huge adnexa tumors. This approach might be reasonable alternative to conventional laparoscopic surgery. We report two cases with LESS for huge cystic adnexal tumors in whole abdomen. A 58 years old multigravida woman in menopause underwent removal of a huge cystic adnexal mass that occupied her entire abdomen by LESS.(ca.5200ml aspiration) A 15 years old single nulligravida woman had a huge cystic adnexal tumor in whole abdomen reaching to the level of the xyphoid process. A needle through the transumbilical single port was inserted directly under the mass. Subsequently, 8000 ml of cystic fluid was aspirated without spillage.

Waist circumference and Mortality in Korean elderly women

( Hyo Soon Hwang ),( Geum Joon Cho ),( Jong Heon Park ),( Hyun Tae Park ),( Jung Ho Shin ),( Soon-ae Shin ),( Jun Young Hur ),( Tak Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: The aim of this study was to evaluate the association between waist circumference (WC) and mortality in elderly Korean women. 방법: We enrolled Korean women who had undergone National Health Screening Examination through the National Health Insurance Corporation in 2009. A total of 45,408 Korean women over 60 years of age without pre-existing cardiovascular disease or cancer at baseline defined by charlson’s comorbidity index were followed-up until 2014. 결과: During follow-up, 1,759 total deaths occurred. The rate of death from any cause had a U-shaped association with WC. Subjects with a WC < 70 cm and ≥110 cm had higher risks of mortality. The highest risk of mortality was observed in subjects with a WC <70 cm (hazard ratio 1.48; 95% CI 1.28 to 1.72) compared with the reference group (WC 70-79 cm). 결론: Elderly women with lower WC had higher rates of death than those with normal WC.

도라지 추출액과 한약재 함유 도라지 추출액에 의한 면역세포 활성 표지유전자 발현 분석

강신애(Shin Ae Kang),전성식(Sung Sik Chun),강신권(Shin Kwon Kang),정영철(Young Chul Chung),전은우(Eun Woo Cheon),조상욱(Sang Uk Cho),정경화(Kyung Hwa Jung),안순철(Soon Cheol Ahn),유학선(Hak Sun Yu) 한국생명과학회 2014 생명과학회지 Vol.24 No.5

초롱꽃과에 속하는 도라지는 항염증, 항산화, 항암작용뿐 아니라 간기능 강화에도 작용하여 한방에서 만성염증성 질환의 치료제로 널리 사용되고 있다. 이번 연구에서 마우스 대식세포주인 RAW 246.7 세포와 비장으로부터 분리한 T세포에서 도라지 추출액(CC), 도라지 추출물이 함유된 활맥단 추출액(HWAL, 도라지 82% 함유) 및 맥환추출액(MAEK, 도라지 7% 함유)을 처리하여 대식세포와 T세포의 활성과 관련 있는 유전자의 발현을 통해 면역증진 및 항염증 효과를 real-time RT-PCR 기법을 통해 확인해 보았다. 그 결과, 활성화된 T세포에서 많이 발현되는 c-fos (10배 이상), CD40L 유전자(6배 이상)의 경우, 맥환 추출액 처리군에서 가장 높은 발현이 유도되어 면역활성 효과가 높을 것으로 사료되었다. 도라지 추출액과 활맥단 추출액의 경우도 c-fos 유전자의 발현을 유의적으로 증가시켰지만 미약하였고, CD40L의 경우는 영향을 주지 않았다. 도라지 추출액을 처리한 군에서 면역활성을 유도하는 M1 대식세포에서 많이 발현되는 iNOS 유전자의 발현이 유의하게 증가되었다. 반면에 활맥단 추출액을 처리한 대식세포는 M2 표식인자인 Ym1, arginase1 (ARG1) 유전자의 발현이 유의적으로 상승하였다. 결론적으로 도라지가 다량 포함된 맥환 추출액은 면역활성을 유도하는데 탁월한 효과를 나타내며, 도라지 함유가 적게 포함된 활맥단 추출액은 항염증 작용에 탁월한 효과가 있을 것으로 사료된다. Extracts of Platycodon grandiflorum have been reported to show anti-inflammatory, antioxidant, anti-metastatic, and hepato-protective effects. This study was designed to evaluate T-cell activation and M1/M2 differential macrophage activation by extracts of P. grandiflorum or P. grandiflorum containing various medicinal herbs. Using real-time RT-PCR, we analyzed expression levels of c-fos, and CD40L(T-cell activation markers) in splenocytes and iNOS, Ym1, and ARG1 in RAW 246.7 cells after treatment of CC (hot water extract of P. grandiflorum), MAEK (hot water extract of P. grandiflorum [82%]and six different plants), and HWAL (hot water extract of P. grandiflorum [7%] and eight different plants. The results showed that MAEK significantly elevated the expression of T-cell activation markers of splenocytes, with the c-fos gene activated more than 10-fold and the CD40L gene activated more than 6-fold. Although CD40L was significantly increased by CC and HWAL, the increase was only about 2-fold. In addition, CC and HWAL did not significantly activate the expression of the c-fos gene. On the other hand, CC elevated the M1 activation marker iNOS, and HWAL elevated the M2 activation marker Ym1 and ARG1 gene expression. In conclusion, MAEK could be used as an immune stimulant because of its ability to activate T cells (elicited c-fos and CD40L gene expression), whereas HWAL could serve as an anti-inflammatory agent because of its differential activation of M2 macrophages.

Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate

Shin, Jin Soo,Ku, Keun Bon,Jang, Yejin,Yoon, Yi-Seul,Shin, Daeho,Kwon, Oh Seung,Go, Yun Young,Kim, Seong Soon,Bae, Myoung Ae,Kim, Meehyein MICROBIOLOGICAL SOCIETY OF KOREA 2017 JOURNAL OF MICROBIOLOGY -SEOUL- Vol. No.

<P>Influenza viruses are major human respiratory pathogens that cause high morbidity and mortality worldwide. Currently, prophylactic vaccines and therapeutic antiviral agents are used to prevent and control influenza virus infection. Oseltamivir free base (OSV-FB), a modified generic antiviral drug of Tamiflu (oseltamivir phosphate, OSV-P), was launched in the Republic of Korea last year. Here, we examine the bioequivalence of these two compounds by assessing their antiviral efficacy in infected cells and in a mouse model. It was observed that both antivirals showed comparable efficacy against 11 different influenza A and B viruses in vitro. Moreover, in mice infected with influenza A virus (mouse-adapted A/Puerto Rico/8/34), they showed a dose-dependent therapeutic activity and alleviated infection-mediated reductions in body weight, leading to significantly better survival. There was histopathological disappearance of virus-induced inflammatory cell infiltration of the lung after oral treatment with either antiviral agent (at 10 mg/kg). Pharmacokinetic analysis also exhibited similar plasma concentrations of the active drug, oseltamivir carboxylate, metabolised from both OSV-B and OSV-P. This is the first report showing bioequivalence of OSV-FB to its phosphate salt form in the mouse system. The free base drug has some beneficial points including simple drug formulation process and reduced risk of undesirable cation-phosphate precipitation within solution. The long term stability of OSV-FB requires further monitoring when it is provided as a national stock in readiness for an influenza pandemic.</P>

Eating habits, obesity related behaviors, and effects of Danhak exercise in elderly Koreans

Ae Wha Ha,Jong Hyun Kim,Dong Joo Shin,Dal Woong Choi,Soo Jin Park,Nam-E Kang,Young Soon Kim 한국영양학회 2010 Nutrition Research and Practice Vol.4 No.4

The aims of this study were to evaluate obesity-related dietary behaviors and to determine long-term exercise effects on obesity and blood lipid profiles in elderly Korean subjects. A total of 120 subjects, aged 60-75 yr, were recruited, and obesity-related dietary behaviors were determined. An exercise intervention was conducted with 35 qualified elderly females for 6 months, and body composition and blood lipids were measured 6 times at 4 week intervals. At baseline, mean BMI (kg/㎡) was 24.8 for males and 23.1 for females. The females had better eating habits than the males and were more concerned with reading nutrition labels on food products (P < 0.001); they also preferred convenience foods less than the male subjects (P < 0.05). Obese individuals were more likely than overweight or normal weight individuals to misperceive their weight (P < 0.001). Those with a high BMI responded feeling more depressed (P < 0.01), lacking self-confidence (P < 0.01), and feeling isolated (P < 0.01), as well as having more difficulty doing outdoor activities (P < 0.01). After exercise, body fat (%) and WHR were significantly reduced (P < 0.05), while body weight and BMI were also decreased without statistical significance. Total cholesterol and blood HDL were significantly improved (207.1 mg/dl vs. 182.6 mg/dl, HDL: 45.6 mg/dl vs. 50.6 mg/dl, P < 0.05). Other benefits obtained from exercise were improvements in self-confidence (26.4%), movement (22.6%), stress-relief (18.9%), and depression (13.2%). In conclusion, elderly females had better eating habits and were more concerned with nutrition information and healthy diets compared to elderly males. However, misperceptions of weight and obesity-related stress tended to be very high in females who were overweight and obese, which can be a barrier to maintain normal weight. Long-term Danhak practice, a traditional Korean exercise, was effective at reducing body fat (%) and abdominal obesity, and improved lipid profiles, self-confidence, and stress.

Increased interaction between heat shock protein 27 and mitogen-activated protein kinase (p38 and extracellular signal-regulated kinase) in pre-eclamptic placentas

Shin, Jeong-Kyu,Jeong, Young-Taek,Jo, Hyun-Cheol,Kang, Min-Young,Chang, In-Suk,Baek, Jong-Chul,Park, Ji-Kwon,Lee, Soon-Ae,Lee, Jong-Hak,Choi, Wan-Sung,Paik, Won-Young Blackwell Publishing Asia 2009 JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH -TO Vol.35 No.5

<P>Abstract</P><P>Aims: </P><P>Heat shock protein 27 (Hsp27) is a well-known stress response protein that is characterized by its phosphorylative capacity. Hsp27 becomes phosphorylated in response to various stimuli through interaction with several different kinases. The purpose of this study was to evaluate the interaction between Hsp27 and mitogen-activated protein kinase (MAPK) (p38, extracellular signal-regulated kinase [ERK], and c-Jun N-terminal kinase) in the human placenta derived from patients with pre-eclampsia.</P><P>Methods: </P><P>Western blot analysis was used to examine the levels of expression of Hsp27 and MAPK (p38, ERK, and c-Jun N-terminal kinase). Immunoprecipitation analysis was used to determine the interaction between Hsp27 and MAPK (p38 and ERK).</P><P>Results: </P><P>Western blotting analysis and immunohistochemistry showed that the expression of Hsp27 and p-Hsp27 in the placental tissues of the pre-eclampsia group were significantly higher than that in the normal pregnancy group. Immunoprecipitation analysis showed that the interaction between Hsp27 and MAPK (p38 and ERK) was significantly increased in the pre-eclamptic placenta tissues.</P><P>Conclusion: </P><P>The interaction between Hsp27 and MAPK was increased, suggesting that phosphorylation of Hsp27 might be induced by p38 and ERK in placentas from patients with pre-eclampsia.</P>

Paenibacillus lycopersici sp. nov. and Paenibacillus rhizovicinus sp. nov., isolated from the rhizosphere of tomato (Solanum lycopersicum)

Shin Ae Lee,Tae-Wan Kim,Jun Heo,Mee Kyung Sang,Jaekyeong Song,Soon-Wo Kwon,Hang-Yeon Weon 한국미생물학회 2020 The journal of microbiology Vol.58 No.10

Two Gram-stain-positive, rod-shaped, endospore-forming bacteria, designated 12200R-189T and 14171R-81T were isolated from the rhizosphere of tomato plants. The 16S rRNA gene sequence similarity between strains 12200R-189T and 14171R-81T were 97.2%. Both strains showed the highest 16S rRNA gene sequence similarities to Paenibacillus sacheonensis SY01T (96.3% and 98.0%, respectively). The genome of strain 12200R-189T was approximately 6.7 Mb in size with 5,750 protein-coding genes (CDSs) and the G + C content was 58.1 mol%, whereas that of strain 14171R-81T comprised one chromosome of 7.0 Mb and two plasmids (0.2 Mb each) with 6,595 CDSs and the G + C content was 54.5 mol%. Comparative genome analysis revealed that average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values among 12200R-189T, 14171R-81T, and other closely related species were below the cut-off levels 95% and 70%, respectively. Strain 12200R-189T grew at a temperature range of 15–40°C, pH 6.0–9.0, and 0–3% NaCl (w/v), whereas strain 14171R-81T grew at a temperature range of 10–37°C, pH 6.0– 8.0, and 0–1% NaCl (w/v). Menaquinone-7 (MK-7) was the only isoprenoid quinone detected in both strains. The predominant cellular fatty acids (> 10%) were iso-C15:0, anteiso- C15:0, and iso-C16:0. The polar lipids of strain 12200R- 189T were diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), phosphatidylethanolamine (PE), aminophospholipid (APL), phospholipid (PL), phosphatidylglycolipid (PGL), and four aminophosphoglycolipids (APGLs) and those of strain 14171R-81T were DPG, PG, PE, APL, three PLs, two PGLs, and three APGLs. Based on phylogenetic, genomic, phenotypic, and chemotaxonomic analyses, strains 12200R- 189T and 14171R-81T represent two novel species of the genus Paenibacillus, for which the names Paenibacillus lycopersici sp. nov. and Paenibacillus rhizovicinus sp. nov. are proposed. The type strains are 12200R-189T (= KACC 19916T = CCTCC AB 2020027T) and 14171R-81T (= KACC 19915T = CCTCC AB 2020026T).

환자 중증도 분류를 통한 간호업무량 측정과 적정 간호인력 산정

신동순,문원희,정애란,민신홍,이윤경,황윤신,송재금,심희숙,김태숙 충남대학교 간호과학연구소 2004 충남대 간호학술지 Vol.7 No.1

Purpose : The purpose of this study is to determine the appropriate nursing personnel required for nursing units by estimating both the total hours needed for nursing care and the amount of nursing activities based on the patient classification system. Method : The subjects of this study consisted of 1122 patients and 78 nursing staff in a tertiary hospital. The data was collected through personal observations from march 3, 2003 to June 30, 2003. The data was analyzed by the SPSS(ver. 10.0) computer program. Results : The amount of nursing activities and the total hours needed for nursing care were increased, depending on the severity of the patients. The number of nursing personnel required for each nursing unit, based on a 10 bed system, was seen as 5.6 nursing personnel in the medical nursing unit, 7.4 nursing personnel in the surgical nursing unit, 20.6 nursing personnel in the ICU nursing unit. Conclusion : According to the results, it is necessary to consider both the patient classification system and the nursing workload needed for nursing care when we estimate the proper nursing manpower.