과민성 대장 증후군 환자에서 Colpermin 투여의 임상 효과

금민수,조창민,김대현,이창형,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 과민성 대장 증후군은 장기능 이상의 증상군으로, 인지할 수 있는 기질적 위장관 병태 생리가 없는 경우로 기능적인 장관의 이상 경축과 가장 밀접한 관련이 있을 것으로 생각된다. 그러나 치료면에서는 아직 뚜렷한 방침이 정립되어 있지 않고 다양한 방법들이 제시되고 있는 실정이다. 저자들은 장용성 캅셀로 조제된 박하유 성분인 Colpermin® 의 임상 효과를 평가하고자 본 연구를 시행하였다. 대상 및 방법 : 1996년 2월부터 1996년 11월까지 경북대학교병원 소화기 내과를 방문하여 과민성대장 증후군으로 진단된 34명의 환자를 대상으로 Colpermin® 을 1회 2캅셀씩, 1일 3회, 경구로 2주간 투여하였다. 결과 : 투여전의 증상의 빈도는 복통 88.2%(30/34) 및 설사 73.5%(25/34)를 호소하는 경우가 가장 많았으며, 그 다음으로 변비 50.0%(17/34), 복부 팽만 47.1%(16/34), 고창 38.2%(13/34)순이었다. 약물 투여후 증상별 개선율은 설사를 보였던 환자들에서 호전 11예와 매우 호전 11예로 88.0%(22/25)의 가장 높은 개선율을 보였고, 그 다음으로 복통 73.3%(22/30), 고창 69.2%(9/13), 변비 64.7%(11/17), 복부 팽만 56.3%(9/16)의 순이었다. 종합적인 증상의 개선도는 현저한 개선이 2예(5.9%), 중등도 개선이 9예(26.5%), 약간 개선이 18예(52.9%), 불변이 4예(11.8%), 악화가 1예(2.9%)였으며, 종합적인 유효율은 85.3%(29/34)였다. 약물의 부작용으로 3예의 환자에서 각각 복부 팽만의 발생, 변비의 악화, 복통의 발생이 있었으나, 그 외의 환자들에서는 아무런 부작용도 관찰되지 않았다. 결론 : 과민성 대장 증후군의 약물치료에 있어서 Colpermin®이 유용한 약제가 될 수 있을 것으로 기대된다. Irritable bowel syndrome (IBS) is a disease characterized by a collection of symptoms of intestinal dysfunctions, without any recognized organic gastrointestinal pathology. This study was performed to evaluate clinical effectiveness of peppermint oil (Colpermin®) in the treatment of patients with IBS. 34 patients (18 males and 16 females) with IBS were treated with peppermint oil 0.4ml (as menthol 176㎎) three times daily for 2 weeks and the efficacy of the treatment was evaluated according to the degree of the improvement. The improvement of symptoms was 88.0% (22/25) in diarrhea, 73.3% (22/30) in abdominal pain, 69.2% (9/13) in flatulence, 64.7% (11/17) in constipation, and 56.3% (9/16) in abdominal distension, respectively. Overall effectiveness of subjective symptoms was 85.3% (29/34). Side effects of the drug were noted in only 3 cases, those were aggravation of constipation, development of abdominal distension and abdominal pain. As a result, Colpermin® might be considered as an effective drug in relieving symptoms of IBS.

A novel rat model of preeclampsia using sFlt-l overexpressing human adipose ti ssue-derived mesenchymal stem cells

( Geum Joon Cho ),( Hee Woo Lee ),( Hye Mi Jin ),( Ki Hoon Ahn ),( Soon Cheol Hong ),( Min Jeong Oh ),( Hai Joong Kim ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

OB-17 : The effect of pravastatin on vascular reactivity in pregnant mice model of preeclampsia

( Geum Joon Cho ),( Ji Hye Heo ),( Min Woo Lee ),( Suhng Wook Kim ),( Oye Sun Seok ),( Suk Hyo Suh ),( Soon Cheol Hong ),( Hai Joong Kim ),( Min Jeong Oh ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

The aim of this was to evaluate the effect of pravastatin on vascular reactivity in a pregnant mouse model of preelampsia. At day 8 of gestation pregnant CD-1 mice were randomly allocated to injection using the tail vein of the lentivirus carring sFlt-1 (109 plaque- forming units in 100 microliters; sFlt-1 group) or the mock lentivirus (109 plaque-forming units in 100 microliters; mock group used as a control for the virus) or control group and then to receive pravastatin (5 mg/kg/d) dissolved in drinking water (sFlt-1-pravastatin group). The mice in four groups (sFlt-1, sFlt-1-pravastatin, mock and control) were killed at day 18 of gestation and abdominal aorta was harvested for the study of vascular reactivity. The vasorelaxant responses to acetylcholine (endothelium-dependent relaxant) were decreased in sFlt-1 group compared with control and mock groups. However, the vasorelaxant responses were increased in sFlt-1-pravastatin group compared with sFlt-1 group. There was no difference in vasorelaxant responses to sodium nitroprusside (the endothelium-independent relaxant) between four groups. In this study, pravastatin improved the detrimental effect of over-expression of sFlt-1 on vascular reactivity in a pregnant mouse model of preeclampsia. Pravastatin may provide potential therapeutic approach for the prevention and treatment of preeclampsia.a

OB-08 : Gestational diabetes and pre-pregnancy factors as long-term risk factors for developing diabetes mellitus

( Geum Joon Cho ),( Jong Heon Park ),( Hee Young Lee ),( Seughyun Yoo ),( Soon Ae Shin ),( Min Jeong Oh ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: The aim of our study was to identify a subgroup at high risk for developing DM among women with and without a diagnosis of GDM in their first pregnancy using pre-pregnancy factors. 방법: We enrolled 53,109 Korean women who had undergone medical evaluation through the National Health Insurance Corporation between 2002 and 2003 and had their first delivery in 2004 with a follow-up period until 2012. 결과: In women with GDM, the cumulative risk of developing diabetes was 8.4% after 8 years compared with 3.3% in women without GDM in their first pregnancy. In a Cox proportional hazards model, adjusted for age, family history of DM and HTN, alcohol intake, smoking status and exercise, GDM in first pregnancy, pre-pregnancy obesity, high glucose (≥92 mg/dL), and HTN were independently associated with developing diabetes. Among pre-pregnancy factors including obesity, high glucose and HTN, the risk of developing DM was highest when both of pre-pregnancy obesity and GDM were present. 결론: Our results show that development of DM in later life was related to GDM in first pregnancy and pre-pregnancy factors, especially to the combination of pre-pregnancy obesity and GDM. Weight control counseling should be extended to all obese women before pregnancy.

Postpartum changes in body composition.

Cho, Geum Joon,Yoon, Hyo Jin,Kim, Eung-Ju,Oh, Min-Jeong,Seo, Hong-Seog,Kim, Hai-Joong NAASO, the Obesity Society 2011 Obesity Vol.19 No.12

<P>Parity is associated with weight retention and has long-lasting and detrimental effects on the health of women. Previous studies have shown that increasing parity was independently associated with an increased prevalence of metabolic syndrome. Postpartum weight is made up of several components including uterine and mammary tissues, body water (intracellular (ICW) and extracellular water (ECW)), and fat. These components change in variable amounts postpartum, thereby distinctly affecting the interpretation of individual weight retention; however, it is unclear which components contribute to weight retention. The aims of this longitudinal study were to evaluate changes in body composition during the postpartum period and to investigate their effects on weight retention. This prospective study examined 41 healthy, pregnant women who gave birth at Korea University Guro Hospital. We measured body composition at 2 days, 2 weeks, and 6 weeks postpartum using bioelectrical impedance analysis. Weight decreased during this postpartum period (P < 0.001); the postpartum weight retention from prepregnancy to 6 weeks postpartum was 4.43 ± 4.0 kg. Among various body composition components, ECW, ICW, total body water, and fat-free mass (FFM) decreased postpartum. However, fat mass (FM) and visceral fat area, the components that experienced the greatest changes, increased postpartum. Our results demonstrate that the postpartum period is associated with a preferential accumulation of adipose tissue in the visceral compartment, even though overall body weight is decreased. Further studies are needed to evaluate the changes in body composition over longer time periods and their long-term effects on health.</P>

The association between orexin-A and idiopathic polyhydramnios

( Geum Joon Cho ),( Hye Ri Hong ),( Soon Cheol Hong ),( Hai Joong Kim ),( Min Jeong Oh ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

Idiopathic polyhydramnios is an independent risk factor for perinatal morbidity and mortality, although the precise mechanism is unknown. Orexin-A is neuropeptide which is present in the lateral hypothalamic area of the brain and may be involved in regulating various brain functions such feeding. Orexin-A protein was also detected in the placenta and in neurons of the gastrointestinal tract, especially, the myenteric plexuses from 26 gestational weeks. In general, hunger has been found to induce an increase of orexin-A, which increases gut motility. Given the human fetus swallows large volumes of amniotic fluid, which is almost completely resorbed within the gastrointestinal tract of the fetus, orexin-A may play an important role in regulating gastrointestinal functions, including absorption of amniotic fluid (AF) or mortility of the gut in the fetus. The aim of this study was to evaluate the association of orexin-A with idiopathic polyhydramnios. This case-control study included 10 pregnant women with idiopathic polyhydramnios and 20 age and gestational age-matched pregnant women with normal AF as the control group. Orexin-A levels were determined by ELISA, and compared for correlation between umbilical cord and maternal serum orexin-A levels and neonatal birth weight and differences between control and idiopathic polyhydramnios group. Mean umbilical serum orexin-A level was significantly higher than maternal serum orexin-A level. Umbilical serum orexin-A level was positively correlated with maternal serum orexin-A level and negatively with neonatal birth weight. Umbilical serum orexin-A level in idiopathic polyhydramnios group were higher compared with those in control group. However, there was no difference in maternal serum orexin-A levels in between two groups. In this study, idiopathic polyhydramnios was associated with decreased level of orexin-A in umbilical cord. Our results provide evidence that downregulation of orexin-A may induce polyhydramnios through decreases of absorption of amniotic fluid or mortility of the gut.

Use of the angle of progression on ultrasonography to predict spontaneous onset of labor within 7 days.

Cho, Geum Joon,Hong, Hye-Ri,Seol, Hyun-Joo,Koo, Bo Hae,Hong, Soon-Cheol,Oh, Min-Jeong,Kim, Hai-Joong De Gruyter 2015 Journal of perinatal medicine Vol.43 No.2

<P>To investigate the relationship between angle of progression (AoP) on ultrasonography at 37-40 weeks' gestation and delivery within 7 days.</P>

The neuroprotective effect of magnesium sulfate in preterm fetal mice

Cho, Geum Joon,Hong, Hye-Ri,Hong, Soon-Cheol,Oh, Min-Jeong,Kim, Hai-Joong Walter de Gruyter GmbH 2015 Journal of perinatal medicine Vol.43 No.5

<B>Abstract</B><P>To investigate the use of magnesium sulfate (MgSO</P><P>On embryonic day 15 of gestation, lipopolysaccharide (LPS) and mifepristone (RU486) were used, respectively, to create mouse models of inflammation and noninflammation-associated preterm birth. After intraperitoneal injection of LPS, RU486, or normal saline solution (NS), dams were randomized to intraperitoneal MgSO</P><P>The expression of S100B significantly differed among the groups and was decreased in the LPS+MgSO</P><P>We observed that prenatal treatment with MgSO</P>

Maternal smoke during pregnancy programs for bone disturbance in offspring

( Geum Joon Cho ),( Hye Ri Hong ),( Soon Cheol Hong ),( Hai Joong Kim ),( Min Jeong Oh ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

Epidemiological studies have focused on the deleterious effects of smoking on human health. Of particular the number of epidemiological studies reported that cigarette smoke decreases bone mineral density (BMD) and increases the risk of bone fracture and is a risk factor for osteoporosis. Maternal smoking during pregnancy results in a variety of adverse developmental outcomes with intrauterine growth restriction. Moreover, maternal smoking is associated with future onset of attention deficit hyperactivity disorder, cardiovascular diseases and obesity in offspring. However, little is known about the effect of maternal smokE during pregnancy on bone mineral density in offspring. Pregnant CD-1 mice were exposed to cigarette smoke (1 or 2 cigarettes/day, 5 days/week) (smoke group) or sham exposed (control group) throughout the pregnancy. After delivery, nursing dams and offspring were kept together in individual cages for 21 days, which corresponds to the lactation period. At weaning, the fourth lumbar vertebral body from each of offspring was scanned with micro-CT apparatus. Trabecular parameters including bone volume fraction (BV/TV, %), thickness (mm), separation (mm), and number (1/mm) were evaluated. The BMD was also measured. There were no differences in trabecular bone volume fraction, thickness, separation and number and the BMD between offspring from control and 1 cigarette smoke dams. However, trabecular bone volume fraction, thickness, and number, and the BMD were significantly lower, but trabecular separation was higher in offspring from 2 cigarettes smoke dams compared with offspring from control dams. In this study, maternal smoking during pregnancy decreased the bone mineral density and disturbed the microarchitecture of bone in offspring. Further studies are needed to evaluate the long term effect of maternal smoke during pregnancy on bone of offspring.

Cerclage is associated with the increased risk of preterm birth in women who had cervical conization

( Geum Joon Cho ),( Log Young Kim ),( Geun U Park ),( Hye Mi Jin ),( Ki Hoon Ahn ),( Soon Cheol Hong ),( Min Jeong Oh ),( Hai Joong Kim ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-