방사선 치료후 시간경과에 따른 염색체이상 빈도의 변화

송명재,하성환,이춘자,김희근,김미숙 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.1

임파구의 염색체이상 빈도로부터 피폭자의 흡수선량을 구하는 방법은 사고로 인해 급성피폭을 받는 경우 유용하게 사용될 수 있다. 그러나 방사선 피폭 후 시간이 경과함에 따라 불안정 염색체이상을 가진 임파구는 감소하게 된다. 이에 방사선 치료후 시간 경과에 따른 불안정 염색체이상 빈도의 변화를 규명하고자 한다. 전골반에 50.4 Gy의 방사선 치료를 받은 총 20명의 자궁경부암 또는 자궁내막암 환자를 대상으로 41개의 검체를 얻었다. 채혈의 시기는 방사선 치료후 1일 3주, 6주, 12주, 24주, 52주, 104주, 156주, 208주, 520주로 하였다. 이들 말초혈액의 임파구에 대해 전혈미세배양을 실시한 후 임파구의 불안정 염색체이상을 관찰하여 Ydr, Qdr, Qdra를 얻었다. Ydr 값은 방사선 치료가 끝난 직후부터 3주까지 plateau를 보였고 이후 감소하는 경향이었다. Ydr의 평균값은 치료후 3주에 0.29에서 급격히 감소하여 2년후 0.05로 감소하였으며 이후 5년까지 서서히 감소하였다. 회귀분석을 실시한바 Ydr = 0.259×exp(-0.0429T)+0.0560×exp(-0.00106T)(time in weeks)로 나타났다. Qdr값은 치료 직후부터 24주까지 1.51 전후로 거의 변화가 없었으며 이후 감소하여 52주 이후에는 1.17 전후로 거의 일정하였다. Qdra 값은 치료 직후부터 12주까지 1.10 전후이며 이후 감소하여 52주 이후에는 0.81 전후였다. 피폭 후 시간경과에 따른 Ydr 값의 감소는 두 component exponential 모델을 잘 맞고 이 식을 이용하여 생물학적 선량측정이 가능하다. Qdr 값 및 Qdra 값은 피폭후 시간경과가 짧은 경우 피폭선량을 추정하는 지료로 사용할 수 있다. It is good method to use frequency of chromosome aberration in lymphocytes for a biological dosimetry in cases of accidental exposure to radiation. But in cases of past edposure, biological dosimetry is limited because the friquency of aberration decreases by time after exposure. To provide a basic data for estimationof past radiation exposure, the changing pattern of frequency of unstable chromosome aberration by time interbal after exposure was studied. Observation was made on peripheral lymphocytes of 41 blood samples from 20 patients treated for uterine cervical carcinoma and endometrial caricinoma. The patients received 50.4 Gy radiation to whole pelvis. Elapsed times after the completion of radiation therapy were 1 day, 3, 6, 9, 12, 24, 52, 104, 156, 208, 260 and 520 weeks. All the blood sample were microcultured. The Ydr, Qdr and Qdra were calculated form frequency of unstable aberration. Ydr did not decrease for 3 weeks after radiation therapy, and thereafter, decreased very rapidly and reached 0.05 at two years after radiation therapy and decreased very slowly until 5 years after radiation therapy. Relationship between unstable chromosome aberration and time interval after radiation therapy was described as Ydr = 0.2590.259×exp(-0.0429T)+0.0560×exp(-0.00106T)(time in weeks) Qdr remained constant at 1.51 until 24 weeks after radiation therapy and then decreased to 1.17 at 52 weeks. Therafter, it did not change. Qdra remained constant at 1.10 for 12 weeks after radiation therapy and decreased to 0.81 at 52 weeks. Thereafter, it remanined constant. Two superimposed exponential Ydr disappearance rate wuggests that it is possible to calculate the past exposure dose. When the elapsed time after exposure is short, Qdr and Qdra are useful papameters for biological dosimetry for past radiation exposure.

중·고등학교 아랍어 교재 집필 및 교재 내용에 관한 연구 보고서

오명근,송경숙,전완경,사희만,이규철,조희선,정규영,최진영 한국아랍어아랍문학회 1999 아랍어와 아랍문학 Vol.3 No.1

Dysphagia in Infants After Open Heart Procedures

Yi, Sook-Hee,Kim, Sang-Jun,Huh, June,Jun, Tae-Gook,Cheon, Hee Jung,Kwon, Jeong-Yi Lippincott Williams Wilkins, Inc. 2013 AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITA Vol.92 No.6

OBJECTIVE: The aims of this study were to evaluate the prevalence and the clinical predictors of dysphagia and to determine the characteristics of videofluoroscopic swallowing study findings in infants after open heart procedures. DESIGN: This study is a retrospective review of 146 infants who underwent open heart surgery. The infants with dysphagia were compared with those without dysphagia. The videofluoroscopic swallowing study findings of the infants with dysphagia were also evaluated. RESULTS: Of the 146 infants who underwent open heart surgery, 35 (24.0%) had dysphagia symptoms. The infants with dysphagia had lower body weight at operation, more malformation syndromes, longer operation times, and more complex operations than did the infants without dysphagia. In addition, the infants with dysphagia required more time to achieve full oral feeding and had longer hospital stays. Thirty-three infants underwent videofluoroscopic swallowing study: 32 (97.0%) exhibited at least one abnormal finding among the videofluoroscopic swallowing study parameters and 21 (63.6%) exhibited tracheal aspiration. CONCLUSIONS: Given the high rate of aspiration in the infants who underwent open heart procedures, monitoring and prompt recognition of the signs and the risk factors of dysphagia may substantially improve infant care with oral feeding and reduce the duration of hospital stays.

Chŏng Yag-yong’s ‘One and Only Mind’: in Comparison to B. Lonergan’s Cognitive Process

( Yi Sook-hee ) 성균관대학교 유교문화연구소 2012 儒敎文化硏究(中文版) Vol.0 No.18

本论文以丁若镛用‘灵’字代替‘心’字的这一点为着手点, 用朗尼根(Bernard Lonergan)的认知论来进行了分析解释。朗尼根的认知论即人类通过体验-理解-判断-决断的认知过程, 得出人类生存的最终意义和价值。这一理论展开的基础是:认识活动和作为认识活动结果的认识内容, 认识活动中存在的四种认知活动, 以及以自身的认识活动(1)为对象的另一种认识活动(2)。 如果将朗尼根的认知理论应用在分析丁若镛的‘灵’上, 那么对丁若镛‘心’的关注就会增加, 相应的对此的理解也会有更进一步的发展, 对他所说的心体虚灵-‘大体’-‘灵体’等词语的理解也会更加明了。 在《大学讲义》(1789, 1814)的‘心体虚灵’中我们可以看到丁若镛所理解的‘心’的一般性特征, 在《论语古今注》(1813)的‘大体’中丁若镛批判性的看待了生理性·心理性的气质与价值判断的关系, 在《心经密验》(1815)中丁若镛对价值判断的理解上升到价值实现的问题上, 认为“灵体”这一概念是由以下三个要素形成的:对于价值先天的指向性(性), 价值的分别(权衡), 选择价值并去实现(行事)。‘灵体’这一概念在《答李汝弘》(1816)《南雷黃宗羲序》(1827)中成立, ‘独一无二的心’也是在这里言及的, 本论文认为可以将此看作是意识的力量。 ‘灵体’的概念即是发现意识力量, ‘灵体’的三要素即是像我们展示了追求价值意识的机械论。‘灵体’这一概念与朗尼根的认识过程论也是相符合的, 验证了其普遍性, 而且这一概念的最大意义是能够发现认识和实践价值的意识主体, 也是因此我们才能够发现丁若镛的思想中主体, 理性, 合理性中所具有的近代性特征。 This paper focuses on the fact that Tasan Chŏng Yag-yong represents ‘mind’ with ‘ling(靈)’ and then explicates the reason by applying Bernard Lonergan’s cognitive process. Lonergan argued that human achieves the ultimate value and meaning through the cognitive processes of experiencing - understanding - judging - deciding / choosing. In so doing Lonergan developed the cognitional theory to elucidate human consciousness. Lonergan’s cognitional theory is developed based on cognitive acts and its content, four cognitive processes immanent within one owns consciousness, and other conscious act that objectify the one’s own conscious acts. To apply Lonergan’s cognitional theory on analyzing Tasan’s concept of ‘ling’ helps us to understand that Tasan had profound interest in the structure of mind. As his understanding of it had developed, empty ling (虛靈) - the great constitution(大體) - ling constitution(靈體)’ that appear in his text correspond to the clarification process of his understanding of ‘ling.’ From the notion of ‘mind constitution as empty ling (心體虛靈)’ in the Lecture on the Mean (中庸講義 1789, 1814), Tasan’s understanding of ‘mind’ can be seen generally. In ‘the great constitution’ of his Old and New Commentaries of Analects (論語古今註, 1813), he critically deliberates the relation between judgment of value and physical temperaments. In Deep Examination of the Classic of Mind (心經密驗 1815), as the understanding of value judgment transforms into the matter of value practice, the concept of ‘ling’ had been formulated to include preference(嗜好, which is nature 性 in Tasan’s philosophy) toward value, value discernment (權衡, weighing), choosing and practicing values (行事, carrying out events). The concept of ‘ling’ had been standardized in Reply to Yi Yeo-hong (答李汝弘 1816), and Critique of Namloe Hwang Jong-hŭi (南雷黃宗羲序 1827) and in those had ‘the one and only mind’1 been mentioned. This paper thus proposes that it can be considered as a capability of consciousness. The concept of ‘ling,’ that followed a discovery of the capability of consciousness and its three attributes, has shown the mechanism of consciousness that knows and applies value. Furthermore the universality of the concept of ‘ling’ can be recognized in correspondence with Lonergan’s cognitive process. Most of all the implication of the concept of ‘ling’ is the discovery of the conscious subject that perceives and practices the value. The reason that we could find modern thoughts such as subject, reason, and rationality in Tasan’s thinking is due to his rigorous inquiries into the notion of ‘ling.’ [Article in Chinese]

다산 정약용의 종교적 의식

이숙희(Yi, Sook-hee) 한국종교학회 2011 宗敎硏究 Vol.65 No.-

신초증식을 통한 식방풍(Peucedanum japonicum Thunb.)의 기내 대량번식

이숙이(Sook-Yi Yi),박춘근(Chun-Geun Park),한봉희(Bong-Hee Han) 한국약용작물학회 2014 한국약용작물학회 학술대회논문집 Vol.2014 No.2

Job Analysis of Operating Room Nurses

Kyung Sook Cho,Hyun Sook Kang,Nan Young Lim,Haeng Mi Son,Eun Hee Lee,Dong Oak Kim,Sung Bok Kwon,Young Sook Park,Yeo Jin Yi,Hye Ja Han,Joo Hyun Kim,Kye Sook Yoon 한국간호과학회 2007 한국간호과학회 학술대회 Vol.2007 No.11

표준화 환자를 이용한 관절질환 간호사정 실습교육의 평가

이여진(Yi Yeo-Jin),임난영(Lim Nan-Young),이은희(Lee Eun-Hee),한혜자(Han Hye-Ja),김주현(Kim Joo-Hyun),손행미(Son Haeng-Mi),박영숙(Park Young-Sook),강현숙(Kang Hyun-Sook),조경숙(Cho Kyung-Sook),김동옥(Kim Dong-Oak),권성복(Kwon Sung-Bok 대한근관절건강학회 2007 근관절건강학회지 Vol.14 No.2

How much do Nursing Students Observe and Perform Nurse's Roles in Hospitals during Nursing Practicum

Kyung-Sook Cho,Dong Ok Kim,Joo Hyun Kim,Haeng Mi Son,Eun Hee Lee,Hyun Sook Kang,Sung Bok Kwon,Young Sook Park,Young Hee Shon,Yeo Jin Yi,Nan Young Lim,Hye Ja Han,Young Hee Sung 한국간호과학회 2005 한국간호과학회 학술대회 Vol.2005 No.10

Job Analysis of Clinical Research Coordinators Using the DACUM Process

Kang, Hyun-Sook,Son, Haeng-Mi,Lim, Nan-Young,Cho, Kyung-Sook,Kwon, Sung-Bok,Yi, Yeo-Jin,Park, Young-Sook,Lee, Eun-Hee,Kim, Joo-Hyun,Han, Hye-Ja,Baik, Jung-Mi,Jeong, Younhee 한국간호과학회 2012 Journal of Korean Academy of Nursing Vol.42 No.7

Purpose: This study was done to analyze the job of clinical research coordinators (CRCs). Methods: Through the “developing a curriculum (DACUM)” workshop, the definition of CRCs’ role was described and CRCs’ duties and tasks were identified. Finally, the developed duties and tasks were validated for importance, difficulty, and frequency. Results: A CRC is defined as the one who coordinates and performs tasks related to clinical research/trials among investigators, participants, and sponsors according to the Good Clinical Practice at institutions conducting clinical trials. Twelve duties and 78 tasks were identified on the DACUM chart which represented the importance, difficulty, and frequency of tasks represented as A, B, and C respectively. Based on determinant coefficient (DC) of the task, the highest ranked task was confirming the eligibility of participants for research (DC=8.03) and the lowest was inventory management for clinical study materials (3.95). Conclusion: In this study, the job of a CRC was analyzed through the DACUM process and it was found that CRCs were doing various duties and tasks. Based on these results, it is suggested that it is necessary to develop CRC education programs considering the career ladder of CRCs.