Geometric predictors of left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy: a 3D computed tomography analysis

Song, Yunsun,Yang, Dong Hyun,Ó,Hartaigh, Brí,ain,Cho, Se Jin,Kang, Joon-Won,Kim, Young-Hak,Kim, Joon Bum,Kim, Dae-Hee,Song, Jong-Min,Kang, Duk-Hyun,Song, Jae-Kwan,Lim, Tae-Hwan Oxford University Press 2018 European heart journal cardiovascular Imaging Vol.19 No.10

Whole Exome Sequencing in Patients with Phenotypically Associated Familial Intracranial Aneurysm

Song Yunsun,Lee Jong-Keuk,Lee Jin-Ok,Kwon Boseong,Seo Eul-Ju,Suh Dae Chul 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.1

Objective: Familial intracranial aneurysms (FIAs) are found in approximately 6%–20% of patients with intracranial aneurysms (IAs), suggesting that genetic predisposition likely plays a role in its pathogenesis. The aim of this study was to identify possible IA-associated variants using whole exome sequencing (WES) in selected Korean families with FIA. Materials and Methods: Among the 26 families in our institutional database with two or more IA-affected first-degree relatives, three families that were genetically enriched (multiple, early onset, or common site involvement within the families) for IA were selected for WES. Filtering strategies, including a family-based approach and knowledge-based prioritization, were applied to derive possible IA-associated variants from the families. A chromosomal microarray was performed to detect relatively large chromosomal abnormalities. Results: Thirteen individuals from the three families were sequenced, of whom seven had IAs. We noted three rare, potentially deleterious variants (PLOD3 c.1315G>A, NTM c.968C>T, and CHST14 c.58C>T), which are the most promising candidates among the 11 potential IA-associated variants considering gene-phenotype relationships, gene function, co-segregation, and variant pathogenicity. Microarray analysis did not reveal any significant copy number variants in the families. Conclusion: Using WES, we found that rare, potentially deleterious variants in PLOD3, NTM, and CHST14 genes are likely responsible for the subsets of FIAs in a cohort of Korean families.

Rare Neurovascular Diseases in Korea: Classification and Related Genetic Variants

Song Yunsun,Kwon Boseong,Al-Abdulwahhab Abdulrahman Hamed,Nam Yeo Kyoung,Ahn Yura,Jeong So Yeong,Seo Eul-Ju,Lee Jong-Keuk,Suh Dae Chul 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.8

Rare neurovascular diseases (RNVDs) have not been well-recognized in Korea. They involve the central nervous system and greatly affect the patients’ lives. However, these diseases are difficult to diagnose and treat due to their rarity and incurability. We established a list of RNVDs by referring to the previous literature and databases worldwide to better understand the diseases and their current management status. We categorized 68 RNVDs based on their pathophysiology and clinical manifestations and estimated the prevalence of each disease in Korea. Recent advances in genetic, molecular, and developmental research have enabled further understanding of these RNVDs. Herein, we review each disease, while considering its classification based on updated pathologic mechanisms, and discuss the management status of RNVD in Korea.

20대의 선호색 및 색채 이미지 조사 연구

박연선(YunSun Park),송선아(SunA Song) 한국색채학회 2014 한국색채학회 논문집 Vol.28 No.3

색이란 많은 사람들이 공통적인 감정을 가지고 사회적으로 일반화되면서 특정한 것을 의미하는 상징성을 갖는다. 색은 별도의 언어가 없어도 일반적으로 이해할 수 있는 감각언어이고, 사회규범으로써의 시각 언어이다. 특히 선호색은 교육환경, 주위 환경에서 오는 심리적 영향과 성격, 기질과 연관성을 가진다. 본 연구는 일반적인 선호색이 현대에 어떻게 변화되었고, 색채 이미지에 대한 언어적 표현이 실제 어떻게 쓰이고 있는지 알기 위해 색에 대해 가장 민감하게 인식하고, 다양성과 개성을 추구하는 것에 가장 발빠른 20대 대학생을 대상으로 KS산업규격에 따른 표준화된 155가지 색을 기본차트로 사용하여 샘플을 보여주고 설문 조사를 실시하였다. 그리하여 선호색 계열과 그에 따른 성격?성향별 분석을 하고, 선호 색채에 따라 연상되는 감성언어(형용사 이미지)를 분석하였다. 첫째, 20대의 성별에 따른 선호색의 구분이 존재하였다. 전체적으로 20대는 남?여 모두 파란색을 선호하였으며, 남자의 경우는 파랑과 검정을, 여자는 경우 파랑 다음으로 빨강과 분홍을 좋아한다고 응답하였다. 둘째, 20대의 성격유형별 선호색의 특징으로 주도형은 빨강을, 사교형은 파랑을, 안정형은 분홍을, 신중형은 파랑, 청록을 좋아한다고 분석되어 일반적으로 모든 사람이 공통적으로 인식되는 색채의 감성적 이미지와 DISC 성격 유형별로 분류되는 성향과의 일치성을 보였다. 셋째, 20대의 선호색과 선호톤의 경우 대다수가 생각하는 형용사 이미지가 비슷한 것으로 보아 일정한 패턴과 상관성이 존재하였다. 난색 중 "노랑"의 경우 귀여운 이미지를, 갈색과 어두운톤의 경우 "고상한"을, 초록과 하양의 경우 "맑은"을, 무채색 톤은 "모던한"이미지를 선택하여 색에 대해 느끼는 일반적인 감성 이미지는 크게 다르지 않았다. 자신을 표현하고 드러내는 것에 익숙한 20대들은 색 선호에 있어서 본인의 취향과 느낌을 가장 중요시하여 선택한다. 하지만 과거로부터 이어져 온 공통되는 색채의 연상적, 상징적 성질이 현대에도 반영되는 것으로 보아 주요 색채와 톤의 감성적 이미지는 크게 변하지 않고 있다. 본 연구를 통해 오늘날과 같은 다원화된 감성시대에 있어 빠르게 변화하는 20대의 선호색을 확인하여 20대를 위한 심리적 활동이나 색채를 통한 심리 요법, 또는 상품 이미지 전략을 위한 마케팅 활동 등에 이용되어 감성 색채 정보의 데이터 기반 구축에 도움이 될 수 있기를 기대한다. As many people become socially generalized with common emotions, a color becomes symbolic of something specific. Even without separate language, a color is sensory language that can be understood in general and visual language as a social code. In particular, a preferred color is correlated with the education environment, the psychological effects of the surroundings, personality, and disposition. To determine how generally preferred colors have changed and how verbal expressions of color image were used in practice, a survey was conducted in college students in their twenties, who are most active in expressing themselves and are sensitive to fashion and to analyze the preferred color groups by personality and disposition and determine emotional language (adjective image) associated with the preferred color. First, in terms of the general characteristics of those in their twenties, preferred colors differed insignificantly by blood type but varied by gender. In general, both men and women in their twenties preferred blue; the former preferred blue and black and the latter preferred blue, followed by red and pink. Second, in terms of personality type, the dominance type preferred red, the influence type blue, the steadiness type pink, and the conscientiousness type blue and bluish green; thus, the emotional image of colors commonly perceived by all the people generally agreed with dispositions classified by the DISC personality type. Third, there were certain patterns and correlation in preferred colors and tones since the majority of them had similar adjective images. Yellow among the warm colors was associated with the cute image, blue and dark tones with noble one, green and white with clear one, and achromatic tones with modern one; thus, there were significant differences in emotional images of colors in general. Those in their twenties, who give the first priority to their own taste and feelings in preferring and selecting colors. However, there has been insignificant variation in emotional images of principal colors and tones, given that associative and symbolic properties of colors which have long been common are reflected these days. In this era of diversified emotions, this study is expected to be used in psychological activities, color-based psychotherapy, or marketing activities with product image strategies for those in their twenties, who are quick to respond, by identifying their preferred colors and to assist in building databases for information about emotional colors.

Preventive effects of ginseng against atherosclerosis and subsequent ischemic stroke: A randomized controlled trial (PEGASUS trial)

Boseong Kwon,Yunsun Song,Joong-Goo Kim,Dongwhane Lee,Sang-hun Lee,Young-Keol Cho,Jong S. Kim,Dae Chul Suh 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4

Background: Korean Red Ginseng (KRG) extract has been shown to have beneficial effects in patientswith atherosclerosis, suggesting that KRG extract may be effective in preventing subsequent ischemicstroke in patients with severe atherosclerosis. Methods: This double-blind, placebo-controlled trial randomized patients with severe atherosclerosis inmajor intracranial arteries or extracranial carotid artery, to ginseng group and placebo group. They weregiven two 500-mg KRG tablets or identical placebo tablets twice daily for 12 months according torandomization. The primary endpoint was the composite of cerebral ischemic stroke and transientischemic attack during 12 months after randomization. The secondary endpoints were change in volumetricblood flow of the intracranial vessels and the incidence of newly developed asymptomaticischemic lesions. Any adverse events were monitored. Results: Fifty-eight patients were randomized from June 2016 to June 2017, 29 to ginseng and 29 toplacebo, and 52 (28 and 24, respectively) completed the study. One patient in the placebo group, butnone in the ginseng group, experienced ischemic symptoms (p ¼ 0.46). Changes in volumetric blood flowand the presence of ischemic brain lesions did not differ significantly in the two groups, and none ofthese patients experienced adverse drug reactions. Conclusion: Ginseng was well tolerated by patients with severe atherosclerosis, with these patientsshowing good compliance with ginseng dosing. Ginseng did not show significant effects compared withplacebo, although none of the ginseng-treated patients experienced ischemic events. Long-term studiesin larger patient populations are required to test the effect of ginseng.

Physiologic Flow Diversion Coiling Technique for Wide-Necked Aneurysms with an Asymmetric Bidirectional Flow at the Aneurysm Neck

Kwon Boseong,Song Yunsun,Choi Yun Hyeok,Suh Dae Chul 대한신경중재치료의학회 2022 Neurointervention Vol.17 No.3

Purpose: Wide-necked aneurysms in the circle of Willis (CoW) are prone to recur due to reciprocal bidirectional flow. We present a novel concept of coil embolization to prevent recurrence that uses physiologic flow diversion at the CoW. Materials and Methods: We enrolled 14 patients (15 aneurysms) who underwent aneurysm coiling for wide-necked aneurysms with asymmetric bidirectional inflow into the aneurysm. Four patients had recurrent aneurysms after coiling. The concept of physiologic flow diversion included obliterating antegrade flow into the aneurysm sac as well as opposite CoW flow by performing compact coil packing with intentional protrusion out of the aneurysm neck to the communicating part. Results: Fifteen aneurysms, including 4 recurrent aneurysms, in an anterior communicating artery (n=7), posterior communicating artery (n=5), and tip of the basilar artery (n=3) were treated with coil embolization (n=10) and stent-assisted coiling (n=5). All aneurysms had a wide neck, and the mean largest diameter was 9.0 mm. The mean packing density was 45.1%. Twelve aneurysms were completely occluded, and 3 aneurysms had tiny residual neck remnants. There was neither a neurological event nor recurrence during the mean 12.5 months of follow-up. Conclusion: Wide-necked aneurysms at the CoW tend to recur. As a strategy to prevent a recurrence, physiologic flow diversion can be an option in treating wide-necked aneurysms in the CoW.

A Patient with Neutropenia and Splenomegaly: A Case Report from Department of Family Medicine in Tertiary Hospital Center

Cho Jaehee,Song Youhyun,이지연,Lee Daeun,Go Yunsun,Kang Hee Cheol 대한가정의학회 2021 Korean Journal of Family Medicine Vol.42 No.3

Pancytopenia represents a unique challenge for primary care doctors and its etiological causes encompass various specialties, including hematology and rheumatology. Despite the existence of effective tests such as bone marrow biopsy and immunoassays to rule out the potential causes of pancytopenia, it is often difficult to pinpoint the exact diagnosis. In this case report, we have described such a ‘gray zone’ patient, who presented with pancytopenia, neutropenia, and splenomegaly, and was being treated for fungal pneumonia before being transferred to Severance Hospital (department of family medicine). As the patient had a 10-year history of multiple, long-term hospital admissions that were having a severely debilitating impact on the quality of life, we performed a partial splenic embolization as a potential cure for the symptoms. Although this induced acute blood count recovery, it failed to prevent eventual mortality from septic shock.

Facilitated Retrograde Access via the Facial Vein for Transvenous Embolization of the Cavernous Sinus Dural Arteriovenous Fistula with Isolated Ophthalmic Venous Drainage

AlAli Meshari,Kwon Boseong,Song Yunsun,Lee Deok Hee 대한신경중재치료의학회 2024 Neurointervention Vol.19 No.1

Management of cavernous sinus dural arteriovenous fistula (CSDAVF) continues to present significant challenges, particularly when the inferior petrosal sinus is thrombosed, collapsed, or angiographically invisible. In this study, we introduce facilitated retrograde access via the facial vein, which is employed in the transvenous embolization of CSDAVF with isolated superior ophthalmic venous drainage. We also present illustrative cases and technical points.

Safety and Effectiveness of Percutaneous Low-Dose Thrombin Injection for Femoral Puncture Site Pseudoaneurysms in Neurointervention: Single-Center Experience

Shin Jae Ho,Song Yunsun,신재전,Lee Dongwhane,정재우,Lee Ga Young,Jeong Hyunhee,Han Seongsik,Choi Joon Ho,황선문,Lee Deok Hee 대한신경중재치료의학회 2020 Neurointervention Vol.15 No.1

Purpose: We present ultrasound-guided percutaneous low-dose thrombin (200–250 IU) injection for the treatment of iatrogenic femoral pseudoaneurysms. Second, we compared patient and procedure factors between subcutaneous hematoma and pseudoaneurysm groups.Materials and Methods: From April 2012 to May 2018, 8425 patients underwent neurointervention. Among these patients, 18 had small subcutaneous hematomas and 6 had pseudoaneurysms. Pseudoaneurysms in the neck and entire sac were visualized, and low-dose thrombins were injected while visualizing a “whirlpool” hyperechoic core in the pseudoaneurysm sac. Subcutaneous hematomas were treated with simple compression. We compared the following parameters between the subcutaneous hematoma group and pseudoaneurysm group: sex, age, body mass index (BMI), type of procedure, heparin usage, sheath size, procedure time, and number of previous neurointervention procedures with the Mann-Whitney U test.Results: Most of the pseudoaneurysms were successfully occluded with 200 IU of thrombin (n=5). Only 1 pseudoaneurysm required a slightly higher thrombin concentration (250 IU, n=1). During the short-term follow-up, no residual sac was observed and no surgical repair was necessary. Pain in the groin region was alleviated. During the 1-month follow-up, no evidence of pseudoaneurysm recurrence nor subcutaneous hematoma was noted. Patient factors (sex, age, and BMI) and procedure factors (heparin usage, sheath size, procedure time, number of previous procedures) were not statistically different between the subcutaneous hematoma and pseudoaneurysm groups.Conclusion: Ultrasound-guided percutaneous low-dose thrombin injection (200–250 IU) is safe, effective, and less invasive for treating iatrogenic femoral pseudoaneurysm in neurointervention.

New grading system for the clinical evaluation of patients with spinal vascular lesions

Suh, Dae Chul,Song, Yunsun,Park, Danbi,Han, Minkyu,Lim, Young-Min,Park, Ji Eun,Lee, Sang Hun,Jeon, Sang Ryong,Kim, Kwang-Kuk Springer-Verlag 2018 Neuroradiology Vol.60 No.10