Two-Track Medical Treatment Strategy According to the Clinical Scoring System for Chronic Rhinosinusitis

Kim, Dong-Kyu,Kang, Seong Il,Kong, Il Gyu,Cho, Young Hoon,Song, Seul Ki,Hyun, Se Jin,Cho, Sung Dong,Han, Sang-Yoon,Cho, Seong-Ho,Kim, Dae Woo The Korean Academy of Asthma, Allergy and Clinical 2018 Allergy, Asthma & Immunology Research Vol.10 No.5

<P><B>Purpose</B></P><P>The previously reported Japanese clinical scoring study (JESREC) suggests that chronic rhinosinusitis (CRS) can be divided into 4 subtypes according to the degree of eosinophilic CRS (ECRS) and offers the information regarding the prognosis of CRS to clinicians. However, this scoring system has not yet been validated by an immunological study and needs to provide treatment guidelines based on underlying immunologic profiles. We investigated the immunologic profile of each CRS subgroup according to the JESREC classification and suggest its clinical application.</P><P><B>Methods</B></P><P>A total of 140 CRS patients and 20 control subjects were enrolled. All patients were classified into 4 groups according to the JESREC (non-, mild, moderate and severe ECRS). Nasal tissues were analyzed for mRNA expression of major cytokines (IL-5, IL-10, IL-13, IL-17A, IL-22, IL-23p19, IFN-γ, periostin, thymic stromal lymphopoietin [TSLP] and ST2), major chemokines (CCL11, CCL24, CXCL1 and CXCL2), transcription factors (T-bet, GATA3, RORC and FOXP3) and COL1A1 for type I collagen. Protein levels of 3 major cytokines (IL-5, IL-17A and IFN-γ) were also measured by multiplex immunoassay. Principal component analysis (PCA) was conducted to investigate the overall profile of multiple mediators.</P><P><B>Results</B></P><P>The moderate/severe ECRS showed up-regulation of type 2-related mediators (IL-5, IL-13, periostin, TSLP and ST-2), whereas INF-γ (type 1 cytokine) and CXCL1 (neutrophil chemokine) expressions were increased in non-/mild ECRS compared with moderate/severe ECRS. The JESREC classification reflected an immunological endotype. In PCA data, PCA1 indicates a relative type 2 profile, whereas PCA2 represents a type 1/type 17-related profile. In this analysis, mild ECRS was indistinguishable from non-ECRS, whereas moderate to severe ECRS showed a distinct distribution compared with non-ECRS. The JESREC classification could be divided into 2 categories, non-/mild vs. moderate/severe ECRS based on underlying immunological analyses.</P><P><B>Conclusions</B></P><P>The CRS clinical scoring system from the JESREC study reflects an inflammatory endotype. However, the immunologic profile of mild ECRS was similar to that of non-ECRS. Therefore, we propose type 2-targeted medical treatment for moderate to severe ECRS and type 1/type 17-targeted for non-ECRS and mild ECRS as the first treatment option.</P>

침전극저주파 자극이 해마의 세포사 차단에 미치는 영향

이정숙 ( Jung Sook Lee ),김병기 ( Byung Ki Kim ),김성원 ( Sung Won Kim ),김지성 ( Ji Sung Kim ),김동일 ( Dong Il Kim ),송치원 ( Chi Won Song ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.2

Objectives: This study was performed to investigate the effects of Needle Electrode Electrical Stimulation (NEES) on ischemia-induced cerebrovascular accidents. After obstruction and reperfusion of ** arteries in white mice, the amounts of necrosis and inflammation related substances IL-6, Caspase-3, and PARP, C-fos were measured in neurons of the hippocampus. The following results were obtained. Methods: This study used 21 male specific pathogen free (SPF) SD (Sprague Dawley) rats, 8 weeks of age and approximately 300 g in weight, that were given at least 1 week to adapt to the lab environment Each exposed artery was completely occluded with non-absorbent suture thread and kept in that state for 5 minutes. The sutures were then removed to allow reperfusion of blood. Test group is control group for comparison with the common carotid artery occlusion models, a GI group that underwent common carotid artery occlusion, and a needle electrode electrical stimulation (NEES) group that underwent NEES after artery occlusion. The GI and NEES groups were given 12, 24, or 48 hours of reperfusion before NEES. NEES device (PG6, ITO, Japan, 9V, current, 2Hz) was used to stimulate the right and left acupoint ST36 of the SD rats for 30 minutes while they were sedated with 3% isoflurane. An immunohistochemistry test was done on the forebrains of the GI induced rats. All the data collected from this study was symbolized and analyzed using a statistics processing program (SPSS 12.0K/PC). The level of significance was set at α=0.05 and a T-TEST analysis was used to find out the effects of treatment on each of the groups: the normal group, the CVA induced group, and the treatment after CVA induction group. Results: Both PARP and C-fos immuno-reactive cells, related to apoptosis, were greater in the GI groups than the NEES group. Caspase and IL-6 immuno-reactive cells, related to inflammation, were greater in the GI and NEES groups than the control group. Conclusions: This research was conducted to study the effects of NEES on CVA due to ischemia. Occlusion and reperfusion was performed on the common carotid arteries of white rats, after which amounts of substances related to neuron necrosis and inflammation-PARP, IL-6, Caspase-3, and C-fos - were measured in the Hippocampus.

有機色素分子와 陰이온 界面活性劑 사이의 相互作用에 關한 吸收分光學的 硏究

송기동,김일두,박성규,김준태,김성현 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

The metachromatic behavior of methylene blue (MB) ia aqueous solution and in the presense of sodium dodecyl sulfate (SDS) have been studied by the absorption spectroscopic method. The results are as follows. The association force of the MB molecules in aqueous solution seems to be complex of three factors, i.e., London's dispersion force, the hydrophobic interaction and the interaction between permanent dipoles it has been measured of critical micelle concentration (CMC) in aqueous solution of SDS and that of MB-SDS to be 8.0mM and 7.9mM respectively. This indifference between CMC values of the pure SDS and MB-SDS system would mean the formation of dye-rich induced micelles(drim). The spectral changes of MB-SDS system with the addition of the inorganic salts have been observed. The addition of the salt into the solution causes the redistribution of MB molecules in the complex(D_n^+ S_m^-). It would be resulted from the decrease of the stacking effect between the bound MB molecules. The spectral changes observed in the MB-SDS system with the increase of the S/D values are analyzed and the behavior of the meta band is explainsd in terms of the stacking theory and micelle formation theory

병식 평가 척도-한국판(SUMD-K)의 신뢰도와 타당도 검증

송지영,김기태,이서경,김용희,노준호,김종우,장환일,반건호,강원섭 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.4

Objectives : This study was conducted to evaluate the reliability and the validity of the Korean version of the Scale to Assessment Unawareness of Mental Disorder (SUMD-K). Methods : The subjects were 55 schizophrenic patients between ages of 26 and 58 who were recruited from the psychiatric unit of the university hospital and the out-patient clinic. The SUMD-K and insight scale of PANSS were applied to the patients. Results : The range of inter-rater (Spearman's rho) of the general items of SUMD-K were .97-.98 on the current illness and .58-.98 on the past illness. The correlation coefficient between the sum and the general items of the SUMD-K showed high scores. The concurrent validity between SUMD-K and insight item of PANSS was high (scores between .59-.96). However,the reliability and the validity of the attribution items of symptoms showed low scores compared to the current symptoms. Conclusion : The SUMD-K was confirmed in its reliability and validity. It can be a useful clinician-rating scale for evaluating insight in schizophrenic patients as well as patients with other neuropsychiatric conditions.

지방자치단체 웹 사이트 구축 전략 연구 : 관광정보 안내를 중심으로

송기범,박일록,유도삼 조선대학교 통계연구소 1999 統計硏究所論文誌 Vol.1 No.1

Many people can get various services from Internet by spreading of rapid provision of the high quality and low price of personal computer in recent development of network communication. WEB service especially did a great job of spreading the use of Internet and as a result, many works are in the progress of constructing successful WEB sites over the world. Each local autonomous entities in Korea analyze the aspect of Home-page, suggest the case of foreign country, the effective way of constructing of Home-page and the way of advertising Home-page to set up successful WEB sites. The effort is well shown to suggest an effective solution for constructing local autonomous entity's tourism publicity. indicating the problem of present local autonomous entity's Home-page and the solution especially with the tourist information.

유기색소분자(MB)와 고분자음이온(PVS)사이에 염효과에 관한 연구

송기동,김일두,박성규,김성현 조선대학교 기초과학연구소 1989 自然科學硏究 Vol.12 No.1

The metachromatic behavior of methylene blue(MB) in aqueous solution and in the presence of polyvinylsulfate potassium(PVS) was carried out by use of absorption spectroscopy. The salts examining the addition effect were salts (NaCl, KCl, LiCl, NH_4Cl, CH_3)_4NCl and urea). The remarkable increment of methylene blue aggregation with increase of various salts concentration was observed. This phenomenon is due to couter ions from salt which presumably reduces the repulsion force among the molecules of cation dye. In this study, the degree of aggregation appeared differently according to the addition of various salts and these effect was ascribed not only to concentration of counter ions, but also to cation of the salts. The characteristic changes of metachromatic band with the change of P/D value were discussed in terms of stacking theory. The appearance of metachromatic band is explained as a stacking effect of bound dye molecules on the surface of polymer chain and the disappearance of the band at higher P/D values is attributed to the redistribution of bound dye molecules over the excessive binding sites.

海南 綠雨堂 所藏 典籍의 考察

宋日基,盧基春 전남대학교 호남문화연구소 2002 호남학 Vol.31 No.-

The main purpose of this research is to clarify the state and characteristics of classical books which are owned by Yoon Gosan's house(Nokwoodang 緣雨堂), in Youn-dong, Haenam county, Cholla south province. The result is as follows. First, the most of these classical books were written for 1600∼1700, and collected by Yoon Sun-Do(尹善道), Yoon Doo-Seo(尹斗緖), Yoon Deuk-Hee(尹德熙). Second, the majority of these classical books are writing books (201 books) which are scientific and artistic product of Haenam Yoon's family.

Sol-Gel 법에 의한 친수성 무기-유기 혼성 코팅 용액의 제조

이동일,장상홍,송기창 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.6

소수성 고분자 필름의 무적성을 향상시키기 위하여 우수한 친수성을 보이는 무기-유기 혼성 코팅용액을 Sol-Gel법으로 합성하였다. 코팅용액은 무기물인 콜로이드 실리카 용액(Ludox)에 유기 조성을 함유한 화합물인 APS(3-aminopropyl triethoxysilane)를 첨가하여 제조하였다. 실란 커플링제인 APS는 콜로이드 실리카와 주변의 매트릭스인 고분자 필름(PET)에 각각 강한 결합을 형성하여 두 개의 서로 다른 물질을 강하게 연결하는 결합제 역할을 한다. 산성과 중성인 조건에서(pH 2,7) APS가 첨가되어 제조된 경우에는 순간적으로 용액은 겔이 되어 고분자 필름 위에 코팅 할 수 없었다. 반면 염기성 조건에서(pH 9, 11) 만들어진 혼성 코팅용액으로 고분자필름 위에 코팅한 경우에는 코팅 필름의 표면이 거의 균열이 없는 미세 구조를 보이며, 낫은 접촉각을 보여 우수한 친수성을 나타내었다. In order to improve the anti-fogging property of hydrophobic polymer films, inorganic-organic hybrid coating solutions with a good hydrophilic property were synthesized by the sol-gel method. The coating solutions were prepared by adding 3-aminopropyl triethoxysilane (APS) to a colloidal silica solution(Ludox). APS as a silane coupling agent forms strong bonds to the colloidal silica and surrounding polymer matrix (PET), and links two different materials together. Solutions prepared by the addition of APS at acidic and neutral conditions (pH 2.7) resulted in gels which can not be used as coating solutions. On the other hand, those at basic conditions (pH 9, 11) resulted in coatings that were less prone to cracking and showed a good hydrophilic property.

동충하초 급여 돈육의 물리적 및 관능적 품질특성

김일석,진상근,송영민,하경희,류현지,하지희,박기훈 진주산업대학교 농업기술연구소 2005 農業技術硏究所報 Vol.18 No.-

90kg 전후의 3원 교잡종(LY × D) 돼지를 이용하여 처리구별로 각 10두씩 배치하여 출하전 30일간 비육후기 사료를 급여하여 시험하였고, 기본사료(C)에 누에동충하초를 0.01% 첨가한 것을 처리구(T)로 하였으며 주요결과는 다음과 같다. 일반성분(수분, 조단백, 조지방, 조회분), 가열감량, 보수성, 전단가, 콜레스테롤에서는 유의적인 차이가 없었다. 육색의 밝기를 나타내는 L^(*)값에 있어서 육색과 지방색 모두 대조구가 유의적으로 높았다(P<0.05). 유의적인 차이는 없었으나, 전체 포화지방산 비율은 처리구에서 불포화지방산 비율은은 대조구에서 높은 경향을 나타내었고, 필수지방산의 함량은 처리구에서 다소 높았다(P>0.05). 대조구에 비해 처리구가 Proline을 제외한 모든 아미노산 구성 비율이 낮은 것으로 나타났다(P<0.05). 신선육 및 가열육에서 전반적인 기호도는 동일하였다. 이상의 결과로 볼 때, 향후 누에동충하초의 급여량과 급여방법 및 시기 등과 육질과의 상호관련성에 대해 더 많은 연구가 필요하다. This study was conducted to investigate the physical and sensory characteristics of the loin from pigs fed Peacilomyces Tenuipes. A total of 20 pigs average 90kg of live weight were assigned into 2 pens(10 pigs/pen). Pigs were fed finishig diets(C; basal feed) or finishing diets containing 0.01% Peacilomyces Tenuipes(T) from 30 days to market weight. The results obtained were as follows; In proximate analysis, there were no significantly difference among the samples of C and T in moisture, crude protein, crude fat and crude ash. Also, cooking loss, water holding capacity, shear force and cholesterol were not different(P>0.05). L^(*) value of meat and fat color in C were higher(P<0.05) than that of T. In fatty acids, saturated fatty acid and essential fatty acids of pork loin from T was higher than that of C, while, unsaturated fatty acid of pork loin from C was slightly higher(P>0.05) than that of T. Amino acid compositions of T was lower(P<0.05) than that of C, except proline. The sensory score of fresh and cooked meat showed similarity. Further studied are needs on the relation between physico-chemical properties and feeding dietary Peacilomyces Tenuipes

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.