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송준영,박의수,이원석,김석주 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3
We report a case of twenty-nail dystrophy accompanied by alopecia universalis in a 45-year old woman. She had developed dystrophic nail changes on her all finger and toe nails for 26 years and alopecia universalis for 10 years. On examination, 20 nails were affectedwith opalescent, thickening, longitudinal ridging, and total hair loss were in scalp, eyebrow, axilla, and pubic area. Mycologic study of involved nails was performed, but negative results were obtained. Histologic findings of dystrophic nails revealed prominent hyperkeratosis, acanthosis, and mild infiltration of mononucler cells in the upper dermis. The histologic findings of scalp showed a few atrophic hair follicle, thining of epidermis, and slightly hyperkeratosis. All of these clinical and histologic findings were considered as twenty-nail dystrophy accompanied by alopecia universalis. She was treated with intralesional injection of triamcinolone acetonide and topical application of dinitrochlorobenzene, but no significant improvement was made. The further observation is being conducted.
송의석,오하령 국민대학교 생산기술연구소 2004 공학기술논문집 Vol.27 No.-
This paper proposes a heuristic load balancing method for multiprocessor systems. The method minimizes the number of idle links to distribute load traffic and reduces its communication cost. Each processor iteratively tries to transfer unit load to/from every neighbor processors. However, real load transfer is collectively done after complete load traffic calculation to minimize useless traffic. The proposed method can be employed in various interconnection topologies. In this paper, it is applied to general graph environments. For performance evaluation, simulation studies are performed. The performance of proposed method is compared to those of two well-known algorithms. The results show that the proposed method always balances the loads perfectly. Furthermore, it reduces the communication costs by 13-42% compared to existing algorithms.
이원석,송준영,김용대,박의수 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2
We report a case of lupus erythematosus profundus in a 16-year old male. He had multiple pea-nut to bean sized subcutaneous nodules with dark brownish colored overlying skin was present on the upper arm, trunk & other systemic disease. Histologically, deep dermis & subcutaneous layer had dense patch lymphocytic infiltration and homogenized hyaline fat necrosis. Direct immunofluorescene studies showed IgM and C?? deposit on the vessel wall. We treated him with chloroquine and corticosteroid.
Cutis Marmorata Telangiectatica Congenita 의 1예
김용대,송준영,이원석,박의수 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2
Cutis marmorata telangiectatica congenita is a rare congenital vascular anomaly, characterized by congenital cutis maromrata, phlebectasia, opider nevi, ulceration, and in most instances, steady improvement from birth. We report a case of cutis marmorata telangiectatica congenita in 3-month-old boy who has developed localized, dark red reticulated mottling with shiny atrophic scars on the inner side of the left leg. Diagnosis was confirmed by clinical and histopathologic features.
A Novel Anti-cancer Agent, SJ-8029, Inhibits Angiogenesis and Induces Apoptosis
Yi Eui-Yeun,Jeong Eun-Joo,Song Hyun-Seok,Kang Dong-Wook,Joo Jeong-Ho,Kwon Ho-Seok,Lee Sun-Hwan,Park Si-Kyung,Chung Sun-Gan,Cho Eui-Hwan,Kim Yung-Jin The Korean Society for Biomedical Laboratory Scien 2006 Journal of biomedical laboratory sciences Vol.12 No.3
A new piperazine derivative, 8J-8029, is a synthetic anti-cancer agent which exhibits both microtubule and topoisomerase II inhibiting activities. In this study, we investigated the ability of 8J-8029 for anti-angiogenesis and apoptosis. 8J-8029 decreased the bFGF-induced angiogenesis in the CAM and the mouse Matrigel implants, in vivo. 8J-8029 inhibited the proliferation, migration, invasion, tube fonnation, and expression of MMP-2 in BAECs. In addition, 8J-8029 reduced the cell viability in HepG2 cells, caused the production of fragmented DNA and the morphological changes corresponding to apoptosis. 8J-8029 also elicited the release of cytochrome c and the activation of caspase-3. Taken together, these results suggest 8J-8029 may be a candidate for anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells.
직장암의 수술 전 항암화학방사선치료 후 병리학 및 임상적 효과 분석
송진호(Jin-Ho Song),장홍석(Hong-Seok Jang),김연실(Yeon-Sil Kim),정수미(Su-Mi Chung),손석현(Seok-Hyun Son),강진형(Jin-Hyeong Kang),육의곤(Eui-Gon Youk),이두석(Doo-Seok Lee),이숙희(Suk-Hi Lee),윤세철(Sei-Chul Yoon) 대한방사선종양학회 2011 Radiation Oncology Journal Vol.29 No.1
목 적: 수술 전 항함화학방사선치료는 국소 진행된 직장암에서 표준치료로 알려져 있다. 이 연구는 동시 항암화학 방사선치료를 받은 국소 진행된 직장암 환자의 생존율 및 병기하향률에 영향을 미치는 인자들을 분석하였다. 대상 및 방법: 2004년 3월부터 2008년 8월까지 수술 전 항암화학방사선치료를 받은 국소 진행된 직장암 환자 33명을 대상으로 하였다. 모든 환자는 전 골반 방사선조사를 시행하였으며, 28명(84.8%)은 동시적 소조사야 추가 방사선치료, 5명(15.2%)은 조사영역축소 방사선치료를 실시하였다. 총 방사선량은 50.4 Gy이었으며, 5-fluorouracil를 동시 투여하였다. 추적관찰 기간은 중앙값 24.2개월(9.8∼64.7개월)이었다. 결 과: 33명 중 31명(93.9%)에서 수술이 시행되었으며, 24명(72.7%)은 항문괄약근보존술, 7명(21.2%)은 복회음부 절제술이 시행되었다. 3년 생존율과 무병생존율은 각각 78.8%, 63.4% 이었다. 무병생존율에 영향을 미치는 인자로 수술 후 병리학적 소견이 중요하였다. 병리학적 N 병기(p=0.001), 절제면 침윤 여부(p=0.029) 및 분화도 (p=0.030)가 통계학적으로 의미 있게 영향을 미치는 인자였다. 종양 크기(p=0.081), 림프혈관과 신경주위 침윤여부 (p=0.073) 모두 영향을 미치는 인자로서의 경향성을 보였다. 한편, 수술 전 임상 소견으로는 임상적 T 병기만이 유의한 결과를 보였다(p=0.018). 병리학적 완전관해율은 9.1%였으며, T병기하향률은 30.3%, N 병기하향률은 72.7%로 나타났다. 단변량 분석에서 항암화학방사선치료 후 수술까지의 기간 및 임상적 T 병기가 의미 있는 병기하향의 예측인자로 분석되었다(p=0.029, 0.027). 치료 전 carcinoembryonic antigen 수치는 예측인자의 경향성을 보였다 (p=0.068). 결 론: 국소 진행된 직장암 환자의 생존율은 임상적 병기보다 수술 후 병리학적 소견에 더 의존되었다. 그러므로 수술 전 항암화학방사선치료로 병기하향을 얻는 것이 의미가 있으며, 수술까지의 기간, 임상적 T 병기가 이러한 병기하향을 예측하는 인자였음을 알 수 있었다. Purpose: To evaluate the pathological and clinical effects of preoperative chemoradiation (CCRT) in cases of locally advanced rectal cancer and to determine the predictive factors for tumor downstaging. Materials and Methods: From March 2004 to August 2008, 33 patients with locally advanced rectal cancer were treated with preoperative CCRT. Twenty-eight patients (84.8%) were treated using a concomitant boost technique while five (15.2%) patients were treated using a cone down boost technique. All patients received 50.4 Gy of irradiation and concurrent chemotherapy with 5-fluorouracil. The median follow-up duration was 24.2 months (range, 9.8 to 64.7 months). Results: Thirty-one (93.9%) patients underwent surgery. Twenty-four patients (72.7%) underwent anal sphincter-preserving surgery. The 3-year disease free survival (DFS) and overall survival rates were 63.4% and 78.8%, respectively. Post-operative factors were more important for DFS. Pathologic N stage, margin status, and pathologic differentiation were significant prognostic factors (p=0.001, 0.029, 0.030). Tumor size and lymphovascular invasion were also associated with marginal significance (p=0.081, 0.073). However, only pre-treatment T stage was a significant pre-operative factor (p=0.018). The complete pathological response rate was 9.1%. T-downstaging was observed in ten (30.3%) patients, whereas N-downstaging was found in 24 (72.7%) patients. Pre-treatment T stage and the interval between CCRT and operation were the predictive factors for downstaging in a univariate analysis (p=0.029, 0.027). Pre-treatment carcinoembryogenic antigen was also associated with marginal significance (p=0.068). Conclusion: The survival of rectal cancer patients can be better determined based on post-operative findings. Therefore, pre-operative CCRT for downstaging of the tumor seems to be important. Pre-treatment T stage and the interval between CCRT and operation can be used to predict downstaging.
송준영,박의수,이원석,최윤애 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3
Acute febrile neutrophilic dermatosis, which was introduced to the dermatologic literature by Sweet in 1964, is characterized by persistent higt fever and preceding upper respiratory infection like symptom, polymorphonuclear leukocytosis in the peripheral blood, raised painful plaque on the face, neck and limbs, histologically a dense dermal infilteration with polymorphonuclear leukocytosis, dramatic reponse to corticosteroids, and the absence of scarring. A 41 year-old female who had suffered from malaise, arthragia, upper respiratory tract infection like symptoms one month before the each episode of the cutaneous manifestation. Erythematous, well demarcated, slight scaly plaque appeared on the face with tendency of recurrences. Histologically a dense inflammatory cell infilteration, composed predominantly of polymorphonuclear leukocyte, lymphocytes and histiocytes were seen in dermis. The skin lesion and general symptoms were well controlled with orally administered corticosteroid.