방사선 치료를 받은 암환자에 대한 염색체 이상과 동위 효소에 관한 연구

김진영,김영진,김종봉 한국유전학회 1983 Genes & Genomics Vol.5 No.1

Dose response relationship between chromosome aberration and therapeutic irradiation was determined in peripheral lymphocytes obtained from cancer patients treated with therapeutic radiation. Enzyme activities and isozyme patterns as a biochemical genetic marker were also investigated in blood samples of cancer patients and normal group. Various types of structural aberrations of chromosome such as dicentrics, acentrics, ring chromosomes and chromatid breaks were observed in cancer patients. These types of aberrations were not usually observed in the normal cells. The frequencies of the structural aberrations ranged from 0.07 to 0.33 per cell according to the exposed doses. The incidence and prevalence of structural aberrations seen in cancer patients were consistently higher than those of control, suggesting the chromosomal effects of therapeutic irradiation. Isozyme patterns of cancer patients showed that enzyme activities and gene frequencies were found to be normal distribution except 6-Pgd isozyme. The heterozygosity of 6-Pgd in the cancer group was higher than that of healthy control.

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

大學綜合試驗 出題에 關한 硏究

卞烘圭,吳鎭坤,申鎔鎭,金泳喆,鄭求福,柳哲鍾,洪允杓 全北大學校 1977 論文集 Vol.19 No.-

The Comprehensive Examination for the undergraduate students is planned to adopt the Jeonbug National University for the purpose of enhancing the quality of its educational outputs. In order to effectively measure and evaluate the level of student progress toward the minimun standard as the students who have finished their general education and basic education for their major field study, the university has decided to make an item pool related to the subjects for the examination. This study is an attempt to make good items of five required courses among general education subjects which are Korean Language, English, Korean History, National Ethics. and Natural Science and are expected to be the subjects of the examination. Instead of making those items separately from the regular examination during the academic semesters, the university plans to collect and use good items from the usual mid-term and final examinations of those subjects. A key concern, in this study, therefore, is to analyze all the items used for the mid-term and final examinations of those subjects during the regular academic semesters. From the data of an about 100 sample in each subject at each time of total three tests, the difficulty index, discrimination index, the response rate of students on each item, and other general descriptive statistics are calculated and then good items are pooled for the future use for the Comprehensive Examination. Anhother important concern in this study is this study is given to the collection and analysis of controversial issues and problems on the process of operating the examination at other universities where the Comprehensive Examination is already adopted. The data from four institutions and from opinions of six participants of this study are used. The following main findidings are summarized : 1. The items have generally shown to be easy while the degree of discrimination is low. 2. Among the five subjects, Korean Language shows the highest rate of right answer (difficulty index) while English the strongest one in the discrimination index. 3. When comparing two types of test between the multiple choice and the short-answer, the latter seems to be powerful in both difficulty and discriminative. 4. The only one question of essay type test reveals clear limitations in scoring and evaluating students progress. 5. All items are constructed under the consideration of content-referenced base, not of the basis on behavioral aspect. 6. The analysis of issues and problems related to the Comprehensive Examination suggests that it is acceptable to test in terms of required subjects of general education and a few most basic subjects of major areas of study. 7. The examination can be functionally operated when it is held at the end of the first year of and before the beginning of the second year of the college years. The length of the examination is usally held from three to five hours. 8. Since the examination should be existed on the idea of criterion-referenced base rather than of norm-referenced one because of its testing the qualification of the entering behavior of students for the further study in their major field, the standard of the pass-and-failure should be set on at least 60 percent of correct answers in each subject. But there must be provided at least two additional opportunities for the make-up examination for those who failed in the first one. 9. A special committee must be established in order to deal with all the details related to the Comprehensive Examination.

액체결정을 이용한 온도측정

김욱,고영주,이경진,김신 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.2

Temperature is one of the most important variables in thermal-hydraulic system. Many methods like, thermo couple, thermistor, semi-conduct sensor and so on have been divised for the temperature measurement. Recently optical method has attracted much interest due to its insensibility to electromagnetic environment. When liquid crystal film is attached to an object, its color changes sensitively as according to the temperature of the object. If a specific light is flashed on the film, the amount of light reflection depends on the color of the film. The purpose of this study is to develop an optical temperature measuring system using liquid crystal film.

加水分解 牛皮粉의 飼料的 價値에 관한 硏究

金大鎭,孟元在,高永杜 東亞大學校 大學院 1984 大學院論文集 Vol.9 No.-

Protein quality of hydrolyzed cattle skin meal was estimated by the pepsin-HCL digestion with various concentration and incubation time, and by chemical score to determine the limiting amino acids. Protein efficiency ratio(PER), net protein ratio(NPR) and net protein utilization(NPU) were also studied with chicks fed semipurified diet with and without supplementation of the limiting amino acids. Broiler chick growth trials were also conducted to determine the supplementation level of hydrolyzed cattle skin meal by replacing with soybean meal and feather meal. The results are summarized as follows: 1. Protein digestibility of hydrolyzed cattle skin meal was 66.31%, 80.69%, 83.72%, 84.65%, and 87.45%, respectively for 4, 8, 12, 16 and 20 hours incubation of 0.2% pepsin-HCl. Protein digestibility maintained above 80% after 8hours incubation and increased by increasing incubation time. 2. Protein digestibilities of hydrolyzed cattle skin meal incubated for 16 hours at 0.2%, 0.1%, 0.05%, 0.025%, and 0.0125% pepsin-HCl solution were 85.10%, 82.08%, 76.18%, 74.67% and 64.82%, respectively. 3. Chemical scores of methionine, isoleucine, threonine, leucine and histidine estimated based on NRC(1977) broiler(03 weeks) feeding standard were 27%, 38%, 44%, 48% and 51%, respectively 4. Growth rate, feed intake and feed conversion were improved by the addition of the limiting amino acids in the hydrolyzed cattle skin meal as compared with hydrolyzed cattle skin meal alone. 5. PER, NPR and NPU were also improved by the addition of the limiting amino acids. 6. Feed intake was not statistically significant upto 5% hydrolyzed cattle skin meal in the diet with was 100% replacement of hydrolyzed cattle skin meal with soybean meal and feather meal. Growth rate and feed conversion were not statistically significant at 3% but were significant 5% hydrolyzed cattle skin meal(p<0.05). These experiments were clearly indicated that hydrolyzed cattle skin meal could supplement in the diet upto 3% when mixed with 2 or 3 other protein sources.

기존 축열벽 시스템과 투명단열 축열벽 시스템의 열성능 평가 실험 연구

김병수,윤종호,윤용진,이진숙 대한건축학회 2003 대한건축학회논문집 Vol.19 No.10

TI-wall is an Mass-wall with TIM used instead of an usual single, double and triple glassed windows. The aim of this study is to analyze the thermal performance through Test-Cell of TI-wall in domestic climate. This study is carried out as follows: 1) Test-cells of TI-wall and Mass-wall are designed through the investigation of previous paper and work. The type of the TIM used in test-cell is small-celled(diameter 4㎜ and thickness 50㎜) capillary and cement brick(density 1500㎏/㎥) is used by thermal mass. 2) individual and combination test with various variants, such as thickness(190㎜, 380㎜) and surface absorption(60%, 95%) of thermal mass wall, measured for winter and spring, and the thermal effects are analyzed. Finally, as results indicated that the peak point time of the temperature of in-and-out surface is cut down approximately by an hour when the surface absorption of thermal mass wall is changed from 60% to 95% In case of applying for 1B(190㎜) in thickness of thermal mass wall. In case of applying for 2B(380㎜) in thickness of thermal mass wall, the temperature difference between in-and-out surface is showed about 23℃ in terms of Spring and Autumn. It means that the heat could not be delivered enough because the distance for heat transmission is too far. Therefore, in case of more than being 2B in thickness of thermal mass wall, it is not right for heating in Winter, Spring and Autumn. Experiment in term of su㎜er, the thermal mass wall is heated enough by outside temperature and solar radiation, the temperature difference between in-and-out surface is indicated 10℃. Also, inside temperature is sustained more than average 28C. Therefore, radical temperature rising will be released by changing its thickness, but the inside temperature still remains in high.

골반 경사로 인한 요추부 측만증에서 신발 높이기의 효과

김용민,김동수,최의성,손현철,박경진,김융성 대한척추외과학회 2004 대한척추외과학회지 Vol.11 No.2

최근 일간지에 보도된 정신병에 대한 기사 분석

김성완,윤진상,이무석,이형영 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 정신병에 대한 사회적 편견과 낙인은 질병의 예방, 조기치료 및 재활을 어렵게 한다. 이러한 부정적 시각은 다양한 대중매체에 의해서 강화될 수 있다. 본 연구는 질병에 대한 일반인의 인식에 큰 영향을 줄 수 있는 신문이 정신병에 대해 기술하는 내용을 분석하였다. 방법: 1998년 3월부터 2000년 2월까지 2년 동안 동아일보와 조선일보의 신문기사를 천리안의 뉴스복수정보 검색 프로그램을 이용하여 조사하였다. 검색어로는 일반인과 신문기사가 정신병을 지칭한다고 생각되는 정신분열, 정신병, 정신질환, 정신이상을 선택하였다. 이러한 검색어를 포함한 총 326건의 기사를 정해진 범주에 따라 분류하여 양적 및 질적 분석을 하였다. 정신병에 대한 시각을 알아보기 위해 신문기사를 부정적(직접적 또는 간접적) ② 객관적 또는 긍정적, ③특별한 시각 없음으로 분류하였다. 결과: 326건의 기사 중 부정적 기사는 직접적 177건, 간접적 51건으로 모두 228건(69.9%)이었다. 반면 객관적 또는 긍정적인 기사는 각각 29건, 14건으로 총 43건(13.2%)이었고 특별한 시각 없음은 55건(16.9%)이었다. 부정적 기사 중 가장 많은 것은 정신병 환자는 위험하거나 난폭하며 범죄를 잘 저지른다는 용을 전달하는 기사였다(118건). 이외에도 정신병 환자는 엉뚱하거나 특이하다(27건), 사회적 기능 행을 잘 못한다(18건), 정신병은 사회적으로 창피한 병이다(14건), 낫지 않는 만성질병이며 가족은 힘들고 부담스럽다(16건), 격리 수용해야 한다(6건)는 부정적 측면의 내용이 있었다. 또한 병의 원인에 대한 편견(18건), 상대를 비하하거나 어떤 현상의 심각성을 표현하기 위해 정신병이란 용어가 사용되는 경우(35건)와 더불어, 정신병원 입원에 대해서도 수용, 감금, 처넣다 등의 단어로 부정적인 기술(18건)을 하였다. 정신이상, 정신병이라는 용어를 사용하는 경우에 부정적 기사의 비율이 높았고, 기사에 환자가 직접 묘사되는 경우에 부정적 기사의 빈도가 높았다. 사건뉴스, 정치, 방송, 문화 기사에서 부정적 기사가 많았다. 반면 건강 기사에서 부정적 기사가 상대적으로 적었고 객관적 또는 긍정적 기사의 비율은 가장 높았다. 결론: 정신병에 대한 신문의 올바른 보도를 유도하는 것은 일반인의 질병개념 형성과 치료방법의 선택에 긍정적인 영향을 미칠 것이며, 나아가 환자의 효율적인 사회적응에 도움이 될 것이다. 이를 위해 정신병에 대한 신문기사의 부정적인 기술과 편견 전달을 체계적으로 모니터 하는 것이 필요하다고 생각한다. 또한 대중매체를 적극적으로 활용하여 정신병에 대한 정보를 일반인에게 사실적으로 전달하려는 노력이 요구된다. 중심단어:정신병·신문·대중매체·낙인·정신분열. Object: Social stigma and prejudice against schizophrenia hinder the prevention of the disease, early treatment and social rehabilitation. This stigma and the negative viewpoint against schizophrenia are enhanced by the mass media. This study investigated newspaper articles on psychosis, which strongly influence the public recognition of the illness. Method: The newspaper atricles of Dong-A Ilbo and Chosun Ilbo from March 1998 to February 2000 were reviewed through a news-searching program in Chollian. The search words, which were regared as psychotic illness, were Schizophrenia, Psychosis, Mental illness, and Mental derangement. A total of 326 articles were classified by category and analyzed quantitatively and qualitatively. The viewpoint of articles on psychosis consisted of these : ①negative(direct or indirect) ② neutral or positive ③ no specific viewpoint. Result: Of the 326 articles, the number with a negative description was 228(69.9%), the number with a neutral or positive description was 43(13.2%), and the number with no specific viewpoint was 55(16.9%). The most frequent negative theme was psychotic patients are dangerous or violent or may commit a crime(n=118). Other negative themes were these : psychotic patients are bizarre or grotesque(n=27), psychotic patients can't function in society well(n=18), psychosis is incurable and families should bear great burden(n=16), psychosis is shameful(n=13) and psychotic patients should be institutionalized(n=6). There were also prejudices against the cause of the illness(n=18), the description of psychosis in degrading terms(n=22) and the negative description of psychiatric hospitalization(n=18) with the words such as institutionalization, imprisonment and put into etc. In the artcles using the terms mental derangement or psychosis compared with mental illness, schizophrenia and in the articles describing psychotic patient compared with illness itself, the frequency of negative articles was high. Within each type of artcle, news, politics and culture artcles more frequently had a negative description, while health artcles less frequently had a negative description and most frequently had a neutral or positive description. Conclusion: There should be a program for monitoring newspapers for appropriate in-formation on psychosis. It might reduce social stigma and consequently help rehabilitation of psychotic patients. Also there should be endeavors to monitor other mass media and to develop a public education campaign through the mass media. KEY WORDS:Psychosis·Newspaper·Media·Stigma·schizophrenia.

醫科大學生의 睡眠樣相과 性格特性

김욱,윤진상,이형영 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6

This study was carried out in order to find out the possible relationships between sleep patterns and psychological characteristics. The subjects were 160 young normal students, 114 men and 46 women, aged 21∼25 years(21.64±1.31). Four aspects of sleep patterns(length, regularity, circardian rhythm and refreshed feeling at the time of awakening) were investigated, based on the sleep questionnaire, a sleep diary of two weeks and a Korean version of the morningness-eveningness questionnaire of Horne and Ostberg(1976). The subjects belonging to the two extreme groups of each aspect of sleep patterns(long vs. short, regular vs. irregular, morning vs. evening, refreshing vs. nonrefreshing) were compaired using the Korean version of MMPI(1989). The results were as follows : 1) With each sleep pattern, the long sleepers were 23(14.38%), short sleepers 16(10.00%) ; regular sleepers 105(65.63%), irreqular sleepers 19(11.88%) ; morning type sleepers 176(10.63%), evening type sleepers 17(10.63%); refreshing sleep 45(28.12%), nonrefreshing sleep group 27(16.87%). 2) There was no significant difference between the long- and short-term sleeping groups. 3) The irreqular sleeping group showed significantly higher scores than the reqular sleeping group in Hs(p<.01), Pd(p<.05), and Scsubscales(p<.05). 4) The evening sleeping groups showed significantly higher scores than the morning sleeping group in F(p<.05) and Hs subscales(p<.01). 5) The nonrefreshing sleep showed significantly higher scores than the refreshing sleep group in Hs(p<.001), D(p<.01), Hy(p<.001), and Pt subscales(p<.001).

연료정책에 따른 대기오염 개선효과 분석에 관한 연구 : 대구지역을 중심으로

김차영,백성옥,박영규,최진수,장윤영 嶺南大學校 環境問題硏究所 1995 環境硏究 Vol.14 No.2

청정연료와 저유황유의 공급확대에 따른 대구지역의 대기오염 개선효과를 분석하기 위하여 향후 1996, 2001년 대구지역의 유종별, 소비부문별 소비량을 추정하고 이에 따른 아황산가스, 분진, 질소산화물 및 일산화탄소에 대한 배출량을 각각 산정하였다. 특히 향후 대구지역 대기중 아황산가스농도에 대하여 개정된 환경기준치의 달성가능성 여부를 연간 총배출량측면에서 검토한 결과 2001년의 아황산가스 배출량이 추정된 허용배출량 이하로 떨어질 것으로 나타나 저황유의 공급과 청정연료 사용의무화정책을 현재 계획대로 추진할 경우 아황산가스 농도는 대체로 환경기준을 충분히 달성할 수 있을 것으로 판단되었다. A study was carried out to evaluate the improvement of air quality in Taegu area in the years of 1996 and 2001 with the extended supply of cleaner fuels such as town gas and low sulfur fuel oil. The emission quantities of the air pollutants from the combustion of various fuel were estimated with respect to the sections of end-use in this area. With the implementation of the planned fuel policy to this area, the level of sulfur dioxide in the ambient air will satisfy the revised ambient air quality standard based on the yearly total quantity of the sulfur dioxide emission. If the fuel policy is implemented as scheduled, the attainability of the ambient air quality standard of sulfur dioxide will be possible as the total quantity of sulfur dioxide emission will be well below of that of the predicted value obtained under current fuel policy.