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만성 알코올성 췌장염이 의심되는 환자에서 내시경초음파의 진단적 가치
남승우,신기철,이재현,노임환,이만용,허재형,신현덕,장효식 대한소화기학회 2002 대한소화기학회지 Vol.39 No.2
Background/Aims: This study was to evaluate the usefulness of endoscopic ultrasonography (EUS) in diagnosing suspected chronic alcoholic pancreatitis. Methods: EUS was performed on 48 patients who underwent endoscopic retrograde pancreatography (ERP) for recurrent episodes of alcohol induced pancreatitis. According to the ERP findings, the patients were divided into two groups: the group I showing normal pancreatogram (n=18) and the group II showing abnormal dilatated pancreatogram of Cambridge classification II or higher (n=30). EUS evaluated parenchymal changes (inhomogeneity, interlobular septae, echogenic foci, pseudocyst) and ductal changes (dilatation, tortuosity, thickened wall, stone or calcification, and side branch ectasia). Results: Group I showed one or more abnormal parenchymal features were found in 17 patients (94.4%), two or more in 11 patients (61.1%), and three or more in 6 patients (33.3%). However, no abnormal ductal features were found in the Group I. In the group II, all patients had three or more abnormal EUS features. Conclusions: EUS shows definite parenchymal changes in patients suspected of having chronic alcoholic pancreatitis. Therefore, EUS can be an useful diagnostic tool in the early stage of chronic alcoholic pancreatitis.
Sin Do Kim,Ra-Young Park,Young-Rang Kim,In-Je Kim,Taek Won Kang,Kwang Il Nam,Kyu Youn Ahn,Choon Sang Bae,Baik Youn Kim,Sung Sik Park,Chaeyong Jung 대한해부학회 2010 Anatomy & Cell Biology Vol.43 No.4
During the prostate cancer (PCa) development and its progression into hormone independency, androgen receptor (AR) signals play a central role by triggering the regulation of target genes, including prostate-specific antigen. However, the regulation of these AR-mediated target genes is not fully understood. We have previously demonstrated a unique role of HOXB13 homeodomain protein as an AR repressor. Expression of HOXB13 was highly restricted to the prostate and its suppression dramatically increased hormone-activated AR transactivation, suggesting that prostate-specific HOXB13 was a highly potent transcriptional regulator. In this report, we demonstrated the action mechanism of HOXB13 as an AR repressor. HOXB13 suppressed androgen-stimulated AR activity by interacting with AR. HOXB13 did neither bind to AR responsive elements nor disturb nuclear translocation of AR in response to androgen. In PCa specimen, we also observed mutual expression pattern of HOXB13 and AR. These results suggest that HOXB13 not only serve as a DNA-bound transcription factor but play an important role as an AR-interacting repressor to modulate hormone-activated androgen receptor signals. Further extensive studies will uncover a novel mechanism for regulating AR-signaling pathway to lead to expose new role of HOXB13 as a non-DNA-binding transcriptional repressor.
南炯臣,趙忠植,金哲中 대전대학교 한의학연구소 2001 한의학연구소 논문집 Vol.10 No.1
Oryoungsan which first recorded in Sanghanron, the clinical medical book consists of treating acute febrile disease according to its change, is one of the frequently used oriental medicines. these days, it has been prescribed in symptoms accompanied by edema mostly. therefore it is easy to consider it as a type of diuretics. In Sanghanron it was originally used in the symptoms of perspiration, decreased urine volume, thirsty, flatulence, these symptoms indicate loss of body fluid and the prescription which orders "taking warm water sufficiently" supports this. On this background, it is supposed that Oryoungsan treats dehydration after providing water and electrolytes. To consider that herbal medicines consisted of Oryoungsan make electrolytes go out of the body, The healing mechanism of dehydration doesn't meet this. Because Oryoungsan was used in condition of fever or in similar condition, it is more resonable to understand that restoration of increasing blood flow to the subcutaneous venous plexus regulating body temperature in febrile condition into body circulation, resulting into maintaining main blood volume and into treating decreased urine volume and thirsty is Oryoungsan's function in the dehydration or febrile condition. That is, symptoms are decreased or disappeared through restoring unbalance of internal body fluid. The other target is pain controls, especially chronic headache, facial pain and trigeminal neuralgia, it is suggested that the funciton of pain control of Oryoungsan is related to 5-HT(5-hydroxytrypamine), nerve transmitter in the endogenous analgesic system. Moreover it is also suggested that Oryoungsan is relate to 5-HT, considering the fact that gastroparesis, a symptom of cyclic vomiting syndrome treated with 5-HTID receptor agonist is similar to the 'bi(??)', symptoms appeared in the Oryoungsan-related disease.
보행패턴에 영향을 미치는 요소를 고려한 보행성 분석 네트워크 설계에 관한 연구
남대식(Nam, Dae-Sik),신성일(Sin, Seong-Il),이신해(LEE, Shin-Hae) 대한교통학회 2013 대한교통학회 학술대회지 Vol.69 No.-
본 연구는 보행의 서비스 수준에 대한 평가 및 분석을 네트워크 차원에서 수행하기 위한 기본적인 네트워크를 구상하고자 하였다. 이를 위해 보행환경 및 행태에 영향을 미치는 여러 요소들을 기존 연구의 고찰을 통해 정립하였고, 도심부의 보행환경을 모사하는 네트 워크를 설계하였다. 보행은 걸을 수 있는 모든 영역으로 보행하며 보행가능영역은 차로 옆 인도, 이면도로, 골목길, 공원, 운동장 등의 오픈스페이스 내 도로, 보행시설물 등이 있으며 도심부에서는 차량의 네트워크보다 복잡하고 그 총 연장 또한 길다. 또한 보행자는 보 행에 필요한 에너지 소비를 최소화하기 위해 동일한 길이의 경로가 주어진다면 언덕길이나 횡단보도, 육교, 지하보도 등의 보행시설물 을 회피한다. 특히 보행시설물 중 계단, 에스컬레이터, 엘리베이터 등의 보행 장애물 및 편의시설이 경로 선택에 큰 영향을 미친다. 마 지막으로 스페이스신택스 이론적인 관점에서 보행자는 이동시 회전을 최소화 하려한다. 이러한 설계요소를 고려하여 서울시내 도심부 네트워크를 시범적으로 구축하고 이를 평가하였다.
김남식 ( Nam Sik Kim ),윤성한 ( Sung Han Yun ),이승은 ( Seung Eun Lee ),오혜주 ( Hyeo Ju O ),손영기 ( Young Ki Son ),신용훈 ( Yong Hun Sin ),김중경 ( Jung Kyung Kim ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.4
Acute fulminant invasive fungal sinusitis in an immunocompromised host and bacterial rhinosinusitis with intracranial or orbital extension is challenging to manage. And it sometimes constitutes true otolaryngologic emergencies. In the absence of rapid diagnosis and treatment, these diseases can be fatal. A 57-year-old female was admitted for chills and headache, who received a deceased donor renal transplantation 3 months ago. Paranasal sinus CT showed enhanced soft tissue density and MRI showed low-signal with hyperintense signal of around paranasal sinus cavity. The histological investigation revealed invasive aspergillosis of paranasal sinuses. Clinical improvement occurred after endoscopic sinus surgery and post-operative systemic antifungal therapy with amphotericin B and voriconazole.
순차패턴과 연관규칙을 이용한 고혈압 환자 관리 시스템 개발
박남열 ( Nam Youl Park ),홍재신 ( Jae-sin Hong ),박두순 ( Doo-soon Park ),홍민 ( Min Hong ),이화민 ( Hwa-min Lee ),정영식 ( Young-sik Jeong ) 한국정보처리학회 2009 한국정보처리학회 학술대회논문집 Vol.16 No.1
최근 의료 패러다임은 치료에서 예방과 관리의 개념으로 변화하고 있다. 특히 우리나라 성인 인구 중 20~30%에서 발견되는 만성질환은 예방과 관리가 더욱 필요한 성인병이다. 본 논문에서는 만성 질환 중 지속적인 치료와 예방 그리고 관리가 필요한 고혈압 환자들을 관리하기 위하여 생체 데이터, 검진 데이터, 문진 데이터, 생활 습관 등을 이용하여 순차패턴 방법을 적용한 고혈압 환자에 대한 약제 처방 시스템과 연관규칙을 적용하여 고혈압 환자들에게 24시간 관리가 가능하도록 하는 고혈압 환자 관리 시스템을 개발한다.