The role of miRNA‑155 in monocrotaline‑induced pulmonary arterial hypertension through c‑Fos/NLRP3/caspase‑1

Shou‑Dong Chai,Zhen‑Kun Li,Rui Liu,Tao Liu,Ming‑Feng Dong,Pei‑Zhe Tang,Jian‑Tang Wang,Sheng‑Jun Ma 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Nisoldipine can effectively suppress pulmonary arterial smooth muscle cell proliferation and c-Fos expression. Objective To identify the mechanism of the anti-inflammatory effects in monocrotaline-induced pulmonary arterial hypertension (PAH), focusing on the c-Fos/NLRP3/caspase-1 pathway. Results In a mice model of monocrotaline-induced PAH, miRNA-155 expression was increased. In an in vitro model, overexpression of miRNA-155 promoted inflammation and induced c-Fos, NLRP3, and caspase-1 protein expression. The inhibition of c-Fos reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. The inhibition of NLRP3 reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. Conclusions miRNA-155 increased inflammation in monocrotaline-induced PAH through c-Fos/NLRP3/caspase-1.

論中國傳統企業效率問題

康 埈 荣,张守鑫 韓國外國語大學校 外國學綜合硏究센터 中國硏究所 2005 中國硏究 Vol.35 No.-

1997~2000년에 발생된 황사에 관한 연구

정용승,김학성,낫짜가도르지 엘,적데어 디,첸 수잰 한국교원대학교 환경과학연구소 2002 환경연구논문집 Vol.- No.7

Joint monitoring of yellow sand (YS) phenomena occurred from 1997 to 2000 was carried out. It was found that the YS in source regions occurred in any time during the year, while the severe dust storms occurred frequently from March to May after the spring thaw. Wind erosion occurred usually with wind greater than about 8 ms^-1 in the source region in any seasons. However, severe YS phenomenon found to occur with wind greater than 15 ms^-1 at least for 3 hours or more. In source regions, YS occurred over 60∼120 days per year. In Korea, YS was found to occur 8∼12 cases per year with 12-22 YS days. It was recorded that maximum concentrations of TSP were 989∼1396 ㎍ m^-3 with PM10 values of 861∼996 ㎍ m^-3 and with the lowest visibility of 1.4∼1.6km. In Mongolia, however, it was observed that the number of dusty days decreased due to the increase in rainy days.

ADAPTIVE SLIDING MODE CONTROL OF LATERAL STABILITY OF FOUR WHEEL HUB ELECTRIC VEHICLES

Shou-Tao Li,Hui Liu,Di Zhao,Qiu-Yuan Li,Yantao Tian,De-Jun Wang,Ding-Li Yu 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.3

Some physical parameters of a hub motor-driven four-wheel electric vehicle will change when the vehicle turns or maneuvers and the parameter change is caused by the change of the driving conditions. An adaptive sliding mode control is proposed in this paper to maintain the vehicle’s stability by compensating for the change of these parameters. The control parameter being adapted is the converging rate of the system state towards the sliding mode. As the Lyapunov method is used, so both the vehicle stability and adaptive rate convergence are guaranteed. Moreover, the hierarchical control structure is adopted for this vehicle stability control system. The above adaptive sliding model control forms the upper-layer; while the lower-layer control is to distribute the upper torque to the four wheels in an optimal way, subject to several constraints. In addition, the best feasible reference of the yaw rate and the vehicle side slip angle are obtained and used in the control system. The developed method is simulated under the CarSim/MATLAB co-simulation environment to evaluate the system performance. The simulation results are compared with the non-adaptive existing sliding mode control, and show that the proposed method is superior under different conditions.

A Study of User Experience Resulting From AI Artwork Production - Focus On Character Creation

Shou Yi Yu,Jun Ping Xu,장수민,반영환 대한인간공학회 2024 大韓人間工學會誌 Vol.43 No.1

Objective: The aim of this study is to improve the performance of AI artists from a technical perspective by using AI platforms and training methods that encompass aspects such as image quality, text alignment, text generation, inference time, and training efficiency. Background: With the rise and rapid development of Artificial Intelligence (AI), the art market has embraced its use. The rise of AI in the art market has simultaneously increased the productivity of designer characterization. AI painting is developing rapidly, It would also be interesting to study attribution in this area. Method: By analyzing traditional and AI-based character creation methods using questionnaires and conducting in-depth interviews with 14 participants. Results: Anthropometry was the most dominant area all the time. Health and safety area has been steadily increasing in publication amount. Conclusion: The research aims to improve the performance of AI artists in terms of image quality, text alignment, text generation, inference time and training efficiency through AI platforms and training methods. Users tend to use AI to improve artist efficiency and believe that images generated through AI have commercial uses. However, AI cannot replace the joy and exploration of artists in creation, but serves as a valuable tool to improve creativity and painting efficiency. AI tools will completely change our work and lives when the technology matures. Application: Research contributes to the application of AI in character creation and promotes sustainable development in the art field. This study contributes to the process of AI in character creation, which can help to promote the sustainable development of AI in the field of art, and provides further expansion of the IP of painted characters in the possible space.

CMAC-based compound control of hydraulically driven 6-DOF parallel manipulator

Shou-Kun Wang,Jun-Zheng Wang,Da-Wei Shi 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.6

The movement precision of the hydraulically driven 6-six degrees of freedom (6-DOF) parallel manipulator is determined mainly by the precision of the valve-controlled asymmetrical cylinder (VCAC). Unfortunately, the asymmetrical movement of the VCAC caused by its asymmetrical structure can significantly compromise control precision. Owing to this asymmetry and, more fundamentally, the inherent nonlinearity of hydraulic systems as well as complicated load variations, it is very difficult to achieve ideal control precision with traditional (PID) control. In the present study, the working principle and characteristics of VCAC were analyzed, with particular focus on the asymmetry problem. In order to improve the precision of both VCAC control and 6-DOF parallel manipulator movement,this paper presents a new, cerebellar model articulation control (CMAC)-based control method. Experiments on both the single VCAC system and the parallel manipulator were developed to verify the validity and effectiveness of the new compound control method. The theoretical analysis and testing results, compared with those for the PID control, proved that the proposed CMAC-based control method can acquire high movement precision on the 6-DOF motion simulator while eliminating the need to build a mathematical model or obtain accurate loading conditions.

Angiotensin I Converting Enzyme 유전자다형성과 IgA 신변증의 진행성 위험인자와의 상관관계

정수환(Shou Huan Zheng),김연수(Yon Su Kim),안규리(Cu Rie Ahn),한진석(Jin Suk Han),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee),채동완(Dong Wan Chae),윤형진(Hyung Jin Yoon),오윤규(Yoon Kyu Oh),진호준(Ho Jun Chin),김현리(Hyun Lee Kim) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.4

IgA nephropathy(IgAN) is the most common glomerulonephritis(GN) in worldwide, and accounts for 2096 to 40M of all patients with primary GN in Korea. IgAN has diverse clinical courses, but the risk factors affecting the deterioration of renal function are not established. Recently, there were some suggestions that systemic or local expression of peptides of angiotensin system exerts several effects on the progression of renal disease, and the genetic polymorphisms may associated with peptide expression. To evaluate the role of genetic polymorphism of angiotensin I converting enzyme(ACE) polymorphism in the progression of IgAN, the genotypic distributions in 278 biopsy-proven cases of IgAN were studied, which had undergone a renal biopsy at Seoul National University Hospital, between 1979 and 2000. We also compared the genotypes with clinical manifestations to evaluate the clinical implications of genetic polymorphism. The study shows that there was no difference in the ACE genotype frequencies between the patients (II: 26.6%, ID: 55.0%, DD: 18.4%) and normal controls(II: 31.4%, ID: 57.4%, and DD: 11.2%). Seventy- two percent and 48% of patients maintained renal function for 10 years and 20 years after the initial diagnosis in 278 patients, respectively. However, in 153 patients who were followed more than 5 years, the DD genotype was more prevalent in patients with deteriorating renal function than in those with stable renal function(31.8% vs. 13.8%, p=0.0146). Presence of systemic hypertension increased the risk of renal disease progression(OR=3.3), and it was showed 7.4 fold risk whenever the creatinine was increased by 1 mg/dL. Renal disease progression is not associated with DD genotype among normotensive patients at the biopsy. But, in patients with hypertension, II and DD/ID genotypes have an in- creased risk for disease progression when compared with II genotype of normotensive patients(OR=1.4, OR=7.8; respectively). ACE polymorphisms did not have any interaction with the levels of serum creatinine at the time of biopsy in our patients. Our results suggested that ACE genotypes(D allele) affected the progression of IgAN, especially in hypertensive patients. One of the prospects of the present study is the potential for screening high risk individuals, thus helping to develop a practical application of the molecular findings in clinical practice.

Supply chain coordination via auction mechanisms under procurement with uncertain demand

Ma Jun,ZhANG Jie,WANG Shou-yang 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

The focus of this paper is on supply chain coordination in the procurement environment. Previous studies have shown that auction mechanisms have a remarkable effect on the participants" profits and the efficiency of the whole chain. This paper demonstrates the expected profit of individual suppliers and buyer through three different auction mechanisms, i.e., Wholesale Price Auction, Catalog Auction and Two-Part Contract Auction under the given conditions of multiple suppliers vs. one buyer in Independent Private Value environments. Moreover, it is proven that the system can be refined into an efficient channel coordination under the mechanism of the Two-part Contract Auction with information intermediaries when the market inverse demand function is multiplicative.

Analysis of Esophageal Cancer Time Trends in China, 1989-2008

Zhao, Jun,He, Yu-Tong,Zheng, Rong-Shou,Zhang, Si-Wei,Chen, Wan-Qing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

National cancer incidence data were utilized to analyze trends in esophageal cancer incidence in China in order to provide basic information for making cancer control strategy. We retrieved and re-sorted valid esophageal cancer incidence data from National Central Cancer Registry Database over 20 years period from 1989 to 2008. Crude incidence and age-standardized incidence rates were calculated for analysis, with annual percent change estimated by Joinpoint software for long term trend analysis. The crude incidence rate of esophageal cancer was found to have remained relatively stable in both urban and rural areas over the 20 year period. Age standardized incidence rate (ASR) in cancer registration areas decreased from 39.5/100,000 in 1989 to 23.0/100,000 in 2008 in all areas (AAPC=-3.3%, 95% CI:-2.8~-3.7). The trend was no change in urban areas and 2.1% average annual decrease observed in rural aras. Before the year of 2000, esophageal cancer incidence rates significant decreased with 2.8% annually and then the rates kept stable. Over 20 years from 1989 to 2008, esophageal cancer age standardized incidence rate in cancer registration areas decreased with time. However, esophageal cancer is still a big issue and efforts for control should be continuously enhanced. Cancer registration is playing an important role in cancer control with the number of registries increasing and data quality improving in China.

Human Liver Specific Transcriptional Factor TCP10L Binds to MAD4

( Dao Jun Jiang ),( Hong Xiu Yu ),( Sa Yin Hexige ),( Ze Kun Guo ),( Xiang Wang ),( Li Jie Ma ),( Zheng Chen ),( Shou Yuan Zhao ),( Long Yu ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.4

A human gene T-complex protein 10 like (TCP10L) was cloned in our lab. A previous study showed that it expressed specifically in the liver and testis. A transcription experiment revealed that TCP10L was a transcription factor with transcription inhibition activity. In this study, the human MAD4 was identified to interact with TCP10L by a yeast two-hybrid screen. This finding was confirmed by immunoprecipitation and subcellular localization experiments. As MAD4 is a member of the MAD family, which antagonizes the functions of MYC and promotes cell differentiation, the biological function of the interaction between TCP10L and MAD4 may be to maintain the differentiation state in liver cells. Also, we propose that the up-regulation of Myc is caused by the down-regulation of TCPIOL in human hepatocarcinomas.