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( Zhen Zhen Lian ),( Xiao Jing Yin ),( Hua Li ),( Li Li Jia ),( Xiu Zhen He ),( Yong Bo Yan ),( Nai Hua Liu ),( Ka Yiu Wan ),( Xiao Kun Li ),( Shao Qiang Lin ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.1
Background: Diabetic wounds are a major clinical challenge, because minor skin wounds can lead to chronic, unhealed ulcers and ultimately result in infection, gangrene, or even amputation. Studies on bone marrow derived mesenchymal stem cells (BMSCs) and a series of growth factors have revealed their many benefits for wound healing and regeneration. Platelet-rich plasma (PRP) may improve the environment for BMSC development and differentiation. However, whether combined use of BMSCs and PRP may be more effective for accelerating diabetic ulcer healing remains unclear. Objective: We investigated the efficacy of BMSCs and PRP for the repair of refractory wound healing in a diabetic rat model. Methods: Forty-eight rats with diabetes mellitus induced by streptozotocin were divided into four groups: treatment with BMSCs plus PRP, BMSCs alone, PRP alone, phosphate buffered saline. The rate of wound closure was quantified. A histopathological study was conducted regarding wound depth and the skin edge at 7, 14, and 28 days after surgery. Results: Wound healing rates were significantly higher in the BMSC plus PRP group than in the other groups. The immunohistochemistry results showed that the expression of platelet/endothelial cell adhesion molecule 1, proliferating cell nuclear antigen, and transforming growth factor-β1 increased significantly in the BMSC plus PRP group compared to the other treatment groups. On day 7, CD68 expression increased significantly in the wounds of the BMSC plus PRP group, but decreased markedly at day 14 compared to the controls. Conclusion: The combination of BMSCs and PRP aids diabetic wound repair and regeneration. (Ann Dermatol 26(1) 1∼10, 2014)
A Genetic Variant in MiR-146a Modifies Digestive System Cancer Risk: a Meta-analysis
Li, Ying-Jun,Zhang, Zhen-Yu,Mao, Ying-Ying,Jin, Ming-Juan,Jing, Fang-Yuan,Ye, Zhen-Hua,Chen, Kun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to digestive system cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of digestive system cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by cancer site revealed decreased risk in colorectal cancer above allele model (OR=0.90, 95%CI 0.83-0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric cancer. When stratified by ethnicity, genotyping methods and quality score, decreased cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to digestive system cancers, especially in Asian populations.
Kun Zhao,Fang He,Zhen Huang,Guoqiang Wei,Anqing Zheng,Haibin Li,Zengli Zhao 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.6
The effects of Mn substitution of LaMnxFe1−xO3 (x=0, 0.3, 0.5, 0.7, 1.0) on the oxidation activity and resistance to carbon formation for chemical-looping steam methane reforming (CL-SMR) were investigated. The desired crystalline perovskite phases were formed by transferring from the orthorhombic structure of LaFeO3 to rhombohedral lattice of LaMnO3 as the degree of Mn-doping increased. Manganese ions have a mixed state of Mn3+ and Mn4+ in the LaFe1−xMnxO3, meanwhile inducing the states of highly mixed character of Fe2+, Fe3+ and Fe4+ in iron ions. Substitution of Mn for Fe with proper value not only increases the lattice oxygen, which is conducive to the partial oxidation of CH4 to produce syngas, but also enhances the lattice oxygen mobility from the bulk to the surface of the oxygen carrier particles. Judging from the points of the redox reactivity, resistance to carbon formation and hydrogen generation capacity, the optimal range of the degree of Mn substitution is x=0.3-0.5.
Zhen-nan Fan,Li Han,Yong Liao,Li-dan Xie,Kun Wen,Jun Wang,Xiu-cheng Dong,Bing Yao 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.3
This study optimises the no-load voltage waveform of tubular hydro-generators by a simple design scheme. For different centerlines of the pole shoe and damper bar, the optimisation effects on the no-load voltage waveform are investigated in two tubular hydro-generators with different weighted powers (34 MW and 18 MW). The results are compared with those of the traditional stator-slots skewed design. The quality of the no-load voltage waveform was related to the shifting degree, and the different optimisation effects between the integer slot generator (q = 2) and the fractional slot generator (q = 11/2) were analysed. This research can improve the quality of the power output and no-load voltage waveform, and provide an effective reference for improving the industrial design and manufacture level of tubular hydro-generators.
Kun Wen,Li Han,Zhi-ting Zhou,Zhen-nan Fan,Yong Liao,Jun Wang,Zhang Sun,Bing Yao,Bide Zhang 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3
To obtain more precise and rational calculation details of the loss and heat of a damper winding in a tubular hydro-generator, this study develops a three-dimensional, fi nite-element, electromagnetic-temperature fi eld close-coupling model of the damper winding. On the basis of multi-physical fi eld coupled theory, the model fully considers the temperature eff ects of the damper winding resistivities and heat conductivities, and the eddy current loss in the end region of the damper winding. The model was verifi ed by direct tests of the damper winding temperature. Unlike the conventional weak-coupling model, the proposed close-coupling model fully captures the interaction between the electromagnetic and temperature fi elds. Therefore, of the model more accurately and reasonably calculates the loss and heat of the damper winding than the conventional model. The proposed calculation model can properly assess the loss and heat of damper windings in large hydro-generators, which is helpful for improving the design standards of hydro-generators.
Research of Circuit Working Construction Elevator with Single-guide Rail and Multi-cages
Kun Zhang,Kaiqiang Wang,Di Li,Qing Sun,Zhen Ye,Wei Liu Council on Tall Building and Urban Habitat Korea 2022 International journal of high-rise buildings Vol.11 No.2
As one of the most important vertical transportation equipment in super high-rise buildings, the construction elevator directly affects the project period, cost, and effectiveness. The paper proposes a new construction elevator with single-guide rail and multi-cages. It can solve the problems of single construction elevator capacity shortage and efficacy decrease with height reduction, the occupancy of plan and elevation position of multiple construction elevators, and extension of total construction period by cycling operation of multi-cages on a single-guide rail. The paper focuses on the design and research of the main components of the equipment, such as the rotating guide rail mechanism, vertical bearing mast tie system, segmented electrical power supply system, group control scheduling system, and safety anti-collision system.
Zhen-nan Fan,Zhi-ting Zhou,Jian-fu Li,Kun Wen,Jun Wang,Zhang Sun,Tao Wang,Bing Yao 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.3
A generator-grid coupling calculation model is established to study the leading-phase operational capability of a 770 MW jumbo hydro-generator in a Chinese ultra-mega hydropower station. The static and dynamic stability of the generator are analyzed and calculated to obtain stability limits under leading-phase operating conditions. Three-dimensional (3D) time-varying nonlinear moving electromagnetic and temperature field models of the generator end-region are also established and used to determine the magnetic field, loss, and temperature of the end-region under the leading-phase operating condition. The simulation results agree with data measured from the actual 770 MW hydro-generator. This paper provides reliable reference data for the leading-phase operation of a jumbo hydro-generator, which will help to improve in the design and manufacture of future hydro-generators.
Anticancer, Antioxidant, and Antimicrobial Activities of Anemone (Anemone cathayensis)
Jun-li Wang,Kun Liu,Wei-zhen Gong,Qian Wang,Dong-ting Xu,Ming-fei Liu,Kai-li Bi,Yun-fei Song 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.2
This study was performed to evaluate the anticancer, antioxidant, and antimicrobial activities of fractions and isolated compounds from anemone (Anemone cathayensis). Fourteen compounds were isolated from extracts. Anticancer activities of fractions and compounds were determined by MTT assay, and all tested fractions showed inhibition activity on human breast cancer cells (MDA-MB-231). The fraction 6 displayed the strongest anticancer activity, and inhibition percent was 50.32%. The antioxidant effect of fractions was evaluated by using DPPH scavenging assays. Fraction 5 had a higher DPPH radical scavenging activity with low IC50 value of 30.578μg/mL. The antimicrobial activity of the fractions was evaluated against 3 microorganisms using the agar well diffusion method. The fractions also showed moderate antimicrobial activity. These results suggest that anemone could hold a good potential source for human health.