http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
β-cell serotonin production is associated with female sex, old age, and diabetes-free condition
Kim, Yeong Gi,Moon, Joon Ho,Kim, Kyuho,Kim, Hyeongseok,Kim, Juok,Jeong, Ji-Seon,Lee, Junguee,Kang, Shinae,Park, Joon Seong,Kim, Hail Academic Press 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Serotonin is known to be present in pancreatic β-cells and to play several physiological roles, including insulin secretion, β-cell proliferation, and paracrine inhibition of α-cells. However, the serotonin production of different cell lines and islets has not been compared based on age, sex, and diabetes related conditions. Here, we directly compared the serotonin concentrations in βTC and MIN6 cell lines, as well as in islets from mice using ultra-performance liquid chromatography tandem mass spectrometry. The average serotonin concentration was 5–10 ng/mg protein in the islets of male and non-pregnant female mice. The serotonin level was higher in females than males at 8 weeks, although there was no difference at 1 year. Furthermore, we observed serotonin by immunofluorescence staining in the pancreatic tissues of mice and human. Serotonin was detected by immunofluorescence staining in a portion of β-cells from islets of old female mice, but not of male or young female mice. A similar pattern was observed in human pancreas as well. In humans, serotonin production in β-cells was associated with a diabetes-free condition. Thus, serotonin production in β-cells was associated with old age, female sex, and diabetes-free condition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Actual serotonin concentrations in cell lines and islets are compared. </LI> <LI> Serotonin over-production in mouse β-cell is aged and female specific. </LI> <LI> Ovariectomy lowers serotonin concentrations in islets. </LI> <LI> Serotonin over-production in human β-cell is aged, female, and non-diabetes specific. </LI> </UL> </P>
Fashion brand green demarketing: Effects on customer attitudes and behavior intentions
Shina Kim,Eunju Ko,김상진 한국마케팅과학회 2018 Journal of Global Fashion Marketing Vol.9 No.4
The authors focus on a fashion brand, Patagonia, to study green demarketing advertising in the fashion industry, a strategy for enhancing sustainability by encouraging consumers to avoid buying unneeded products. The study shows that green demarketing advertising positively affects consumer attitudes and behavior intentions in consumers who have either analytic or intuitive cognitive styles. All cognitive styles react most positively to concrete rather than abstract demarketing advertisements. Theoretical and managerial implications are discussed.
Kim, Hye Su,Kim, Jaemin,Kim, Shinae,Park, Yeong Don,Mun, Junyoung Elsevier 2017 ELECTROCHIMICA ACTA Vol.246 No.-
<P><B>Abstract</B></P> <P>For high energy density and long cycle life of rechargeable lithium ion batteries, the positive electrode of LiNi<SUB>0.6</SUB>Co<SUB>0.1</SUB>Mn<SUB>0.3</SUB>O<SUB>2</SUB> (NCM-613) is post-surface treated by poly(4-vinylphenol) (PVP) though a spin coating method. The additional PVP coating on the electrode is highly beneficial for improving the cycle life of the cell. It is also found that the PVP coating initially causes a polarization for lithium surface transportation but enhances the rate capability after long cycling by reducing the growth of polarization from the repeated sequences of charge and discharge. To adjust these conflicting behaviours, the coating condition of PVP should be optimized. By using a systematic analysis of X-ray diffraction and surface analyses of field emission scanning electron microscopy and X-ray photoelectron spectroscopy, it is concluded that the PVP surface coating on NCM-613 prevents crystal structure deterioration leading to irreversible structure changes from hexagonal to monoclinic at a high potential of 4.3V vs. Li/Li<SUP>+</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Surface of NCM is modified by PVP coating </LI> <LI> Spin coating is very facile for post electrode coating. </LI> <LI> PVP coating is finely modified by controlling crosslinking. </LI> <LI> Surface failure of NCM is highly relieved by PVP coating. </LI> <LI> Post electrode coating with PVP is effective for long cyclability. </LI> </UL> </P>
Incontinentia Pigmenti with Multiple Missing Teeth : Case Reports
Shinae Choi,Youngjin Kim,Soonhyeun Nam,Hyunjung Kim 大韓小兒齒科學會 2015 大韓小兒齒科學會誌 Vol.42 No.2
색소실조증은 외배엽 이형성증과 같이 다수의 치아결손을 동반하는 선천성 질환으로 Bloch-Sulzberger syndrome이라고불리며 X 연관 우성 유전질환이므로 주로 여아에서 많이 발병한다. 외배엽 및 중배엽 기원 조직인 피부, 눈, 머리카락, 치아및 중추신경계에 증상이 나타나며 Xq28 염색체의 NEMO 유전자의 돌연변이에 의해 발병된다. 본 증례는 유치의 선천적 결손을 주소로 내원한 3명의 환아의 증례를 다루고 있으며 이들은 다수의 유치와 영구치의 선천적 결손, 전치부 원뿔형 치관, 구치부 과잉 교두 등을 보이고 있었다. 치아결손부에 공간 유지 장치를 장착하여 저작기능을회복해 주고 심미적인 문제를 개선해주었으며 계속적인 관찰이 필요하다. Incontinentia pigmenti, also called Bloch-Sulzberger syndrome, is a rare X-linked inherited dominant disorder that affects females, but causes spontaneous abortion of prenatal males. Incontinentia pigmenti is a systemic disease with clinical features similar to ectodermal dysplasia, including congenitally missing teeth. The pathogenesis is related to gene mutations in NF-kappa-B essential modulator on chromosome Xq28. Incontinentia pigmenti is caused by a defect in the developmental stage of organs originating from the ectoderm or mesoderm and involves the skin, eyes, hair, teeth and central nervous system. This report discusses the management of three cases of 3 to 5 years old females with incontinentia pigmenti and accompanying multiple missing teeth. The cases had sparse hair, and showed oligodontia and anomalous crowns with supplementary cusps in the posterior teeth and conical anterior teeth. Removable space maintainers were applied, achieving improved esthetics, recovery of mastication and increased self-esteem in the patients.
Mechanisms for Hfq-Independent Activation of rpoS by DsrA, a Small RNA, in Escherichia coli
Kim, Wonkyong,Choi, Jee Soo,Kim, Daun,Shin, Doohang,Suk, Shinae,Lee, Younghoon Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.5
Many small RNAs (sRNAs) regulate gene expression by base pairing to their target messenger RNAs (mRNAs) with the help of Hfq in Escherichia coli. The sRNA DsrA activates translation of the rpoS mRNA in an Hfq-dependent manner, but this activation ability was found to partially bypass Hfq when DsrA is overproduced. The precise mechanism by which DsrA bypasses Hfq is unknown. In this study, we constructed strains lacking all three rpoS-activating sRNAs (i.e., ArcZ, DsrA, and RprA) in $hfq^+$ and $Hfq^-$ backgrounds, and then artificially regulated the cellular DsrA concentration in these strains by controlling its ectopic expression. We then examined how the expression level of rpoS was altered by a change in the concentration of DsrA. We found that the translation and stability of the rpoS mRNA are both enhanced by physiological concentrations of DsrA regardless of Hfq, but that depletion of Hfq causes a rapid degradation of DsrA and thereby decreases rpoS mRNA stability. These results suggest that the observed Hfq dependency of DsrA-mediated rpoS activation mainly results from the destabilization of DsrA in the absence of Hfq, and that DsrA itself contributes to the translational activation and stability of the rpoS mRNA in an Hfq-independent manner.
Kim, Hyunwook,Kim, Kyoung Hoon,Park, Kisoo,Kang, Shin-Wook,Yoo, Tae-Hyun,Ahn, Song Vogue,Ahn, Hyeong Sik,Hann, Hoo Jae,Lee, Shina,Ryu, Jung-Hwa,Kim, Seung-Jung,Kang, Duk-Hee,Choi, Kyu Bok,Ryu, Dong-Ry Springer-Verlag 2014 Kidney international Vol.86 No.5
To date, only a few large-scale studies have measured the effect of dialysis modality on mortality in Asian populations. Here, we sought to compare survival between incident hemodialysis (HD) and peritoneal dialysis (PD) patients using the Korean Health Insurance Review & Assessment Service database. This enabled us to perform a population-based complete survey that included 32,280 incident dialysis patients and followed them for a median of 26.5 months. To reduce biases due to nonrandomization, we first matched 7049 patient pairs with similar propensity scores. Using the log-rank test, we found the mortality rate in PD patients was significantly higher than that in HD patients. Subsequent subgroup analyses indicated that in older patients (55 years and older), with the exception of the subgroup of patients with no comorbidities and the subgroup of patients with malignancy, PD was consistently associated with a higher mortality rate. In younger patients (under 55 years), regardless of the covariates, the survival rate of PD patients was comparable to that of HD patients. Thus, while the overall mortality rate was higher in incident PD patients, mortality rates of some incident PD and HD patients were comparable in Korea.
Bortezomib Induced Tumor Lysis Syndrome in Multiple Myeloma
Shinae Yu,Sung Woo Ryu,Kyoung-Ha Kim,Se-Hyoung Kim,Nam-Su Lee,Sung-Kyu Park,Jong-Ho Won 순천향대학교 순천향의학연구소 2013 Journal of Soonchunhyang Medical Science Vol.19 No.1
The tumor lysis syndrome (TLS) commonly occurs in the lymphoproliferative disorder, either spontaneously or in response to therapy. TLS is uncommon in multiple myeloma. However, with the use of bortezomib in the treatment of multiple myeloma, cases of TLS have been reported. We report here threepatients who presented with TLS after the administration of bortezomib. Two of them presented mild symptoms and recovered with hydration only. However, death of the other patient was associated with TLS. We should monitor patients who had high tumor burden, especially in early phase of bortezomib therapy and appropriate prophylaxis for high risk patient is also needed.