VARIATION OF 24-HOUR INTRAOCULAR PRESSURE IN SILICONE OIL–FILLED EYES

Chang, Joo Hyun,Shin, Jae Pil,Kim, In Taek,Park, Dong Ho Lippincott 2016 Retina Vol.36 No.1

<P>Purpose:To evaluate the variation of 24-hour intraocular pressure (IOP) in silicone oil (SO)-filled eyes.Methods:Prospective, nonrandomized comparative case series of 42 eyes of 21 patients, each with an SO-filled eye after vitrectomy. The fellow eyes served as controls. Each subject slept the usual 8 hours, and IOPs were measured at 4-hour intervals over 24 hours, twice before sleep (5:30 and 9:30 pm), twice during sleep (1:30 and 5:30 am), and twice after sleep (9.30 am and 1:30 pm). Intraocular pressure was measured in the sitting position using a Goldmann applanation tonometer. The SO-filled eyes and fellow eyes were compared with respect to diurnal-to-nocturnal and nocturnal-to-diurnal IOP changes.Results:At all 6 time points, SO-filled eyes had higher mean IOPs than fellow eyes (all P < 0.05). For both groups, mean nocturnal IOP was higher than mean diurnal IOP (both P < 0.001). Changes in diurnal-to-nocturnal IOP and nocturnal-to-diurnal IOP between SO-filled eyes and fellow eyes did not differ significantly (P > 0.05, respectively). The peak IOP occurred in the nocturnal period for all fellow eyes and for 94.7% of SO-filled eyes.Conclusion:The IOP of SO-filled eyes varied over a 24-hour period, peaking largely in the nocturnal period, as observed for the IOP of fellow eyes.</P>

Effects of viscoelastic material on the corneal endothelial cells in trabeculectomy with adjunctive mitomycin-C

Dong Bin Shin,Seung Bok Lee,Chang Sik Kim 대한안과학회 2003 Korean Journal of Ophthalmology Vol.17 No.2

We evaluated the change of corneal endothelium after trabeculectomy with mitomycin-C soaking (0.2 mg/ml, 2.4 ± 1.2 minutes) and the effect of viscoelastic material in reducing this change. In randomly selected cases, 0.05 ml of sodium hyaluronate (Healon??) was injected into anterior chamber (Healon group, n = 20), and same amount of balanced salt solution was injected in the other eyes (Control, n = 18) at the beginning of surgery. There were no differences in clinical variables and specular microscopy result between 2 groups before surgery. After surgery, the change of endothelial cells were significantly reduced in Healon group (cell density; -2.5 ± 1.6%, variability of cell area; 5.8 ± 2.5%, and percentage of hexagonal cell; -2.2 ± 0.7%) compared to control group (-7.7 ± 6.0%, 8.9 ± 4.4%, and -4.8 ± 3.5% respectively, p < 0.01). In trabeculectomy with mitomycin-C, the damage to the corneal endothelium was reduced significantly by injecting the viscoelastic material without significant complication.

Safety of a Traditional Korean Medicine, Cheonggan extracts (CGX): A 2-week Single-dose Toxicity Study in SD Rats and Beagle Dogs

Shin, Jang-Woo,Cho, Jung-Hyo,Seo, Dong-Seok,Sung, Nak-Won,Kwon, Min,Son, Chang-Gue The Society of Korean Medicine 2009 대한한의학회지 Vol.30 No.6

Objectives: To evaluate the acute toxic effects and approximate lethal dose of Cheonggan extracts (CGX) in SD rats and beagle dogs. Methods: Male and female rats were divided into 4 groups (Control, CGX 1250, CGX 2500, CGX 5000) respectively and male and female dogs were divided into two groups respectively (Control, CGX 5000) respectively. A single oral dose of CGX was treated to the rats and dogs. Mortality, signs of gross toxicity, and behavioral changes were observed over 14 days. All animals were observed every hour for 4 hours after administration and once a day thereafter for 14 days. Body weights were determined at $0_{th}$, $7_{th}$, and $14_{th}$ days. All surviving animals were sacrificed and necrotized. Major organs were inspected visually for gross findings. Results: No animals died in any of the groups during the experimental period (2 weeks), rats or dogs. Body weights of rats and dogs during the experiment continuously increased in all groups but there was no significant change. No abnormal clinical signs were observed for 2 weeks after a single administration of CGX in any dose group of CGX, rats or dogs. No abnormal findings in major organs were observed in any group of rats or dogs. Conclusion: CGX does not have acute toxic effects in rats or dogs. Therefore, an approximate lethal dose is assumed to exceed 5000 mg/kg in both rats and dogs.

마이크로-플레이트릿 광간섭 안료를 이용한 태양광용 고투과 컬러 유리에 대한 연구

신동윤(Dong-Youn Shin),이진섭(Jin-Seob Lee),신창수(Chang-Soo Shin),성창환(Chang-Hwan Seong) 대한기계학회 2020 大韓機械學會論文集B Vol.44 No.7

인위적인 기후 변화를 유발하는 이산화탄소 배출량을 줄이기 위해 제로에너지 건축이 법제화 되었으나, 종래의 건물 일체형 태양광 모듈은 태양광 발전 효율을 최대화하기 위해 흑색으로만 제작되었기에 심미성을 중요시하는 건축물의 외관에 적용하는데 장애물이 되어왔다. 본 연구에서는 마이크로-플레이트릿 광간섭 안료를 이용한 태양광용 고투과 컬러 유리의 제작에 대해 소개하도록 한다. 광간섭 안료의 함량이 광학 투과율에 미치는 영향을 조사함으로써 색상을 구현하는데 요구되는 광간섭 안료의 최소 함량을 결정하였다. 3wt% 광간섭 안료 함량의 컬러 유리로 태양광 모듈을 제조하고 전기적 특성을 측정하였다. 마이크로-플레이트릿 광간섭 안료의 사용은 진공 증착 다층 박막 적층법으로 색상을 구현하는 방식보다 저렴한 인쇄 공정을 적용할 수 있기 때문에 제조 비용을 절감할 수 있으며, 발전 효율도 기존 태양광 모듈의 76.15%에 이르렀다. The construction of zero-energy buildings will become mandatory to curtail the amount of CO₂ emissions, which lead to anthropogenic climate changes. However, conventional building-integrated photovoltaics are monotonously black in color to ensure high photoconversion efficiency. Hence, this has been a hurdle in aesthetically decorating the skin of a building. In this study, a micro-platelet light-interference pigment is explored for the fabrication of a highly transparent color glass for photovoltaic applications. The impact of pigment concentration on optical transmittance is investigated and the minimum pigment concentration for realizing a vivid color is determined. A photovoltaic module is fabricated using a color glass with a pigment concentration of 3 wt%, and its electrical properties are measured. The use of a micro-platelet light-interference pigment lowers the fabrication cost (by using a printing process) when compared to that of a costly color glass with multi-layered thin films deposited in vacuum. Furthermore, the relative photoconversion efficiency of the proposed method when compared to a conventional photovoltaic module is as high as 76.15 %.

종 분포 모형을 활용한 새로운 구상나무 서식지 탐색, 그리고 식물보전 활용

김남신 ( Nam Shin Kim ),한동욱 ( Dong Uk Han ),차진열 ( Jin Yeol Cha ),박용수 ( Yong Su Park ),조현제 ( Hyeun Je Cho ),권혜진 ( Hye Jin Kwon ),조용찬 ( Yong Chan Cho ),오승환 ( Seung Hwan Oh ),이창석 ( Chang Seok Lee ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2015 한국환경복원기술학회지 Vol.18 No.6

Korean fir(Abies koreana E.H.Wilson 1920), endemic tree species of Korean peninsula, is considered as vulnerable and endangered species to recent rapid environmental changes such as land use and climate change. There are limited activities and efforts to find natural habitats of Korean fir for conservation of the species and habitats. In this study, by applying SDMs (Species Distribution Models) based on climate and topographic factors of Korean fir, we developed Korean fir’s predicted distribution model and explored novel natural habitats. In Mt. Shinbulsan, Youngnam region and Mt. Songnisan, we could find korean fir’s two novel habitat and the former was the warmest(13°C in annual mean temperature), the driest(1,200mm∼1,600mm in annual rainfall) and relatively low altitude environment among Korean fir’s habitats in Korea. The result of SDMs did not include mountain areas of Gangwon-do as habitats of A. nephrolepis, because there were different contributions of key habitat environment factors, summer rainfall, winter mean temperature and winter rainfall, between A. koreana and A. nephrolepis. Our results raise modification of other distribution models on Korean fir. Novel habitat of Korean fir in Mt. Shinbulsan revealed similar habitat affinity of the species, ridgy and rocky site, with other habitats in Korea. Our results also suggest potential areas for creation of Korea fir’s alternative habitats through species reintroduction in landscape and ecosystem level.

SM 30 C강의 중공 중실축 단면변화가 부식피로강도에 미치는 영향

신규동(Kyou-Dong Shin),장백선(Paik-Sun Chang),김웅집(Woong-Jib Kim) 한국해양공학회 1997 韓國海洋工學會誌 Vol.11 No.2

The corrosion fatigue test was conducted in air to investigate the corrosion fatigue strength of SM 30 C steel by which was corroded in the under sea and the sea surface in the conditions of 3.0% NaCl salt solution. The fatigue tests were carried out on a rotary bending testing machine of cantilever type. The corrosion effect of the sea surface condition was severed more than that of the under sea condition which was due to the periodic contact of air thus accelerated the corrosion. The difference of the fatigue strength between sea surface and under sea conditions decreased with increase of stress level and corroded period. In the case of the solid shaft and thickness 2㎜ of hollow shaft, the difference of corrosion fatigue strength decreased as stress level and corrosion periodic increasing. On the contrary in the case of thickness 1㎜ of hollow shaft, the difference of it increased as stress level, corrosion periodic increasing and also the condition of corrosion changed. The main factors affecting the degradation of fatigue strength due to corrosion were the reduction of sectional area and the increase of surface roughness. The interference phenomenon increased with stress level got higher.

Combination of Vitamin C and Rutin on Neuropathy and Lung Damage of Diabetes Mellitus Rats

Sohn, Uy-Dong,Je, Hyun-Dong,Shin, Chang-Yell,Park, Sun-Young,Yim, Sung-Hyuk,Kum, Chan,Huh, In-Hoi,Kim, Jin -Hak The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.2

We investigated the role of vitamin C or rutin on neuropathy and lung damage of diabetic mellitus(DM) rats. Norepinephrine content was significantly decreased in sciatic nerves of DM rats compared with non-DM controls but vitamin C had no effect on decreases of norepinephrine. 2,4-dinitrophenylhydrazine (DNPH) incorporation, which is biomarker of protein oxidation, was increased in sciatic nerve of DM rats as compared with normal control. However, vitamin C had no effects on increases of DNPH incorporation . We measured the content of conjugated dienes (CD) as a biomarker of lipid oxidation in sciatic nerve. CD was increased in DM as compared with normal control, Vitamin C or rutin had no effects on increases of CD. However, Rutin plus vitamin C significantly decreased the content of CD as compared with CIM rats. In lung of DM rats, DNPH incorporation or CD was increased as compared with normal control. Vitamin C or Rutin had no effects on increases of CD However, Rutin plus vitamin C significantly decreased the content of DNPH incorporation or CD in lung tissue. Vitamin C caused marked pathological changes such as the increases of parenchyma and the thickening of alveolar septa in the lung of DM. Rutin had protective effects on the pathological changes in the lung of DM rats. In conclusion, Vitamin C had no effects on oxidative parameter, such as DNPH incorporation or CD, and on the decreases of norepinephrine content in DM rats. Vitamin C caused the marked pathological changes in the lung of DM rats but rutin had protective efforts against the pathological changes.

Safety of a Traditional Korean Medicine, Cheonggan extracts (CGX)

Jang-Woo Shin,Jung-Hyo Cho,Dong-Seok Seo,Nak-Won Sung,Min Kwon,Chang-Gue Son 대한한의학회 2009 대한한의학회지 Vol.30 No.6

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

가교시스템이 다른 고무재료의 경도에 대한 온도의 영향

진현호 ( Hyun Ho Jin ),홍창국 ( Chang Kook Hong ),조동련 ( Dong Lyun Cho ),강신영 ( Shin Young Kaang ) 한국고무학회 2008 엘라스토머 및 콤포지트 Vol.43 No.4

본 연구에서는 다양한 온도에서 고무재료의 경도에 대한 가교시스템의 영향에 대해 고찰하였다. 다양한 가교밀도의 시편을 얻기 위하여, NR과 SBR에 여러 가지 함량의 황 또는 peroxide를 첨가하여 가교하였다. 가교된 고무시편의 온도변화에 따른 경도변화와 가교밀도 변화를 측정하고 상호관계를 고찰하였으며, 시편에 발생하는 온도응력을 측정하여 온도변화에 따른 엔트로피의 변화를 조사하였다. 실온 이상에서 NR과 SBR 시편은 온도가 증가함에 따라 경도가 증가하였으며, 측정된 온도응력도 온도가 증가함에 따라 증가하였다. 그러나 측정조건 내에서 시편의 가교밀도 변화는 온도의 변화에 의해 거의 영향이 없었고 가교시스템에도 무관하였다. In this study, the effects of curing system on the hardness of rubber materials at various temperature were investigated. NR and SBR were compounded with various sulfur or peroxide content, in order to obtain various crosslink densities. The changes of hardness and crosslink density were measured as a function of temperature and the relationship was examined. The thermal stresses were also measured in order to investigate the effect of entropy as a function of temperature. The hardness of NR and SBR compounds increased with increasing temperature above room temperature, and the measured thermal stress increased as temperature increased. However, the crosslink densities were not changed by temperature change.