Sesquiterpene Components from the Flower Buds of Magnolia fargesii

Jung, Keun-Young,Kim, Dong-Seon,Oh, Sei-Ryang,Lee, Im-Seon,Lee, Jung-Joon,Lee, Hyeong-Kyu,Shin, Dong-Hyuk,Kim, Eun-Hee,Cheong, Chae-Joon The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.4

From the Chinese crude drug shin-i, the flower buds of Magnolia fargesii, four sesquiterpene, oplopanoe (1), oplodiol (2), homalomenol A (3) and $1{\beta},4{\beta},7{\alpha}$-trihydroxyeudesmane (4) were isolated. These structures were elucidated and the ${13}^C-NMR$ chemical shifts of these compounds were revised by means of various 2D-NMR techniques.

중증 재생불량성빈혈에서 타인 혹은 HLA 불일치 혈연간 골수이식을 위한 cyclophosphamide와 antithymocyte globulin전처치 요법

이정희,이제환,김신,설미이,이정신,김우건,김상희,지현숙,박찬정,이규형 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.1

배경: Cyclophosphamide와 ATG의 전처치 요법은 HLA가 일치하는 형제간 골수이식에서는 매우 효과적인 것으로 알려져 있으나, 타인 혹은 HLA 불일치 혈연간 골수이식에서는 전처치 요법으로서 불충분한 것으로 보고되었는데, 주요 문제는 착상 부전이었다. 우리나라를 포함하는 극동아시아 지역의 국가들에서 발표되는 보고에 의하면 타인이식을 포함하여 골수이식 후 착상 부전과 이식편대숙주질환의 발생이 서구 국가들로부터의 보고에서보다 적은 것으로 알려져 있다. 저자 등은 6예의 중증 재생불량성빈혈 환자들에서 질병 초기에 Cyclophosphamide와 ATG만을 이용하여 전처치를 한 후에 타인 혹은 HLA 불일치 혈연간 골수이식을 시행하였다. 방법: 1999년 5월부터 2000년 4월까지 서울중앙병원에서 타인 혹은 HLA 불일치 혈연간 골수이식을 시행 받은 성인 중증 재생불량성빈혈 환자들을 대상으로 하였다. 골수이식을 위한 전처치 요법으로 cyclophosphamide (50 mg/kg/d x 4)와 ATG (30 mg/kg/d x 3)를 투여하였는데, 골수이식 전에 ATG에 대하여 과민 반응을 보였던 한 예 (UPN 120)에서는 ATG 대신에 fludarabine (30 mg/m2/d x 3)을 투여하였다. 이식편대숙주질환의 예방을 위하여 cyclosporine과 methotrexate를 투여하였다. 결과: 연구 기간 중에 모두 6예가 타인 혹은 HLA 불일치 혈연간 골수이식을 시행 받았는데, 5예는 타인으로부터 골수를 공여 받았으며, 1예는 HLA의 표현형이 하나의 유전자좌에서 일치하지 않는 형제로부터 골수를 공여 받았다. 타인 골수이식을 받은 5예 중에서 3예의 공여자는 HLA의 표현형이 일치하였으며, 1예는 하나의 유전자좌가 major mismatch였고, 1예는 하나의 유전자좌가 minor mismatch였다. 추적기간의 중앙값은 406일 (범위, 328-643일)인데, 6예 모두에서 착상된 상태를 유지하면서 생존해있다. 2예에서 3도의 급성 이식편대숙주질환과 전신성 만성 이식편대숙주질환이 발생하였다. 결론: Cyclophosphamide와 ATG의 전처치 요법은 재생불량성빈혈의 초기에 타인 혹은 HLA 불일치 혈연간 골수이식을 시행 받은 한국인 환자들에서 충분히 착상을 가져올 수 있는 요법으로 생각된다. 비록 본 연구의 대상 환자 수가 적지만 결과는 매우 고무적이다. HLA가 일치하는 형제가 없는 중증 재생불량성빈혈 환자의 경우에 타인 골수 공여자에 대한 검색을 조기에 시행해야 하며, 타인 혹은 HLA 불일치 혈연간 골수이식을 질병 초기에 적극적으로 고려해야 할 것으로 생각된다. Background: Cyclophosphamide (CY) and ATG regimen was reported to be insufficient for alternative donor BMT in SAA patients due to high incidence of graft rejection. The rates of graft rejection and GVHD after allogeneic BMT including unrelated donor transplants seemed to be lower in reports from Asian countries of Far East. We applied CY/ATG regimen to six patients with early stage of SAA transplanted with marrow from alternative donors other than HLA-identical siblings. Methods: Three patients were transplanted from HLA-phenotypically identical unrelated donors, two from one-locus mismatched unrelated donors, and one from an one-locus mismatched sibling donor. Four patients received no previous therapy for SAA, and two received one course of immunosuppressive therapy with ATG. Preparative regimen was CY (200 mg/kg) plus ATG (90 mg/kg) in all patients except one who had had an anaphylactic reaction to ATG prior to BMT and received fludarabine (90 mg/m2) in place of ATG. Cyclosporine plus methotrexate were given for GVHD prophylaxis. Results: All six patients engrafted and all are alive with durable engraftment at a median follow-up of 406 days (range, 328 to 643). Two patients developed grade III acute GVHD and extensive chronic GVHD. Conclusions: CY/ATG regimen may be sufficient in Korean patients with early stage of SAA transplanted with marrow from alternative donors. Although the number of patients in present study is small, results are encouraging. Stem cell transplantation using alternative donors may be considered at early stage of aplastic anemia.

Systematic Review of Heavy Metal Concentrations in Fish and Shellfish in Korea

Shinhee Ye,Jiyoung Shin,Jueun Lee,Eun Mi Jung,Jeongsook Lee,Eunsun Yun,Yeosook Kim,Younghee Oh,Eun-Hee Ha 이화여자대학교 의과학연구소 2018 EMJ (Ewha medical journal) Vol.41 No.1

Objectives: Heavy metals ingested through the consumption of aquatic products can accumulate in the human body over the long-term and cause various health problems. This study aims to present comprehensive data on the amount of heavy metals found in fish and shellfish in Korea using a systematic review of studies that report on that issue. Methods: The study used the following databases: PubMed, Korean Studies Information Service System, and Research Information Sharing Service. The search terms for PubMed included fish OR shellfish OR seafood AND mercury OR cadmium OR lead OR heavy metal AND Korea. The search terms for Korean Studies Information Service System and Research Information Sharing Service included eoryu sueun, eoryu kadeumyum, eoryu nab, eoryu jung-geumsog, paeryu sueun, paeryu kadeumyum, paeryu nab, paeryu jung-geumsog, eopaeryu sueun, eopaeryu kadeumyum, eopaeryu nab, and eopaeryu jung-geumsog. Results: A total of 32 articles were selected for review. The total mercury, lead, and cadmium concentrations in fish and shellfish reported in each of the articles are summarized, as are the species of fish and shellfish with relatively high concentrations of heavy metals. Total mercury concentrations tended to be higher in predatory fish species, such as sharks, billfishes, and tuna, while lead and cadmium concentrations tended to be higher in shellfish. Conclusion: This paper is the first to report a comprehensive summary of the concentrations of heavy metals in fish and shellfish. This data could be used as evidence to protect Koreans from exposure to heavy metals due to the consumption of highly polluted aquatic products.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

숯 날염에 의한 부직포의 특성 변화

신정숙,박순자,정명희,田村照子,小紫朋子 한국의류학회 2004 한국의류학회지 Vol.28 No.2

The purposes of this study were to investigate characteristic changes on nonwoven fabric by the charcoal printing. It separate grind charcoal as two different size of particles 45-52㎛ and 53-65㎛ for hand screen printing on three kind of nonwoven fabrics. To examine the effect of charcoal printing on nonwoven fabric were to obwerve surface changes by a scanning electron microscope, dyeability by using spectrophotometer, moisture regain by oven method, air permeability, anion property, deodorization and antibacterial activity. The results were as follows: When charcoal powder concentration increased from 3 to 9%, K/S value also increased from 3.06to 8.55. When charcoal concentration increased, moisture regain also increased. In same concentration, moisture regain occurred higher as particle of small size. Air permeability decreased when the charcoal printing concentration increased. Anion occurrence appeared 140-160ion/㏄ from three different kinds of nonwoven fabrics in 3% and 9% charcoal concentration. Therefore, occurred anion ineffectively. In concentration of 3%, rate of deodorization measured as 89%, 83% and 87%, and 9% concentration caused 96%, 86% and 93% of high deodorization. Antibacterial activity examination in nonfinished nonwoven fabric resulted range of 60% however, 3% and 9% concentration finished nonwoven fabric resulted 99.9% of excellent antibacterial activity.

정상아동 4,5세를 대상으로 한 상자와 나무토막검사의 검사-재검사의 신뢰도검사 : Test-Retest Reliability for 4,5 Years Old Children

정민예,이재신,두정희 한국전문물리치료학회 1996 한국전문물리치료학회지 Vol.3 No.3

정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

유기농업에서의 작물의 양분관리

안난희, 신재훈, 옥정훈, 이상민, 김석철, 사동민 忠北大學校 農業科學硏究所 2016 農業科學硏究 Vol.32 No.2

Soil fertility is fundamental in determining the productivity of all farming systems and is most�ﾠ�ﾠ commonly defined in terms of the ability of the soil to supply nutrients to crops. Organic farming systems rely on the management of soil organic matter to enhance the chemical, biological and physical properties of the soil, in order to optimize crop production. Organic agriculture excludes the use of chemical nitrogen fertilizers, instead requiring a balance between supply and demand nutrients through the use of organic matter. Nutrient management is one of the main challenges facing organic farming. The short term challenge is supplying sufficient nutrients to crops at the correct point in their development to achieve economically viable yield, while in the long term, the difficulty is to balance nutrient inputs and runoffs to avoid nutrient rundown or environmental pollution. This paper reviews information from the literature to investigate strategies of managing nutrients by supplying organic matter in organic agriculture during the major phases of crop growth.

경량 기포콘크리트의 특성에 관한 연구

신현택,정희천 국립경상대학교 공과대학 부설 첨단소재연구소 1991 尖端素材 Vol.1 No.-

The effects of the addition of fly ash and carbon fiber on the mechanical properties of aerated concrete were studied by varing the compositions and curing conditions. Samples were steam cured at atmospheric (90℃-5hrs.) and high pressure (175℃-5hrs.) respectively. The highest compressive and flexural strength (56, 31 ㎏/㎠) was obtained at autoclave curing condition, and optimum composition was in weight ratio of portland cement : fly ash = 55 : 45, which contained 0.4 vol.% carbon fiber. The specific gravity and thermal conductivity of cured cement in autoclave was smaller than that in atmospheric. In the case of autoclave curing (portland cement : fly ash = 55 : 45 ), hydration products were CSH and 11 Åtobermorite, which were considered to the increase of strength.

그레이트 데인에서 발생한 위확장염전 증례

신희승,안지영,이영원,최호정 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 4-month-old female Great Dane dog with abdominal distention and non-productive retching after gulping of food and water yesterday was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Depression and abdominal distention with tympany were observed on physical examination. Decreased RBC and PCV were observed on CBC. And ALKP, BUN, Glu and P were increased on a serum chemistry. Severe gas filled distention of the stomach and intestines were shown on the abdominal radiographs. Pylorus was displaced craniodorsally toward the left side and gastric body was deviated to the right side on the abdominal radiographs. Deviating cranially of the diaphragm and decreased size of the heart were observed on thoracic radiographs. Therefore this case was diagnosed as gastric dilatation-volvulus.