대형 화재로 인한 사상자의 손상 유형과 합병증 : 동인천 라이브호프 화재를 중심으로

신중호,김재광,염석란,신종환,민순식,임용수,양혁준,이근,황성연 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: High risks of fire alway exist for buildings in urban areas, especially those in downtown. Crowds, as well as more complex and larger structures, may cause more victims in the event of fire; therefore, emergency medical service plans must be established for such disastrous events. Methods: On the evening of October 30,1999, a fire broke out in downtown, Dong-Incheon Live-Hof restaurant; 56 people were killed and 76 were injured. Most of them were teenagers. We retrospectively reviewed the medical records of the victims, Results: 1) Among the 56 dead, 54 died from smoke inhalation, one from extensive burns, and one from sepsis during treatment. 2) Among the 76 injured, 70 patients suffered from smoke inhalation, 53 from burns, and 9 from several types of trauma (sprains, contusions, lacerations, abrasions, fractures, etc.). 3) Later complications were laryngeal edema, pulmonary edema, scar contracture, and hypoxic brain damage, and so forth. 4) Post traumatic stress syndrome was unexpectedly more prevalent in mildly to moderately injured survivors and witnesses than in seriously injured survivors. Conclusion: Many complications exist after a fire. Some may be resolved in time, but others may result in permanent sequelae. Early rescue, early triage, and early management during transport by emergency medical service (EMS) personnel can result in fewer complications and a lower mortality rate. Therefore, we propose the establishment of plans to be followed during various major disasters.

濟州道公務員의 特性과 庶政刷新에 관한 硏究

申宗淳,鄭允武,朴瑾浩,金武昌 동국대학교 행정대학원 1977 행정논집 Vol.7 No.-

全蝎 抽出物의 抗癲癎效果에 關한 硏究

신현철,윤철호,김종대,정지천,신억섭,허근 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

In convulsion state by PTZ in rat, anticonvulsive effect and some γ-aminobutyric acid (GABA)-related mechanisms of Bythus extract in brain was experimented. It was ingibited GABA-T activity, lipid peroxide generation and xanthine oxidase activity as scheduled administration in vitro and vivo. And the content of brain gutathione was increased as scheduled administration in rat. In convulsion state by PTZ of previously managed rat by Buthus extract, onset eime and duration were non-specific changes but recovery time and severity was remarkably reduced. In conclusion speculated that Buthus extract inhibits convulsion by control of GABA content in brain.

방역작업자의 브롬화메틸(methyl bromide) 노출수준과 생물학적 모니터링

이종성,이용학,신재훈,최정근,오차재,정호근 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.3

This study was performed to estimate environmental and biological monitoring of worker exposed to methyl bromide through quarantine fumigation. Airborne methyl bromide and it's metabolites were analyzed by gas chromatography and ion chromatography, respectively. The results are as followings; airborne concentration of methyl bromide(TWA) was 2.08±1.56 ppm(N=8). Dispersion and setting/degas groups were 0.67±0.12 ppm(N=2) and 2.54±1.53ppm(N=6), respectively. Bromide ion concentration in serum was 23.40±14.91㎎/ℓ(N=10) in the exposed workers and 4.74±0.82㎎/ℓ(N=21) in the non-exposed workers. Bromide ion concentration in urine was 35.56±26.89㎎/ℓ(N=11) in exposed group and 6.62±2.31㎎/ℓ(N=21) in non-exposed group. Good correlation was observed between concentration of serum and urine(r^2=0.890 p<0.01). No significant correlations of other determinanats were observed. Calcuated from a regressive curve. the biological half lifes of serum and urine were 10.7 and 5.9 days. In these results, biological monitoring of bromide ion of serum and urine provided useful information for evaluating exposure of workers to methyl bromide, so that an availability of bromide ion of biological samples was showed as biological monitoring indices for methyl bromide.

천마의 항경련작용기전 연구

허근,이수진,신억섭,박종민 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

Gastrodia elata is a medicinal plant which has been used as anticonvulsant in Korea, Japan and China. This study was conducted to examine the action mechanism of Gastrodia elata centering around the change of GABA and glutamic acid level in brain while observing the anticonvulsive effect in PTZ-induced seizure model Seizures were reduced effectively by pretreatment of ether soluble part of methanol extract of, Gastrodia elata. The pretreatment of ether soluble part inhibited not only the decreses of brain GABA level but also the increase of brain glutamic acid level observed in PTZ model of convulsive dose. Although there was not any change in glutamic acid level, the same development was also observed in the model of subconvulsive dose. From above results, it seems that the anticonvulsive component of Gastrodia elata is lipophilic, and its action mechanism is originated from both control action of GABA level and inhibition of glutaminergic neurotransmission.

수종 식물추출물의 항히스타민작용

이신웅,이윤주,손종근 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

The antihistaminic action of eighteen herbal medicines was investigated by the radioligand binding and functional assays. The hexane fractions of Trichosanthis radix, Mori cortex radicis and Evodiac fructus dose-dependently inhibited [³H]mepyramine binding to H, receptor in guinea-pig brain homogenates and histamine-induced contraction of isolated guinea-pig ileum. Antihistaminic action of the hexane and ethyl acetate fractions of Mori cortex radicis and the hexane fraction of Evodiae fructus was more potent than their antimuscarinic action evaluated from the inhibition of [³H]QNB binding and carbachol response. The ethyl acetate and chloroform fractions from Scutcllariae radix also inhibited histamine-induced contraction, but antihistaminic potencies of these fractions were almost identical with their antimuscarinic potencies. The hexane fractions of Mori cortex radicis and Evodiae fructus inhibited selectively the increase of histamine-induced cutaneous vascular permeability in the rat dorsal skins. However, the ethyl acetate fraction from Scutellariae radix inhibited eqipotently the effects of histamine and serotonin on the vascular permeability. These results demonstrate that the hexane and ethyl acetate fractions of Mori cortex radicis and the hexane fraction of Evodiae fructus have the selective histamine H₁ receptor blocking activity.

Transthyretin의 Glutathione 자동산화 촉진작용

박종근,정신,김재휴,김수한,강삼석,이제혁,안봉환 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.8

When reduced glutathione(GSH) was incubated at neutral pH and at 37°, its concentration decreased slowly with formation of oxidized glutathione(GSSG). Autooxidation of GSH was accelerated by Cu^(2+) and Hg^(2+), but not by other common mono-, di-, and tri-valent cations. Transthyretin was found to stimulate autooxidation of GSH in the presence or absence of Cu^(2+) and Hg^(2+). EDTA inhibited perfectly the autooxidation of GSH regardless of the presence of transthyretin. The stimulating activity of transthyretin was maximal at pH 7.0, declining progressively with increase or decrease of pH from 7.0. Sulfhydryl-blocking agents such as p-hydroxymercuribenzoic acid and Nethylmaleimide markedly inhibited the stimulating activity of transthyretin. Transthyretin stimulated autooxidation of other sulfhydryl compounds such as clithiothreitol and cysteine. However, it did not show a significant effect on autooxidation of sulfhydryl group of egg albumin and eye lens proteins. And transthyretin did not cause any oxidative change to thyroxine(T₄), 3, 5, 3Ltri iodo thyronine(T₃) and 3, 3: 5~triiodothpnine(rT₃) bound to it in the presence of GSH and Cu^(2+). The above results suggest that transthyretin may play a role in regulation of oxidized status of sulfhydryl groups in blood plasma and cerebrospinal fluid

운동전·후 淸暑益氣湯 투여방법이 2,000m 달리기시 선수들의 운동피로회복에 미치는 영향

유종만,이규성,강명신,오재근,최용어 韓國體育大學校附屬 體育科學硏究所 1994 韓國體育大學校附屬 體育科學硏究所論文集 Vol.13 No.1

The purpose of this study was to investigate the effects of two different chung-seo-ik-gi-tang administration types on fatigue induced during 2,000 m running in 12 healthy-male elite boxer. All subjects were divided randomly with two groups, Pre-administration Group(A: N=7) and Pre- and Post-administration Group(B: N=7) and performed 2,000 m maximal running. The blood samples were collected from antecubital vein by 10ml syranges(6ml/each) at before exercise, immediately after exhaustion, recover-10 min, recover-20 min and recover-30 min. These samples were used to analyze for the level of glucose, lactate, TG, LDH, pH, HCO₃?, Na??, K??. The statistically analyzed results of various blood parameters were summarized as follow, 1. Plasma glucose were not showed significant difference between two groups. but glucose lwvel at post-exercise and rest-30 min in B group wes significantly decreased. 2. Lactate accumulation in B group was significantly decreased at post-exercise and rest-30 min.. And lactate level at rest-30 min. was showed significant difference between two gruops. 3. Serum LDH response to 2,000 m running at post-exercise and recovary periods was showed significant changes in B group. 4. Venous pH at post-exercise, HCO₃? at post-exercise and rest-30 min. in A group and pH at post-exercise and rest-10, 20 min., HCO₃? at post-exercise were showed significant changes. But there were not showed significant difference between two groups. 5. K?? level in B group was showed significant difference compared to A group. And also K?? level at rest-30 min. in B group was showed significant change. The results indicated that Chung-seo-ik-pi-tang had the effects of ergogenic aids on fatigue and recovery during 2,000 m maximal running.

광도와 온도가 가시광선 중합형 치과용 레진의 중합에 주는 영향

이종근,최주열,임범순,신현철 大韓齒科器材學會 2004 대한치과재료학회지 Vol.31 No.4

본 연구에서는 2종의 다이메타크릴레이트 치과용 레진 (urethane dimethacylate, UDMA와 bisphenol A glycerolate dimethacylate, Bis-GMA)이 광중합 반응하는 과정에서 변화되는 물성을 동역학분석법 (dynamic mechanical analysis, DMA)으로 관찰하였다. 광중합에 사용한 가시광선 (λ=400-500 nm)의 광도는 20 mW/㎠에서 70, 120, 300 및 600 mW/㎠로 변화시켜 그에 따른 저장탄성율 (storage modulus, G')과 손실탄성율 (loss modulus, G")의 변화를 측정하였고, 측정온도도 25 ℃에서 37, 50 및 60 ℃로 변화시켜 온도가 중합과정에 주는 영향을 관찰하였다. 광조사 시간은 모든 시편에 대하여 측정 시작 직후 30초로 일정하게 하였다. 각 조건에서 측정한 G' 과 tan δ (=G"/G') 결과를 이용하여 겔화 (gelation)와 유리화 (vitrification) 전이시점 (transition point)을 결정하였으며, 이를 이용하여 TTIT (Time-Temperature-Intensity-Transformation) 중합 도표를 작성하였다. 이 중합도표를 보면 광도 변화가 온도 변화보다 중합반응에 더 민감하게 영향을 주었으며, 특히 광도는 겔화보다 유리화에 훨씬 크게 영향을 주는 것을 알 수 있었다.

콜레스테롤 생합성 저해제 검색법의 개발

임종철,이남훈,김한균,염형렬,이대호,강현석,류형선,명재일,김완,신부안 全南大醫大 2001 전남의대학술지 Vol.37 No.2