자율신경계의 활성도 측정을 위한 Data Acquisition System의 개발 및 임상응용

신동구,박종선,김영조,심봉섭,이상학,이준하 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Power spectrum analysis method is a powerful noninvasive tool for quantifying autonomic nervous system activity. In this paper, we developed a data acquistion system for estimating the activity of the autonomic nervous system by the analysis of heart rate and respiratory rate variability using power spectrum analysis. Materials and methods: For the detection of QRS peak and measurement of respiratory rate from patient's ECG, we used low-pass filter and impedance method respectively. This system adopt an isolated power for patient's safety. In this system, two output signals can be obtained: R-R interval(heart rate) and respiration rate time series. Experimental ranges are 30∼240 BPM for ECG and 15∼80 BPM for respiration. Regults: The system can acquire two signals accurately both in the experimental test using simulator and in real clinical setting. Conclusion: The system developed in this paper is efficient for the acquisition of heart rate and respiration signals. This system will play a role in research area for improving our understanding of the pathophysiologic involvement of the autonomic nervous system in various disease states.

희생양극을 이용한 자동차 소음기의 음극방식에 관한 연구

신동호,심재주,최윤석,김정구 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.12

In order to apply a sacrificial anode cathodic protection system for automotive muffler materials, determination of reliable sacrificial anode and its protection ability were evaluated by laboratory tests in synthetic condensed water. Three kinds of sacrificial anodes were selected: aluminum (AI), zinc (Zn) and magnesium (Mg), and the muffler materials were Al-coated steel and uncoated steel. The corrosion behavior in synthetic condensed water for the muffler materials and sacrificial anodes was investigated by potentiodynamic tests. The cathodic protection ability was evaluated by galvanic corrosion test and weight-loss test. The results of the potentiodynamic test indicated that Al was less suitable for sacrificial anode because it became passive. Mg was also unqualified due to the high dissolution rate. However, Zn was adequate for sacrificial anode because of its low dissolution rate, high stability and suitable potential difference. Results of weight-loss test demonstrated that the corrosion rate of Al-coated steel was reduced from 0.028 to 0.018 mm/year, and that of uncoated steel was 0.08 to 0.002 mm/year by coupling with Zn anode. In addition, the proper area ratio of anode to cathode was 1 : 10. From these results, it can be concluded that Zn anode can protect both the Al-coating with passivation, and steel substrate with low dissolution rate. (Received January 8, 2004)

Melittin-Hybrid 합성 폡타이드가 Fusarium oxysporum의 성장에 미치는 저해효과

이동건,신송엽,이성구,이명규,함경수 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.5

꿀벌의 독액으로부터 분리된 ME은 강항 항균활성을 가지나, 진핵세포에 대하여 세포독성 활성을 포함하고 있다. 본 연구에서는 구조와 항진균활성과 상관관계를 검토하며, 세포독성을 가지지 않으며 보다 강한 항진균활성을 가진 펩타이드의 디자인하기 위하여, ME와 CA 또는 MA으로 이루어진 hybid 펩타이드인 MA(10-17)ME(1-12) 및 CA(1-8)ME(1-12)을 고상합성법의 의하여 합성 하였다. CA(1-8)ME(1-12) 및 MA(10-17)ME(1-12)는 인간의 적혈구에 대하여 용혈현상을 나타내지 않으며, Fusarium oxysporum에 대하여 ME 만큼의 강한 항진균활성을 나타내었다. 또한 이들 hybrid 펩타이드는 (1,3)-β-D-glucan synthase의 활성을 강하게 억제하였다. 이 결과는 Fusarium oxysporum에 대한 hybrid 펩타이드의 활성은 균의 세포벽의 합성의 억제에 의한 것과 관련성이 있는 것을 시사한다. 또한 본 연구의 결과는 세포독성을 가지며 강한 항진균활성을 가지는 펩타이드의 설계에 기초를 제공하였다고 생각된다. Melittin (ME) from honeybee venom has a broad range of strong antimicrobial activity, but it has hemolytic activity against eukaryotic cells. In order to design peptides with powerful antifungal activity without cytotoxic property of ME and understand structure-antifungal activity relationships, the hybrid peptides derived from the sequences of ME and cecropin A (CA) or magainin 2 (MA), MA(10-17) ME(1-12) and CA(1-8)ME(1-12), were synthesized by solid phase method. MA(10-17)ME(1-12) showed potent antifungal activity comparable to ME against Fusarium oxysporum with no hemolytic activity against human red blood cells. The hybrid peptides showed strong inhibition of (1,3)-β-D-glucan synthase. This result indicates that the antifungal activity of the hybrid peptides against Fusarium oxysporum is attributed to the inhibition of cell wall synthesis. The results therefore showed a successful design of a peptide having antifungal activity without hemolytic property.

심장재동시화치료

김형준,신동구 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Heart failure is a clinical syndrome comprised of a number of symptoms and signs associated with congestion and/or hypoperfusion. Specific pharmacologic therapies have been developed to slow disease progression from early to more advanced stages, Once symptoms have developed, aggressive multimodality interventions are instituted to alleviate symptoms and improve clinical status and quality of life; especially in those patients that present symptoms. Recently, an evolving adjunctive therapeutic modality, that involves using implanted electrical devices; cardiac resynchronization with or without implantable cardioverter defibrillators (ICD). has been used for management. Cardiac resynchronization therapy (CRT) is a proven treatment for selected patients with heart failure-induced conduction disturbances and ventricular dyssynchrony. When used in combination with stable, optimal medical therapy, CRT is designed to reduce symptoms and improve cardiac function by restoring the mechanical sequende of ventricular activation and contraction. This review summarizes the rationale, procedure, clinical trials, and clinical indications for CRT.

Cr, Co, Cu, Ni와 Ca의 첨가에 따른 지하매설배관의 전기화학적 특성에 관한 연구

최윤석,신동호,심재주,김정구 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.1

Aqueous corrosion characteristics of low carbon steel with small amounts of Cr, Co, Cu, Ni and Ca, in synthetic groundwater was studied by electrochemical corrosion tests (potentiodynamic test and electrochemical impedance spectroscopy (EIS) measurements) and analytical techniques. Neither carbon steel nor newly alloyed steels showed passive behavior in this synthetic groundwater. Newly alloyed steels, containing Cr-Co, Cr-Cu-Ni and Cr-Cu-Ni-Ca showed higher corrosion resistance than carbon steel in the potentiodynamic tests. EIS measurements showed that the Nyquist plot presented two time constants. The high frequency resistance component (R_(rsut)) and low frequency resistance component (R_(et)) were affected by the alloying elements. The polarization resistance (RP= R_(et) +Ra) of steels could be clearly ranked as Cr-Cu-Ni-Ca steel >> Cr-Cu-Ni steel > Cr-Co steel > carbon steel. Results of surface analyses (XPS and EPMA) showed that Cr and Cu were concentrated in the inner region of rust. However, Co and Ni were uniformly distributed all over the rust layer. These alloying elements improved corrosion resistance of low alloy steel in synthetic groundwater. Especially, Cr-Cu-Ni-Ca steel had the lowest corrosion rate due to the inner rust film formation during the initial stage of corrosion, which suggested a potential for substituting carbon steel in soil environment (Received October 29, 2004)

중소기업형 CIM시스템 구축을 위한 생산계획수립 및 실적파악 모듈

최후곤,신완선,장중순,서준성,여명구,안동근,김진봉 成均館大學校 科學技術硏究所 1996 論文集 Vol.47 No.2

This study Focuses on developing several modules involved in an integrated production information system for medium- or small-sized industries. The modules of order management, quality control, production scheduling, and shop management are executed for an example case industry. The potential values of this research includes that the major information modules to collect, analysis, and display production data and shop data for constructing the computer integrated manufacturing system(CIMS) are programmed with various features of medium- or small-sized industries

상수도 배관의 부식감지시스템 개발 (Ⅱ)

최윤석,신동호,김상현,김정구 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.4

In order to develop a new corrosion sensor for detecting and monitoring the corrosion of buried pipeline, the electrochemical property of sensors and the correlation of its output to corrosion rate of steel pipe, were evaluated by electrochemical methods in synthetic groundwater, two soils of varying resistivity (5,000 ohm-cm, 10,000 ohm-cm), and synthetic tap water. In this paper, two types of electrochemical probes were used: galvanic cells containing of pipeline steel-copper and pipeline steel-stainless steel (Type 304). The results of EIS measurement indicated that the sensor current was inversely related to sensor resistance, which was governed by the corrosion behavior of cathode. In galvanic corrosion tests, the galvanic current of Cu-CS probe was higher than that of SS-CS probe. The comparison of the sensor output and corrosion rates revealed that a linear relationship was found between the probe current and the corrosion rates. A good linear quantitative relationship was found between the Cu-CS probe current and the corrosion rate of pipeline steel coupons in the soil resistivity of 5,000 ohm-cm, and synthetic tap water. In the case of the soil resistivity of 10,000 ohm-cm, although the SS-CS probe showed a better linear correlation than that of Cu-CS probe, the Cu-CS probe is more suitable than SS-CS probe, due to the high current output. (Received February 1, 2005)

수돗물에서 동 배관의 부식특성에 관한 연구

심재주,신동호,최윤석,김정구,유승재 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.12

The corrosion behavior of copper in neutral aerated synthetic tap water was investigated using electrochemical methods, SEM and XPS. All potentiodynamic polarization curves showed active corrosion behavior, and the corrosion rate was more sensitive to flow velocity than Cl^(-) ion concentration and temperature. The result of potentiostatic test indicated that the current density decreased with increasing time regardless of Cl^(-) ion concentration and temperature in stagnant condition because copper compounds were formed uniformly on the surface. The EIS plot was changed from two time constants to three time constants with the formation of Cu₂O, and the charge transfer resistance (R_(ct)) was very large and increased with increasing immersion time. From all results, copper had good corrosion resistance in this potable water system.

혈액투석 환자에서 대퇴신경범증으로 발현된 장골근 및 요근 농양 1예

이준상,강동구,신상열,윤재호,조영일,고성은,유영범,전혜정,진춘조,송종오 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

단일 사례 사격선수의 집중루틴 훈련의 효과

장덕선,김병준,구해모,신동성 한국스포츠심리학회 2004 한국스포츠심리학회지 Vol.15 No.1

본 연구는 소총사수 P의 집중력 훈련에 관한 것이다. P 선수는 만 21세의 남자선수로서 운동경력은 8년이며, 10M 공기소총이 주종목이다. 집중력훈련은 단일사례실험 중 가장 단순한 시계열 설계인 AB 설계를 적용하였다. A단계에서 집중력, 주의력 질문지가 1-2주 간격으로 4회 반복측정 되었으며, B단계는 7월-10월까지 집중력 훈련이 진행되는 기간으로 개별면담과 질문지 측정, 수행평가를 위한 시합기록이 수집되었다. 집중력 질문지는 1개월에 1회 측정되었고, 주의력 검사지는 집중훈련 전과 후에 각각 한차례 시행되었다. 집중 루틴은 선수의 개인적 습관과 장점을 최대한 존중하여 훈련과 최고시합 때 습관적으로 하는 행동과 생각을 포함시켜 상당한 시합 부담 상황에서도 최고시합때의 행동과 생각의 흐름을 유지할 수 있도록 강력한 의미를 가진 행위와 키워드로 구성하였다. 완성된 루틴 프로그램은 4개월 훈련 후 집중력과 주의력, 수행평가를 실시하였다. 훈련결과 루틴 훈련은 집중조절 능력을 향상시켰으며, 주의유형은 긍정적인 형태는 증가하고 부정적 형태는 감소하였다. 수행 기록은 루틴 훈련 과정에서 출전한 5회 시합에서 모두 결선에 진출하므로서 수행향상에도 기여한 것으로 밝혀졌다. This study is about a concentration training of a rifle Marksman, P, The male Marksman P is 21 years old, and has played a rifle for eight years. His major is 10M air rifle. We apply AB design which is the simplest time-series design among single case experiments. In A step, we have applied the questionnaire for examining the ability of concentration and attentiveness for four times at an interval of 1 or 2 weeks. In B step, we developed a programme for improving the concentration training and applied it to the player. During the training in B step, which had continued from July to October, we have collected individual interviews, survey, records of games in order to evaluate achievement. The questionnaire for concentration has been served once a month, and the TAIS has been operated once each time before and after the concentration training. The concentration routine is directed to the way of considering the athlete's personal habit and merit most. Therefore, the concentration routine includes the essential matters of habitual acting and thought in ordinary training and in the final match. The concentration routine is consist of powerful meaningful movement and keyword in order to maintain the stream of movement and thought at the final match even though the Marksman is under the heavy pressure of the game. The practice evaluation has been done by a completed routine programme after the four-month-training. After examining the result of the evaluation, the concentration training improves the ability of controlling concentration. The positive type of TAIS is increased and the negative type is decreased. About the record of achievement, the player had advanced to the final once before the training, on the other hand, advanced to all the five final matches after the training. Consequently, it is discovered that the concentration training contributes to the achievement.