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Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target
Ming-Shian Tsai,Po-Huang Lee,Cheuk-Kwan Sun,Ting-Chia Chiu,Yu-Chun Lin,I-Wei Chang,Po-Han Chen,Ying-Hsien Kao 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy on liver injury and hepatic SIRT1 expression in a bile duct ligation (BDL) mouse model. Histopathological and molecular analyses showed that the hepatocytes of human diseased livers expressed NGF, proNGF (a precursor of NGF), TrkA and p75NTR, whereas only p75NTR was upregulated in hepatolithiasis, compared with non-hepatolithiasis livers. In the BDL model without NGF therapy, p75NTR, but not TrkA antagonism, significantly deteriorated BDL-induced liver injury. By contrast, the hepatoprotective effect of NGF was abrogated only by TrkA and not by p75NTR antagonism in animals receiving NGF therapy. Intriguingly, a positive correlation between hepatic SIRT1 and NGF expression was found in human livers. In vitro studies demonstrated that NGF upregulated SIRT1 expression in mouse livers and human Huh-7 and rodent hepatocytes. Both NGF and proNGF induced protective effects against hydrogen peroxide-induced cytotoxicity in Huh-7 cells, whereas inhibition of TrkA and p75NTR activity prevented oxidative cell death. Mechanistically, NGF, but not proNGF, upregulated SIRT1 expression in human Huh-7 and rodent hepatocytes via nuclear factor (NF)-κB activity, whereas NGF-induced phosphoinositide-3 kinase/Akt, extracellular signal–regulated kinase and NF-κB signaling and SIRT1 activity were involved in its hepatoprotective effects against oxidative injury. These findings suggest that pharmacological manipulation of the NGF/SIRT1 axis might serve as a novel approach for the treatment of cholestatic disease.
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Xinwen Gong,Dongxue Yang,Nannan Wang,Shian Sun,Jun Nie,Guiping Ma 한국섬유공학회 2020 Fibers and polymers Vol.21 No.10
In order to improve the adsorption capacity of chitosan to organic dyes, the amino rich functionalized chitosanelectrospun nanofibers membrane was prepared. In the process of high efficiency synthesis, PGMA and PEI were grafted onthe surface of CS NFMs in turn. By means of XRD, ATR-FTIR and XPS, the successful introduction of amino group into CSwas confirmed. The selective adsorption capacity of CS-PGMA-PEI NFMs for anionic dyes was studied. The adsorptionkinetics analysis shows that the adsorption process of CS-PGMA-PEI NFMs is mainly pseudo second-order model. Itsadsorption isotherms can be described by the Langmuir model and it conforms to monolayer adsorption. The maximumadsorption capacity of Congo red calculated by Langmuir model is 657.47 mg/g. CS-PGMA-PEI NFMs has selectiveadsorption capacity for Congo red/methylene blue mixture. CS-PGMA-PEI NFMs also showed good circulation stability. This study provides a method for the synthesis of water purification membrane.
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Yang Guogang,Wang Hao,Su Fengmin,Li Shian,Zhang Guoling,Sun Juncai,Shen Qiuwan,Jiang Ziheng,Liao Jiadong,Chen Pengyu 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7
Proton exchange nembrane fuel cells (PEMFCs) are highly promising energy devices for future transportation and distributed power stations. The electrochemical performance of PEMFCs assembled with gas diffusion layer (GDL) of different porosity gradient distributions has been analyzed using the lattice Boltzmann method. A single-phase multi-component lattice Boltzmann model employing the active approach was developed to investigate the reactive gas flow within the GDL. Two types of GDLs with the same porosity, namely multilayer porosity gradient GDLs and linear porosity gradient GDLs, were generated to investigate the effect of the porosity gradient of the GDL on the electrochemical performance of PEMFC. The results show that the two types of porosity gradient GDL improve oxygen starvation problems and enhance water management, and that the GDLs with smaller porosity gradients can increase the mean current density. This paper develops the study of pore-scale analysis of PEMFC performance and can provide guidance for the design of GDL structures.
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Jian-Zhe Huang,Li-Hung Lin,Chin-An Chang,Chi-Te Liang,Kuang Yao Chen,Kui-Ming Chen,N. C. Chen,P. H. Chang,Shiou-Shian Han,Zhi-Hao Sun 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.3
We report on experimental studies of an Al$_{0.15}$Ga$_{0.85}$N/GaN high-electron-mobility transistor structure grown on a $p$-type Si (111) substrate. This structure is compatible with complementary metal-oxide-semiconductor (CMOS) technology and, thus, has great potential device applications. The low-temperature magnetoresistivity shows a parabolic dependence on the applied perpendicular magnetic field. This effect is ascribed to electron-electron interaction (EEI) effects in a weakly-disordered two-dimensional system. Our experimental results agree with the EEI theory when the correction term in the ballistic region has been subtracted.
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