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Choi Miyoung,Lee Hyeon-Jeong,Yu Su-Yeon,Kim Jimin,Park Jungeun,Ryoo Seungeun,Kim Inho,Park Dong Ah,Yoon Young Kyung,Joh Joon-Sung,Park Sunghoon,Yun Ki Wook,Choi Chi-Hoon,Kim Jae-Seok,Shin Sue,Kim Hyun 대한의학회 2023 Journal of Korean medical science Vol.38 No.23
Background: In Korea, during the early phase of the coronavirus disease 2019 (COVID-19) pandemic, we responded to the uncertainty of treatments under various conditions, consistently playing catch up with the speed of evidence updates. Therefore, there was high demand for national-level evidence-based clinical practice guidelines for clinicians in a timely manner. We developed evidence-based and updated living recommendations for clinicians through a transparent development process and multidisciplinary expert collaboration. Methods: The National Evidence-based Healthcare Collaborating Agency (NECA) and the Korean Academy of Medical Sciences (KAMS) collaborated to develop trustworthy Korean living guidelines. The NECA-supported methodological sections and 8 professional medical societies of the KAMS worked with clinical experts, and 31 clinicians were involved annually. We developed a total of 35 clinical questions, including medications, respiratory/critical care, pediatric care, emergency care, diagnostic tests, and radiological examinations. Results: An evidence-based search for treatments began in March 2021 and monthly updates were performed. It was expanded to other areas, and the search interval was organized by a steering committee owing to priority changes. Evidence synthesis and recommendation review was performed by researchers, and living recommendations were updated within 3–4 months. Conclusion: We provided timely recommendations on living schemes and disseminated them to the public, policymakers and various stakeholders using webpages and social media. Although the output was successful, there were some limitations. The rigor of development issues, urgent timelines for public dissemination, education for new developers, and spread of several new COVID-19 variants have worked as barriers. Therefore, we must prepare systematic processes and funding for future pandemics.
Seungeun Choi,Young Hoon Choi,Hoo Seung Lee,Kyong Won Shin,Yoon Jung Kim,Hee-Pyoung Park,Won-Sang Cho,Hyongmin Oh 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.6
Objective : This study compared the quality of recovery (QoR) after minicraniotomy for clipping of unruptured intracranial aneurysms (UIAs) between patients with and without scalp nerve block (SNB). Methods : Patients were randomly assigned to the SNB (SNB using ropivacaine with epinephrine, n=27) and control (SNB using normal saline, n=25) groups. SNB was performed at the end of surgery. To assess postoperative QoR, the QoR-40, a patient-reported questionnaire, was used. The QoR-40 scores were measured preoperatively, 1–3 days postoperatively, at hospital discharge, and 1 month postoperatively. Pain and intravenous patient-controlled analgesia (IV-PCA) consumption were evaluated 3, 6, 9, and 12 hours and 1–3 days postoperatively. Results : All QoR-40 scores, including those measured 1 day postoperatively (primary outcome measure; 155.0 [141.0–176.0] vs. 161.0 [140.5–179.5], p=0.464), did not significantly differ between the SNB and control groups. The SNB group had significantly less severe pain 3 (numeric rating scale [NRS]; 3.0 [2.0–4.0] vs. 5.0 [3.5–5.5], p=0.029), 9 (NRS; 3.0 [2.0–4.0] vs. 4.0 [3.0–5.0], p=0.048), and 12 (NRS; 3.0 [2.0–4.0] vs. 4.0 [3.0–5.0], p=0.035) hours postoperatively. The total amount of IV-PCA consumed was significantly less 3 hours postoperatively in the SNB group (2.0 [1.0–4.0] vs. 4.0 [2.0–5.0] mL, p=0.044). Conclusion : After minicraniotomy for clipping of UIAs, SNB reduced pain and IV-PCA consumption in the early postoperative period but did not improve the QoR-40 scores.
최정원(Choi Jyungwon),오승은(Oh Seungeun),최다은(Choi Daeun),이강현(Lee Ganghyon),이관형(Lee Kwanhyeong) 한국정보기술학회 2020 Proceedings of KIIT Conference Vol.2020 No.10
본 연구는 특정 지역 방역을 실시하기 위해서 드론 설계 및 제작 방법을 연구하였다. 드론 설계 및 제작은 드론에 탑재하는 무게를 고려하여 멀티 콥터로 드론을 제작하였고 자율 비행은 웨이포인트 기능설정을 위해서 3D 맵핑으로 비행 경로 프로그램을 작성하였다. 제작된 방역 드론의 성능을 확인하기 위해서 필드 실험을 진행하였으며 실험 설정방법은 방역드론이 특정 지점을 이동비행 할 수 있도록 하기 위해서 특정 좌표 지점을 설정하여 비행시험을 실시하였다. 실험결과 제작된 방역드론은 특정 지점을 모두 비행하는 결과를 나타내었다. This study studied the drone design and manufacturing method in order to implement quarantine in a specific area. For the design and manufacture of drones, the drone was manufactured with an multi-copter in consideration of the weight of the drone, and a flight path program was prepared for setting the way-point function of the autonomous flight by 3D-mapping. Field experiments were conducted to confirm the performance of the manufactured defense drones, and the experimental setting method was to set specific coordinate points and conduct flight tests in order to allow the defense drones to move and fly to specific points. As a result of the experiment, the prepared defense drone showed the result of flying all the specific points.
Choi Seung-Hoon,Hwang Jung-Min,Lee Seungeun,Lee So-Yeon,Jung Joon-Yong 대한자기공명의과학회 2023 Investigative Magnetic Resonance Imaging Vol.27 No.2
Purpose: To assess the diagnostic performances of diffusion-weighted imaging (DWI)-included non-contrast magnetic resonance imaging (MRI) compared to standard contrast-enhanced MRI for infectious spondylitis. Materials and Methods: This study involved 154 participants: a spondylitis group (n = 76) and a control group (n = 78) with Modic type 1 degeneration or recent compression fractures. Two readers independently reviewed paraspinal soft tissue signal change and abscess with 5-scale confidence scores based on two image sets: one featuring both non-contrast-enhanced MRI (NCEI) and DWI and the other consisting of NCEI and contrast-enhanced fat-suppressed T1-weighted imaging (CEFST1). The diagnostic performance of the two image sets was compared using McNemar tests for sensitivity, specificity, and area under the receiver operating characteristics (AUROC) analysis. Interobserver agreements (κ) for each images sets were also calculated. Results: The sensitivity and specificity for infectious spondylitis were 90.8% and 69.2% for NCEI + DWI, 96.1% and 60.3% for NCEI + CEFST1 in reader 1, whereas it was 92.1% and 66.7% for NCEI + DWI, and 96.1% and 68.0% for NCEI + CEFST1 in reader 2. Sensitivities and specificities were not significantly different between NCEI + DWI and NCEI + CEFST1 (reader 1: p = 0.289, 0.065; reader 2: p = 0.250, > 0.999, respectively). However, the AUROC was not considerably different between the two modalities in only one reader (p = 0.306 in reader 1, p = 0.031 in reader 2). Interobserver agreement for infectious spondylitis was moderate (κ = 0.55) in NCEI + DWI and substantial (κ = 0.66) in NCEI + CEFST1. Conclusion: Non-contrast enhanced MRI with additional DWI is as effective for diagnosing infectious spondylitis as a contrast-enhanced MRI.
Anti-quorum sensing and anti-biofilm formation activities of plant extracts from South Korea
Choi, Okhee,Kang, Dong-Wan,Cho, SuKyung,Lee, Yeyeong,Kang, Byeongsam,Bae, Juyoung,Kim, Seunghoe,Lee, JeongHoon,Lee, SeungEun,Kim, Jinwoo Medknow Publications 2018 Asian Pacific journal of tropical biomedicine Vol.8 No.8
Seungeun Ryoo,Miyoung Choi,Su-Yeon Yu,Young Kyung Yoon,Kyungmin Huh,Eun-Jeong Joo 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.1
Background/Aims: The effectiveness of remdesivir treatment in reducing mortality and the requirement for mechanical ventilation (MV) remains uncertain, as randomized controlled trials (RCTs) have produced conflicting results. Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and other data resources to find RCTs published prior to April 10, 2023. The selection of studies, assessment of risk of bias, and meta-analysis were conducted according to PRISMA guidelines. The primary outcomes were all-cause mortality and the need to initiate MV. Results: A total of 5,068 articles were screened, from eight RCTs comprising 11,945 patients. The meta-analysis found that, compared to standard care or placebo, remdesivir treatment provided no significant all-cause mortality benefit (pooled risk ratio [RR], 0.93; 95% confidence interval [CI], 0.85–1.02; 8 studies; high certainty evidence), while subgroup analyses revealed a trend towards reduced mortality among patients requiring oxygen but not MV (pooled RR, 0.88; 95% CI, 0.77–1.00; 6 studies; I2 = 4%). The need to initiate MV (pooled RR, 0.74; 95% CI, 0.59–0.94; 7 studies; moderate certainty evidence) in remdesivir-treated patients was also reduced compared to controls. Remdesivir significantly increased clinical improvement and discharge and significantly reduced serious adverse events. Conclusions: In this systematic review and meta-analysis of RCTs, it was found that remdesivir treatment did not show a substantial decrease in the risk of mortality. However, it was linked to a reduction in the necessity for additional ventilatory support, suggesting remdesivir could be beneficial for COVID-19 patients, particularly those who are not on MV.
Choi Miyoung,Lee Su Jung,Park Chan Mi,Ryoo Seungeun,Kim Sunghyun,Jang Ju Yeon,Kim Hyun Ah 대한의학회 2021 Journal of Korean medical science Vol.36 No.45
Background: Meniscal tears are commonly observed in patients with knee osteoarthritis (OA), however, clinical significance of such lesions detected by magnetic resonance imaging is in many cases unclear. This study aimed to determine the clinical effectiveness of arthroscopic partial meniscectomy (APM) compared with non-operative care in patients with knee OA. Method: We used existing systematic reviews with updates of latest studies. Three randomized controlled studies were selected, where two studies compared the effects of APM plus physical therapy (PT) with PT alone and one compared APM alone and PT alone. While 1 study exclusively included OA patients, 2 studies included 21.1 and 12% of patients with no radiographic OA. Patients with knee locking were unanimously excluded. Results: Upon comparison of APM plus PT and PT alone, there was no significant difference observed in knee function, physical activity, or adverse events. Knee pain was observed to be significantly lower in the APM plus PT group at 6 months, but there was no difference between the two groups at 12 and 24 months. With respect to the comparison between APM alone and PT alone, PT was non-inferior based on the criteria for knee function during 24 months; however, knee pain was significantly reduced in the APM alone group. Conclusions: Our study showed that knee pain was significantly improved in the APM group compared to non-operative care group at 6 months and over 24 months. Our result was based on only 3 randomized controlled trials (RCTs) revealing a significant knowledge gap, hence demanding more high-quality RCTs in OA patients.