Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

오존 발생기용 전원장치 개발 및 특성에 관한 연구

김동희,이달해,성현직,오승훈,이봉섭,배상준 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

The power semiconductor switching devices(PSSD) continuously developed, Power Electronic Technology using PSSD is gradually extended. The high frequency inverter to generate the large power high frequency subject to power electronic technology pursuit various application. Also, in emboss with environmental destruction problem cause the atmosphere and the water pollution to growth of the commercial society, the research in favor of cleansing environmental a pollutant actively proceed. Cause of having a strong oxygenization in the physical world, the ozone has sterillization effect predominantly against virus, bacteria, etc and has application in decolorization, deodorization, food storage and air cleansing and has a merit that does not cause the secondary pollution by being restored to oxygen lastly. Therefore, This project describe study on the ozone generation power supply using the high frequency electric field method and the lamp type ozone generator using photochemistry, one of method of generate ozone.

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

Targeted Exome Sequencing of Deafness Genes After Failure of Auditory Phenotype-Driven Candidate Gene Screening

Kim, Bong Jik,Kim, Ah Reum,Park, Gibeom,Park, Woong Yang,Chang, Sun O,Oh, Seung-Ha,Choi, Byung Yoon by Otology Neurotology, Inc. Image copyright © 2015 Otology & neurotology Vol.36 No.6

OBJECTIVE: To demonstrate the efficacy and advantages of targeted exome sequencing (TES) of known deafness genes in cases with failed or misleading auditory phenotype-driven candidate gene screening. STUDY DESIGN: Prospective cohort survey. SETTING: Otolaryngology department of a tertiary referral hospital. PATIENTS: Six hearing-impaired probands with seemingly non-syndromic features from six deaf families were enrolled in this study after failure of genetic diagnosis using auditory phenotype-driven candidate gene screening. INTERVENTION: TES of known deafness genes was performed in the six probands, and a final causative variant was pursued using subsequent filtering steps. MAIN OUTCOME MEASURE: Potential causative variants determined using TES were confirmed by previously introduced filtering steps. RESULTS: We detected causative variants in three (50%) of six families, and these variants were in the COCH, PAX3, and GJB2 genes. Additionally, we also recapitulated the recent finding from other report arguing for the non-pathogenic potential of MYO1A variant. CONCLUSIONS: TES of a deafness panel provides a comprehensive genetic screening tool that can be implemented without being misled by the audiogram configuration information and can complement incomplete clinical physical examinations. In addition, the secondary incidental finding obtained by TES contributes useful information regarding the deafness field.

Prediction of Dispersal Directions and Ranges of Volcanic Ashes from the Possible Eruption of Mt. Baekdu

Seung-Yeon Lee,Gil-Yong Suh,Soo-Yeon Park,Yeon-Su Kim,Jong-Hyun Nam,Seung-Hyun Yu,Ji-Hoon Park,Sang-Jik Kim,Yong-Sun Kim,Sun-Yong Park,Ja-Young Yun,Yu-Jin Jang,Se-Won Min,So-Jung Noh,Sung-Chul Kim,Kyo 한국토양비료학회 2018 한국토양비료학회지 Vol.51 No.1

To predict the influence of volcano eruption on agriculture in South Korea we evaluated the dispersal ranges of the volcanic ashes toward the South Korea based on the possibilities of volcano eruption in Mt. Baekdu. The possibilities of volcano eruption in Mt. Baekdu have been still being intensified by the signals including magmatic unrest of the volcano and the frequency of volcanic earthquakes swarm, the horizontal displacement and vertical uplift around the Mt. Baekdu, the temperature rises of hot springs, high ratios of N₂/O₂ and ₃He/₄He in volcanic gases. The dispersal direction and ranges and the predicted amount of volcanic ash can be significantly influenced by Volcanic Explosivity Index (VEI) and the trend of seasonal wind. The prediction of volcanic ash dispersion by the model showed that the ash cloud extended to Ulleung Island and Japan within 9 hours and 24 hours by the northwestern monsoon wind in winter while the ash cloud extended to northern side by the south-east monsoon wind during June and September. However, the ash cloud may extent to Seoul and southwest coast within 9 hours and 15 hours by northern wind in winter, leading to severe ash deposits over the whole area of South Korea, although the thickness of the ash deposits generally decreases exponentially with increasing distance from a volcano. In case of VEI 7, the ash deposits of Daejeon and Gangneung are 1.31 × 10<SUP>4</SUP> g m<SUP>-2</SUP> and 1.80 × 10<SUP>5</SUP> g m<SUP>-2</SUP>, respectively. In addition, ash particles may compact close together after they fall to the ground, resulting in increase of the bulk density that can alter the soil physical and chemical properties detrimental to agricultural practices and crop growth.

자가면역 호중구 감소증 1 예

김지수,양용석,김승영,부철수,이헌직,박병엽,조현장,양승호,김두형 대한내과학회 1998 대한내과학회지 Vol.55 No.5

Autoimmune neutropenia is characterized by severe neutropenia with cell-bound neutrophil antibodies or circulating antibodies for neutrophils. Diagnosis of disease is made of the basis of the presence of antibodies for neutrophil. Corticosteroid or rhG-CSF have been reported to be effective in some patients. Recently we experienced one case of autoimmune neutropenia patient who was admitted to our hospital in 1997 because of stomach cancer and degenerative joint disease. She had severe neutropenia without underlying autoimmune disease. And cell-bound neutrophil antibodies were detected by indirect immunofluorescence test. Treatments with rhG-CSF and steroid result in transient improvement of neutropenia and subtotal gastrectomy was done successfully. We herein report one case of autoimmune neutropenia patient, to our best knowledge, the first report in Korea, with a brief review of literature.

Characterization of Detailed Audiological Features of Cytomegalovirus Infection: A Composite Cohort Study from Groups with Distinct Demographics

Kim, Bong Jik,Han, Jae Joon,Shin, Seung Han,Kim, Han-Suk,Yang, Hye Ran,Choi, Eun Hwa,Chang, Mun Young,Lee, Sang-Yeon,Suh, Myung-Whan,Koo, Ja-Won,Lee, Jun Ho,Choi, Byung Yoon,Oh, Seung-Ha Hindawi 2018 BioMed research international Vol.2018 No.-

<P>Congenital cytomegalovirus (cCMV) infection is a common congenital infection that causes sensorineural hearing loss (SNHL). Despite its substantial impact on public health and cost burden, epidemiology and clinical features of CMV-related SNHL have never been reported in the Korean populations. This study investigated the detailed audiologic phenotypes of cCMV infection to see if a specific SNHL pattern is associated with a particular clinical setting. A total of 38 patients with cCMV infection were studied retrospectively. Patients were classified into three groups with distinct demographics: clinically driven diagnosis (n=17), routine newborn CMV screening according to the NICU protocols (n=10), or referral to ENT for cochlear implant (CI) (n=11). The incidence of cCMV infection was 3.6%, showing 33.3% of SNHL among cCMV patients, 38% of asymmetric hearing loss, 29% of late-onset hearing loss, and diverse severity spectrum in patients with CMV-related SNHL. CI recipients with CMV-related SNHL showed a significantly improved speech perception. Surprisingly, in 36.4 % of CI implantees, initial audiological manifestation was significant asymmetry of hearing thresholds between both ears, with better ear retaining significant residual hearing up to 50dB. CMV turns out to be a significant etiology of SNHL, first to date reported in the Korean pediatric population. Analysis of audiologic phenotypes showed a very wide spectrum of SNHL and favorable CI outcomes in case of profound deafness. Especially for the patients with asymmetric hearing loss, close surveillance of hearing should be warranted and CI could be considered on the worse side first, based on the observation of rapid progression to profound deafness of better side.</P>

Effects of transient auditory deprivation during critical periods on the development of auditory temporal processing

Kim, Bong Jik,Kim, Jungyoon,Park, Il-Yong,Jung, Jae Yun,Suh, Myung-Whan,Oh, Seung-ha ELSEVIER 2018 INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGO Vol.104 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>The central auditory pathway matures through sensory experiences and it is known that sensory experiences during periods called critical periods exert an important influence on brain development. The present study aimed to investigate whether temporary auditory deprivation during critical periods (CPs) could have a detrimental effect on the development of auditory temporal processing.</P> <P><B>Materials and methods</B></P> <P>Twelve neonatal rats were randomly assigned to control and study groups; Study group experienced temporary (18–20 days) auditory deprivation during CPs (Early deprivation study group). Outcome measures included changes in auditory brainstem response (ABR), gap prepulse inhibition of the acoustic startle reflex (GPIAS), and gap detection threshold (GDT). To further delineate the specific role of CPs in the outcome measures above, the same paradigm was applied in adult rats (Late deprivation group) and the findings were compared with those of the neonatal rats.</P> <P><B>Results</B></P> <P>Soon after the restoration of hearing, early deprivation study animals showed a significantly lower GPIAS at intermediate gap durations and a larger GDT than early deprivation controls, but these differences became insignificant after subsequent auditory inputs. Additionally, the ABR results showed significantly delayed latencies of waves IV, V, and interpeak latencies of wave I-III and wave I-V in study group. Late deprivation group didn't exhibit any deterioration in temporal processing following sensory deprivation.</P> <P><B>Conclusion</B></P> <P>Taken together, the present results suggest that transient auditory deprivation during CPs might cause reversible disruptions in the development of temporal processing.</P>

빌딩관리시스템 구축을 위한 푸시알림 클라이언트 개발 및 시설물에 대한 경고 정보 확인을 위한 앱 개발

오승진(Seung-Jin Oh),이희열(Hee-Yeol Lee),이영지(Young-Ji Lee),김정윤(Jeong-Yoon Kim),김홍직(Hong-Jik Kim),김기범(Gi-Beom Kim),박혜지(Hye-Ji Park),이승호(Seung-Ho Lee) 대한전자공학회 2021 대한전자공학회 학술대회 Vol.2021 No.11

Prediction of Dispersal Directions and Ranges of Volcanic Ashes from the Possible Eruption of Mt. Baekdu

Lee, Seung-Yeon,Suh, Gil-Yong,Park, Soo-Yeon,Kim, Yeon-Su,Nam, Jong-Hyun,Yu, Seung-Hyun,Park, Ji-Hoon,Kim, Sang-Jik,Kim, Yong-Sun,Park, Sun-Yong,Yun, Ja-Young,Jang, Yu-Jin,Min, Se-Won,Noh, So-Jung,Kim Korean Society of Soil Science and Fertilizer 2018 한국토양비료학회지 Vol.51 No.1

To predict the influence of volcano eruption on agriculture in South Korea we evaluated the dispersal ranges of the volcanic ashes toward the South Korea based on the possibilities of volcano eruption in Mt. Baekdu. The possibilities of volcano eruption in Mt. Baekdu have been still being intensified by the signals including magmatic unrest of the volcano and the frequency of volcanic earthquakes swarm, the horizontal displacement and vertical uplift around the Mt. Baekdu, the temperature rises of hot springs, high ratios of $N_2/O_2$ and $_3He/_4He$ in volcanic gases. The dispersal direction and ranges and the predicted amount of volcanic ash can be significantly influenced by Volcanic Explosivity Index (VEI) and the trend of seasonal wind. The prediction of volcanic ash dispersion by the model showed that the ash cloud extended to Ulleung Island and Japan within 9 hours and 24 hours by the northwestern monsoon wind in winter while the ash cloud extended to northern side by the south-east monsoon wind during June and September. However, the ash cloud may extent to Seoul and southwest coast within 9 hours and 15 hours by northern wind in winter, leading to severe ash deposits over the whole area of South Korea, although the thickness of the ash deposits generally decreases exponentially with increasing distance from a volcano. In case of VEI 7, the ash deposits of Daejeon and Gangneung are $1.31{\times}10^4g\;m^{-2}$ and $1.80{\times}10^5g\;m^{-2}$, respectively. In addition, ash particles may compact close together after they fall to the ground, resulting in increase of the bulk density that can alter the soil physical and chemical properties detrimental to agricultural practices and crop growth.