Sarcomatoid Carcinoma Arising from Mature Cystic Teratoma

Ho-Chang Lee1, Seung-Myoung Son, Yong-Moon Lee, Ji Hae Koo, Song-Yi Choi, Ok-Jun Lee, Eun-Hwan Jeong 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

Malignant transformation of mature cystic teratoma (MCT) is rare. Sarcomatoid carcinoma is a neoplasm comprising malignant mesenchymal cells and a conventional carcinomatous area. Here, we report on a case of sarcomatoid carcinoma arising from an MCT in the left ovary of a 45-year-old female. A unilocular cyst consistent with MCT was observed; however, a nodule within the cyst was confirmed from the resected ovary. Microscopically, the nodule showed both squamous cell carcinoma and pleomorphic sarcomatous components admixing with each other. Lining epithelial cells at the periphery of the main tumor showed squamous metaplasia. When a sarcomatous component is observed in the ovary tumor, it is important to find a squamous cell component, either benign or malignant.

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

한국인에게 적절한 기관삽관 위치

이승한,최옥경,정구영,정성필 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Endotracheal intubation is one of the important procedures in ED and various fields. Endobronchial intubation can lead to hypoxemia secondary to tension pneumothorax of intubated side and atelectasis of contralateral side. The placement of tube beyond the vocal cords may results in inadvertent extubation, larygeal spasm and aspiration pneumonia. The conformation methods of endotracheal intubation are auscultation of the chest, observation of a vapor trail, oximetry and capnography, and radiologic evaluation. Owen and associates recommended that oral intubation tubes at the upper incisor teeth at the 23cm in men and the 21cm in women of average adult size would have led to proper placement. We studied that whether the proper depth of endotracheal tube in American is appropriate to Korean. We studied adult patients admitted to ED (of both hospitals during March in 1995. Endotracheal tubes in men were positioned at the 23cm and women had positioned at the 21cm at the upper incisor teeth. The distance of the tip of the endotracheal tube to the tracheal carina on the postintubation chest X-ray then determined. Correct placement of intubation was defined with the tip of the tube≥3cm above the carina and below the level of the larynx. Fifty adult patients were enrolled in the study ; 29 men (58%) and 31 women (42%). Mean height and weight were 170±5.2cm, 68±9kg in men and 158±6.5cm, 56±10kg in women. Reasons for intubation were ; respiratory failure(38%), trauma(16%), increased intracramial pressare(16%), drug intoxication(12%), shock(8%), cardiac arrest(7%)and others(3%). The mean distance from the tip to carina on chest X-ray was 4.13±1.5cm in men and 3.45±2.1cm in women. Proper position was 27/29(93%) in men, 14/21(67%) in women or 41/50(82%). this means the placement of endotracheal tube of our patients was positioned deeper than prion study group(97.6%).(p<.05) We recommend that the 22cm tube mark for men and 20cm tube mard for women at upper incisor teeth would have led to proper placement in Korean adult patient.

글루코오스의 분해반응에 미치는 금속이온의 영향

이민규,이송우,허목,송승구 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

The objective of this research was to study the chemical kinetics of the decompo-sition of glucose in the presence of acid catalyst and metal ion. In this experiment. the range of variables investigated was covered temperature from 160℃ to 180℃ and concentration of 4% to 11% (W/V) sulfuric acid and metal sulfate concentrations, 1.0×10^(-3) to 2.5×10^(-2) gmol/l. It is shown that glucose disappearance follows a first-order reaction mechanism and the glucose decomposition reaction is dependent on both the reaction temperature and the catalyst concentration. And the presence of chromic ion accelerates the decompo-sition reaction of glucose, but presence of ferric and nickel ion rarely influence the reaction.

집진용 세라믹 필터의 제조 및 공기 투과 특성

이승인,박재구,정재화 한양대학교 환경공학연구소 2000 環境科學論文集 Vol.21 No.-

슬러리발포 및 겔캐스팅법을 이용하여 세라믹 다공체를 제조하였다. 또한, 이를 분진제거용 여과재로 응용하기 위해 기공구조 및 공기 투과율에 관한 연구를 실시하였다. 기공률은 80% 정도이며, 100㎛와 200㎛, 두 종류의 기공크기를 갖는 다공체를 제조하였다. 기공들은 창(window)을 통해 연결된 연속성 기공구조를 갖는다. 미세분진을 제거하기 위해, 다공체의 한쪽 면은 표면여과층을 형성하였으며, 기공크기는 10 ㎛이하이다. 기공크기가 200㎛인 다공성지지체의 경우, 900∼1000×10-13 ㎥의 투과율은 나타내었으며,기공크기가 100㎛인 지지체의 투과율은 600∼700 × 10-13 ㎥로 각각 측정되었다. 표면여과층이 형성된 여과재의 투과율은 약 200 × 10-13 ㎥로서 지지체의 기공크기에 관계없이 거의 일정한 값을 나타냈다. 또한, Flyash 분진을 이용하여 측정한 여과재의 집진효율은 99.9% 이상인 것으로 나타났다. This study was carried out to evaluate the pore structure and air permeability of the foam ceramic filter prepared by using foam method. Two different types of agents, Benzethonium chloride(C27H42NO2Cl) and Sodium Lauryl Sulfate(CH3(CH2)11OSO3Na) were used for foaming slurry. Porosity of foam ceramics was about 80 % and pore sizes were differed as 200 and 100 ㎛ respectively according to types of agents. It was observed that foam ceramics had continuous pore structure that pores were connected each other by small pathways called windows. For collecting dust, one side of foam ceramic support was coated with fine particles that the size was 20∼50 ㎛. Pore size of the coating layer was under 10 ㎛. Permeability of foam ceramics is proportional to pore size. But coated ceramic filters have similar values without regard to pore size of supports. The permeability of supports was varied with pore size in the range of 600 × 10-13 ㎥ to 1000 × 10-13 ㎥. And for the case of the coated ceramic filter, it was about 200 × 10-13 ㎥. As a result of dust collection test with fly ash, the particle removal efficiency for the oeramic filter specimen was estimated over the 99.9%.

강의 현대화 추진 및 활용방안 연구

구경완,이근복,장종국,김재홍,김영환,최제영,이승훈 永同大學校 1997 硏究論叢 Vol.3 No.1

본 연구는 각종 첨단 기자재를 활용한 강의 현대화 방안을 모색함으로서 공학교육의 효율성을 도모하고 학생들의 학습동기를 유발하여 창조적 능력을 갖츤 전문기술 인력을 양성하는 데 도움을 주고자 하는 것이다. 이를 위하여 현행 공학교육의 현황과 문제점을 분석하고 강의 현대화 사례를 조사하여 본 연구의 기초자료로 삼고자 하였으며, 학부·전공별 강의 현대화 추진 실태분석 및 개선방안을 모색한 후 이상의 연구결과를 종합하여 향후의 강의 형대화 추진방향을 걸정하였다. This study aims to help bring up the well-skilled and creative engineers by searching the modernization of education using various high technology facilities. For this, we analyzed the general condition and problems of current engineering education and surveyed the case study of the modernization of education as basic study. After analyzing the existing situation of promotion searching the proper improvement methods of it, we proposed the new direction of the modernization of education from now on.

착화제와 유기산이 Wistar rat체내의 Sr 분포에 미치는 영향

이기호,이제호,박상윤,이승훈,유용운,윤택구 대한방사선 방어학회 1990 방사선방어학회지 Vol.15 No.2

Wistar rat에 85SrCl2를 꼬리 정맥에 주사하여 체내 기관과 혈액 내 분포, 잔존율을 조사하였고 착화제와 유기산을 투여하여 혈장 단백질에 결합하는 Sr양의 변화를 측정하였다. 혈액내에서 Sr은 혈장에 60%, 세포에 40%부착되어 이동하였다. 혈장에 존재하는 Sr중 약 50%정도는 혈장 단백질과 결합한 상태였고, 세표에는 세포 표면에 가볍게 부착되어 있었다. Erythrocyte나 granulocyte보다 lymphocyte에 많은 양의 Sr이 부착되어 있었다. 투여후 초기 1시간 이내에 혈액 내에서 급격히 감소하여 뼈에 침착되었다. 이때 각 기관에서도 Sr의 잔존율은 24시간 이내에 크게 감소하였고, 뼈로 침착된 Sr은 24시간 이후에 서서히 감소하였다. 착화제 EDTA, EGTA 및 DTPA를 투여한 경우, 혈장 단백질에 결합하는 Sr의 양은 대조군의 57%에서 27-33%로 감소하였으며 citrate 및 oxalate의 투여시는 이값이 19%와 40%로 각각 감소하였다. 85SrCl2 was injected to the tail vein of Wistar rats and investigated its distribution and clearance in the tissues and blood. We also measured the changes in Sr binding to the blood plasma protein by administrating chelating agents and organic acids. For the blood, 60% of the Sr occurred in the plasma and 40% on the cell membrane. Fifty percent of Sr in the blood plasma was bound to plasma protein. Sr on the cell membrane seemed to be bound loosely. The binding in the lymphocyte was higher than in the erythrocyte and granulocyte. Within one hour Sr was quickly disappeared from the blood stream, to be accumulated in the bone. Twenty four hours after the injection, Sr decreased rapidly in the organs of soft tissue, but slowly in the bone. The binding of Sr to plasma protien decreased from 57% of the control to 27-33% in the group treated with chelating agents. EDTA. EGTA and DTPA and to 19% and 40% in the groups treated with organic acids, citrate and oxalate, respectively.

양안 근점거리의 분포형

구정완,오민화,이승한 가톨릭대학산업의학센타 산업의학연구소 1991 韓國의 産業醫學 Vol.30 No.2

Near point distance for both eyes of 71 healthy subjects. who no special eye conditions, were measured in order to clarify their distribution form and to select a measure that is suited to continuous observation of visual fatigue of VDT workers. The results were as follows: 1. Near point distance for both eyes(appear. disappear) followed normal distribution only after natural log-transformation(Shapiro-Wilk test). 2. The variance and the coefficient of variation of near point distance(appear) were 0.04 and 4.13, respectively, while they were 0.08 and 6.30 in near point distance(disappear). The findings suggested that near point distance(appear) could be a preferable measure to near point distance(disappear)in the sequential monitoring of visual fatigue. 3. The mean near point distance(appear, disappear)for both eyes of study subjects were 138,82 mm in the age4 group of 20-29 years and were 156,97 mm in the age group of 30-39 years. respectively.

중심구 부위에서 발생하는 간질의 수술적 치료

이상구,홍승철,홍승봉,서대원,김종현 대한간질학회 1998 대한간질학회지 Vol.2 No.1

은행원의 VDT작업에 따른 안자각종상

구정완,이승환,이자영 가톨릭대학산업의학쎈타 산업의학연구소 1991 韓國의 産業醫學 Vol.30 No.5

In order to investigate the effects due to visual display terminal(VDT) work of banking operations, the questionnaire survey for subjective eye symptoms was carried out on 378 bank clerks who had been engaged in VDT work for various length of work hours. The results were as follows: 1. Of the 17 items of questionnaire, the highest percentage was accounted for by 'eye strain' (61.1%),follwed by 'feel pressure in eyes'(33.3%),'eyes feel ache' (26.7%),'eyes feel heavy'(21.4%) and 'blurred vision of objectl'(16.7%) in the order of sequence. 2. The average weighetd score of subjictive eye symptoms was 13.75, 14.39, 16.78 and 13.13 in the age groups of less than 25,25-29, 30-34, and 35-44 years, respectively, it was significantly increased from the age group of less than 25 years to 30-34 years. Also, it was significantly increased according to increasing with work duration. 3. The average weighted score of female was larger than that of male and the score of green color was larger than that of black-white color by the color of cathode ray tube display. 4. Aggravating time of subuective symptioms was during the end of month in period of a month, a monday in a day of week and on duty (P.M.) in a daily work.