한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

XML과 컴포넌트 생성 시스템을 이용한 소프트웨어 재사용

최승훈 덕성여자대학교 자연과학연구소 2002 자연과학 논문집 Vol.8 No.-

대규모의 소프트웨어 개발 시 생산성을 높이고 신뢰성 있는 프로그램 개발을 위하여 컴포넌트 단위의 재사용에 대한 연구가 최근 활발히 진행되고 있다. 본 논문에서는, 컴포넌트 재사용자가 자신의 목적과 환경에 보다 적합한 컴포넌트를 자동 생성할 수 있도록 해주는 컴포넌트 생성 시스템을 제안한다. 컴포넌트 생성 시스템은, XML 형태의 컴포넌트 코드 명세서 생성을 위한 사용자 인터페이스를 자동 생성하는 '컴포넌트 마법사 생성기'와 XML형태의 컴포넌트 코드 명세서를 읽어들여 컴포넌트 코드를 자동 생성하는 '컴포넌트 코드 생성기'로 구성된다. 컴포넌트 생성 시스템 개발자는,개발하고자 하는컴포넌트 패밀리에 도메인 공학을 적용하여 특성 모델(Feature Model)을 정의하고 이로부터 각 컴포넌트의 차이점(variability)을 분석하여 컴포넌트 생성 시스템을 구축한다. 컴포넌트 재사용자는 컴포넌트 마법사를 이용하여 각 컴포넌트의 차이점을 XML형태의 코드 명세서로 표현함으로써, 자신의 목적에 맞는 컴포넌트를 자동 생성한다. 사례 연구로서, Button 자바빈즈를 위한 컴포넌트 자동 시스템 구축 과정과 재사용 과정을 보인다.

≪黃帝內經≫의 體質論 : 韓醫學의 體質論에 關한 硏究,其一

崔昇勳 대한동의병리학회 1992 동의생리병리학회지 Vol.7 No.-

One's constitution is formed congenitally and is also acquired, and is relatively stable in its individually manifested function, structure and temperament. It has characteristics of universality, complexity, generality and continuity. It is also manifested in physiological responses and expresses pathologic tendencies including susceptibility. Attempts at understanding constitution has had a long history throughout the world. In Traditional Chinese Medicine(TCM), the constitution had been acknowledged from the Huangdi Neijing, which has been a Bible in TCM for about two thousand years. In many aspects, the Huangdi Neijing provides the basis for both basic and practical fields. In order to derive the ideal structure from the Neijing to Lee Jay-ma's Four Type Constitutional Ideas, which can strengthen the understanding of the ideal core of TCM's constitutional characteristics, the author launched his analysis of the constitutional understandings in the Neijing as a first step and came to the following: 1. The constitutional understanding in the Neijing was done both via the physiological responses to heat, pain and acupuncture treatment and the pathologic tendencies via body structure strength, body heat, courage and obesity. 2. It was recognized that the constitution was formed congenitally and also acquired factors like living conditions including food customs and residents, geographical and social conditions were explained in detailed. 3. The constitutional typology was suggested both by the general and systematic criterion according to the Yin-yang and the Five Phase theories and by single criterion such as obesity, courage and the response to acupuncture treatment. 4. As diagnosis is to the constitution, courage was adopted for the disease caused by emotions, obesity was for its manifestations of chi and blood, the quantities of chi-blood and Yin-yang in the typology by the Yin-yang and the Five Phase theories were suggested. 5. In the cases of obesity, Yin-yang and Five Phase theory, treatment according to the constitutional ideas was mentioned, and their goals were concluded as "being the balancing between Yin and Yang" which means the Yin-yang theory is more practical than the Five Phase theory in the Traditional Chinese constitutional medical field. According to the above understandings, the author would like to suggest that the constitutional ideas in the Huangdi Neijing based on the Yin-yang theory blossomed via the practical spirit of Zhang Zhong-jing's《Shang Han-Lun》and at last from Lee Jay-ma's Four Type Constitutional Medicine which realized "the balancing between Yin and Yang" through the practical application of herbal treatments.

鬱金이 Angiogenesis 抑制機轉에 미치는 影響

崔昇勳,安圭錫,成熙根 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

This experimental study was carried out to evaluate the effects of Curcuma on angiogenic inhibition mechanism. In order to investigate the effects of Curcuma on angiogenic inhibition mechanism evaluate cell survival rate by MTT assay, cell adhesive inhibition effect, DNA fragmantaion analysis. Nuclear Condensation assay FACScan analysis, angiogenesis inhibition assay. Immunocytochemistry analysis, RT-PCR for mRNA expression. Western Blot analysis. The results were summarized as follows : 1. The IC50 was 10㎍/ml to ECV 304 cell. 2. The cell adhesive inhibition ability was strong from 5㎍/ml. 3. The G0/G₁arrest peak was existed on ECV304 cell-line. 4. The cells on Collagen plate were inhibition of proliferation and inducement of apoptosis by Cur water extract. 5. Lumen formation was inhibited by Cur water extract. 6. LFA-1 and ELAM-1's expression were inhibited by Cur water extract, they are commenly participation on inflammation and tumor regeneration. 7. The expression of MMP-9 and uPA were inhibited by Cur water extract. 8. The expression of integrin αvβ₃ was inhibited by Cur water extract. 9. The expression of intracellular molecule were successively inhibited by Cur water extract therefore the proliferation of ECV304 cell line was stopped and apoptosis was induced. According to the results Curcuma has been shown to be a key antagonist of intergrin αvβ₃and which seems to be apoptosis by P53 through Flow cytometry. This report demonstrated that expression of MMP-9 and uPA blocked to under angiogenesis model. Thus, we suggested that Curcuma water block angiogenesis by inducing unscheduled apoptosis in ECV304 and ECVPAR cell lines and another orient herbal medicine that treat Qi-stagnation and Blood-stasis type also have angiogenic inhibition effects.

새로운 무기 응집제 개발에 따른 특성

최성우,우성훈,윤철종,곽명화,서향미,박승조 동아대학교 환경문제연구소 2000 硏究報告 Vol.23 No.1

This study has carried out the coagulation tests for tannery wastewater including high-level suspended solids and organic matters to determine the optimum pH and coagulant dosage and to characterize several coagulants for coagulation. In case of optimum pH range test, we know that multi-coagulants are not only cost-effective but also applicable from acidic pH range to alkaline pH range widely, while single-coagulant are useful in limited pH range. Removal efficiency for using of the multi-coagulants appeared more efficient than that of single-coagulant. Especially, sulfates(alum-ferric sulfate : AFS & alum-magnesium sulfate : AMS) are more effective than chlorides (alum-ferric chloride : AFC & alum-magnesium chloride AMC). In comparison of residual turbidity related to settling time between alum and alum-ferric sulfate-magnesium sulfate(AFM), it took to 40 minutes using of alum but 5 minutes using of alum-ferric sulfate-magnesium sulfate(AFM) until constant residual turbidity are reached.

영암농협의 산지유통전문조직 유통활성화 사업에 관한 고찰 : 완숙 토마토를 중심으로

최훈,이승현 東新大學校 2002 論文集 Vol.12 No.-

The price of fruits and vegetables is very fluctuating according to the unbalance of demand and supply. Thus, price depreciation causes burdens to farmers. Agricultural cooperative needs to be ready to accept the quickly changing marketing environment. The main objective of this study is focused on giving directions how Young-Arms's Agricultural cooperative should set up the new framework so that farmers could be able to receive reasonable prices of matured-tomatoes. In addition this study pointed out guidelines how agricultural cooperative manages producer's organization, group selection and group computing and billing systems. This study also introduced how to improve import of tomatoes to Asian countries as well as how to widen distribution channels domestically. Researchers state that agricultural cooperative will accomplish its goal of effective distribution channel when producer's organization trust cooperative fully.

『管子』四篇 等에 나타난 精氣說 考察

崔昇勳,朴奭濬 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 본 논문은 韓醫學 이론의 가장 기본이 되는 氣槪念의 역사적 형성 과정을 추적하여 한의학의 철학을 확립하기 위한 연구의 한 부분이다. 『黃帝內徑』이 저작된 시기를 전후하여 어떠한 사상적 흐름이 있었으며, 그것이 한의학 이론의 형성에 어떤 영향을 미쳤는지를 氣개념 형성을 중심으로 해명하고자 한다. 이를 위해 『管子』의 사상에 대하여 氣(精氣)論을 중심으로 알아보고 그것이 당시의 韓醫學 理論의 形成過程에 어떤 영향을 미쳤으며 그 결과 韓醫學의 내용과 방향은 어떻게 변해 갔는지를 알아보고자 하였다. 방법 : '『管子』四篇' 과 더불어 「水地」編, 「四時」編, 「五行」編 등을 주요한 연구 대상으로 하여, 당시의 시대적 배경과 사상사적 배경을 알아보고 특히 黃老之學의 내용이 무엇이었는지를 살피고 주제와 연관된 『管子』의 원문을 정리·분석하여 그 결과를 요약하는 것으로 한계를 설정하였다. 결과 : 戰國未에서 漢初에 걸친 사상계의 큰 흐름은 도가였으며 그 주류는 다름 아닌『관자』를 중심으로 한 黃老之學이다. 黃老之學은 단순한 諸思想의 集合이 아니라 "당대의 과학의 총채" 나아가 패러디임 혹은 사상의 전환으로도 이야기될 수 있다. 『관자』의 정기설은 고대의 氣개념과 '精'개념을 결합시킨 것으로 이는 '精氣一元論'이라고도 할 수 있는데 『內徑』의 精氣개념과는 그 기본 발상에서 일치하고 있다. 결론 : 養生이 精氣의 문제와 결합되어 의학이론발전에 많은 역할을 했다. 「水地」篇은 물이 만물의 근원이라는 입장에서 인체 역시 물에서 근원하는 것으로 본다. 한편 「水地」篇의 오행체계는 古文·今文의 문제와 함께 앞으로 연구해야 할 과제이다. 四象醫學의 '四元論' 역시 새롭게 연구할 대상으로 부각되었다. In order to investicate into the process of formation of Oriental Medicine Theory in ancient China Kuan Tzu(『管子』) may be a proper source. Especially five chapters of the text(「心術」上,「心術」下,「內業」,「白心」,「水地」) are abudant in the concept of 'Ch'i’or 'Jing'(精). The results of the analysis of Kuan Tzu are as follows. 1. Kuan Tzu was constituted in the time of Warring States and became one of the most important works of Huang-Lao school(黃老學派). Huang-Lao school is characterized by the unification of Taoists and Legalists. It was the summit of all sciences at that time, and became the basis of further unification of all thoughts. 2. Besides Kuan Tzu, the famous works of Huang-Lao school are Four Books of Huang-ti(黃帝內經),Huang-ti nei-ching(『黃帝內經』),Huai-nan-tzu(『淮南子』),Annals of Spring and Autumm(『呂氏春秋』), and they made a contribution to the establishiment of Confucian classics(經學). 3. Inspite of the concepts like Tao that is inherited from Taoism, Kuan Tzu proceeds the Taoism. That is, the concept of Tao in Kuan Tzu is more realistic and concrete than that of Taoism. Tao in Kuan Tzu is unificated into the concept of ‘Jing CH'i’(精氣), thus it may be called ‘Jing CH'i monism.’ 4. Kusn Tzu is combined with health preservation, so it contributed to the formation of medical theory, and is closely related with the formation of Huang-ti nei-ching. 5. The chapter ‘Sui-chi’(「水地」篇) recognizes Water to be a source of the world. Man is derived from Water, too. Water can be substituted for‘Jing CH'i’. So-called ‘Jing CH'i monism’is a fluent and open system. 6. The expression that “Water is a blood vessle in the Earth. It is just like the blood vessle in the body” gives us the fact that the concept of Meridian was generalized at that time. 7. The systems(arrangements) of Five Elements in Kuan Tzu are different from those of Huang-ti nei-ching. And the system of Sasang-EuiHak(四象醫學) is different from that of other medical systems. The reason why they are so different from each other should be invesgated into forward. These are the results of this paper.

胃癌에서의 辨證分型에 關한 文獻的 考察

崔昇勳,沈範相 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 최근 생활상의 변화에 따른 종양의 발생빈도가 증가하고 있으며 이에 따른 각종 임상보고 및 실험보고가 활발하게 이뤄지고 있으나 암에 대한 동서의학간의 인식과 접근의 차이에 따라 실제 임상상에서 많은 혼란이 일고 있다. 가령 胃癌의 경우 이에 해당하는 한의학적 병증으로는 積聚, 비하, 현벽, 反胃, 伏梁, 胃脘通, 심하비 등이 거론될 수 있으며 각각의 변증분형까지 살펴본다면 더욱 혼란스럽다. 이에 따라 본 논문에서는 위암의 변증분형을 예로 삼아 문헌적인 고찰을 통해 그 규범화 가능성을 살펴보았다. 방법 : 위암의 주된 증상중에서 한의학적 병증으로 대표적이라고 생각되는 위완통, 반위의 병인병기 및 변증분형을 고찰하였고 이를 현대 중국의 중서외결합에 의한 변병의 기초위에서 행해진 위암의 변증분형과 상호 비교하였다. 결과 : 병인병기 방면에서는 대개 위암, 위완통, 반위가 별 차이없이 중복되고 있으나 변증분형에서는 위완통의 경우 氣滯(肝胃不和)만이, 반위의 경우 反胃初氣를 제외한 脾胃虛寒, 命門火衰, 眞陰枯虧, 酒濕傷脾 등이 위암의 변증분형과 대체로 일치하고 있다. 결론 : 위완통은 早期胃癌에, 반위는 進行癌 혹은 胃癌의 末期에 상당하는 것으로 생각된다. 위암의 발생과 발전 등에 따른 病期別로 해당하는 한의학적 병증들에 대한 문헌적 비교고찰이 필요하며 보다 심화된 연구와 변증분형의 규범화를 위해서는 정확한 임상적 보고가 필요한 것으로 생각된다.