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Synthesis and NIR Absorption Properties of Triethylene Glycol Substituted Metallo-Naphthalocyanines
Seong-Hun Han(한성훈),Gopal Balamurugan(고팔 발라무루간),Jae Woong Jang(장재웅),Fayong Sun(손법용),Nguyet N. T. Pham(팜티누구엣),Seung Geol Lee(이승걸),Jong S. Park(박종승) 한국고분자학회 2021 폴리머 Vol.45 No.6
다양한 전이 금속의 존재하에서 트리에틸렌 글리콜(TEG) 치환체를 가지는 함금속 나프탈로시아닌 유도체(MNPcs)을 합성하고, 이들의 광학적 및 근적외(NIR) 영역에서 흡수 특성을 조사하였다. UV-Vis 스펙트럼 측정 결과에 따르면 MNPcs는 나프탈로시아닌 구조 주변부에 부가된 페닐링과 비주변부(non-peripheral) 위치에 치환된 전자주게 치환체로 인해 NIR 영역에서 강한 흡수 특성을 나타내었다. 또한, MNPcs의 최대 흡수파장은 중앙부 금속의 종류에 따라 780에서 950 nm까지 광범위하게 조정할 수 있었다. 또한, 친수성이 강한 TEG 치환체가 존재함에 따라 극성 용매에서의 용해도와 고분자 매트릭스에 대한 상용성이 크게 증진하는 효과를 나타내었다. 높은 NIR 영역 흡수 및 가시광 투과도를 보이는 MNPc의 특성을 이용하여 근적외 차단 필름을 제조하였다. 니켈-나프탈로시아닌(nickel naphthalocyanine)을 포함하여 근적외 차단 필름을 제조하였을때 안티몬 주석 산화물(ATO) 단독 대비 가시광선 투과성은 그대로 유지하면서 근적외 차단 성능을 향상할 수 있는 것으로 확인되었다. 상기 결과로 보건데 근적외 차단 물질로서의 함금속 나프탈로시아닌의 효능을 확인할 수 있으며, 이는 근적외 흡수성과 극성 매체에 대해 상용성을 동시에 발휘하는 것에 기인하는 것이다. Naphthalonitrile substituted with triethylene glycol (TEG) in the presence of transition metals synthesized a series of metallo-naphthalocyanine derivatives (MNPcs), and it was investigated that the optical and near-infrared (NIR) absorption properties. In UV-Vis spectra measurements, these MNPcs exhibited strong absorption in the NIR regions because of the annulated benzene ring of naphthalocyanine and highly electron-donating substituents attached at the non-peripheral positions. The absorption wavelength of MNPcs was effectively adjusted in NIR ranges from 780 to 950 nm by inserting various central metals. Additionally, the presence of TEG-substituents in MNPcs significantly enhanced the solubility in highly polar solvents and the compatibility with the polymer matrix. NIR blocking films were fabricated for taking advantage of high NIR absorption and visible transmittance. When NIR film was fabricated with nickel-napthalocyanine, it was confirmed that the NIR cutting property can be improved while maintaining the visible light transmittance compared to the antimony tin oxide (ATO). From the observations, the feasibility of designed MNPcs as an effective NIR blocking material was evidenced, which is attributed to its strong NIR absorption and compatibility in the polar mediums.
막성 신병증 환자에서 병발된 특발성 자가면역성 혈소판 감소증
김지현 ( Kim Ji Hyeon ),한성훈 ( Han Seong Hun ),유영진 ( Yu Yeong Jin ),박원도 ( Park Won Do ),전윤경 ( Jeon Yun Gyeong ),이현순 ( Lee Hyeon Sun ) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
Membranous glomerulonephropathy is the most common cause of nephrotic syndrome in adults and idiopathic autoimmune thrombocytopenic purpura is autoimmune disease caused by autoantibody to platelet membrane glycoprotein. Although there are some pathologic similarity between two diseases that `membrane attack complex` play a role in pathologic process, but only 3 cases worldwide are reported about membranous glomerulonephropathy associated with idiopathic autoimmune thrombocytopenic purpura. So we report a case of sixty eight years of woman who had symptoms of generalized edema, foamy urine, anorexia and thrombocytopenia on admission and developed more severe symptomatic thrombocytopenia there after. She was diagnosed membranous glomeulonephropathy on renal biopsy and also diagnosed idiopathic autoimmune thrombocytopenic purpra on bone marrow biopsy and on the basis of exclusion.
경쾌수 ( Kwae Soo Kyung ),송영수 ( Young Soo Song ),한성훈 ( Seong Hun Han ),김정수 ( Jung Su Kim ),이혜경 ( Hye Kyung Lee ),이윤우 ( Yun Woo Lee ) 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.1
Dermatomyositis is a group of connective tissue disorders characterized by nonsuppurative inflammation of the skeletal muscle and skin lesions. It is associated with malignancy, especially of the stomach, lung, overy and breast. we report a case of dermatomyositis with uterine cervical concer. A 78 year old female patient was admitted because of progressive proximal muscle weakness, skin rashes, and vaginal spotting. She was bedridden because of severe proximal muscle weakness and atrophy, unable to elevate her head, and suffered from dysphagia. Gottron`s patches were found on the knuckles of the hands, scaly erythematous rashes on the extensor surfaces of bilateral elbows, wrists and knees. The serum concentrations of muscle enzymes were elevated, the biopsy of quadriceps muscle showed the features compatable with myositis, and the uterine cervical biopsy revealed squamous cell carcinoma, which was determined to be in stage IIb by pelvic CT. Radiotherapy(total 3240 cGy) was done for the cervical cancer and prednisolone (initially 60mg/day) was given for the dermatomyositis. The muscle power improved only a little although the concentrations of serum muscle enzmes returned to normal. She deceased of aspiration pneumonia 43 days after the admission.
슬관절 골관절염 환자에서 Tylenol-ER(extended relief)과 Naproxen의 치료 효과 및 위장관 부작용 비교: 다기관 임상연구
이상헌 ( Sang Heon Lee ),김성일 ( Sung Il Kim ),류완희 ( Wan Hee Yoo ),서창희 ( Chang Hee Suh ),이수곤 ( Soo Kon Lee ),김진석 ( Jin Seok Kim ),고은미 ( Eun Mi Koh ),한성훈 ( Seong Hun Han ),이윤우 ( Yun Woo Lee ),지종대 ( Jong Dae 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.2
Objectives: The symptomatic treatment for knee pain due to osteoarthritis(OA) often involves drugs with antiinflammatory and/or analgesic effects, but the needs for antiinflammatory agents has been argued because of serious gastrointestinal adverse events. Accordingly, we compared the efficacy and gastrointestinal side effects of a nonsteroidal antiinflammatory agent, naproxen with those of Tylenol-ER, a newly developed sustained release form of acetaminophen. Methods: One hundred six patients with OA of the knee were enrolled in a single blinded short term 8-week multicenter trial, randomly assigned to receive Tylenol-ER(acetaminophen 3900mg/day, 52 cases) or naproxen(1000mg/day, 54 cases). They were evaluated for pain score(visual analog scale, 0-10cm) and Lequesne index after 4, 8 weeks of treatment as well as the physician`s and patient`s global assessment at the end of study. Gastrointestinal side effects were evaluated by questionnaire for various gastrointestinal symptoms and total ingestion of antacids during the study. Results: After 4 weeks of therapy, both Tylenol-ER(TYR) and naproxen(NPX) group had significant improvement in pain score and Lequesne index. Among studied patients, 33 patients(31.1%) did not complete 8 weeks of treatment for various reasons such as side effects and patient`s intolerance, but the withdrawal rate was similar in each group. The improvement in patient`s and physician`s global assessment was seen in 65.7% of TYR group, 60.5% of NPX group. Gastrointestinal adverse events such as epigastric pain and dyspepsia were slightly more frequent in NPX group(29.6% vs 23.1%), and mean ingestion of antacids was slightly more in NPX group than in TYR group. Abnormal transaminase elevation was noted in minority of patients(TYR: 2, NPX: 1 case). Conclusion: In short-term trial, the efficacy of high dose Tylenol-ER(3900mg/day), an simple analgesics, in the control of knee pain due to OA of knee was similar to that of naproxen. The frequencies of gastrointestinal side effects tended to be lower in Tylenol-ER group than in naproxen.