고호모시스테인증과 동반된 소뇌출혈 1예

홍석찬,안재영,조수진,정진상,이광호,홍승철,변홍식 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

顎關節機能障碍 診斷을 爲한 頭部軸方向 放射線寫眞에서의 下顎顆頭의 位置分析

卞鍾秀,崔珣哲,金碩鎬 大韓口腔顎顔面 放射線學會 1991 Imaging Science in Dentistry Vol.21 No.1

저자는 顎關節機能障碍의 소견을 가진 환자 75명과 顎關節機能障碍의 病歷 및 現症이 없는 정상인 75명을 표준화된 조건하에서 頭部軸方向放射線撮影을 하여 顆頭水平角과 initial 및 final depth of cut를 측정하고 통계학적으로 분석한 결과를 다음과 같이 요약할 수 있었다. 환자군과 정상군, 患側과 非患側에 있어 顆頭水平角과 initial 및 fianl depth of cut는 통계학적으로 유의한 차가 없었으므로 頭部軸方向放射線寫眞은 임상에서 顎關節機能障碍의 유무 및 患側과 非患側의 감별에 이용하기에 부적합한 방법이라 사료된다. 본 연구의 계축치는 편차가 심하므로 환자마다 顆頭水平角을 측정하여 이각에 맞추어 顎關節斷層撮影을 해야 한다고 사료된다. The purpose of this study was to analyze the position of mandibular condyle on the submentovertex radiopgraph, thereafter to evaluate the usefulness of submentovertex radiograph in diagnosis of temporomandibular joint dysfunction, and to check the best method of tomographic techniques. Submentovertex radiographs which were taken in 75 temporomandibular joint dysfunction patients and 75 normal persons were used as the sample for this study. The obtained results were as follows: The submentovertex radiograph was a improper method in diagnosis of temporomandibular joint dysfunction and discrimination of affected side. The selective tomography was a better method than any other tomographic techniques in diagnosis of temporomandibular joint dysfunction.

顎關節機能장애 珍斷을 爲한 頭部軸方向放射線寫眞에서의 下顎顆頭의 位置分析

金碩鎬,卞種秀,崔珣哲 慶北大學校 齒科大學 1986 慶北齒大論文集 Vol.3 No.1

著者는 顎關節機能障碍의 소견을 가진 환자 75명과 악관절기능장애의 炳歷 및 現症이 없는 정상인 75명을 표준화된 조건하에서 頭部軸方向放射線撮影을 하여 顆頭水平角과 initial 및 final depth of cut를 측정하고 통계학적으로 분석한 결과를 다음과 같이 요약할 수 있었다. 환자군과 정상군, 患側과 非患側에 있어 顆頭水平角과 initial 및 final depth of cut는 통계학적으로 유의한 차가 없었으므로 頭部軸方向放射線寫眞은 임상에서 악관절기능장애의 유무 및 患側과 非患側의 감별에 이용하기에는 부적합한 방법이라 사료된다. 본 연구의 계측치는 편차가 심하므로 환자마다 顆頭水平角을 측정하여 이각에 맞추어 顎關節斷層撮影을 해야 한다고 사료된다. The purpose of this study was to analyze the position of mandibular condyle on the submentovertex radiograph, thereafter to evaluate the usefulness of submentovertex radiograph in diagnosis of temporomandibular joint dysfunction, and to check the best method of tomographic techniques. Submentovertex radiographs which were taken in 75 tempormandibular joint dysfuction patients and 75 normal persons were used as the sample for this study. The obstients results were as follows : The submentovertex radiograph was a improper method in diagnosis of temporomandibular joint dysfuction and discrimination of affected side. The selective tomography was a better method than any other temographic techniques in diagnosis of temporomandibular joint dysfunction.

특허취득의 공시효과

김석진,변현수,진명용 慶北大學校出版部 2004 經商論集 Vol.32 No.1

Using a sample of 352 patent registrations announced by 65 firms during the 1990~2000 period, this paper investigates the announcement effect and factors affecting three-day, from -1 to +1 day, cumulative abnormal returns(CAR). We find that both abnormal returns on the announcement day and CAR(-1, +1) are 1.41% and 1.46%, respectively and all are significantly positive at the 1% level. This evidence means that the patent registrations increase shareholder wealth. Cross-sectional regression analysis reports that investment size in research and development (R&D) has a significantly positive effect on CAR(-1, +1) and firm size significantly negatively affects it.

근치적 전립선적출술 후의 병리학적 결과 예측인자로서의 전립선특이항원, 직장수지검사, 경직장 전립선초음파검사및 경직장초음파유도 침생검의 의의

백성현,정병창,박달우,김정현,정성진,변석수,곽철,이상은 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.3

Molecular Characteristics of Lamina Propria Infiltrating and Non-infiltrating Rat Bladder Tumor Induced by N-butyl-N-(4-hydroxybutyl) Nitrosamine (BBN)

Seok-Soo Byun,Cheol Kwak,Sung Kyu Hong,Sangwook Lee,Jeong Hyun Kim,Eun Sik Lee 대한비뇨기종양학회 2004 대한비뇨기종양학회지 Vol.2 No.1

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis

Byun, Seok-Soo,Hwang, Eu Chang,Kang, Seok Ho,Hong, Sung-Hoo,Chung, Jinsoo,Kwon, Tae Gyun,Kim, Hyeon Hoe,Kwak, Cheol,Kim, Yong-June,Lee, Won Ki Hindawi Publishing Corporation 2016 BioMed research international Vol.2016 No.-

<P><I>Background</I>. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis.<I> Methods</I>. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated.<I> Results</I>. Patients with higher NLR had larger tumors (<I>p</I> < 0.001), higher T stage (<I>p</I> < 0.001), worse Eastern Cooperative Oncology Group performance status (<I>p</I> < 0.001), worse symptoms (<I>p</I> = 0.003), sarcomatoid differentiation (<I>p</I> = 0.004), and tumor necrosis (<I>p</I> < 0.001). The 5-year RFS and CSS rates were significantly lower in patients with high NLR than in those with low NLR (each <I>p</I> < 0.001). Multivariate analysis identified NLR to be an independent predictor of RFS and CSS (each <I>p</I> < 0.05). Moreover, predictive accuracy of multivariate models for RFS and CSS increased by 2.2% and 4.2%, respectively, with NLR inclusion.<I> Conclusions</I>. Higher NLR was associated with worse clinical behavior of non-mRCC. Also, NLR was a significant prognostic factor of both RFS and CSS.</P>

The establishment of KORCC (KOrean Renal Cell Carcinoma) database

Byun, Seok-Soo,Hong, Sung Kyu,Lee, Sangchul,Kook, Ha Rim,Lee, Eunsik,Kim, Hyeon Hoe,Kwak, Cheol,Ku, Ja Hyeon,Jeong, Chang Wook,Lee, Ji Youl,Hong, Sung Hoo,Kim, Yong-June,Hwang, Eu Chang,Kwon, Tae Gyun The Korean Urological Association 2016 Investigative and Clinical Urology Vol.48 No.6

<P><B>Purpose</B></P><P>The purpose of this article is to report establishment of the 1st Web-based database (DB) system to collect renal cell carcinoma (RCC) data in Korea.</P><P><B>Materials and Methods</B></P><P>The new Web-based DB system was established to collect basic demographic and clinicopahtological characteristics of a large cohort of patients with RCC in Korea. Data from a total of 6,849 patients were collected from 8 tertiary care hospitals that agreed to participate in organizing the Korean Renal Cell Carcinoma (KORCC) study group as of 1 July 2015. Basic demographic and clinicopathological characteristics were collected. The data of patients who underwent surgical treatments were analyzed to characterize Korean RCC.</P><P><B>Results</B></P><P>We established the 1st Web-based DB of Korean RCC, a database comprising renal mass management cases from multiple centers in Korea. The data of 5,281 patients who underwent surgical management (mean follow-up, 32 months) were analyzed. The most common symptom was incidentally detected renal mass (76.9%). Clinical T1a was the most common (54.3%) stage and mean tumor size was 4.8±4.2 cm. Radical nephrectomy accounted for 62.7% of cases and an open approach was used in 50.7% and 52.2% of radical and partial nephrectomies, respectively. The 5-year overall, cancer-specific and recurrence-free survival rates were 88.1%, 92.2%, and 88.0%, respectively.</P><P><B>Conclusions</B></P><P>We report the 1st establishment of a Web-based DB system to collect RCC data in Korea. This DB system will provide a solid basis for the characterization of Korean RCC.</P>

만성 B형 간염에서 라미부딘 치료중 발생한 Viral Breakthrough 예의 임상 결과

안수현,장윤정,오성남,최도원,백수정,정원석,최창원,김경오,임형준,조남영,박종재,김재선,박영태,이명석,연종은,변관수,이창홍 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.4

목적: 만성 B형 간염의 치료 중 발생하는 약제 내성 변이종은 임상적으로는 치료 중 음전되었던 혈청 HBV DNA가 다시 양전되는 viral breakthrough 로 진단할 수 있다. 현재 약제 내성 변이종이 발생했을 경우라도 라미부딘 치료를 계속 유지하는 것을 권장하고 있으나, viral breakthrough 발생 예들의 장기적 임상경과가 아직도 불명확하여 이것을 일반화하기는 어려운 상황이다. 이에 라미부딘 사용 중 viral breakthrough 가 발생한 예들을 대상으로 그 임상경과를 알아보고자 하였다. 대상과 방법: 9개월 이상 라미부딘을 투약한 만성 B형 간염 환자로 viral breakthrough가 발생한 74명을 대상으로 하였다(남/여 54/20, 평균연령 42세). Viral breakthrough 후 혈청 ALT치, 총 빌리루빈치, HBV DNA 역가, HBeAg, anti-HBe를 정기적으로 검사하면서 임상경과를 관찰하였다. Viral breakthrough 후 라미부딘의 투약기간은 평균 13개 월(1-41개월)이었다. 결과: Viral breakthrough 발생후 혈청 ALT치가 정상으로 유지되었던 환자는 8예(11%)에 불과했고 나머지 66예(89%)에서는 ALT치가 증가하였으며, 이중 30예(41%)에서 급성 악화(ALT 정상 상한치의 5배 이상 상승)를 보였다. 급성악화는 viral breakthrough 후 3개월 내에 19예 (63%)에서 발생하여 3개월 내에 발생한 예가 많았으나 12개월 이상 지나서 나타나는 예도 약 20%에서 있었다. 비대상성 악화는 6예에서 관찰되었다. Viral breakthrough 후 급성악화가 일어난 예와 없었던 예의 비교에서 급성악화를 예측할 수 있는 인자는 발견할 수 없었다. Viral breakthrough 후 발견할 수 없었다. Viral breakthrough 후 HBeAg이 음전된 예는 8예(11%)였으나 그 임상경과는 양호하지 않았다. 결론: 만성 B형 간염 환자 에서 라미부딘 투여 중 발생한 viral breakthrough 예 중 상당수에서 급성악화가 발생하였으며, HBeAg 이 소실되더라도 그 임상경과는 양호하지만은 않았다. Viral breakthrough 발생 후 주의 깊은 임상경과 의 관찰이 요구되며, 앞으로 viral breakthrough 후 급성악화 예에 대한 대규모 연구와 적절한 치료방향의 제시가 이루어져야 할 것으로 생각된다. Background/Aims: Long-term lamivudine therapy can induce the emergence of lamivudine resistant hepatitis B virus (HBV) mutants. Clinically emergence of the mutant is expressed by the reappearance of disappeared HBV DNA in serum. Continued lamivudine treatment has been usually recommended in cases of viral breakthrough. However, the clinical outcome in patients with viral breakthrough is not clear. The aim of this study was to investigate the clinical course of chronic hepatitis B patients after viral breakthrough during lamivudine therapy. Methods: A total of 74 patients with chronic hepatitis B who showed viral breakthrough after at least 6 months of lamivudine treatment were included in this study. They had positive HBeAg and HBV DNA before treatment. The median follow-up duration after breakthrough was 13 months. Results: After viral breakthrough, only 8 patients (11%) maintained normal ALT levels and 66 patients (89%) showed elevation of ALT. 30 patients (41%) showed acute exacerbation of hepatitis (ALT increase over five-times upper normal limit). These acute exacerbations occurred within three months after breakthrough in 19 patients (63%). In the cases of acute exacerbation, 6 patients showed decompensated progression such as elevation of serum total bilirubin. One of them died of hepatic failure. A predictive factor for acute exacerbation was not found. HBeAg seroconversion occurred in 8 patients after viral breakthrough but their clinical course was highly variable. Conclusions: Chronic hepatitis B patients who had viral breakthrough during lamivudine therapy should be followed carefully and regularly in mind of potential clinical deterioration. New strategies are needed to manage the cases of acute exacerbation after viral breakthrough.(Korean J Hepatol 2002;8:389-396)

부자간에 발생한 가족 크론병

조현석 ( Hyun Seok Cho ),변태준 ( Tae Jun Byun ),안상봉 ( Sang Bong Ahn ),김태엽 ( Tae Yeob Kim ),은창수 ( Chang Soo Eun ),전용철 ( Yong Cheol ),김용석 ( Yong Seok Kim ),한동수 ( Dong Soo Han ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.4

Crohn`s disease (CD), one of the major forms of idiopathic inflammatory bowel disease (IBD), is thought to be related to genetic susceptibility coupled with environmental factors. A positive family history is the strongest risk factor for the development of CD. The 10-fold increase in the familial risk of CD strongly suggests that these disorders have a genetic background. The prevalence of IBD in Asian populations is lower than in Western populations, which may be due to genetic influences, environmental factors, or a combination of both. In a Korean study, only 0.25% of parents had IBD in CD probands and all of them had ulcerative colitis. The term of familial CD was used only for those with one or more first-degree relatives with confirmed CD. There are few case reports about familial Crohn`s disease in Korea. We report a case of familial CD that the father, the first degree relative was diagnosed as small bowel CD after confirming his son as having CD. (Korean J Gastroenterol 2008;52:247-250)