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알지네이트 비드를 이용한 메틸 오렌지의 봉입 및 방출에 미치는 키토산의 영향
변종찬, 이상은. 장우석, 이은주, 최진석, 박정숙 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-
In this study, methyl orange-loaded alginate beads were prepared and compared to investigate the effect of chitosan on the encapsulation and release of hydrophilic methyl orange in alginate beads. Particle size and encapsulation efficiency of alginated beads were determined. Swelling ratio and disintegration of al-ginate beads were investigated in gastrointestinal environment. Particle size of beads was 1.1-1.5 mm and shape was spherical. Weight of beads was increased depending on the content of chitosan. Content of chitosan affected on the encapsulation of methyl orange. Encapsulation of methyl orange in alginate beads without chitosan was 15%, while encapsulation efficiency was increased with addition of chitosan. Beads were not disintegrated in HCl solution (pH 1.2) within 4 h, with floating and swelling. Swelling ratio of beads was in-creased to 222%. Release of methyl orange from alginate beads without chitosan was up to 70% within 2 h in HCl solution (pH 1.2). When chitosan was added to the alginate beads, release of methyl range from beads was significantly reduced. It is supposed that release of methyl orange from beads is resulted from diffusion and erosion of beads, which is pH-dependent. In condusion, chitosan-alginate beads have potentials to control release of small hydrophilic drugs by the addition of chitosan.
동력수상레저기구 조종면허 시행에 따른 효율적인 개선 방안
정종석 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5
After scrutinizing the problems involved with the motorized marine leisure vehicle operator's license, the following Conclusions were reached. First of all, in order to guarantee fairness, objectivity, and efficiency in grading, as well as for the sake of relieving test-takers of anxiety, the exam should be computerized, and For each subsection and type, problems should be randomly selected from a computerized database. Secondly, the number of test opportunities during the high-demand season of July and August should be increased, and the boat used for the practical examinations should be replaced so that practical exams can be carried out during the winter time as well. Thirdly, the applicant capacity should be raised according to the conditions and absence rate of Bath test site, and test opportunities should be expanded by increasing the number of tests hosted every year. Because of the limitations of a database-type exam, new problem types need to be developed, and pre-existing types need to be modified. Finally, the program must be modified, improved upon and rationally redefined so that we can extract data elements that are needed from the system We should also execute exam related affairs with more consistency through a drastic reform in the previous 'guide to license exam administration', while reflecting the various new plans that are in progress.
유한 요소 방법을 이용한 인간 움직임 추적에 관한 연구
丁鍾泌,魏丞廷,梁桓碩 順天靑巖大學 1997 論文集-順天靑巖大學 Vol.21 No.2
In this paper, we propose a motion of people tacking using Snakes Model. Snakes Model is an active contour model defined by an energy function in terms of the internal energy, the image energy, and the external energy. Then we can find the people contour model in the image by minimizing the energy function using Finite Element Methods. In order to increase and effect of object tracking and adaptable motion prediction, it used temporary motion information existing in an image and led to the transformating matrix from the motion tracking algorithm for the transformating process and motion of object.
새로운 항암성 백금(Ⅱ) 착체류의 in vivo 독성연구
정광원,임종석,정세영,노영수,최병기 한국환경독성학회 1995 환경독성보건학회지 Vol.10 No.2
The general toxicological study of new platinum(Ⅱ) compounds, KHPC-002, KHPC-005 and KHPC-006 were investigated in rats. The effects of these Pt(Ⅱ) complexes on renal, hematopoietic and hepatic system in rats showed lower toxicity compared with cisplatin. In the consideration of the maximal dose of these Pt(Ⅱ) complexes using in this experiment is 4-8 times higher than cisplatin, these novel compounds will have the less general toxicity in vivo.
정종철,김성범,서지훈,송민석,전창훈,최세훈,김현민 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4
Various surgical approaches to the orbits have been used. But the transconjunctival approach, also called the inferior fornix incision, provides adequate access to the orbital floor with esthetic results. Additionally, transconjunctival approach with lateral canthotomy allows more wide surgical field and good access to the orbital area. Generally, preseptal approach is more used rather than postseptal approach in the transconjunctival incision for the prevention of fat herniation during surgery. There are some complications in transconjunctival approaches but these complications can be prevented with careful surgical techniques. We report clinical results in 12 patients who were treated by preseptal transconjunctival incision with lateral canthotomoy for the treatment of orbital trauma. We were satisfied with this technique for reduction and reconstruction of the orbital trauma and we could also observe relatively good esthetic results.
정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2
연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.