고양이 중뇌 흑색질의 Dopamine 면역반응세포에 관한 면역세포화학적 연구

모근석,문정석,김종중,김준수,정윤영,장인엽,김흥중 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.5

흰쥐 뇌에서 Neuropeptide-Y 분비세포의 출현시기 및 발육에 관한 면역조직화학적 연구

모근석,김종중,정윤영,장인엽,문정석,김준수,김흥중 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.5

영아마취 1436 예의 통계적 고찰

조영례,모근석,이경천,김홍순 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.31 No.6

Background: Infants are very different from children and adults in the point of anatomy, physiology, pharmacology and psychology. The mortality rate of infant anesthesia is higher than that of child and adult. So that this study is to analyze the infant's operation and to recognize the tendency and problems of infant's anesthesia and also to improve the outcome. Methods: A retrospective analysis was performed on 1436 infants who had operations from april 1987 to february 1995 according to age, sex, department, disease, operation time, postoperative complications, mortality rate and anesthetic method. Results: Total number of operation tend to increase annually. The male to female ratio was 67.5% to 32.5%. The distribution of patients by department was 60.6% of general surgery, 21.0% of plastic surgery and small percentage of other department. The distribution of disease was the following: inguinal hernia - the most common; cleft lip and palate, intussusception and others. The postoperative complications developed in 98 of 1436. The most common complication was the respiratory problems, the others were sepsis, electrolyte unbalance, gastrointestinal and CNS problems. The total mortality rate was 3.6%. The emergency operation case was 17.9%. Conclusions: The most common distribution of age was neonate and the most commm department was general surgery and the most common disease was inguinal hemia. The most common pestoperative complication was respiratory problems and the second was infection and sepsis. The mortality rate in preterm infant, neonate, emergency operation and long duration operation was higher than total motality rate.

체외순환을 사용하지 않은 관상동맥우회술 마취

권진형,조영례,모근석 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.2

Coronary artery bypass grafting(CABG) without extracorporeal circulation(ECC) is now an accepted technique of myocardial revascularization in selective cases of coronary arterial occlusive disease. We experienced a case of CABG without ECC in a 20 year old female patient with complete occlusion of the right coronary artery. Anesthesia was induced and maintained with fentanyl, midazolam and isoflurane. Nitroglycerine and dopamine were given to stabilize the hemodynamics during intra- and post-operative periods. And esmolol was administered with a loading dose of 30 mg over 1 min, followed by a continuous infusion of 50∼100 g/kg/min to maintain the heart rate(50∼60 beats/min) and systolic blood pressure(60∼80 mmHg) during distal anastomosis. The patient was recovered uneventfully and discharged on the 8th postoperative day. (Korean J Anesthesiol 1997; 33: 381∼384)

운동장애질환의 뇌정위적 수술시 Propofol 마취

박희권,장영진,이경천,모근석,조영례,이언 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.1

Background : Stereotactic thalamotomy and pallidotomy for Parkinson's disease or essential tremor have been performed under local anesthesia. But some neurosurgeons have been reluctant to utilize this technique because of patient discomfort and neurological complications. So we used the propofol that provides excellent sedation and rapid and smooth recovery of mental abilities with minimal side effects. Methods : After the patients were placed into the Leksell's stereotactic frame, anesthesia was induced by continuous infusion of propofol at the rate of 150 mcg/kg/min and then maintained at the rate of 50 mcg/kg/min. We investigated the hemodynamic changes, ABGA, total dose of propofol, time to loss of consciousness, recovery time from the end of infusion to eyes opening and side effects. Results : The blood pressure decreased significantly at infusion start 15 min and 30 min (p<0.05) and heart rate decreased significantly at infusion start 30 min (p<0.05). The PaCO2 increased significantly at infusion sta 15 min and 30 min (p<0.05). Total dose of propofol was 202.4 59.8 mg, time to loss of consciousness was 13.0 4.4 min, recovery time was 9.0 4.7 min and side effects were pain on infusion (2 cases) and postoperative nausea (1 case). Conclusions : Stereotactic thalamotomy and pallidotomy for Parkinson's disease or essential tremor were performed by infusion of propofol with minimal side effects and no neurological complications. (Korean J Anesthesiol 1998; 35: 64∼69)

폐기능이 저하된 환자의 폐수술시 Enflurane 흡입마취와 Ketamine Hydrochloride 지속적 정주마취의 비교

박희권,권도현,이경천,조영례,모근석 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.33 No.3

Background : Serious pulmonary complications after lung surgery increase morbidity and mortality in perioperative period. Ketamine hydrochloride produces strong analgesic effect in spite of the psychomimetic effects. Intravenous anesthesia with ketamine was performed in lung surgery of patients with decreased pulmonary function and compared with inhalation anesthesia with enflurane. Methods : Sixty patients, scheduled for elective lung surgery, were randomly assigned to two groups. Patients received either enflurane(Group 1, n=30) or ketamine(Group 2, n=30) as main anesthetic drug. Blood pressure and heart rate were compared in preinduction, postinduction, postintubation, postincision, intraoperative period(30 minutes, 60 minutes) and recovery room between groups, and in each group. Arterial blood gas analysis was compared in preoperative period, intraoperative period and recovery room between groups. Postoperative psychological complications evaluated in group 2. Results : Blood pressure and heart rate were significantly different in postinduction, postintubation and recovery room between groups. PaO2 in group 2 was higher than in group 1 during intraoperative period and recovery room. Postoperative psychological complications occured in 4 patients(13%) in group 2. Conclusions : Ketamine affords advantage over enflurane anesthesia in terms of PaO2 during intraoperative period and recovery room in lung surgery of patients with decreased pulmonary function. (Korean J Anesthesiol 1997; 33: 447∼452)

Chinchilla 달팽이핵에서 calbindin D-28ka 양성세포에 관한 면역조직화학적 연구

장인엽,윤상필,정윤영,정종중,문정석,허영,모근석,김흥중 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.5

개 시상하부의 Neuropeptides에 대한 면역조직화학적 연구

장인엽,정윤영,김종중,문정석,김준수,모근석,임용,유호진 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

The distribution and localization of somatostatin(SOM), neuropeptide Y(NPY), vasopressin(VP), and oxytocin(OT) were studied with a immunohistochemical technique in the canine hypothalamus. The SOM-immunoreactive perikarya were concentrated in the anterior periventricular and the arcuate nuclei. Immunoreactive terminals were observed in the arcuate, the ventromedial hypothalamic, the suprachismatic nuclei and the external layer of the median emmence. A great number of NPY-immunoreactive cell bodies were found in the arcuate nucleus and NPY fibers were located throughout the hypothalamus with the highest concentration especially in the paraventricular (PVN) and the acuate nuclei. Moderately or densely stained fibers were also observed in the median eminence, the suprachiasmatic. the periventricular, the ventromedial hypothalamic, the dorsomedial hypothalamic and the medial preoptic nuclei, and the stria terminalis. Both VP-and OT-containing perikarya were found mainly in the PVN and supraoptic nucleus(SON). but a few were seen in the perifornical area, the lateral hypothalamus, the dorsal hypothalamic and the periventricular nucleus. The fibers originated from the PVN were projected to the SON via ventral or dorsal area of the fornix.