올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.

The effect of combined Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max(OPB) extracts on bone mineral density in ovariectomized rats.

Kim,Jung-Keun 대한구강생물학회 2007 International Journal of Oral Biology Vol.32 No.4

This study was conducted to investigate the preventingeffects of OPB (Rehmannia glutinosa Libosch and Eleuth-erococcus senticosus Max extracts) and combined OPB/Calcium therapy on bone loss in ovariectomized rats. SixtySprague Dawley rats of 12-week-old were divided into eightgroups: OVX (ovariectomized), OPBL (OPB 50mg/kg),OPBM (OPB100mg/kg), OPBH (OPB 200mg/kg), OPBL/CAL(OPBL+CAL), OPBM/CAL (OPBM+CAL), OPBH/CAL (OPBH+CAL) and CAL (Calcium citrate 88.33mg/kg+1α, 25-dihydroxy-vitamin D3 33.33IU/kg). Bone mineraldensity (BMD), bone mineral content (BMC), bone strengthindices and cortical thickness were analyzed by peripheralquantitative computerized tomography (pQCT). pQCTscanning showed that OVX induced a significant decreasein trabecular bone mineral density and bone mineralcontent in the proximal tibia (-36.4±2.4%, -21.8±12.7%).These decreases were significantly prevented by theadministration of OPBM and OPBM/CAL. Cortical BMDand BMC of tibia were slightly enhanced by OPB and OPB/CAL. However there was no significant difference betweenOVX and OPB, OPB/CAL treated group. Bone strengthindices and cortical thickness were not significantly different.Our results suggest that OPB and combined OPB/Calciumtherapy are effective in preventing the development of boneloss induced by ovariectomy in rats.

Resilon을 이용한 근관충전 시 수종의 치면처리제에 따른 미세누출 평가

오종현,박세희,신혜진,조경모,김진우 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.2

이 실험의 목적은 Resilon으로 근관충전된 치아에서 자가산부식전처리제에 따른 치근단 미세누출을 평가하고자 함이다. 70개의 단근치를 사응하였고 .04 Taper ProFile을 사용하여 ISO #40까지 근관성형 하였다. 치아는 근관충전 재료와 자가산부식 전처리제에 따라서 15개씩 4개의 실험군과 5개씩 2개의 대조군으로 나누었다. 실험 치아는 치아 장축에 평행하게 잘라내어 염색액의 최대 침투 길이를 측정하였다. 통계분석은 One-way ANOVA test로 분석하였으며 Scheffe test로 사후검정 하였다. 실험결과 자가산부식전처리제를 사용한 2, 3, 4군 사이에서는 통계적으로 유의한 차이를 나타내지 않았다. 그러나 1군과 4군 사이에서는 통계적으로 유의한 차이가 나타났으며 (p < 0.05), 1군에서 가장 적은 치근단 미세누출을 나타냈다. 이 실험 결과에 따르면 Resilon으로 근관충전을 한 치아는 gutta percha와 AH26^(ⓡ)으로 근관충전할 치아와 비교했을 때 더 좋은 치근단 밀폐를 나타내지 않는다는 결론을 얻었으며, Resilon을 사용하여 근관충전을 한 경우에 자가산부식 전처리제의 차이에 따른 치근단 밀폐효과의 차이를 보이지 않는다는 결론을 얻었다. The purpose of this study was to compare the apical microleakage in root canal filled with Resilon by several self-etching primers and methacrylate-based root canal sealer. Seventy single-rooted human teeth were used in this study. The canals were instrumented by a crown-down manner with Gate-Glidden drills and .04 Taper Profile to ISO #40. The teeth were randomly divided into four experimental groups of 15 teeth each according to root canal filling material and self-etching primers and two control groups (positive and negative) of 5 teeth each as follows: group 1 - gutta percha and AH26^(ⓡ) sealer; group 2 - Resilon, RealSeal™ primer and RealSeal™ sealer; group 3 - Resilon, Clearfil SE Bond^(ⓡ) primer and RealSeal™ sealer group 4 - Resilon, AdheSe^(ⓡ) primer and RealSeal™ sealer. Apical leakage was measured by a maximum length of linear dye penetration of roots sectioned longitudinally by diamond disk. Statistical analysis was performed using the One-way ANOVA followed by Scheffe' s test. There were no statistical differences in the mean apical dye penetration among the groups 2, 3 and 4 of self-etching primers. And group 1, 2 and 3 had also no statistical difference in apical dye penetration. But, there was statistical difference between group 1 and 4 (p < 0.05). The group 1 showed the least dye penetration. According to the results of this study, Resilon with self-etching primer was not sealed root canal better than gutta precha with AH26^(ⓡ) at sealing root canals. And there was no significant difference in apical leakage among the three self-etching primers.

韓末 湖南義兵 抗爭의 一斷面 : 全北地方을 中心으로 in the Ho Nam Province, 1895-1909

李世賢 群山敎育大學 1977 論文集 Vol.11 No.-

톨루엔 노출 근로자에서 유전자적 요인, 생활습관 및 식이가 요중 마뇨산 배설에 미치는 영향

임현우,박정일,노영만,이강숙,이정민,이원철,이세훈,정치경 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 본 연구는 생물학적 지표 특성 연구를 위한 단면조사 연구로서 톨루엔 노출과 톨루엔의 생물학적 모니터링으로 이용되는 요중 마뇨산 농도간의 양-반응 관계에서 효과 변경인자로서 작용하는 유전자 ALDH2, CYPIAI, CYP2El의 다양성 분포를 조사하고, 이들 유전자가 요중 마뇨산 배설 농도에 미치는 영향을 알아보고자 하였다. 방 법 : 연구대상자는 경인지역에 위치한 22개의 사업체에서 페인트 제조 72명, 제조업에서 도장작업 50명, 인쇄업 12명, 접착작업 12명, 벽지의 코팅작업 14명등 160명의 근로자이었다. 성, 연령, 유기용제 작업장 근무경력, 흡연습관, 음주습관, 검사일 이전 밤에 음주 여부, 시료 채취전 6시간 이내에 섭취한 식품조사, 측정일 개인보호구의 착용 여부에 대하여 설문조사를 시행하였다. 톨루엔에 대한 개인노출량은 passive air sampler로 측정하였고, 요중 마뇨산은 요중 크레아틴으로 보정하여 측정하였다. 또한 aldehyde dehydrogenase 2 (ALDH2) , cytochrome P45O IAI(CYPIAI), 그리고 cytochrome P45O 2El(CYPfEl)의 유전적 다양성은 혈액으로부터 백혈구의 DNA를 추출하여 제한 효소 절단 길이 다양성 (restiction fragment length polymorphism, RFLP)법으로 검사하여 다음의 결과를 얻었다. 결 과 : 연구대상자의 요중 마뇨산 농도의 기하평균은 0.44g/g creatinine, 기하표준편차 2.80이었다. 톨루엔 노출 농도, 개인 보호구 착용여부, 안식향산이 함유된 식품의 섭취여부중 요중 마뇨산 배설농도에 영향을 미치는 인자는 톨루엔 노출 농도뿐이었다. ALDH2, CYPIAI, CYPfEl, 연령, 흡연, 근무기간에서 회귀계수간에 차이를 보이는 경향이 있었다. 요중 마뇨산 농도에 대한 다중회귀분석에서 톨루엔, ALDH2, CYPIAI, CYP2El유전자형의 회귀계수가 통계적으로 유의하였다. 결 론 : 톨루엔 노출로 인한 요중 마뇨산 배설 농도는 ALDH2, CYPIAI, CYP2El유전자 다양성에 의해 영향을 받기 때문에, 유전자형의 대사능의 차이를 고려하여 마뇨산 기준 농도를 찾는 연구가 이루어져야 하겠다. Objectives The purpose was to investigate the distributions and the effects of genetic polymorphism of aldehyde dehydrogenase 2(ALDH2), cytochrome P45O IAI (CYPIAI), and cytochrome P45O 2El (CYPfEl) on the toluene metabolism. Methods : The subacts consisted of 160 workers who were exposed to toluene in different industries such as paint manufacturing, painting on steel and wood products, printing, bonding, and coating. The exposed toluene level was monitored by passive air sam paler, and the questionnaire variables were age, sex, smoking, drinking, previous night's drinking, use of personal protectlve equipment, work duration, and taking benzoic acid containing food. The urinary hippurric acid collected in the end of shift was corrected by urinary creatinine concentration. The genotypes of ALDH2, CYPIAI, and CYP2El were investigated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods with DNA extracted from venous blood. Results'The geometric mean and the geometric standard deviation of urinary hippuric acid concentration were 0.44 g/g creatinine and 2.80. The urinary hippuric acid concentration was significantly related to personal exposed toluene level among personal exposed toluene level, use of personal protective equipment, and benzoic acid containing food diet. The slope differences of the regression for ALDH2, CYPIAI, and CYP2E1 genetic polymorphism, age, smoking, and work duration tended to be significant. In multiple regression analysis, the regression coefficient of toluene, ALDH2, 7YPIAl, CYP2E1 genetic polymorphism were significant. Conclusions : From the above results, urinary hippuric acid level after toluene exposure was significantly affected by the genetic polymorphism of ALDH2, CYPIAI, CYPfEl. It is needed further investigation of the urinary hippuric acid level considering the effect of genetic polymorphism.

西海 島嶼 地域의 民俗 調査 硏究 (Ⅰ) : 全北 西海 島嶼 地域을 中心으로 Chiefly of the Western Islets in Cholla -puk- do Province

李世賢 群山敎育大學 1973 論文集 Vol.6 No.-

Ⅰ. Introduction The Western islets which still remain under-developed areas have shown many real aspects of our simple folk-lore. But it has been disappeared rapidly by the spread of modern school education, propagation of christianity, and development of communication In this paper I have researched only the real aspects of primitive religion at the islet areas. I have found out the fact that they had subjectivity of our racial culture in it. Ⅱ. Results of the research A). On the religious services of the villages 1. 18 villages out of 28 at the western islets of Chon-puk province performed the religious service of the village and it was after 1960s when the religious service of the village had abolished. 2. The god of a mountain was their chief god revered in the religious service of the village and the place performed the services was likely to be the mountain-top in the vicinity of the village. 3. They performed their religious services chiefly in January by lunar calendar and the date was designated or chosen by the villagers according to their circumstances. 4. Almost all the service expenses were collected from each house and the ammounts of the expenses differed from others, depending on the village populations and its scale. 5. The service sacrifices were mainly wine, rice cakes, cooked rice, dried pollacks, meat and fruits, such as chestnuts, jujubes, and pears. 6. For the performance of the religious services, they had villagemeetings in advance and they consulted with the villagers about the matters such as date-deciding, expense-allotting, choice of the officiating person, and the kinds of the sacrifices. They also had a meeting after performing the religious service in which They consulted with then about the settlement of accounts and village-matters etc. B) On the religious services of the joint-groups The religious services of the joint-groups performed at the western islets of Chon-puk province are as follows : 1. Religious service for Jang-seung(장생) at Seon-yu. do islet(Jang-seung is a gurdian god made of wood which keeps the village standing at the doorway of the village) 2. Religious service for Chi-dong(淄東) shrine at Eo-cheong-do islet(They preformed the religious service for Jeon-hoeng(田橫) 3. Religious service for the Sea-god at Seon-yu-do islet 4. Religous service for the land and Sea-god at O-shik-do islet 5. Religious service for the spring-god at O-shik-do islet 6. Religious service for Seo-nang god(城隍) at Nae-cho-doiselt(Seo-nang-is a guardian god for the village) 7. Religious service for Mang-ju-dae-kamg-god(望主大監) at Seon-yu-do islet 8. Religious service for having a good haul at Wi-do islet C). On the religious services of the individuals The kinds of the religious services of the individuals performed at the western islets of Chon-puk province are as follows : 1. Religious service for the house-god 2. Religious service for the dragon-god 3. Religious service for the seven-stars 4. Religious service for the mountain-god 5. Religious service for the tree-god 6. Religious service for the vessel-seo-nang-god 7. Religious service for the sea-god 8. Religious service for the road-god 9. Religious service for the Seo-nang-god Ⅲ. Conclusions We can easily find out the fact that the lives of the islet-inhabitants in the western sea are restrained by the primitive religious regulations. They performed the religious services of the villages, joint-groups, and the individuals for the best wishes of the village welfare and happiness. Besides, they have had the important religious roles which contributed in giving the villagers spritual consolation and lessening their unrest. They have tried to develop their villages and elevate the individual life, co-operating and uniting, by such various religious services.

공구흔 동일성 감정기법의 실제 감정대상에 적용

임세혁,김상현,이경화,김윤회 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

유치원의 기본생활교육 내용분석을 통한 교육과정 통합화 방안 탐구

강현석,황윤세 한국영유아보육학회 2004 한국영유아보육학 Vol.0 No.39

유아교육에서 기본생활교육의 중요성에 대한 인식이 증가하고 있고 아울러 현대사회에서는 기본생활교육을 비롯한 가정의 역할을 유아교육기관에서 일부 담당하는 추세이다. 본 연구에서는 유치원 교육과정에서의 기본생활교육과 관련된 ‘유치원 교육 활동 지도 자료집’분석을 통해 유치원 교육과정에서의 기본생활교육을 통합하기 위한 근거를 마련하고자 한다. 유치원 교육 활동 지도 자료집에 나타난 기본생활교육 내용은 다음과 같은 경향을 보였다. 연간교육계획에서 기본생활교육은 주제별 편중 현상이 심하게 나타났으며, 영역별로는 건강생활영역, 사회생활영역, 언어생활영역, 표현생활영역, 탐구생활영역의 순으로 나타났다. 또한 기본생활영역의 덕목별 비중은 예절과 청결이 비슷한 비중을 차지하고 있었으며, 절 제, 질서 순이었다. 기본생활교육은 하루일과에서 집단 활동과 자유선택활동이 약간의 차이는 있는 정도로 활동이 계획되어 있었다. 이러한 분석 결과, 기본생활교육의 내용은 자체가 가지는 특수성으로 인해 교육과정의 특정 영역에 치우치고 있으나, 이를 교육의 실제로 옮기기 위해서는 유아교육과정 운영의 주요한 원리인 통합의 원리를 따라야 할 것으로 판단되며, 그 구체적인 방안으로는 생활주제별 통합과 프로젝트접근법을 제안하였다. This study intends to analyze a precedent study related with basic social education in early childhood curriculum and raise problems about it. Through this process, First, I mean to set up a basis to integrate basic social education in early childhood curriculum, To do this, I analyzed how basic social education was conducted through guide book of early childhood curriculum. Second, on the basis of these analyses, I mean to suggest a educational practice. This is to do integral management about basic social education in early childhood curriculum. Basic social education in guidebook of early childhood curriculum was analyzed as follows. First, basic social education was not planned regularly in annual educational plan. Second, the result of domain analysis about basic social education was that health, social, language, expressive life, and exploration life domain were arranged in sequence. Items of basic social education were made up of manners 32%, cleanness 30%, temperance 22%, order 16%. Basic social education was planned 55% through group activity, 45% through free play in daily life. As a result of these analyses, education of basic social education was titled to specific domain because of the distinct attribute of the education itself. It is necessary to follow integral principle, a major one of early childhood curriculum to make these mentioned above a educational practice. Thanks to need of integral approach, integral approach about basic social education consists of two aspects. One is approach to integrate contents about basic social education by thematic approach. The other is project approach. Thus, first, contents about education of fundamental habits was planned according to unit in annual educational plan. Second, basic social education was integrated to daily life. Third, basic social education was integrated according to domain. Finally, basic social education was attempted through thematic approach and project approach.

錦江下流地域 文化財精密地表調査

李世賢 군산대학교 1988 論文集 Vol.15 No.-

Kunsan National University Museum had already published the result of general surface survey of cultural relics of the Okku area in Ch?nbuk Province(Cultural Relics of the Okku Area in Ch?nbuk Province, Kunsan : Y?ngmun -sa, 1985).It is believed that this publication has supplied elementary source materials to understand the present condition of the Okku area's cultural relics, by reporting numerous remains such as dolmens, shell mound, old temples and local schools, natural monuments, and some old folk customs.But, for various obstacles, as acknowledged in the preface of that publication, it could not cover the whole relics sufficiently, especially the ones of pre-historic and earlier than Three Kingdom period.So, to fill up the deficiency, a series of supplementary survey programs are planned. This report is the first try of the programs which will be carried out divided into several sub - areas successively.It covers the east of the Okku area, particularly Napo-my?n, S?ngsan-my?n, S?su-my?n, Impi-my?n, and a part of Kunsan-si.

유아 교육과정 구성에서 DAP의 재개념화를 위한 예비적 탐색

황윤세,강현석 한국교육과정학회 2003 교육과정연구 Vol.21 No.2

유아교육과정의 변화는 궁극적으로 세계를 보는 인간을 보는 시각의 변화에서 시작된다고 볼 수 있다. 유아교육과정에서 현재 지배적인 논의에 대한 탐구를 통해 현실을 이해하고 반성적 과정을 통해 우리가 갖는 문제의 본질과 성격을 진단하며 유아교육과정 구성에 대한 구체적 지식의 확보 문제가 중요한 과제로 등장하고 있다. 현재 유아교육에서 지배적으로 논의되고 있는 ‘발달에 적합한 실제(DAP)’는 많은 긍정적 측면이 있는 동시에 다양한 경로를 통해 비판이 제기되고 있는 실정이다. 이 DAP의 한계에 대한 비판은 유아교육과정 영역에서 그 기준으로 발달 적절성이 적용되어 문제의 해명에 큰 기여를 해오고 있다. 발달 적절성의 무분별한 적용은 오히려 교육과정의 이론과 실제에 혼란을 가져다 줄 수도 있다. 본 연구는 발달에 적합한 실제를 보다 면밀히 이해하고 교육과정에서 보다 타당한 적용을 위해 반성적 입장에서 주목해야 할 문제를 검토해 본 것이다 외국에서 다양하게 논의되는 유아교육프로그램을 단순히 차입하여 적용해보는 이로다 중요한 것은 우리의 사회 · 문화적 실제를 반성하고 더 나아가 유아교육과정의 이론적 토대를 구축하는 것이다. The approach for childhood education has done in a point of view of phenomenology, analytics or post-modernism deviating from childhood education research of the modernism point of view that can be explained in a science, rationality, objectivity, absoluteness, and universality. The characteristic of the representative model for the early childhood curriculum is lied on the base of the postmodernism thought that pursues a relativity or subjective understanding, on the other hand, denies an absoluteness or objectivity. The changes of the early childhood curriculum is developing with a various ways. Recently, the one of the most active discuss is a DAP approach, which take an important role not only in Korea but also all of the world. The core concept of DAP is the development appropriate. This study re-conceptualizes DAP in an aspect of the construction of the early childhood curriculum and examines the development appropriate. DAP makes the kernel of a rationale as the base of re-conceptualization. Furthermore, this study examines the appropriate of DAP in an aspect of the construction of the early childhood curriculum. The problem of the former focuses on the definition of the terms, and the problem of the latter focuses on the goal-establishment, the choice of the content, and the problem of the teacher's role. That is, at first, this study examines "The Age Propriety and The Individual Propriety: the two dimensions on the development appropriate", which are the core issue and term. Secondly, this study re-conceptualizes on the teacher's role as the determiner about the intention and the problem that teacher utilizes the appropriate or inappropriate practice on the criterion for the construction of the early childhood curriculum. Therefore, for establishing the re-conceptualization base of DAP, this study analyzes the characteristic of DAP in the early childhood curriculum. According to this established base, this study examines the appropriateness of DAP, and then tests the re-conceptualization of DAP. The re-conceptualization does in three parts: the concept of DAP, the problem of constructing the early childhood curriculum, and the problem of teacher's role. According to the result, this study makes a proposal on the direction of the understanding and the study of the early childhood curriculum. In conclusion, DAP is the one of the various factors that consist of the early childhood curriculum, and DAP itself is not the absolute standards. The concept of the development-appropriateness, one of the DAP concept, will be developed in the enlarging and merging direction that social-cultural factors and contents can be considered. Teachers will have to increase their thinking power and analyzing power, but just concentrate on the developed knowledge.