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Single-Port Robotic Cholecystectomy: Early Experience from 8 Cases
( Hyung Jun Kwon ),( Horyon Kong ),( Sang Geol Kim ),( Yun Jin Hwang ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Single-port laparoscopic cholecystectomy (SPLC) is a technical concept to reduced pain and improve cosmetic results when compared to multi-port cholecystectomy. However, SPLC is associated with technical limitation due to the enhanced complexity of the approach and limited number of specialized instruments or platforms. On the other hand, using a robotic platform may overcome these problems and enable more precise surgical actions by increasing freedom of movement and by restoring intuitive instrument control. In this presentation, we report the early clinical experience of our first 8 sing-port robotic cholecystectomy (SPRC) cases. Methods: Between November 2016 and February 2017, eight patients underwent SPRC with the da Vinci Xi robot and single-site instrumentation. We retrospectively reviewed clinical data on those patients. Results: All of 8 patients had completion of SPRC. Seven patients were female and one was male. Average patient age was 43.3±11.8 years and BMI was 22.4±1.4 kg/m2. Three patients (37.5%) were diagnosed with chronic calculous cholecystitis. Three patients (37.5%) underwent operation for polypoid lesions of the gallbladder. One patient (12.5%) was diagnosed with acute calculous cholecystitis. The mean operation time (skin-to-skin) was 83.9±30.7 min, docking time was 13.25±8.1 min, and console time was 42.1±26.4 min. The intraoperative blood loss was negligible. The mean Visual Analog Pain Scale score 6hr after the surgery was 2.9±0.4. The mean length of hospital stay average postoperative hospital stay was 2.3±1.0 day. There were no intraoperative complication and one patient developed seroma on port site. Conclusions: Robotic single-port cholecystectomy appears feasible and safe in our early experience.
Sung Hoon Jun,Duk Jun Yu,Yun Young Hur,Hee Jae Lee 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
Seasonal changes of cold hardiness were compared on the canes of six grapevine cultivars during cold acclimation (CA) and deacclimation (DA). Cane segments for cold hardiness determination were prepared from the 3<SUP>rd</SUP> to 8<SUP>th</SUP> nodes of the grapevines in late October, mid-December, mid-January, mid-February, and late March. Cold hardiness was estimated by electrolyte leakage analysis and expressed LT50, the median lethal temperature. Electrolyte leakage analysis on grapevine canes provided reproducible LT50 during the entire experimental period. Cold hardiness of the canes increased during CA and decreased during DA, although change rate, peak time, and level of cold hardiness varied with cultivars. ‘Cabernet Sauvignon’, ‘Campbell Early’, ‘Shine Muscat’, and ‘Shiny Star’ exhibited similar patterns in seasonal changes of cold hardiness. Their cold hardiness increased rapidly until mid-December, lasted until mid-February of the following year, and then decreased rapidly. ‘Cabernet Sauvignon’ was most sensitive, ‘Shiny Star’ was most tolerant to freezing temperature, and ‘Campbell Early’ and ‘Shine Muscat’ were moderate through the entire experimental period. Cold hardiness of ‘Hongju Seedless’, which was weakest among the grapevine cultivars examined in late October, reached its peak in mid-January, and then decreased slightly until late March, suggesting that ‘Hongju Seedless’ is vulnerable to freezing temperature during the initial CA period. In contrast to ‘Hongju Seedless’, ‘Bailey Alicante A’ maximized its cold hardiness at the initial CA period, lasted it until mid-February of the following year, and then decreased it sharply, suggesting that ‘Bailey Alicante A’ is vulnerable to freezing temperature during DA. These results indicate that seasonal change patterns and levels of cold hardiness in grapevine canes depend greatly on cultivar, and thus cultural practices to cope with freezing stress should be performed on each cultivar.
( Jun Ho Myung ),( Hyun Jeong Seo ),( Soo Jeong Park ),( Bo Young Kim ),( Il Sang Shin ),( Jun Hak Jang ),( Yun Kyung Kim ),( An Soo Jang ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.2
Background/Aims: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness. Methods: We counted eosinophils on nasal smears, and performed spirometry, allergic skin tests, and methacholine challenge tests in 308 schoolchildren plus a questionnaire on respiratory symptoms. The methacholine concentration causing a 20% fall in forced expiratory volume in 1 second (PC20 < 25 mg/mL) was used as the threshold of bronchial hyperresponsiveness (BHR). Results: In total, 26% of subjects had positive nasal eosinophils on a smear, and 46.2% of subjects had BHR at < 25 mg/mL methacholine PC20. Nasal symptoms were higher in subjects with than without nasal eosinophils (p = 0.012). Asthma symptoms did not differ between subjects with and without nasal eosinophils. Nasal eosinophils were higher in subjects with atopy than those without (p = 0.006), and there was no difference in PC20 methacholine according to atopy (15.5 ± 1.07 vs. 17.5 ± 0.62; p > 0.05). No difference in BHR was detected when comparing subjects with and without nasal eosinophils. There were significant differences in the PC20 between subjects with greater than 50% nasal eosinophils and without nasal eosinophils (11.01 ± 2.92 mg/mL vs. 17.38 ± 0.61 mg/mL; p < 0.001). Conclusions: These findings demonstrated that nasal eosinophilic inflammation might contribute to lower airway responsiveness in schoolchildren, based on an epidemiological survey.
Jun Hyeong Kim,Se Yong Park,Hee Chul Lee,Sung Ho Yun,Ho Nyun Lee 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.1
We conducted computational fluid dynamic (CFD) simulations to improve the thickness uniformity of cluster-sputtered porous metal films. The cluster sputtering equipment was divided into a module where the sputtered metal atoms condensed and cluster nanoparticles formed and a chamber where porous metal films were deposited. To optimize the equipment geometry, we performed simulations and deposition experiments for various planar nozzle positions and nozzle-to-substrate distances in the module. The simulated gas velocity distribution 25 mm above the substrate exhibited a similar tendency to the thickness distribution of the deposited porous Cu films. When a 4-mm nozzle was located 40 and 240 mm from the module center and substrate, respectively, the simulated gas velocity distribution exhibited uniformity to within 8.4\% for the substrate with a 70-mm radius. The thickness uniformity and the deposition rate of the deposited porous Cu films were 9.3% and 2 $\upmu$m/min, respectively, using equipment with the same geometry.
Yun, SeungPil,Yun, Chul Won,Lee, Jun Hee,Kim, SangMin,Lee, Sang Hun The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5
Cripto is a small glycosylphosphatidylinositol-anchored signaling protein that can detach from the anchored membrane and stimulate proliferation, migration, differentiation, vascularization, and angiogenesis. In the present study, we demonstrated that Cripto positively affected proliferation and survival of mesenchymal stem cells (MSCs) without affecting multipotency. Cripto also increased expression of phosphorylated janus kinase 2 (p-JAK2), phosphorylated signal transducer and activator of transcription 3 (p-STAT3), 78 kDa glucose-regulated protein (GRP78), c-Myc, and cyclin D1. Notably, treatment with an anti-GRP78 antibody blocked these effects. In addition, pretreatment with STAT3 short interfering RNA (siRNA) inhibited the increase in p-JAK2, c-Myc, cyclin D1, and BCL3 levels caused by Cripto and attenuated the pro-survival action of Cripto on MSCs. We also found that incubation with Cripto protected MSCs from apoptosis caused by hypoxia or $H_2O_2$ exposure, and the level of caspase-3 decreased by the Cripto-induced expression of B-cell lymphoma 3-encoded protein (BCL3). These effects were sensitive to down-regulation of BCL3 expression by BCL3 siRNA. Finally, we showed that Cripto enhanced expression levels of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and hepatocyte growth factor (HGF). In summary, our results demonstrated that Cripto activated a novel biochemical cascade that potentiated MSC proliferation and survival. This cascade relied on phosphorylation of JAK2 and STAT3 and was regulated by GRP78. Our findings may facilitate clinical applications of MSCs, as these cells may benefit from positive effects of Cripto on their survival and biological properties.