Acriflavine-Guanosine 복합제 (AG60)의 조직내 분포에 대한 형광현미경적 연구

고정식,임수재,안의태,김진국,김상건,이경영,강종구,홍은경,정영신,유보림,한영복 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

脂體不自由兒의 特殊學校의 再活訓練 基本模型

鄭載權,金東淵,裵晟洙,姜渭榮,元英祚,安秉輯 大邱大學校 特殊敎育總合硏究所 1983 特殊敎育硏究 Vol.10 No.-

The increasing stress on the need for standardized rehabilitation programs for the crippled has faced the workers in the field with the problems of finding out an ideal model of rehabilitation programs which can most facilitate maximum development of the children in various educational aspects. As part of the basic research, the study has been conducted to analyze the data on the present status of the six schools for the crippled in the country, together with other related survey on the available literature. Most of the data on the present situation of the schools and the status of the workers were obtained through questionnaires. The findings derived from the analysis of those data are as follows: 1. The Present Status of the Rehabilitation Training The survey revealed only forty-nine percent(381) of the entire subjects of 784students had been put to the training, that classroom lesson comprised 50% and 43% of the curricula in primary and secondary courses respectively, and that in the rehabilitation programs, physical therapy accounted for 50%, occupational therapy 31% and speech therapy 19%. As for the qualification of rehabilitation workers, twenty of the twenty-five who are presently serving at the six schools are license holders, averaging three physical therapists, 0ne occupational therapist and 0.2 speech therapist at each school. Ninety-six percent are junior college graduates and fifty-six percent are aged 20∼25,forty percent 26∼30. Eighty percent fall into the monthly pay range of 140,000 to 210,000 won, leaving the others below or above the scale. The study also showed that the cause or motivation of their becoming the workers was out of a sense of duty; seventy-six percent replied that they volunteered to help the crippled. Principals, the workers and special teachers showed in that order their enthusiasm about their enthusiasm about the rehabilitation prgrams. It was also found in the study that the authorities concerned have held a special guidance session once a year, achieving their annual goal only 50% and that most of the schools (82%) organized their own rehabilitation programs. The tools and other materials used in the programs were mostly(67%) domestic products. Four schools (67%) prepared thir own evaluation devices for the achievements of the trainees. 2. Facilities and Equipment for Rehabitition Training In all, thirty-four kinds of equipment and tools are currently provided at the six schools to help the chidren maintain or develop their residual function in the deficient limb. Of them only eighteen kinds were owned by each school, aberaging more than one; they were mats, walkers, parallel bars, mirrors, puzzle patches, stairs, shoulder wheels, tilt tables, walking aids, safety aids safety walking belts restorators, over head pulleys, knee exercise units, rotary wrist macihnes, holdings and gloves. The rest of the tools or apparatus averaged less than one among the schools. Nine kinds of electro therapeutic apparatus were owned by them, but only electrostimulation test machined lamps aberaged more than one. As for the hydro therapeutic apparatus, eight kinds were provided among the schools. Each school had more than one set of these three devices: hydor collator, whirl pool and hydro collator pack, with hydro collator pack averaging 17.33. They maintained thirteen kinds of occupational therapy appraratus, of which only three were owned by every school. Most of the apparatus were meant to deal with metallic works. Eleven sorts of speech therapy devices were found; only breathing exercise apparatus averaged more than one. The rehabilitation facilities and equipment at the schools are far below sufficient both in number and kind to meet the need. 3. Teacher' Attitude and Morale Toward the Rehabilitation Programs The schools for the crippled generally try to put equal emphasis on every field needed to rehabiletate the children but it was found that they were, intentionally or unintentionally, putting varying degrees of stresses on indivdual parts. The findings allowed making a list arranged in order of their priority: physical therapy, occupational therapy, speech therapy, motor development training and play therapy. The teachers responded that facilities, equipments, materials, parental cooperation, administravtive support and the ability of the rehabilitation workers were not sufficient enough to meet expectations. When asked to list the priority of the urgent fields, approximately percent put physical therapy at the top, twenty-one percent human relationships. The study showed teachers thought that the sense of duty (35%), ability and qualifications(21%), training skill(15%), academic career(13%) should be considered as the objective determinants in selecting a teacher, and 34% opined that a worker should have “ardent desire and sense of service”. Others expressed their opinion that understanding children's psychology(20%), having good knowledge of basic theory of the rehabilitation(19%) should be prerequisite to the service. Seventy-five percent of the teachers responded that rehabilitation training should be greatly improved and that they positively cooperated with the workers in the programs. It was inferred that the school administrators were generally affirmative towards the programs. The work-load of the rehabilitation workers was regarded as almost the same as that of special teachers(37%). The public and the education authorities assessed the ability of the workers "fair"(52%). Seventy-six percent of those who replied opined the financial support”, was "not sufficient", and seventy-one percent insisted the Ministry of Education should ear-mark special fund for the rehabilitation programs. As part of promotion measures, the majority of the replied(52%) reommended that authorization of more courses and expansion of the existing courses for the workers should be made, and the great majority(71%) advocated raising the special allowances, which was found to be the first in the order of priority, followed by the government's administrative and legislative support(26%) and development and development and supply of materials and equipment for the rehabilitation(22%). The analysis of the above data helped deduct a reasonable rehabilitation practice pattern in which the rehabilitation programs are adopted with the same weight as other parts of the curriculum such as classroom lessons or extra curricula activities, and the programs should cover, with an equal emphasis on every field physical therapy(functional training), occupational therapy (vocational training), speech therapy, sensory training(perception-motor training) and psychological training. Shown in IV-B are the tentatively listed basic sets of facilities and apparat believed indespensable in the rehabilitation programs. 4. Suggestions The following are the suggestion based on the results of the comprehensive study on the present rehabilitation practice in the country. (1) The rehabilitation programs which is to facilitate maximum motor-skill development should compulsorily be included in the curriculum of the school for the crippled. (2) The present training course of the rehabilitation workers should be reorganized to produce highly skilled rehabilition experts who will satisfactorily meet the need on the part of the children. Also desirable is the change of the present title of the workers "rehabilitation attendant" to "rehabilitation training teacher". In parallel with the intensification on training and requirement of the teachers, an increase in emolument to or level of the other special teachers should be made. (3) It is recommended that the programs be extended to other fields of special education, in view of the fact that the rehabilitation programs are basically meant to maintain, improve or eliminate any human defects.

해양 갈조류를 생물흡착제로 이용한 납흡착 특성 연구

서정호,감상규,오영희,이동환,이민규 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

Lead sorption performances by biomass of nonliving, dried marine brown algae Undaria pinnatifida, Hizikia fusiformis, and Sargassum fulvellum used as biosorbent materials were investigated. As the amount of biosorbent materials added was increased, the lead removal by biosorbent materials increased but the lead biosorption capacities decreased. However, with increasing initial lead concentration the lead biosorption capacities by the biosorbent materials increased but lead removal efficiencies decreased. In the range of initial lead concentration(C_0) 10-500 mg/L the lead biosorption capacities and removal efficiencies by the biosorbent materials increased with increasing pH. Among the biosorbent materials used in this study, the lead biosorption capacities decreased in the following sequence: U. pinnatifida $gt; H. fusiformis $gt; S. fulvellum. The lead biosorption by biosorbent materials were expressed by the Langmuir isotherm better than the Freundlich isotherm. The biosorption rate could be expressed by the first order reaction rate equation for initial lead concentration like that r_ad = 0.288C_0 for U. pinnatifida, r_ad = 0.255C_0 for H. fusiformis, and r_ad = 0.161C_0 for S. fulvellum.

유리재단 전용 CAM 시스템 개발

이건범,정회민,편영식,주상윤 한국공작기계학회 1998 한국생산제조학회지 Vol.7 No.1

In order to increase the modeling power and productivity of CAD/CAM systems, demands for customization of CAD/CAM system increased. Customization of a CAM system involves making it easier to learn and use, adding new modeling features not supported in a general purpose CAM system, and providing parametric inputting mechanisms. A customization from a commercial CAM system (OMEGA) has implemented for two dimensional free curve CNC glass scribing machine of medium size company in Cheonan. A CAD technician who has no CAM experience can operate this customized CAM system satisfactorily.

항암제 AG60이 흰생쥐 위점막 상피세포의 DNA합성에 미치는 영향 : 자기방사법적연구

박경호,안의태,고정식,하상선,한영복,정영신,홍은경,유보림,김상건,이경영,강종구 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

체외충격파 쇄석술의 치료의 성공률과 Hounsfield units 상관관계

김동준,이상익,송동우,정태융 관동대학교 의과학연구소 2006 關東醫大學術誌 Vol.10 No.1

복압성요실금(Stress urinary incontinence)과 절박성요실금(Urge incontinence)환자에서 TVT 수술 결과의 비교

이경구,이준호,권용욱,정태융,심희영,이상익 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

Tension-free vaginal tape(TVT) has been widely used in the management of stress urinary incontinence(SUI), and has been applied to urge incontinence (UI). We evaluated and compared the outcomes between SUI and UI for patients who had undergone TVT. Patients were categorized into SUI(33 patients) and UI(26 patients). Before treatment, we asked about LUTSs using female bladder questionnaire. And we asked about sexual function. After treatment, the same questionnaires were repeated. During the postperative period, the objective and subjective success rate were evaluated. For operation outcome results, in SUI group there were 29 cases of cure (87.9%)and 2 of improvement(6.1%), and in UI group there were 20 cases of cure(76.9%)and 3 of improvement(11.5%) (p>0.05). The operation satisfaction rate of patients was 90.9% in SUI group and 84.6% in UI group(p>0.05). Improvement of sexual satisfaction occurred in 6(20.0%) of SUI group, and 3 (18.8%) of UI group, respectively(p>0.05). The objective success rate, satisfaction rate and sexual satisfaction of SUI patients did not significantly differ from the women with UI. Also, these results shows that TVT procedure improves some LUTSs in both groups. We consider the TVT procedure to be an effective treatment not for stress urinary incontinence but also urge incontinenece.

Unraveling Biohydrogen Production and Sugar Utilization Systems in the Electricigen Shewanella marisflavi BBL25

Kim Sang Hyun,Kim Hyun Joong,Kim Su Hyun,Jung Hee Ju,Kim Byungchan,Cho Do-Hyun,Jeon Jong-Min,Yoon Jeong-Jun,Kim Sang-Hyoun,Park Jeong-Hoon,Bhatia Shashi Kant,Yang Yung-Hun 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5

Identification of novel, electricity-producing bacteria has garnered remarkable interest because of the various applications of electricigens in microbial fuel cell and bioelectrochemical systems. Shewanella marisflavi BBL25, an electricity-generating microorganism, uses various carbon sources and shows broader sugar utilization than the better-known S. oneidensis MR-1. To determine the sugar-utilizing genes and electricity production and transfer system in S. marisflavi BBL25, we performed an in-depth analysis using whole-genome sequencing. We identified various genes associated with carbon source utilization and the electron transfer system, similar to those of S. oneidensis MR-1. In addition, we identified genes related to hydrogen production systems in S. marisflavi BBL25, which were different from those in S. oneidensis MR-1. When we cultured S. marisflavi BBL25 under anaerobic conditions, the strain produced 427.58 ± 5.85 μl of biohydrogen from pyruvate and 877.43 ± 28.53 μl from xylose. As S. oneidensis MR-1 could not utilize glucose well, we introduced the glk gene from S. marisflavi BBL25 into S. oneidensis MR-1, resulting in a 117.35% increase in growth and a 17.64% increase in glucose consumption. The results of S. marisflavi BBL25 genome sequencing aided in the understanding of sugar utilization, electron transfer systems, and hydrogen production systems in other Shewanella species.

Melittin has an inhibitory effect on TNF-α-iduced migration of human aortic smooth muscle cells by blocking the MMP-9 expression

( Yun Jeong Jeong ),( Hyun Ji Cho ),( Key Whang ),( In Seon Lee ),( Kwan Kyu Park ),( Jung Yoon Choe ),( Sang Mi Han ),( Cheorl Ho Kim ),( Hyeun Wook Chang ),( Sung Kwon Moon ),( Wun Jea Kim ),( Yung 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0

Matrix metalloproteinases-9 (MMP-9) plays an important role in the pathogenesis of atherosclerosis and migration of vascular smooth muscle cells (VSMCs) after an arterial injury. In this study, we investigated the potential molecular mechanisms underlying the anti-atheroscleroic effects ofmelittin, a major component of bee venom, in human aortic smooth muscle cells (HASMCs). Melttin significantly suppressed MMP-9 and MMP-2 secretion, as well as TNF-α-induced MMP-9 expression in the HASMCs. In addition, we found that the inhibitory effects of melittin on TNF-α-induced MMP-9 protein expression are associated with the inhibition of MMP-9 transcription levels. Mechanistically, Melittin suppressed TNF-α-induced MMP-9 activity by inhibiting the phosphorylation of p38 and ERK1/2, but did not affect the phosphorylation of JNK and Akt. Reporter gene and western blotting assays showed that melittin inhibits MMP-9 transcriptional activity by blocking the activation of NF-κB via IκBα signaling pathway. Moreover, the matrigel migration assay showed that melittin reduced TNF-α-induced HASMC migration. These results suggest that melittin suppresses TNF-α-induced HASMC migration through the selective inhibition of MMP-9 expression and provide a novel role of melittin in the anti-atherosclerotic action.ⓒ2012Elsevier Ltd. All rights reserved.