토지의 공용수용에 따른 환매제도에 관한 연구

최봉구,이성호 釜山大學校 都市問題硏究所 2002 都市硏究報 Vol.13 No.-

The aims of this study are at large classified into twofold. First, though case laws and academic theories relating to the land expropriation, we investigate the fairness of the purpose of the land expropriation. Second, considering law reports and question-and-answer reports on the right of repurchase, we bring implicity of the institutional repurchase into the view of urban planning. In order to help people pursue a happy and comfortable life in the modern welfare-nation, it may be necessary to acquire some private land in a compulsory way prescribed in law for the construction of such public facilities as railways, roads, dams, power generation plants, housing sites and parks and so on. However, public land acquisition increase on the one land, various public projects are being delayed or given up, worsening the socio-economic conditions for them on other. Under these conditions, legislation relating to the land expropriation secure the rights of repurchase on land expropriated for the purpose of public projects. The repurchase right has developed into more details from case laws and academic theories. Though case laws and academic theories, it has been established that the repurchase right is a type of private right in which its transferability cannot be denied. Therefore, authorities and planners take part in land expropriation must afford deliberative efforts to prevent the purpose of expropriation from making a change. Because socio-economic conditions are so much fluid as time passed.

Gentamicin 제제의 약력학적 비교

최석구,신상구,박찬웅 대한화학요법학회 1984 대한화학요법학회지 Vol.2 No.2

The pharnacokinetic characteristics of 3 different gentamicin formulations, supplied from 3 different producers in Korea, were studied in 15 healthy male volunteers after a single intramuscular injection with a dose of 80mg. Serial serum drug lerels were analysed using a one compartmental open model. Serum gentamicin levels of "C" formulation were higher than those of other formulations. Pharmacokinetic parameters such as absorption rate constant, elimination rate constant and serum half-life for 3 formulations, were nearly identical. Bct areas under the curves(AUC's) for 3 formulations showed significant differences among them. Relati\-e avaiiahilities of "A" and "B" formulation to "C" formulation were 0. 67 and 0.44, respectively. So, it was considered that the differences in serum drug levels after an intram- uscular injection of gentamicin from 3 different producers might be due t o the differences in formulations or manufacturing processes.

이미드 화합물의 함량이 에폭시수주의 물성에 미치는 영향

최호섭,유공식,최상구 群山大學校 自然科學硏究所 1991 自然科學硏究 Vol.6 No.-

이미드반응물[Ⅰ] (DIDCA, diimido dicarboxylic acid), DIDCA와 에폭시를 50/50으로 반응시킨 이미드반응물[Ⅱ], DIDCA와 에폭시를 30/70으로 반응시킨 이미드반응물[Ⅲ]을 합성하였다. 반응물을 전체 액상성분중 0∼50%(중량%) 범위에서 각각 에폭시수지와 혼합하였다. 혼합물에 대하여 경화성질, 열적성질, 기계적성질, 파단면 등을 조사하였다. 이미드반응물을 포함하는 에폭시수지의 경화시간응 포함하고 있지 않은 것보다 빠르게 나타났다. 굴곡강도와 Tg는 이미드반응물 함량 20∼30%(중량)에서 가장 높은 값을 나타내었다. 이미드반응물[Ⅱ]는 섞임성, 기계적성질, 열적성질 등에서 다른 것보다 더 우수하였다. Imide compound [Ⅰ](DIDCA, diimido dicarboxylic acid), imide compound [Ⅱ](reactant of DIDCA/epoxy=50/50) and imide compound[Ⅲ](reactant DIDCA/epoxy=30/70) were each synthesized into chemical reaction. These were seperatly mixed with epoxy resin at a ratio 0∼50%(wt. %) of liquid component. Cure, thermal, mechanical and fractural properties were tested for mixtures. Cure-time of epoxy resin containing imide compound was more fast than uncontaining. Flexural strength and Tg represented vest at imide compound content 20∼30%. Imide compound[Ⅱ]was more excellent than others in miscible, mechanical and thermal properties.

정상 성인에서의 Theophylline의 약동학 및 대사에 관한 연구

최혜란,신상구,이광수 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.2

Theophylline kinetics and metabolism following single intravenous infusion of theophylline dose (6mg/kg) were examined in 8 young non-smoking adults. Study design stressed stringent control of several external factors known to influence theophylline metabolism. The concentrations of theophylline were analyzed over a 24-hr period in plasma. Theophylline and its major metabolites were measured over a 96-h period in urine after the given dose. A 2-compartment model was required to describe the theophylline plasma concentration time course in all 8 subjects. The results are as follows. 1. Theophylline is quickly transferred from plasma to tissue with high rates of intercompartmental clearance (mean ±S.D; 1.04 ± 0.53 L/min). Steady-state volume of distribution of theophylline showed little intersubject variability with average of 0.42 ± 0.02 L/kg. 2. The elimination half-life of theophylline varied greatly among subjects and ranged from 4.56 to 11. 11 hours, Similarly, the non-renal clearance also showed wide intersubject variation (coeffient of variation; 35%). 3. The unbound fraction of theophylline was 62.6 ± 4.1% at the plasma concentration around 10 ㎍/ml. 4. About 82% of theophylline administered was recovered until 96-hr after dose as unchanged form or major metabolites. A 17.55% of theophylline was excreted in urine as unchanged form. Molar fraction of theophylline metabolites 1.3-dimethyl uric acid, 3-methylxanthine and 1-methyl uric acid excreted in urine were 35.14%, 11.62% and 17.64%, respectively. From the above results, It is suggested that great variation of theophylline elimination half-life seems to be mainly due to wide intersubject variation of non-renal clearance of theophylline. Importance of including an assessment of plasma protein binding in studies of theophylline disposition would be emphasized, because theophylline metabolism showed a restrictive pattern. Incomplete recovery of theophylline from the administered dose imply the possbility of exsistence of additional minor pathways in theophylline disposition, which could not be identified in the study.

흡착특성이 다른 내분비계 장애물질 3종, Amitrol, Nonylphenol, Bisphenol-A의 GACs에서의 흡착 특성

최근주,김상구,권기원,지용대,김승현,김창원 한국물환경학회 2004 한국물환경학회지 Vol.20 No.3

Adsorption characteristics of three endocrine disruptors, amitrol, nonylphenol, and bisphenol-A, were evaluated depending on the type and service duration of activated carbon (AC). Bituminous coal-, wood-, and coconut-based coals were tested. Bituminous coal-based AC (BCAC) had the greatest sorption capacity for the three chemicals tested, followed by wood-based AC (WAC) for nonylphenol and coconut palm-based AC (CAC) for bisphenol-A. During the column test, amitrol removal efficiency increased over time, indicating that hydrophilic endocrine disruptors are biodegraded in the AC column. Removal efficiencies of hydrophobic compounds such as nonylphenol and bisphenol-A decreased over time since the main removal mechanism was adsorption. The order of the amitrol removal was: BCAC-5.9 yr , CAC-3.1 yr > BCAC-2.2 yr > BCAC-virgin > CAC-virgin > WAC-virgin > WAC-3.1 yr. In general, used AC had greater removals than virgin AC. The order of the bisphenol-A removal was: CAC-virgin > BCAC-2.2 yr > CAC-3.1 yr > WAC-virgin > BCAC-5.9 yr > WAC-3.1 yr. The order of the nonylphenol removal was: BCAC-virgin > WAC-virgin > CAC-3.1 yr ,WAC-3.lyr> BCAC-2.2 yr > BCAC-5.9 yr > CAC-3.1 yr. Bituminous coal AC performed the best over time. Endocrine disruptors such as these three compounds appear to be removed effectively by activated carbon through biodegradation and adsorption. Wood and coal based among the virgin ACs and 3.1 years used wood base among the used ACs appeared the lowest carbon usage rate(CUR) for nonylphenol removal by prediction model. Virgin and used coconut base ACs except BCAC had the lowest CUR for removal Bisphenol-A. Biodegradation of nonylphenol and Bisphenol-A did not occurred during the 9,800 bed volume experiment period. BCAC had the highest biodegradation capacity of 46% for amitrol among virgin ACs and the used coal based ACs had 33-44% higher biodegradation capacity than virgin's for amitrol so biodegradation is the effective removal technology for hydrophilic material such as amitrol.

Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

저수온기 돔류의 녹간증 혈청성분

최혜승,박승렬,정춘구 한국어병학회 2002 한국어병학회지 Vol.15 No.1

본 연구는 2001년 3월에서 5월까지 어류 해상가두리 양식장에서 사육하고 있던 찰돔, Pagrus major, 감성돔, Acanthopagrus schlegeli 및 돌돔, Oplegnathus fasciatuas과 육상에서 사육한 강담돔, Oplegnathus punctatus의 혈청성분을 분석하여 월동시기 이후에 돔류의 폐사원인으로 판단되는 녹간증을 나타내는 병어의 혈청생화학성분을 분석하여 생화학적특성을 조사하고자 하였다. 조사한 어류는 양식자의 그물 가장자리에서 균형을 잃고 옆으로 눕거나 뒤집어져 유영하는 개체들을 수집하여 혈액을 체취, 혈청을 분리한 후 생화학분석기(DRI-CAM 3000)으로 Albumin 의 9가지의 혈청성분을 분석한 결과, GOT, GPT값이 정상어에 비해 매우 높아 돔류의 정상적인 간기능에 장애가 생긴 것으로 판단되었다. 또한 Albumin, Ca, Glucose 값에는 뚜렷한 영향을 주지 않았으나 NH_3는 기준값에 비해 다소 높았다. TBIL, TP, UA는 정상어에 비해 매우 낮은 수치였다. 따라서 이러한 돔류에는 겨울철 저수온으로 사료를 정상적으로 먹지 못하여 어체에 영향결핍을 초래하고 있어 저수온 스트레스 등의 생태습성 부적합에 의하여 논간현상이 발생하는 것으로 판단되었다 A blood biochemical analysis was carried out for the serum of wintering sea bream (red sea bream Pagrus major, black sea bream Acanthopagrus schlegeli, rock bream Oplegenathus fasciantuas) with green liver syndrome. GOT and GPT were significantaly elavated in the diseased sea bream. The value of NH_3 was slightly higher but those of TBIL. TP and UA were lower than the control. But there were no differences in albumin. Ca and glucose between the diseased and the control. These results suggent that a green liver syndrome in the sea bream might be related with nutritional defects and the stress of low water temperature during the winter.

Cl_2/Ar 프라즈마에 의한 (Ba,Sr)TiO_3 박막의 식각 Damage에 관한 연구

최성기,장의구 중앙대학교 기술과학연구소 2000 기술과학연구소 논문집 Vol.30 No.-

고유전율의 (Ba,Sr)TiO_3 박막을 Cl_2/Ar의 비율을 변화하면서 ICP(inductively coupled plasma) 이용하여 식각하였다. Cl_2(20)/Ar(80)에서 최대 식각률인 400A˚/min을 얻었고, Pt와 감광막과의 선택비는 0.4와 0.2를 나타내었다. XPS (x-ray photoelectron spectroscopy), AFM(atomic force microscopy), XRD (x-ray diffraction)를 이용하여 식각 후 박막 표면을 분석하였다. 높은 비등점 때문에 Ba-Cl과 Ti-Cl 결합의 식각 잔여물이 BST 박막의 표면의그레인 사이에 재증착하여, 표면 rms 거칠기를 감소시키고 결정성을 변화시켰다. High dielectric (Ba,Sr)TiO_3 thin films were etched in an inductively coupled plasma(ICP) as a function of Cl_2/Ar gas mixing ratio. Under Cl_2(20)/Ar(80), the maximum etch rate of the BST films was 400A˚/min and selectivities of BST to Pt and PR were obtained 0.4 and 0.2, respectively. We investigated the etched surface of BST by x-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and x-ray diffraction (XRD). Residues of Ba-Cl and Ti-Cl bonds remained between grains of BST surface for high boiling point, decreased surface rms roughness and changed crystallinity of BST surface.

2-Methylisoborneol(2-MIB)제거를 위한 산화 및 흡착공정의 특성

최근주,김상구,류동춘,신판세,손인식,오광중 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

One of the Musty and earthy smell compounds in raw water is generally attributed to 2-methylisoborneol (2-MIB). It is well known that activated carbon and oxidants such as O_3, ClO_2 are effective ways to control 2-MIB. In isotherm equilibrium experiments, 2-MIB in distilled water was much more adsorbed to the activated carbon(A/C) than raw water containing dissolved organic carbon (DOC). The Freundlich constants(k) of distilled water and raw water were 3.36 and 0.049, and 1/n values were 0.80 and 0.42, respectively. The 2-MIB residual rate were Y = e^(0.55_x)~ e^(-0.54_x) with Ozone(O_3) dose by 5 minutes contact time at the 241 and 353 ng/L initial concentrations. The 2-MIB residual rate were Y = e^(-0.32_X)~ e^(-0.35_X) with Chlorine dioxide(ClO_2) dose by 15 minutes contact time at the 89 and 249 ng/L initial concentrations. 2-MIB was decreased from 1911 ng/L to 569ng/L by post-ozonation(70%removal efficiency) and removal efficiencies of 2-MIB by the following 4 kinds Granular Activated Carbon(GAC) process such as coal base, coconut base, wood base and zeolite+carbon base were 95.8, 89.5, 88.4, and 93.7% respectively.

보강섬유의 배향이 고분자 복합재료의 물성에 미치는 효과

崔相久,李和雨,洪錫杓 全北大學校 1993 論文集 Vol.35 No.-

The tensile and flexural strength of unsaturated polyester laminated with 20% glass-fiber(volume %) were tested. Those were compared with its abtained from Holister's equation. The strengths of laminated polyester were mainly depended on the properties of interface between fiber and resin than the strengths of material itself. For crossplied laminates, correct strength coincided with Holister's were not abtained, but could be explained by Holister's theory. The fractural strength of orientation angle 0∼5˚ was influenced by shear resistance besides the strength of glass fiber.