複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

BMP test를 통한 음폐수와 하수슬러지의 병합소화 특성 평가

이수영ㆍ윤영삼ㆍ강준구ㆍ김기헌ㆍ신선경(Su young LeeㆍYoung Sam YoonㆍJun Gu KangㆍKi Heon KimㆍSun Kyoung Shin) 유기성자원학회 2016 유기물자원화 Vol.24 No.1

혐기성 소화의 주요 조건 중 하나인 C/N비의 경우 하수슬러지는 5.40으로 낮게 나타난 반면 음폐수(Food waste leachate)는 21.84로 높게 나타났다. C/N비가 낮을 경우 혐기성소화의 저해 요인으로 작용될 수 있기 때문에 음폐수의 높은 유기물 농도 및 C/N 비를 활용하여 메탄가스 발생량 증가시킬 수 있었다. Tchobanoglous이 제안한 이론적 메탄가스 발생량 예측수식을 적용하여 메탄 및 바이오가스 발생량을 산정한 결과 하수슬러지 단일 혐기소화의 경우 305.6 mLㆍCH4/gㆍVS, 689.4 mLㆍCH4/gㆍVS의 메탄, 바이오가스가 발생하였고 음폐수 : 하수슬러지를 1:9로 혼합한 시료는 약 322 mLㆍCH4/gㆍVS, 3:7시료에서는 약 354 mLㆍCH4/gㆍVS, 5:5시료에서는 약 386 mLㆍCH4/gㆍVS의 메탄가스가 발생하는 것으로 분석되었다. BMP 실험 결과 1:9, 3:7, 5:5 비율로 병합 처리한 경우 각각 약 233, 298, 344 mLㆍCH4/gㆍVS의 메탄가스가 발생하였다. 따라서 음폐수의 혼합비율이 높아질수록 메탄가스 발생량은 증가하였고 하수슬러지와 음폐수의 혼합 비율에 따른 병합처리 시 하수슬러지 단독처리에 비해 다량의 메탄가스가 발생되었다. BMP 실험을 통해 생산된 메탄가스의 누적생산 곡선을 Modified Gompertz model과 first order kinetic model에 적용하여 추정한 결과, 메탄생성량은 Modified Gompertz model에서는 238.5, 302.3, 353.6 mL/gㆍVS 발생하였고 first order kinetic model에서는 242.8, 312.5, 365.5 mL/gㆍVS로 음폐수와의 혼합비율이 증가할수록 높게 나타났으며, 최대 메탄생성속도의 경우 3:7비율에서 48.2 mL/gVSㆍday로 최대 메탄생성 속도를 보였다. first order kinetic model의 1차 반응속도상수 k값은 1:9, 3:7, 5:5 비율에 따라 0.32, 0.22, 0.08day-1 나타났다. 1차 반응속도 상수의 경우 음폐수의 혼합비율이 낮을수록 높게 나타났다. Modified Gompertz와 first order kinetic model 모두 실험결과를 잘 모사하였으며, 실험결과와 모의결과의 적합도를 나타내는 상관계수(R2)의 경우 0.92∼0.98으로 높은 상관성을 나타내었다. We mix food waste leachate and sewage sludge by the proportion of 1:9, 3:7 and 5:5. It turns out that they produced 233, 298 and 344 CH4ㆍmL/gㆍVS of methane gas. The result suggests that as the mixing rate of food waste leachate rises, the methane gas productions increases as well. And more methane gas is made when co-digesting sewage sludge and food waste leachate based on the mixing ratio, rather than digesting only sewage sludge alone. Modified Gompertz and Exponential Model describe the BMP test results that show how methane gas are produced from organic waste. According to the test, higher the mixing rate of food waste leachate is, higher the methane gas productions is. The mixing ratio of food waste leachate that produces the largest volume of methane gas is 3:7. Modified Gompertz model and Exponential model describe the test results very well. The correlation values(R2) that show how the results of model prediction and experiment are close is 0.92 to 0.98.

최근 10년간 원광의대병원에서 시행한 소아 심장혈관 수술의 임상적 고찰

윤향석,정수미,최두영,오광수,오연균,김종덕,양현웅,이삼윤,김형곤,최종범,최순호,노병석 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

We reviewed 10 years experiences of the clinical aspects and early postoperative results in 544 pediatric patients(age less than 16 years old). Among them. 529 cases had the congenital heart diseases, and 15 had the acquired diseases. Open heart surgery was performed in 413 patients. 115 cases were treated with non-open heart surgery. 16 with interventional catheterization. Annual increase of the cardiac patients was not significant in recent 10 years, except slight increase in 1994. The mean age of the study patients had been evidently changed to younger year by year. Total mortality rate of the open heart surgery was 6.4%. The cyanotic congenital heart diseases were high in early postoperative mortality by 25.7%, whereas 4% in acyanotic group. The age group less than one month was most highest in surgical mortality(66.7%). There were no deaths in patients with patent ductus arteriosus(103 cases), atrial septal defect(83 cases) or pulmonary stenosis(17 cases). Among 220 patients with ventricular septal defects(VSD). 10(4.5%) were died early postoperatively. In cyanotic group, the patients with pulmonary atresia with ventricular septal defects(PAVSD), transposition of the great arteries(TGA), interrupted aortic arch(IAA), complex cardiac anomalies with isomerism seemed to be most susceptible to an early death.

중성자 collimator의 제작 및 Am-Be 중성자 파고스펙트럼 측정

윤정란,노태익,민영기,이삼열 東亞大學校 1997 東亞論叢 Vol.34 No.-

The neutron collimator, 20cm width, 30cm length, 15cm height and 1cm diameter of hole was constructed by using polyethylene block which includes 15% boric acid. The total cross section of average 7.7MeV neutrons for Al, Cu, Au, Pb samples and the scattering angular distribution of the same energy for Al sample were measured by using 10mCi Am-Be fast neutron source. The range of average 7.7MeV neutron energy were selected from 6.45 MeV to 8.95MeV at the measured pulse height spectrum.2"Φ×2" NE-213 organic liquid scintillation detector was used on the measurement of neutron flux. The Pulse Shape Discrimination(P.S.D.) methods were used for the spectra separation of neutron with r-ray at the mixed field. The results of measurement of total cross section and scattering angular distribution for average 7.7MeV neutrons were compared with other researcher’ and ENDF/B-VI, respectively.

기술, 직무구조와 노동소외

金榮治,尹榮三 慶南大學校 産業經營硏究所 1990 産業經營 Vol.13 No.-

^161, ^163Dy의 0.003eV~50keV의 중성자 포획 단면적 측정

민영기,윤정란,노태익,김귀년,이삼열 東亞大學校附設基礎科學硏究所 2002 基礎科學硏究論文集 Vol.19 No.1

교토대학 원자로 연구소의 46MeV 전자선형가속기를 사용하여 중성자 TOF 방법으로, 에너지 영역 0.003eV∼50keV의 ^161, 163Dy sample의 중성자 포획 단면적을 측정하였다. 본 실험에서 사용된 Bi_4Ge_3O_12(BGO) 섬광 검출기는 sample의 핵반응에서 나오는 즉발 포획 감마선 측정에 사용하였다. 이 검출기는 중성자 선원으로부터 거리 12.7±0.02m 위치에 12개의 블록으로 되어 있으며, sample에 포획되는 중성자 flux의 절대치를 구하기 위해 Sm(n, γ) 및 ^10B(n, αγ) 반응을 이용하였다. ^161, 163Dy에 대한 포획 단면적 측정결과는 ENDF/B-VI 결과와 비교하였다. The neutron capture cross sections of ^161, 162Dy has been measured in the energy region from 0.003eV 50keV by using the neutron time-of-flight(TOF) promptγmethod with a 46MeV electron linear accelerator at the Research Reactor Institute, Kyoto University. An assemble of twelve pieces of BGO scintillation detectors, which was placed at a distance of 12.7±0.02mm from the neutron source, was employed as a total energy absorption detector for the prompt capture gamma-ray measurement, to obtain the absolute capture cross section value. The sample of ^161, 163Dy is a form of metallic plate. An enriched boron sample was employed to monitor the neutron flux/spectrum of the TOF beam using the standard reference cross section of the ^10B(n, αγ) reaction. Previous measurements and evaluated data in ENDF/B-VI was compared with the present results.

沙上地域 産業體 勞動者의 職場體育 參與擴大 方案

安永弼,鄭琮勳,鄭三鉉,金海禮,趙在基,朴俊東,金垠利,張禎允,金福善,孔庚鎬 東亞大學校附設스포츠科學硏究所 1989 스포츠科學硏究論文集 Vol.7 No.-

췌십이지장절제술 후 발생한 지속적인 구토증과 Wernicke 뇌병증

박우영,김성완,이삼연,신일선,김재민,박기형,양수진,윤진상 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Wernicke encephalopathy is an acute neurologic disorder attributable to thiamine (vitamin B1) deficiency. We report the case of a 61-year-old female patient who presented Wernicke encephalopathy after surgery for pancreatic head cancer. From the ninth postoperative day, she had suffered from nausea and vomiting and had difficulties ingesting food, she was given total parenteral nutrition (TPN), but lacked adequate vitamin (thiamine) supplementation. After 28 days, she developed ataxia, ophthalmoplegia, and mental confusion. The magnetic resonance image showed pathologic changes in the medial thalamus,periaqueductal gray matter, medulla and mamillary bodies. The blood level of thiamine was very low. After intravenous and oral supplementation of thiamine (200 mg/day), consciousness was soon normalized and neurologic symptoms have gradually been improving. Nausea and vomiting disappeared after administration of a low dose of mirtazapine (7.5 mg/day). We emphasize the importance of thiamine supplementation to the patients who suffer from vomiting which hinders them from taking food and who require prolonged TPN.

전이성 뇌종양에 대한 고식적 방사선치료의 결과

고영삼,오윤경,남택근 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Obiectives : To evaluate the role of palliative radiotherapy in the treatment of metastatic brain tumor with respect to response, survival and prognostic factors, retrospectively Materials ðods : From Jan 1998 to Jan 2003, a total of 57 patients diagnosed as metastatic brain tumor were referred for palliative radiotherapy Of them, forty-four patients were eligible for this study. The most common primary tumor was lung cancer in 31 patients (70.5%). A total doses of 27.5-40.0 Gy were delivered to whole brain with daily doses of 2.0-3.0 Gy To evaluate the treatment response, all patients were evaluated by neurological functional classification prior to and after radiotherapy Results : The positive response was noted in 36 patients (81.8%) and 8 patients (18.2%) did not improve. The median survival time of all patients was 6 months. 1-and 2-year survival rates were 17.4% and 2.9%, respectively. The median survival time of patients younger than 60 vs older were 9 vs 4 months (p=0.009), respectively. The median survival time of patients with stable vs progressive vs unknown primary status were 9 vs 4 vs 5 months (p=0.003), respectively Multivariate analysis showed that age and primary tumor status were independently significant prognostic factors affecting survival. Conclusion : The radiotherapy could relieve neurological symptoms effectively and promptly in most patients and prolong survival of patients. The most significant factors affecting survival were age and primary tumor status, and therefore more definitive treatment modality including surgical resection or radiosurgery should be considered in the patients with favorable prognostic factors.