경기지역 일부 이주노동자들의 직무스트레스와 우울 증상의 상관성

이선웅,김규상,김태균,류향우,이미영,원용림,송윤희 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

목적 경기지역 일부 이주노동자들의 우울 증상을 파악하고 이에 영향을 미치는 요인을 평가하기 위해 직무스트레스를 중심으로 상관성을 분석하고자 하였다 방법 경기지역 9개 이주노동자 센터에 방문한 이주노동자 488명을 대상으로 12개국 언어로 번역된 구조화된 설문지를 사용하였다 조사항목은 사회 인구학적 및 작업관련 요인 건강행태 과거력 직무스트레스 우울 증상이었으며 직무스트레스는 8개 하부항목이 포함된 한국형 직무스트레스 측정도구K0SS-26을 사용하였다 우울 증상은 조맹제 등이 번역한 CES-D 번역판을 사용하였다 단변량 분석결과 유의한 관련 요인과 직무스트레스를 독립변수로 하여 우울 증상자 유무에 대한 다중 로지스틱희귀분석을 시행하여 관련 위험요인들의 상관성을 평가하였다 결과 연구대상 전체의 우울 증상율은 25.2%였지만 비중국 국적 및 불법 체류자는 각각 32.1%, 32.8%에 달하는 결과를 보였다 관련 혼란변수를 보정한 상태에서 직무스트레스 요인(OR 2.55 95% CI=1.30-4.99)이 우울 증상과 유의한 상관성을 나타내었으며 직무스트레스 하위영역 중 물리환경(OR 2.97 95% CI=1.59-5.53) 직무요구(OR 2.33 95% CI=1.26-4.32) 및 직장문화(OR 3.10 CI=1.49-6.48)가 우울 증상자 발생과 유의한 상관성을 나타냈다 결론 연구대상의 우울 증상율은 국내 일반인구집단과는 비슷한 수준이나 국내 근로자 집단에 비해서는 높았으며 특히 내부집단별로 비 중국국적 및 불법 체류자의 우울 증상율이 높았다 하지만 국적구분과 체류자격의 사회인구학적요인보다 직무스트레스요인이 이주노동자들의 우울증상과 보다 직접적인 상관이 있는 것으로 판단되어 이주노동자들의 우울 증상 발생을 예방하기 위해서는 효과적인 직무스트레스 중재방안이 조치되어야 할 것으로 판단된다. Objectives To investigate the mental health status of migrant workers We focused on the relationship between depressive symptoms and job stress Metheod A questionnaire was administered to 488 migrant workers who visited NGO migrant worker centers located in Kyung-gi province A structured self-reported questionnaire was used to assess each responder's sociodemographics work related characteristics health behaviors past medical history job stress and depression symptoms The job stress questionnaire was used according to K0SS-26 and depression symptoms were measured using CES-D which was translated into Korean We used multiple logistic regression analysis to assess the relationship between risk factors included job stress and depression symptoms Results The prevalence of depression symptoms in survey subjects was 25.2%, but the prevalence of non Chinese nationalities and illegal workers were 32.1% and 32.8% respectively Adjusting for confounding factors job stress (OR 2.55, 95% CI=1.30-4.99) had a statistical meaningful relationship with depression symptoms Among job stress domains, physical environment (OR 2.97 95% CI=1.59-5.53) job demand (OR 2.33 95% CI=1.26 4.32) and occupational climate(0R 3.10 CI=1.49-6.48) were most likely to experience depression symptoms Conclusions The prevalence of depressive symptoms among the study subjects was similar to the prevalence among the general population in Korea but higher than that among the Korean workers In particular, the prevalence among non-Chinese and illegal workers was higher However, the job stress factor appeared to have a more direct correlation with depressive symptoms than the sociodemographic factors of nationality or residential status Hence in order to prevent depressive symptoms of the migrant workers we believe that intervention on job stress is necessary

오렌지로부터 아플라톡신B₁의 정량분석에 관한 연구

장향동,백광균,구경림,옥선미,최진석,고은주,류성렬 한국공업화학회 2004 응용화학 Vol.8 No.2

Aflatoxin B₁ was known to have the strongest poisonous character among Aflatoxin compounds. To search the production of Aflatoxin B1 according to the change of temperature, relative humidity and incubation days, orange incubated with Aspergillus parasiticus KCCM 35078 was incubated at 20℃, 25℃, 30℃ at relative humidity 60%, 70%, 80% and for incubation time 3, 4, 5, 6, 7 days.. Production of Aflatoxin B₁ shows that the highest production appeared at 25℃ and its relative humidity 70%. The result that was quantitatively analyzed by using HPLC was 77.41ppm, and by using Fluoroscence detector was 87.87ppm. - Production of Aflatoxin B₁ shows that the lowest production appreared at 20℃ and its relative humidity 80%(HPLC), 60%(Fluoroscence detector). The result that was quantitatively analyzed by using HPLC was 4.47ppm, and by using Fluoroscence detector was 4.17ppm. The structure of Aflatoxin B₁ was identify with authentic sample by using instrumental analysis methods of GC/MS, ¹H-NMR, FT-IR respectively.

Production of Lactic Acid through Cell Recycle Repeated-Batch Fermentation of Lactobacillus sp. RKY2

Hyang-Ok Kim(김향옥),Young-Jung Wee(위영중),Jin-Nam Kim(김진남),Jong-Sun Yun(윤종선),Hwa-Won Ryu(류화원) 한국생물공학회 2004 한국생물공학회 학술대회 Vol.2004 No.10

Production of Lactic Acid from Cheese Whey by Batch Culture of Lactobacillus sp. RKY2

Hyang-Ok Kim,Young-Jung Wee,Jong-Sun Yun,Hwa-Won Ryu 한국생물공학회 2005 한국생물공학회 학술대회 Vol.2005 No.4

Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity

Ryu, Hyang Joo,Kim, Eun Kyung,Cho, Byoung Chul,Yoon, Sun Och John Wiley Sons, Inc. 2019 Head & Neck Vol.41 No.1

<P><B>Abstract</B></P><P><B>Background</B></P><P>The purpose of this study was to comprehensively characterize head and neck squamous cell carcinoma (HNSCC) arising in young patients (<45 years old).</P><P><B>Methods</B></P><P>We performed immunohistochemistry, silver, and fluorescence in situ hybridization using samples obtained from 396 radically resected cases among 1787 HNSCCs.</P><P><B>Results</B></P><P>Young age HNSCCs occurred in 10.9% (194/1787) and were most common in the oral tongue (50.5%). They revealed distinctively lower frequency of p16 positivity, high c‐MET expression, <I>MET</I> copy number gain, and lower pan‐Trk expression. PD‐L1 positivity in tumor cells and ICOS+ tumor infiltrating lymphocytes (TILs) were higher in the young age. Perineural invasion, PD‐L1 positivity, and higher ratio of CD163+ tumor infiltrating macrophages to CD8 + TILs were determined to be independent factors for poor progression‐free survival.</P><P><B>Conclusion</B></P><P>Characterizing these features of young age HNSCC may help to identify the underlying pathogenesis and to improve patient outcome through different treatment strategies.</P>

The implications of TrkA and MET aberrations in de novo salivary duct carcinoma

Ryu, Hyang Joo,Koh, Yoon Woo,Yoon, Sun Och Elsevier 2018 Human pathology Vol.81 No.-

<P><B>Summary</B></P> <P>Salivary duct carcinoma (SDC) is an aggressive carcinoma with poor prognosis. Although anti-HER2 therapy is a potential treatment option for HER2-positive SDC, other potential therapeutic targets are not known, in particular for HER2-negative cases. In this study, the recently identified receptors tyrosine kinases MET and tropomyosin-receptor kinase (Trk) were investigated as potential therapeutic targets. A total of 28 consecutive, surgically resected, de novo SDC cases were selected after evaluating histology and immunohistochemical expression of androgen receptor. Immunohistochemical expression of c-erb2, TrkA, TrkB, TrkC, and c-MET was analyzed, and the genetic status of the <I>HER2</I> and <I>MET</I> genes was investigated through dual-color silver in situ hybridization. High expression of c-MET or Trk was defined as that above the median value. Among the 28 SDC cases, 64.3% (18/28) were HER2-positive. c-MET expression varied, with a median H-score of 65 (range, 0 to 200). Copy number gain and amplification of <I>MET</I> were noted in 57.1% (16/28) and 10.7% (3/28) of cases, respectively. TrkA was variably expressed, with a median H-score of 100 (range, 0 to250). High TrkA expression was significantly related to an inferior overall survival rate in HER2-negative SDC. High expression of TrkA and c-MET and <I>MET</I> copy number gain/amplification were frequent events in SDC, and high expression of TrkA revealed the tendency to be related to poor prognosis in HER2-negative SDC. TrkA and MET may be possible therapeutic targets in SDC, especially in HER2-negative SDC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Salivary duct carcinoma (SDC) is an aggressive carcinoma </LI> <LI> High expression of TrkA and c-MET and <I>MET</I> gene copy number gain/amplification are frequent events in SDC. </LI> <LI> High expression of TrkA reveals the tendency to be related to poor prognosis in HER2-negative de novo SDC. </LI> <LI> TrkA and MET may be possible targets in SDC and in HER2-negative SDC. </LI> </UL> </P>

Molecular Mimicry-Based Repositioning of Nutlin-3 to Anti-Apoptotic Bcl-2 Family Proteins

Ha, Ji-Hyang,Won, Eun-Young,Shin, Jae-Sun,Jang, Mi,Ryu, Kyoung-Seok,Bae, Kwang-Hee,Park, Sung Goo,Park, Byoung Chul,Yoon, Ho Sup,Chi, Seung-Wook American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.5

교육정보공개 정책네트워크의 변화 분석

최선향(Choi, Sun Hyang),류민영(Ryu Min-Young) 한국교육행정학회 2016 敎育行政學硏究 Vol.34 No.3

본 연구는 교육주체의 상호작용에 관심을 두고 교육정보공개 정책네트워크가 어떻게 변화 하는지 그 구성원, 통합성, 자원, 권력을 통해 살펴보고자 하였다. 2005년부터 2015년까지 ‘교 육정보공개’키워드로 검색된 11년간의 주요 10대 일간지 신문기사 11,018건 중 직접 관련된 기사 1,754건을 수집하여 상호작용이 드러난 기사 820건을 최종 분석하였고 그 결과 학교교 육의 절대적인 교육주체라 할 수 있는 학부모와 교사는 정책네트워크 참여 행위가 극히 미약 했음을 알 수 있었다. 구성원수가 다수이며 통합성이 높은 2007년~2008년, 2010년에도 중심참 여주체 5순위내에 해당하지 못하였고, 통합성이 매우 낮은 2013년에도 구조적틈새에 위치한 5순위내에 해당하지 못하였다. 이것은 선행연구결과를 뒷받침하는 것으로 학부모와 교사의 의견수렴을 통하여 시차적인 공개 정보 적용으로 교육정보공개 정책평가 및 환류시스템이 작 동되어야 하겠다. "Special legislation regarding the disclosure of relevant educational institutions," which is suggested by Li Juho Senator has reached the current with conflict and cooperation through the National Assembly on April 30, 2007. This study focuses on educational subjects' interaction and looks into its changing of Education Information disclosure policy networks through its members, integrity, resources and powers. From 2005 to 2015, out of the 1,574 articles I analyzed, 820 cases had interaction, which is founded Education Information disclosure on the 11,018 articles of the 10 major daily newspapers. The result is below parents and teachers who are called absolute education leaders had a very weak participation on the policy network activity. In 2007, 2008 and 2010 many members that have high interaction didn't rank 5 on central participation subject. Furthermore in 2013 people that have low interaction and structural gap didn't rank 5 either. As the pre institute result support, Education Information disclosure policy evaluation system and exchanged system will be operated through their opinion collecting and Information disclosure application gradually.

Dy₂O₃가 첨가된 프라세오디뮴계 ZnO 바리스터의 DC 가속열화특성

류정선(Jung-Sun Ryu),정영철(Young-chul Jung),김향숙(Hyang-Suk Kim),남춘우(Choon-Woo Nahm) 대한전기학회 2001 대한전기학회 학술대회 논문집 Vol.2001 No.11

Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition

Shin, Jae-Sun,Ha, Ji-Hyang,Lee, Dong-Hwa,Ryu, Kyoung-Seok,Bae, Kwang-Hee,Park, Byoung Chul,Park, Sung Goo,Yi, Gwan-Su,Chi, Seung-Wook Informa UK (TaylorFrancis) 2015 Cell Cycle Vol.14 No.4

<P>The p53, p63, and p73 proteins belong to the p53 family of transcription factors, which play key roles in tumor suppression. Although the transactivation domains (TADs) of the p53 family are intrinsically disordered, these domains are commonly involved in the regulatory interactions with mouse double minute 2 (MDM2). In this study, we determined the solution structure of the p73TAD peptide in complex with MDM2 using NMR spectroscopy and biophysically characterized the interactions between the p53 family TAD peptides and MDM2. In combination with mutagenesis data, the complex structures revealed remarkably close mimicry of the MDM2 recognition mechanism among the p53 family TADs. Upon binding with MDM2, the intrinsically disordered p73TAD and p63TAD peptides adopt an amphipathic α-helical conformation, which is similar to the conformation of p53TAD, although the α-helical content induced by MDM2 binding varies. With isothermal titration calorimetry (ITC) and circular dichroism (CD) data, our biophysical characterization showed that p73TAD resembles p53TAD more closely than p63TAD in terms of helical stability, MDM2 binding affinity, and phosphorylation effects on MDM2 binding. Therefore, our structural information may be useful in establishing alternative anticancer strategies that exploit the activation of the p73 pathway against human tumors bearing p53 mutations.</P>