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Rajendra S. Dave,Deepak Kumar Sharma,Kamlesh R. Shah 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.4
Capparis decidua is a valuable medicinal, xerophytic plant. We aim for the first time to compare the therapeutic potency of phytochemicals employing In-silico semblance, and ADME/Tox profiling studies. A solid computational strategy may ensure financial benefits in the phases of drug development, as well as innovation and reliable outcomes. This work investigated analgesic hypocholesterolemia, antidiabetic, and anti-inflammatory potency of Capparis decidua (CD) extract using MeOH:nH:EtAc (1:1:1, v:v:v) a solvent. Hence, GC–MS were used to characterize CD extract, and further, based on Ligand– Protein interaction, revealed Campesterol as a major inhibitor found to be possessing a higher interaction affinity (In kcal/ mole; 2OYE; − 13.4, 1IR3; − 8.4, 3QNT; − 11.3, 3NUP; − 12.3, respectively), which leads to higher therapeutic potential. Further, various components were found to be bioactive including Neophytadiene, Palmitoleic acid, á-Sitosterol, Oleic acid, Rhodopin, 17-Pentatriacontene, Squalene, Piperine, 1-and, Eicosanol. Our results burlier proponent that Capparis decidua could help as a pain reliever, anti-inflammatory, and hypocholesterolemia problem, but more research is needed.
Blistering kinetics in H-implanted 4H-SiC for large-area exfoliation
Sharma Madan,Soni K.K.,Kumar Ashutosh,Ohkubo Tadakatsu,Kapoor A.K.,Singh Rajendra 한국물리학회 2021 Current Applied Physics Vol.31 No.-
Layer transfer of single-crystalline SiC based on layer splitting and wafer bonding on an alternate substrate is a viable approach to fabricate SiC power devices at a lower cost. Dependence of implantation-induced surface blistering and exfoliation of thin layers, on the implantation parameters and subsequent annealing conditions, for large area exfoliation of 4H-SiC have been studied. We report the optimization of the annealing process (one-step or two-step) and annealing parameters like temperature and time to achieve large area exfoliation of SiC. Using the F¨oppl-von Karman (FvK) theory, the pressure inside the blister cavities and implantation-induced stress inside the damage region have been studied. We deduce that pressure inside the blister depends primarily on the blister size. HRXRD analysis has been used to determine the strain relaxation behavior as a function of annealing conditions. Raman spectroscopy and STEM measurements revealed the formation of defects inside the material due to ion implantation. AFM, Nomarski, and SEM were used to measure the size and depth details of the blisters as a function of annealing temperature and time. We have successfully exfoliated large area (up to 500 μm) in a two-step annealing process. The results reported in this paper are useful for SiC layer transfer on an arbitrary substrate by the Smart Cut process.
Kumar, Nishant,Ganguly, Indrajit,Singh, Rajendra,Deb, Sitangsu M.,Kumar, Subodh,Sharma, Arjava,Mitra, Abhijit Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.7
The PCR- restriction fragment length polymorphism (RFLP) in and around TM4 of SLC11A1 gene and its association with the incidences of brucellosis in Hariana breed (Bos indicus) and Holstein Friesian crossbred (Bos indicus${\times}$Bos taurus) cattle was examined. A fragment of 954 bp encoding the TM4 was amplified, and RFLP was identified by digestion of the amplicon independently with AluI and TaqI. The amplicon (GenBank Acc. No. AY338470 and AY338471) comprised of a part of exon V (<59 bp) and VII (62>), and entire intron 5 (423 bp), exon VI (71 bp) and intron 6 (339 bp). Digestion with AluI revealed the presence of two alleles viz, A (281, 255, 79 and 51 bp) and B (541, 255, 79 and 51 bp). The frequency of A allele was estimated as 0.80 and 0.73 in Hariana and crossbred cattle, respectively. Due to presence of a polymorphic TaqI site at intron 5, two alleles: T (552 and 402 bp) and Q (231, 321 and 402 bp) were identified. The frequency of T allele was estimated as 0.96 and 0.97, respectively. For association study, on the basis of serological tests and history of abortion, the animals were grouped into "affected" and "non-affected". However, no association could be established with the observed RFLPs.
Genetic diversity and geographic distribution of Bemisia tabaci species complex in Nepal
Acharya Rajendra,Kumar Shrestha Yam,Raj Sharma Sushant,이경열 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.2
Bemisia tabaci species complex comprises at least 44 cryptic species worldwide. Here, we analyze the nucleotide sequences of mitochondrial cytochrome oxidase subunit 1 (COI) gene obtained from 76 samples of B. tabaci collected from 23 districts in Nepal. This is the first genetic and geographic study of B. tabaci species complex in Nepal. Our phylogenetic study identified the presence of three cryptic species—Asia I, Asia II 1, and Asia II 5—with high interspecific but low intraspecific variations. Among the three cryptic species, Asia II 5 was the most prevalent in Nepal, constituting 64.47% of all the sequenced samples. Based on haplotype network analysis of COI sequences, Asia II 1 was more genetically diversified than the other two cryptic species. Our results provided useful information on the genetic diversity and geographic distribution of B. tabaci in Nepal, which help monitor population changes of B. tabaci at cryptic species level and develop sustainable management strategies for its control.
( Sujan Sharma ),( Raj Kumar Shrestha ),( Siddha Br Magar ),( Prabin Gyawali ),( Rajendra Koju ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The number of people with diabetes is increasing globally; hence necessitate identifying diabetes earlier and more efficiently. Recently, American Diabetes Association (ADA) recommended the use of glycated hemoglobin (HbA1c) as an alternative to glucose based criteria for diagnosing type 2 diabetes and pre-diabetes. Previous studies have suggested that some level of discrepancy may exist between the HbA1c- and glucose-based criteria and may vary by race, ethnicity, sex, and age in various populations. Consequently, evaluation of discrepancies can help to determine which diagnostic criterion should be used to diagnose diabetes in a given population. Hence, we aimed to evaluate the discrepancies between HbA1c- and glucose-based criteria for diagnosis of diabetes and pre-diabetes in Nepalese population. Methods: A total of 2502 subjects aged 30 years or older, who attended university hospital and subjected for measurement of HbA1c, fasting plasma glucose (FPG) and 2-hour plasma glucose (PPG) level were recruited in the study. Newly diagnosed diabetes and pre-diabetes were defined by ADA-glucose based and ADA- HbA1c criteria. Statistical analyses were performed using SPSS software to evaluate discripancies. Results: The percentages of newly diagnosed individuals with diabetes were 12.87 % (322/2502) using the FPG criterion and 14.55 % (364/2502) using the HbA1c criterion. Significant discordance occurred for 3.28% (82/2502) with HbA1c- and Glucose- based criteria and for 1.68% (42/2502) with HbA1c- and FPG- criteria. Among the study subjects, 2.86 % of individuals with a FBG and 2.12% of individuals with HbA1c were found to be pre-diabetes. Conclusions: Significant discordance exists between the HbA1c- and glucose- based diagnostic criteria for diagnosis of diabetes and pre-diabetes in Nepalese population. Hence, we concluded that using glucose based criteria merely may result in an underestimation of diabetes and pre-diabetes.
COMPUTATION OF WEDDERBURN DECOMPOSITION OF GROUPS ALGEBRAS FROM THEIR SUBALGEBRA
Mittal, Gaurav,Sharma, Rajendra Kumar Korean Mathematical Society 2022 대한수학회보 Vol.59 No.3
In this paper, we show that under certain conditions the Wedderburn decomposition of a finite semisimple group algebra 𝔽<sub>q</sub>G can be deduced from a subalgebra 𝔽<sub>q</sub>(G/H) of factor group G/H of G, where H is a normal subgroup of G of prime order P. Here, we assume that q = p<sup>r</sup> for some prime p and the center of each Wedderburn component of 𝔽<sub>q</sub>G is the coefficient field 𝔽<sub>q</sub>.
Structure of some classes of semisimple group algebras over finite fields
Neha Makhijani,Rajendra Kumar Sharma,J. B. Srivastava 대한수학회 2014 대한수학회보 Vol.51 No.6
In continuation to the investigation initiated by Ferraz, Goo- daire and Milies in [4], we provide an explicit description for the Wed- derburn decomposition of finite semisimple group algebras of the class of finite groups G, such that G/Z(G) = C2 × C2, where Z(G) denotes the center of G.
STRUCTURE OF SOME CLASSES OF SEMISIMPLE GROUP ALGEBRAS OVER FINITE FIELDS
Makhijani, Neha,Sharma, Rajendra Kumar,Srivastava, J.B. Korean Mathematical Society 2014 대한수학회보 Vol.51 No.6
In continuation to the investigation initiated by Ferraz, Goodaire and Milies in [4], we provide an explicit description for the Wedderburn decomposition of finite semisimple group algebras of the class of finite groups G, such that $$G/Z(G){\simeq_-}C_2{\times}C_2$$, where Z(G) denotes the center of G.
Saxena, Amit,Sharma, Abha,Singh, Beer,Suryanarayana, Malladi Venkata Satya,Mahato, Timir Haran,Sharma, Mamta,Semwal, Rajendra Prasad,Gupta, Arvind Kumar,Sekhar, Krishnamurthy Korean Carbon Society 2005 Carbon Letters Vol.6 No.3
Room temperature kinetics of degradation of nerve agent simulants and sarin, an actual nerve agent at the surface of different carbon based adsorbent materials such as active carbon grade 80 CTC, modified whetlerite containing 2.0 and 4.0 % NaOH, active carbon with 4.0 % NaOH, active carbon with 10.0 % Cu (II) ethylenediamine and active carbon with 10.0 % Cu (II) 1,1,1,5,5,5-hexafluoroacetylacetonate were studied. The used adsorbent materials were characterized for surface area and micropore volume by $N_2$ BET. For degradation studies solution of simulants of nerve agent such as dimethyl methylphosphonate (DMMP), diethyl chlorophosphate (DEClP), diethyl cyanophosphate (DECnP) and nerve agent, i.e., sarin in chloroform were prepared and used for the uniform adsorption on the adsorbent systems using their incipient volume at room temperature. Degradation kinetics was monitored by GC/FID and was found to be following pseudo first order reaction. Kinetics parameters such as rate constant and half life were calculated. Half life of degradation with modified whetlerite (MWh/NaOH) system having 4.0 % NaOH was found to be 1.5, 7.9, 1206 and 20 minutes for DECnP, DEClP, DMMP and sarin respectively. MWh/NaOH system showed maximum degradation of simulants of nerve agents and sarin to their hydrolysis products. The reaction products were characterized using NMR technique. MWh/NaOH adsorbent was also found to be active against sulphur mustard.