Heterogeneous Sensor-Based Target Tracking With Constant Time Delay

Qilong Wang,Yu Zhang 한국항공우주학회 2021 International Journal of Aeronautical and Space Sc Vol.22 No.1

Aiming to address the problem of constant-step-lag in-sequence measurements (CISM) in the process of heterogeneous sensor tracking, an Unscented Transformation-based CISM indirect update algorithm is proposed in this paper. First, based on the classical A1 algorithm, Unscented Transformation is applied to the nonlinear measurement equation to solve the computation of nonlinear systems. This method does not need to solve the Jacobian matrix or Hessian matrix of nonlinear equations. Second, combined with the complementarity of information from heterogeneous sensor systems, CISM is further analyzed, and an indirect update algorithm is proposed to obtain the approximate estimate of the current time of the delay information, which is substituted into UT-A1 to complete a delay information update algorithm that is suitable for the heterogeneous sensor system in this paper. Finally, the experimental results show that the UT-CISM indirect update algorithm can effectively improve the real-time capability and accuracy of the time-delay sensor system in this paper.

元朝帝師入思巴對中國文化的貢獻

王??(Wang Qilong) 영남대학교 인문과학연구소 2007 人文硏究 Vol.- No.52

元朝 帝師 파스파(1235-1280)는 티베트불교 薩迦派의 유명한 승려로서 중국 역사에 있어 독특하면서도 중요한 지위를 점하고 있다. 그는 원조를 개창한 쿠빌라이의 종교 스승(帝師)으로서 원조 중앙정부가 티베트를 통일하는 데에 커다랗게 기여하였기 때문에, 그를 연구하는 중국 내외의 학자들은 대부분 그의 정치방면의 활동에 대해 치중하여 연구를 진행하였을 뿐, 다른 방면 예컨대 그가 이루어낸 문화방면에 대한 공헌 등에 대해서는 거의 다루지 않았다. 그렇기 때문에 본 논문은 한문과 티베트 史料를 이용하여 “언어문자학자로서의 파스파”, “교육가로서의 파스파”, “종교문화의 전파자와 건설자로서의 파스파” 등 세 자지의 방면에서 이룩한 그의 중국문화에 대한 공헌에 대해 서술하였다. vPhags-pa (1235-1280), who was the imperial preceptor of Yuan Dynasty and a very famous monk of Saskya Sect in Tibetan Buddhism, had played a particular and important role in Chinese history. Because he was the preceptor in Buddhism for Khubilai Khan, the first emperor of Yuan Dynasty, and he played an important role in the unification which for the first time make Tibet as a part of Yuan China, thus nowadays whenever scholars talk about vPhags-pa, they always focus on his political characters and ignore others ways such as culture, religion and so on. Therefore the humble piece of writing, based on the historical source in Tibetan and Chinese, mainly describes his contributions to the development of Chinese culture in three chapters: I.vPhags-pa as a philologist; Ⅱ. vPhags-pa as an educator; Ⅲ. vPhags-pa as a disseminator and promoter in Buddhism.

Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats

Yuan Zhu,Miaomiao Wang,Jiajia Zhang,Wei Peng,Caleb Kesse Firempong,Wenwen Deng,Qilong Wang,Shicheng Wang,Feng Shi,Jiangnan Yu,Ximing Xu,Weiming Zhang 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4

This study innovatively prepared an effectivecapsaicin-loaded liposome, a nanoformulation with fewerirritants, for oral administration. The in vitro and in vivoproperties of the liposomal encapsulation were investigatedand the potential possibility of oral administration evaluated. The liposomal agent composed of phospholipid, cholesterol,sodium cholate and isopropyl myristate was prepared usingfilm-dispersion method. A level A in vitro–in vivo correlation(IVIVC) was established for the first time, which demonstratedan excellent IVIVC of both formulated and freecapsaicin in oral administration. Physicochemical characterizationsincluding mean particle size, zeta (f) potentialand average encapsulation efficiency of capsaicin-loadedliposome were found to be 52.2 ± 1.3 nm, -41.5 ±2.71 mv and 81.9 ± 2.43 %, respectively. In vivo, liposomalencapsulation allowed a 3.34-fold increase in relativebioavailability compared to free capsaicin. The gastricmucosa irritation studies indicated that the liposomal systemwas a safe carrier for oral administration. These resultssupport the fact that capsaicin, an effective drug for thetreatment of neuropathic pain, could be encapsulated inliposome for improved oral bioavailability. The excellentIVIVC of capsaicin-loaded liposome could also be a promisingtool in liposomal formulation development with anadded advantage of reduced animal testing.

Effects of different diets on the growth and development of young silkworms

Wang Yuanfei,Shu Qilong,Gu Haoyi,Feng Piao,Dai Minli,Zhu Qingyu,Liu Wei,Dai Yan,Li Fanchi,Li Bing 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4

To investigate the impact of different diets on the growth and development of the silkworm Bombyx mori (L.; Lepidoptera: Bombycidae), we conducted an analysis of differentially expressed genes (DEGs) between larvae fed an artificial diet (referred to as the AD group) and those fed mulberry leaves (referred to as the ML group) during the first, second, and third instars using RNA sequencing (RNA-Seq) technology. Our results revealed that the DEGs primarily belonged to pathways associated with lipid metabolism, carbohydrate metabolism, amino acid metabolism, the endocrine system, the nervous system, the digestive system, the immune system, and oxida tion–reduction processes. Notably, in the AD group, there was a decrease in transcript levels of genes related to amino acid metabolism synthases, while the transcript levels of antimicrobial peptide genes were up-regulated. Furthermore, genes associated with cytochrome P450 (CYP) enzymes exhibited down-regulation in the AD group. These observed changes likely contributed to the delayed growth and compromised robustness observed in the AD group. Overall, these findings provided valuable insights into the mechanisms underlying the differ ences in growth, development, disease resistance, and adversity resistance between silkworms fed an artificial diet and those fed mulberry leaves.

Transcriptional Profiling and Dynamical Regulation Analysis Identify Potential Kernel Target Genes of SCYL1-BP1 in HEK293T Cells

Wang, Yang,Chen, Xiaomei,Chen, Xiaojing,Chen, Qilong,Huo, Keke Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.9

SCYL1-BP1 is thought to function in the p53 pathway through Mdm2 and hPirh2, and mutations in SCYL1-BP1 are associated with premature aging syndromes such as Geroderma Osteodysplasticum; however, these mechanisms are unclear. Here, we report significant alterations in miRNA expression levels when SCYL1-BP1 expression was inhibited by RNA interference in HEK293T cells. We functionally characterized the effects of potential kernel miRNA-target genes by miRNA-target network and protein-protein interaction network analysis. Importantly, we showed the diminished SCYL1-BP1 dramatically reduced the expression levels of EEA1, BMPR2 and BRCA2 in HEK293T cells. Thus, we infer that SCYL1-BP1 plays a critical function in HEK293T cell development and directly regulates miRNA-target genes, including, but not limited to, EEA1, BMPR2, and BRCA2, suggesting a new strategy for investigating the molecular mechanism of SCYL1-BP1.

Finite-time Set Stabilization of Impulsive Probabilistic Boolean Control Networks via Time-variant Feedback Control

Qilong Sun,Wenying Hou,Haitao Li,Jing Wang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.11

This paper investigates the finite-time set stabilization of impulsive probabilistic Boolean control networks (IPBCNs) by designing time-variant state feedback control. Based on the semi-tensor product method, the algebraic form is established for the given IPBCNs. Then, a constructive method is proposed to design time-variant state feedback controller for the set stabilization of IPBCNs. In order to reduce the control execution time, a specific method is put forward to construct the event-triggered state feedback control (ETSFC). Furthermore, the obtained results are applied to both state synchronization and output synchronization of master-slave IPBCNs.

Transcriptional Profiling and Dynamical Regulation Analysis Identify Potential Kernel Target Genes of SCYL1-BP1 in HEK293T Cells

Yang Wang,Xiaomei Chen,Xiaojing Chen,Qilong Chen,Keke Huo 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.9

SCYL1-BP1 is thought to function in the p53 pathway through Mdm2 and hPirh2, and mutations in SCYL1-BP1 are associated with premature aging syndromes such as Geroderma Osteodysplasticum; however, these mechanisms are unclear. Here, we report significant alterations in miRNA expression levels when SCYL1-BP1 expression was inhibited by RNA interference in HEK293T cells. We functionally characterized the effects of potential kernel miRNA-target genes by miRNA-target network and protein-protein interaction network analysis. Importantly, we showed the diminished SCYL1-BP1 dramatically reduced the expression levels of EEA1, BMPR2 and BRCA2 in HEK293T cells. Thus, we infer that SCYL1-BP1 plays a critical function in HEK293T cell development and directly regulates miRNA-target genes, including, but not limited to, EEA1, BMPR2, and BRCA2, suggesting a new strategy for investigating the molecular mechanism of SCYL1-BP1.

Aptamers against ManLAM of Mycobacterium tuberculosis inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys

Qin Pan,Qilong Wang,Fengling Luo,Min Li,Xianru Xia Dongdong Shi,Xiao-Lian Zhang 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1

Tuberculosis (TB) has been a major world-wide cause of death for centuries. One-third of the world’s population is infected with Mycobacterium tuberculosis (M.tb), the etiologic agent of TB. The development of potent new anti-TB drugs is urgently needed. The major M.tb surface lipoglycans, mannose-capped Lipoarabinomannan (ManLAM) had immunosuppressive effects during M.tb infection. In this study, aptamer ZXL1 which specifically bound to ManLAM from the virulent strain M.tb H37Rv was screened out by Systematic Evolution of Ligands by EXponential enrichment (SELEX). The binding affinity of ZXL1 to ManLAM was measured as 8.907X10-8 M of quilibrium dissociation constant (Kd) value by surface plasmon resonance (SPR) analysis. We found that aptamer ZXL1 prevented the ManLAM-induced immunosuppressive effects on DCs and inhibited M. tb entry into macrophages. More importantly, we found that single injection of aptamer ZXL1 significantly prolonged the survival rate of infected mice, and prevent the infected rhesus monkeys from weight loss. The Bacterial numbers were significantly lower in the lungs and spleens in ZXL1-treated groups. These results suggest that aptamer ZXL1 can be used as antimycobacterial agent or as TB vaccine adjuvent.

The role of La content on microstructure and magnetic characteristics of the Sr1-x LaxFe11.80Cu0.20O19 hexagonal ferrites

Yujie Yang,Fanhou Wang,Juxiang Shao,Qilong Cao 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.6

Hexagonal ferrites Sr1-xLaxFe11.80Cu0.20O19 magnetic powders and magnets were prepared by the solid state reaction. The phasecompositions of the magnetic powders were identified by X-ray diffraction. There is a single magnetoplumbite phase in themagnetic powders with x from 0.12 to 0.32, and for the magnetic powders with x ≥ 0.36, the LaFeO3 phase is observed. Themicrostructures of the magnets were investigated by a field emission scanning electron microscopy. The magnets are formedof hexagonal-shaped crystals and the particles are distributed homogeneously. The magnetic properties of the magnets weremeasured by a magnetic properties test instrument. The remanence of the magnets increases with x from 0.12 to 0.40. However,the intrinsic coercivity, magnetic induction coercivity and maximum energy product of the magnets first increase with x from0.12 to 0.24, and then begin to decrease when x continues to increase.

Ficolin2 defends against virulent Mycobacteria tuberculosis infections in vivo and its insufficiency is associated with infections in human

Fengling Luo,Yubin Wang,Xiaoming Sun,Qilong Wang,Yunfeng Ma,Qin Pan,Xiao-Lian Zhang 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1

Tuberculosis (TB) caused by Mycobacterium tuberculosis (M.tb) remains a major global health problem. Human ficolin2 (L-ficolin/P35) is a recently identified lectin complement pathway activator present in normal plasma associated with infectious diseases, however, little is known about the roles and mechanisms of ficolin2 during M.tb infection.We describe in this study for the first time L-ficolin expression levels in tuberculosis (TB) patients. We found that serum levels of ficolin2 of 107 pulmonary TB patients were much lower compared with 107 healthy controls, and recurrence TB patients have even lower levels than onset TB patients. In vitro analysis showed that Ficolin2 bound to virulent M.tb H37Rv strain much stronger than to non-virulent M. bovis BCG and M. smegmatis. Ficolin2/ficolin A bound to the H37Rv surface glycolipid portion and blocked H37Rv infection to human lung A549 cells. We further determined that the extrogenous ficolin2 had remarkable protecting effects against virulent H37Rv strain infections in C57BL/6J mice. FicolinA (ficolin2 like molecule) knockout mice had greatly increased susceptibility to the H37Rv infection. Ficolin2 activated macrophages via phosphorylation of JNK and stimulated IFN-□, IL-17, TNF-□ and nitric oxide (NO) secretions. Ficolin2 also stimulated IFN-□ production of CD8+T cells, but not CD4+T cells. The opsono-phagocytosis was promoted by ficolin2 as well. Our data demonstrate that ficolin2 can defend against virulent M.tb H37Rv infection both in vitro and in vivo mainly via activating macrophage proinflammatory cytokines IFN-□ and NO production and opsonophagocytosis, and its insufficiency is associated with more susceptible infections in human.