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RISS 인기검색어
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- 저자 : Jiangnan Yu (검색결과 4 건)
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An Efficient Response Distribution Function for 3D MIMO Channel Modeling from a Scatterer View
Sheng Deng,Yuhao Wang,Jiangnan Yu,Henry Leung,Huilin Zhou,Bo Kong 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.10
A Radio Environment Map (REM) maps its geolocation information to the propagation characteristics as complementary information for an adaptive communication of cognitive radio (CR). In this paper we propose a novel theoretical three dimension (3D) Multiple Input Multiple Output (MIMO) channel model. The proposed model parameterizes the geolocation information of interacting obstacles referred as scatterers. An efficient response distribution function (ERDF) is developed to interpolate the array response for an arbitrary scatterer location. It is shown that the mutual information of the proposed model is consistent with a conventional geometry-based model with the lower simulation time. It allows us to generate channels with all possible scatterer distribution on the surface of a building effectively.
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Xiaoping Li,Zongping Zhang,Jiangnan Huang,Lijie Su,Mengjin Zhu,Mei Yu 한국유전학회 2013 Genes & Genomics Vol.35 No.3
In pigs, complex molecular cross-talk between the mother and embryo(s) especially maternal immunotolerance at the maternal-fetal interface has been postulated to play important roles on embryo/fetal loss during the peri-implantation and midgestation. In this study, we collected the endometrium samples in implantation sites at gestational day 15 (gd15), 26 (gd26)) and 50 (gd50)from Meishan pigs to evaluate the contribution of the genes participating in immune response by using porcine Affymetrix GeneChip.The results showed that totally 68immune related genes showed significantly differential expression at three stages, and the expression of these genes underwent drastic changes during the peri-implantation period (between gd15 and gd26). The identified genes including IL6 proinflammatory cytokine family,inflammatory chemokines (CCL28), IGF/IGFBP system,growth factors (FGF7) and adhesion molecules (ITGB3,PCDH15) may prove valuable for further investigations of porcine prenatal mortality.
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Yuan Zhu,Shanshan Tong,Li Wang,Min Peng,Xia Cao,Ximing Xu,Jiangnan Yu 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
Mixed micelles made of polyvinylpyrrolidone (PVP), sodium cholate, and phospholipids were prepared to improve the solubility of poorly water-soluble drugs. Sylibin, a drug used in treating liver diseases, was incorporated into the mixed micelles. The formulation of sylibin containing PVP-sodium cholate-phospholipid mixed micelles with an optimized composition (PVP/sodium cholate/phospholipid/silybin = 3:3:4:1~2 by weight) was obtained based on the study of pseudoternary phase diagrams. The critical micelle concentration was used to evaluate the micellar stability towards dilution. The results showed that addition of PVP to sodium-cholate-phospholipid mixed micelles increased stability. The solubility of sylibin in PVP-sodium cholate-phospholipid mixed micelles was higher than that in pure water or in sodium cholate-phospholipid mixed micelles. In a stability study, we found that PVP-sodium cholate-phospholipid mixed micelles showed good stability. After 3 months storage at 40oC, just 2.6% sylibin was lost with only minor changes of the particle size when compared to a reference formulation containing sodium cholate and phospholipid mixed micelles. In addition, the developed formulation significantly improved in vitro drug release. The time required to release 50% sylibin (t50%) from sodium cholate and phospholipid mixed micelles was 326 h, while the t50% from PVP-sodium cholate-phospholipid mixed micelles was only 51.1 h. Our results suggest that these mixed micelles might have significant potential application to the biomedical field.
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Yuan Zhu,Miaomiao Wang,Jiajia Zhang,Wei Peng,Caleb Kesse Firempong,Wenwen Deng,Qilong Wang,Shicheng Wang,Feng Shi,Jiangnan Yu,Ximing Xu,Weiming Zhang 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
This study innovatively prepared an effectivecapsaicin-loaded liposome, a nanoformulation with fewerirritants, for oral administration. The in vitro and in vivoproperties of the liposomal encapsulation were investigatedand the potential possibility of oral administration evaluated. The liposomal agent composed of phospholipid, cholesterol,sodium cholate and isopropyl myristate was prepared usingfilm-dispersion method. A level A in vitro–in vivo correlation(IVIVC) was established for the first time, which demonstratedan excellent IVIVC of both formulated and freecapsaicin in oral administration. Physicochemical characterizationsincluding mean particle size, zeta (f) potentialand average encapsulation efficiency of capsaicin-loadedliposome were found to be 52.2 ± 1.3 nm, -41.5 ±2.71 mv and 81.9 ± 2.43 %, respectively. In vivo, liposomalencapsulation allowed a 3.34-fold increase in relativebioavailability compared to free capsaicin. The gastricmucosa irritation studies indicated that the liposomal systemwas a safe carrier for oral administration. These resultssupport the fact that capsaicin, an effective drug for thetreatment of neuropathic pain, could be encapsulated inliposome for improved oral bioavailability. The excellentIVIVC of capsaicin-loaded liposome could also be a promisingtool in liposomal formulation development with anadded advantage of reduced animal testing.
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